Digital Commons Network^™

Nanoherbals In Human Healthcare: A Proposed Research And Development Roadmap Ii, Ahmad S, Hashim U

ASEAN Journal on Science and Technology for Development

Bioactive secondary metabolites derived from herbs are examined for their suitability of conversion into nanoforms having flexible morphological controls, surface stabilizations and surface functionalization. This can lead to stable chemical conjugations based on molecular recognition for their possible applications in the form of smart pharmaceuticals, nutraceuticals, cosmaceuticals and many other related areas of human healthcare using green chemistry routes. Using the principles of nanoscience and technology in association with genomics and proteomics, an attempt has been made to decipher whether a suitable form of drug discovery and targeted drug delivery like schemes are feasible in case of such nano phytochemicals …

Mda-7/Il-24; A Promising Cancer Therapeutic Agent, Hossein Hamed

Theses and Dissertations

Glioblastoma multiforme (GBM) is an aggressive cancer that affects millions of patients per year. Conventional therapies combining chemotherapeutic agents with radiation can only extend survival by a few months; therefore, there is a dire need for an effective means of treating this deadly disease. Melanoma differentiation-associated gene-7/interleukin-24 (mda-7/IL-24), currently in the early stages of FDA pre-IND drug trials, has proven to be an effective cancer specific cytokine, able to trigger the onset of mitochondrial dysfunction and/or autophagy. GBM’s have mutations that often result in the activation of cytoprotective cell signaling pathways, preventing cancer therapeutics and even MDA-7/IL-24 treatments from being …

Characterizing The Role Of Nucleosome Remodeling Factor (Nurf) In Tumorigenesis And Metastatic Progression Using Mouse Models Of Breast Cancer., Suehyb Alkhatib

Theses and Dissertations

Increasingly the role of epigenetic machinery as a bridge between underlying DNA sequence and cellular phenotype is being discovered. The establishment of a myriad of unique cellular types sharing identical gene sequences in a multicellular organism gives a broad sense for the inherent role of epigenetic influence on cell differentiation. Importantly, the epigenetic mechanisms involved in establishing cell identity unsurprisingly contribute to diseased states, including cancer. Recent research continues to elucidate contributory roles of epigenetic mechanisms, such as DNA methylation, histone modification, and microRNA regulation, in human cancers. Additionally, chromatin remodelers, such as the Nucleosome Remodeling Factor (NURF), have been …

Zackery Lewis V. Gary Alexander

2012 Decisions

USDC for the Eastern District of Pennsylvania

The Bg News June 20, 2012, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. June 20, 2012. Volume 102-Issue 107.

What's New In Spine Surgery, Keith H. Bridwell, Paul A. Anderson, Scott D. Boden, Alexander R. Vaccaro, Jeffrey C. Wang

Open Access Publications

No abstract provided.

Nanoherbals In Human Healthcare: A Proposed Research And Development Roadmap I, Ahmad S, Hashim U

ASEAN Journal on Science and Technology for Development

Bioactive secondary metabolites derived from herbs are examined for their suitability of conversion into nanoforms having flexible morphological controls, surface stabilizations and surface functionalization. This can lead to stable chemical conjugations based on molecular recognition for their possible applications in the form of smart pharmaceuticals, nutraceuticals, cosmaceuticals and many other related areas of human healthcare using green chemistry routes. Using the principles of nanoscience and technology in association with genomics and proteomics, an attempt has been made to decipher whether a suitable form of drug discovery and targeted drug delivery like schemes arefeasible in case of such nano phytochemicals using …

An Investigation Of The Nutritional Condition Of Low-Latitude Fish Larvae: Growth, Transport, And Implications For Population Connectivity, Martha J. Hauff

Open Access Dissertations

Coral reef fishes are typically characterized by a protracted pelagic larval dispersal period, which creates the potential for connectivity of geographically discrete populations. The degree to which connectivity occurs is affected not only by whether larvae are transported from one reef to another, but also by whether they reach a settlement site in adequate nutritional condition to survive the juvenile period and beyond. It is possible that larvae with different dispersal trajectories (i.e. those that are retained close to shore as compared to those that travel great distances) may differ in their condition levels, and thereby, the extent to which …

Adaptive Policy Mechanisms For Transboundary Air Pollution Regulation: Reasons And Recommendations, J. Andrew Kelly, Herman R.J. Vollebergh

Fondazione Eni Enrico Mattei Working Papers

In the context of transboundary air pollution policy the broad ambition is to achieve reductions in the level of environmental and societal damage associated with certain pollutant concentrations and exposure rates in a cost effective manner. Policy formulation and legislative frameworks in this field, such as the current National Emissions Ceiling Directive in the European Union, are challenged by the degree of scientific complexity involved, the dispersed sources of emissions, and the inherent uncertainties associated with long range forecasting under these conditions. This paper identifies the reasons why varied forms of adaptive policy mechanisms (also termed flexibilities) are necessary and …

Non-Typeable Haemophilus Influenzae Decreases Cilia Beating Via Protein Kinase Cε., Kristina L. Bailey, Tricia D. Levan, Daniel A. Yanov, Jacqueline A. Pavlik, Jane M. Devasure, Joseph H. Sisson, Todd A. Wyatt

Journal Articles: Pulmonary & Critical Care Med

BACKGROUND: Haemophilus influenzae infection of the nasal epithelium has long been associated with observations of decreased nasal ciliary beat frequency (CBF) and injury to the ciliated epithelium. Previously, we have reported that several agents that slow CBF also have the effect of activating protein kinase C epsilon (PKCε) activity in bronchial epithelial cells. The subsequent auto-downregulation of PKCε or the direct inhibition of PKCε leads to the specific detachment of the ciliated cells.

METHODS: Primary cultures of ciliated bovine bronchial epithelial cells were exposed to filtered conditioned media supernatants from non-typeable H. influenzae (NTHi) cultures. CBF and motile points were …

Daily Eastern News: June 19, 2012, Eastern Illinois University

June

No abstract provided.

Florida Sentinel Bulletin, June 19, 2012, Gwen Hayes

Florida Sentinel Bulletin Collection

The June 19, 2012, issue of the Florida Sentinel Bulletin.

W3c Semantic Sensor Networks: Ontologies, Applications, And Future Directions, Cory Andrew Henson

Kno.e.sis Publications

Plenary Talk discussing the W3C Semantic Sensor Network, including the ontology, applications, and future directions.

Political Judgement, Freedom Of Thought, And Standardized Testing: A Critical Enquiry, Matthew Edward Schuler

Dissertations

The practice of “standardized” testing has been embedded in United States federal education policy since at least the passage of the Elementary and Secondary Education Act of 1965. First and foremost, for a test to be “standardized” the knowledge tested must be assumed to be “true”—universally accepted as being outside the bounds of values. This enquiry recognizes that the primary purpose of American public education has been to prepare students for the fundamental political office of citizen. Citizens must ideally be able to make informed political judgements utilizing the full spectrum of thought—knowledge in its broadest sense including knowledge unbounded …

The Problem Of Perception, Radical Reflection, And The Body: Towