Digital Commons Network^™

Hazards At Low-Head Dams, Riley J. Olsen, Michael C. Johnson

International Junior Researcher and Engineer Workshop on Hydraulic Structures

ABSTRACT: Low-head dams are small structures that are built for many purposes, the most common being to impound small amounts of water for various uses. At certain flow conditions, a dangerous countercurrent, known as a roller, can form downstream of a low-head dam. This current possesses an upstream directed surface velocity that can effectively trap debris, as well as unsuspecting humans, at the downstream side of the dam. It is this current that is responsible for the deaths of many individuals that have ventured too close to these structures over the years. It is the objective of this study to …

Carbon And Nitrogen Assimilation In The Bering Sea Clams Nuculana Radiata And Macoma Moesta, Jared Weems, Katrin Iken, Rolf Gradinger, Matthew Wooller

Marine Biology

We analyzed bulk carbon and nitrogen stable isotope values (delta C-13 and delta N-15) of the benthic clams Nuculana radiata and Macoma moesta from the Bering Sea during controlled feeding experiments (spring of 2009 and 2010) using isotopically labeled sea ice algae. The aim was to determine the ability of these clam species to assimilate carbon and nitrogen from sea ice algae. Specimens were collected in the Bering Sea and placed into jars without sediment (2009, N. radiata only) or into natural sediment cores (2010, both species). The clams were offered isotopically enriched (both C and N) or non-enriched algal …

The Cat Who Couldn't Take A Nap, Rebecca Saunders

English Faculty Publication Series

Cleo wakes up to discover that she has become a cat.  At first, leaping about is fun, but alas, she is an elderly cat. And soon, all she wants is to have a nice snooze.

So what keeps getting in her way?

June 16, 2012: Cfp: O-Zone: A Journal Of Object-Oriented Studies, Department Of English

Gleanings: Department of English Blog Archive

No abstract provided.

Murray Ledger And Times, June 16, 2012, Murray Ledger And Times

The Murray Ledger & Times

No abstract provided.

Resilience, Insight, And Causation As Moderators Of The Relationships Between Trauma, Perceived Stress, Distress, Depression, Salivary Cortisol, And Dhea Through A Writing Intervention In A Diverse Sample Of Hiv-Positive Individuals, Courtney Biondi Kelsch

Open Access Theses

Background: Adverse psychological factors such as depression and stressful life events have been found to accelerate HIV disease progression, while positive factors such as optimism and spirituality have been found to slow progression to AIDS. The potentially protective role of the positive psychological factor resilience in HIV/AIDS has not been studied extensively. The relationship of resilience to depression, trauma, stress, and stress-related biological markers in HIV remains to be elucidated. In addition, written emotional expression interventions have shown promise in positively influencing HIV disease course, although the mechanisms require further study. Purpose: The aims of this study were to explore …

Caribbean Bodyscapes: The Politics Of Sacred Citizenship And The Transpersonal Body, Josune Urbistondo

Open Access Dissertations

In this project I explore the relationship of sacred citizenship as an alternative and at times overlapping form of politics to national citizenship. Sacred citizenship creates a possibility of belonging for marginalized identities in Caribbean and Caribbean diasporic women’s writing. All the novels examined in this project, Cristina García’s Monkey Hunting (2004), Shani Mootoo’s Cereus Blooms at Night (2001), Patricia Powell’s The Pagoda (1998), Mayra Montero’s The Red of His Shadow (2001), Ana-Maurine Lara’s Erzulie’s Skirt (2006), and Daína Chaviano’s The Island of Eternal Love (2008), depict protagonists that practice restricted versions of national citizenship. Due to varying degrees of …

Ampk And Akt Differentially Regulate The Upr In Acute Lymphoblastic Leukemia: Therapeutic Implications., Jeffim N. Kuznetsov

Open Access Dissertations

Acute Lymphoblastic Leukemia (ALL) is the most common hematological malignancy and the main cause of cancer-related death in children. Current chemotherapy treatments based mainly on antifolate regimens have lead to high cure rates (≈80%), however event-free survival (EFS) for children and adults diagnosed with chemotherapy resistant phenotypes of ALL or after the relapse, continues to be dismal (EFS ∼10-20%). High-risk chemotherapy treatment based on intensification strategies and/or the use of stem cell transplantation have led to marginal improvements with limited impact on cure rates of resistant/refractory or relapsed ALL phenotypes. Our studies attempted to discover highly effective treatment strategies for …

Differential Effects Of Interleukin-17 Receptor Signaling On Innate And Adaptive Immunity During Central Nervous System Bacterial Infection., Debbie Vidlak, Tammy Kielian

Journal Articles: Pathology and Microbiology

Although IL-17A (commonly referred to as IL-17) has been implicated in the pathogenesis of central nervous system (CNS) autoimmune disease, its role during CNS bacterial infections remains unclear. To evaluate the broader impact of IL-17 family members in the context of CNS infection, we utilized IL-17 receptor (IL-17R) knockout (KO) mice that lack the ability to respond to IL-17, IL-17F and IL-17E (IL-25). In this article, we demonstrate that IL-17R signaling regulates bacterial clearance as well as natural killer T (NKT) cell and gamma-delta (γδ) T cell infiltrates during Staphylococcus aureus-induced brain abscess formation. Specifically, when compared with wild-type (WT) …

Family Affairs Newsletter Business Directory 2012-06-15, Zack Paakkonen

Family Affairs newsletter (2004-2016)

Family Affairs Newsletter Directory of GLBTQIA Businesses.

Digital Community Voices Committee Programming Inventory For July 2012 Meeting, Dana Neugent, Joseph A. Santiago

Digital Community Voices Committee

Digital Community Voices Committee Programming Inventory for the July 2012 meeting. This will be used by the committee to decide what to show on PBS and RI Interstate in order to showcase past and future diversity programing here at URI.

Probing Structural Selectivity Of Synthetic Heparin Binding To Stabilin Protein Receptors, Elizabeth H. Pempe, Yongmei Xu, Sandhya Gopalakrishnan, Jian Liu, Edward N. Harris

Department of Biochemistry: Faculty Publications

As one of the most widely used drugs worldwide, heparin is an essential anticoagulant required for surgery, dialysis, treatment of thrombosis, cancer, and general circulatory management. Stabilin- 2 is a scavenger clearance receptor with high expression in the sinusoidal endothelium of liver. It is believed that Stabilin- 2 is the primary receptor for the clearance of unfractionated and low molecular weight heparins in the liver. Here, we identify the modifications and length of the heparin polymer that are required for binding and endocytosis by both human Stabilin receptors: Stabilin-2 and its homolog Stabilin-1 (also found in liver endothelium). Using enzymatically …

Autophagy And Senescence In Cancer-Associated Fibroblasts Metabolically Supports Tumor Growth And Metastasis Via Glycolysis And Ketone Production., Claudia Capparelli, Carmela Guido, Diana Whitaker-Menezes, Phd, Gloria Bonuccelli, Renee Balliet, Timothy G Pestell, Allison F Goldberg, Richard Pestell, Anthony Howell, Sharon Sneddon, Ruth Birbe, Aristotelis Tsirigos, Ubaldo E. Martinez-Outshoorn, Federica Sotgia, Michael P. Lisanti

Department of Stem Cell Biology and Regenerative Medicine Faculty Papers & Presentations

Senescent fibroblasts are known to promote tumor growth. However, the exact mechanism remains largely unknown. An important clue comes from recent studies linking autophagy with the onset of senescence. Thus, autophagy and senescence may be part of the same physiological process, known as the autophagy-senescence transition (AST). To test this hypothesis, human fibroblasts immortalized with telomerase (hTERT-BJ1) were stably transfected with autophagy genes (BNIP3, CTSB or ATG16L1). Their overexpression was sufficient to induce a constitutive autophagic phenotype, with features of mitophagy, mitochondrial dysfunction and a shift toward aerobic glycolysis, resulting in L-lactate and ketone body production. Autophagic fibroblasts also showed …

Ctgf Drives Autophagy, Glycolysis And Senescence In Cancer-Associated Fibroblasts Via Hif1 Activation, Metabolically Promoting Tumor Growth., Claudia Capparelli, Diana Whitaker-Menezes, Carmela Guido, Renee Balliet, Timothy G Pestell, Anthony Howell, Sharon Sneddon, Richard Pestell, Ubaldo E. Martinez-Outshoorn, Michael P. Lisanti, Federica Sotgia

Department of Stem Cell Biology and Regenerative Medicine Faculty Papers & Presentations

Previous studies have demonstrated that loss of caveolin-1 (Cav-1) in stromal cells drives the activation of the TGF-β signaling, with increased transcription of TGF-β target genes, such as connective tissue growth factor (CTGF). In addition, loss of stromal Cav-1 results in the metabolic reprogramming of cancer-associated fibroblasts, with the induction of autophagy and glycolysis. However, it remains unknown if activation of the TGF-β / CTGF pathway regulates the metabolism of cancer-associated fibroblasts. Therefore, we investigated whether CTGF modulates metabolism in the tumor microenvironment. For this purpose, CTGF was overexpressed in normal human fibroblasts or MDA-MB-231 breast cancer cells. Overexpression of …

Snoqualmia, A New Polydesmid Milliped Genus From The Northwestern United States, With A Description Of Two New Species (Diplopoda, Polydesmida, Polydesmidae), William A. Shear

Insecta Mundi

Snoqualmia, new genus, is described for two species of polydesmid millipeds from the northwestern United States: Snoqualmia snoqualmie, new species, from Washington State, and S. idaho, new species, from Idaho. Males of S. idaho possess unusually complex gonopods, perhaps the most complex to be found in the Order Polydesmida. Snoqualmia is placed in context with other polydesmid genera known from North America. The polydesmid fauna of North America is discussed, as well as characters of the gonopods of the family.

A Novel Ascaroside Controls The Parasitic Life Cycle Of The Entomopathogenic Nematode Heterorhabditis Bacteriophora, Jaime H. Noguez, Elizabeth S. Conner, Yue Zhou, Todd A. Ciche, Justin R. Ragains, Rebecca A. Butcher

Faculty Publications

Entomopathogenic nematodes survive in the soil as stress-resistant infective juveniles that seek out and infect insect hosts. Upon sensing internal host cues, the infective juveniles regurgitate bacterial pathogens from their gut that ultimately kill the host. Inside the host, the nematode develops into a reproductive adult and multiplies until unknown cues trigger the accumulation of infective juveniles. Here, we show that the entomopathogenic nematode Heterorhabditis bacteriophora uses a small-molecule pheromone to control infective juvenile development. The pheromone is structurally related to the dauer pheromone ascarosides that the free-living nematode Caenorhabditis elegans uses to control its development. However, none of the …

Ada Cty. Prosecuting Atty. V. Motorcycle Appellant's Reply Brief Dckt. 39359

Idaho Supreme Court Records & Briefs, All

No abstract provided.

Now It Is Impossible 'Simply To Continue Along Previous Lines': A Partial Design Sketch Of Enactable Social Theorizing, Peter J. Taylor

Working Papers on Science in a Changing World

A compilation of 39 notes provides the basis for two shifts: from shaping a better social theory to allowing for social theorizing; and from representing social dynamics to enacting the social theorizing so as to repeatedly define and pursue engagements in the heterogeneous dynamics that intersect in all kinds of society-making. A key move is to bring the multiple strandedness of changing social life into the center by combining, on one hand, the analysis of intersecting processes, which link across scales in the production of any outcome and in their own on-going transformation, and, on the other hand, a participatory …

Murray Ledger And Times, June 15, 2012, Murray Ledger And Times

The Murray Ledger & Times

No abstract provided.

Who Decides Whether Clarity Is Clear?: An Analysis Of Tila’S Clarity Of Disclosure Requirement In Actions By Consumers Against Creditor Card Companies, Brandon Mohr

Pace Law Review

Section 1 begins by discussing credit card usage and the levels of debt of American consumers. Section 2 outlines the history of TILA, which was promulgated by Congress in 1968, as well as the enforcement power bestowed by Congress on the Federal Reserve Board to implement TILA. This exploration also includes descriptions of Regulation Z and the Schumer Box requirements that state exactly what information needs to be clearly and conspicuously displayed in credit card application materials as well as how the information is to be displayed for consumers to review. Section 3 discusses the recent Ninth Circuit case Rubio …

Book Reviews , Criticism Editors

Criticism

Beyond Poststructuralism: The Speculations of Theory and the Experience of Reading (Ed. by Wendell V. Harris) (Reviewed by Brian G. Caraher, Queen's University of Belfast)

Sacrificing Commentary: Reading the End of Literature (Sandor Goodhart) (Reviewed by Leslie Brisman, Yale University)

Shakespeare among the Moderns (Richard Halpern) (Reviewed by Donald K. Hedrick, Charles University, Prague)

Wollstonecraft's Daughters: Womanhood in England and France, 1780-1920 (Ed. Clarissa Campbell Orr) (Reviewed by Beth Lau, California State, Long Beach)

High Contrast: Race and Gender in Contemporary Hollywood Film (Sharon Willis) (Reviewed by Alison Landsberg, Wayne State University)

Tropical Multiculturalism: A Comparative History of Race in …

Classification Of Phase Transition Behavior In A Model Of Evolutionary Dynamics, Dawn Michelle King

Theses

Amongst the scientific community, there is consensus that evolution has occurred; however, there is much disagreement about how evolution happens. In particular, how do we explain biodiversity and the speciation process? Computational models aid in this study, for they allow us to observe a speciation process within time scales we would not otherwise be able to observe in our lifetime. Previous work has shown phase transition behavior in an assortative mating model as the control parameter of maximum mutation size (µ) is varied. This behavior has been shown to exist on landscapes with variable fitness (Dees and Bahar, 2010), and …

The Body Plan Concept And Its Centrality In Evo-Devo, Katherine E. Willmore

Paediatrics Publications

A body plan is a suite of characters shared by a group of phylogenetically related animals at some point during their development. The concept of bauplane, or body plans, has played and continues to play a central role in the study of evolutionary developmental biology (evo-devo). Despite the importance of the body plan concept in evo-devo, many researchers may not be familiar with the progression of ideas that have led to our current understanding of body plans, and/or current research on the origin and maintenance of body plans. This lack of familiarity, as well as former ties between the body …

The Putative Cannabinoid Receptor Gpr55 Modulates Synaptic Plasticity In The Hippocampus, Corinne Marie Badgley

Theses and Dissertations

Endocannabinoids (eCBs) are small molecules that are capable of modulating synaptic plasticity of both excitatory and inhibitory synapses in the brain. While eCBs bind to transient receptor potential vanilloid 1 (TRPV1) and cannabinoid receptor 1 (CB1) in the central nervous system, we recently identified a form of non-CB1, non-TRPV1 mediated long term depression activated by the eCB anandamide at CA1 hippocampal stratum radiatum interneurons. GPR55, an orphan G-protein receptor, has been identified in the hippocampus and is capable of activation by eCBs, making it a good candidate for mediating this non-CB1, non-TRPV1 form of synaptic plasticity. Here we performed whole-cell …

Enhancing Trust In The Smart Grid By Applying A Modified Exponentially Weighted Averages Algorithm, Andrew T. Kasperek

Theses and Dissertations

The main contribution of this thesis is the development and application of a modified Exponentially Weighted Moving Algorithm (EWMA) algorithm, and its ability to robustly function in the face varying numbers of bad (malicious or malfunctioning) Special Protection System (SPS) nodes. Simulation results support the use of the proposed modified EWMA reputation based trust module in SPSs within a smart grid environment. This modification results in the ability to easily maintain the system above the minimum acceptable frequency of 58.8 Hz at the 95% confidence interval, when challenged with test cases containing 5, 10 and 15 bad node test cases …

Adult Vampire Bats Produce Contact Calls When Isolated: Acoustic Variation By Species, Population, Colony, And Individual, Gerald G. Carter, Ryane Logsdon, Bryan D. Arnold, Angelica Menchaca, Rodrigo A. Medellin

KIP Articles

Bat pups produce individually distinct isolation calls to facilitate maternal recognition. Increasing evidence suggests that, in group-living bat species, adults often use similar calls to maintain contact. We investigated if isolated adults from all three species of the highly cooperative vampire bats (Phyllostomidae: Desmodontinae) would produce vocally distinct contact calls when physically isolated.

Daily Eastern News: June 14, 2012, Eastern Illinois University

June

No abstract provided.

Human Breast Milk And Antiretrovirals Dramatically Reduce Oral Hiv-1 Transmission In Blt Humanized Mice, Angela Wahl, Michael D. Swanson, Tomonori Nochi, Rikke Olesen, Paul W. Denton, Morgan Chateau, J. Victor Garcia

Biology Faculty Publications

Currently, over 15% of new HIV infections occur in children. Breastfeeding is a major contributor to HIV infections in infants. This represents a major paradox in the field because in vitro, breast milk has been shown to have a strong inhibitory effect on HIV infectivity. However, this inhibitory effect has never been demonstrated in vivo. Here, we address this important paradox using the first humanized mouse model of oral HIV transmission. We established that reconstitution of the oral cavity and upper gastrointestinal (GI) tract of humanized bone marrow/liver/thymus (BLT) mice with human leukocytes, including the human cell types important for …

Trends In Mortality From Septicaemia And Pneumonia With Economic Development: An Age-Period-Cohort Analysis, Irene O.L. Wong, Benjamin J. Cowling, Gabriel M. Leung, Mary Schooling

Publications and Research

Background
Hong Kong population has experienced drastic changes in its economic development in the 1940s. Taking advantage of Hong Kong’s unique demographic and socioeconomic history, characterized by massive, punctuated migration waves from Southern China, and recent, rapid transition from a pre-industrialized society to the first ethnic Chinese community reaching ‘‘first world’’ status over the last 60 years (i.e., in two or three generations), we examined the longitudinal trends in infection related mortality including septicemia compared to trends in non-bacterial pneumonia to generate hypotheses for further testing in other recently transitioned economies and to provide generalized aetiological insights on how economic …

Unh Cooperative Extension: Supporting Farmers Markets, Saving Farms, Jim Graham

UNH Today Archive

Program connects farmers with experts, research and customers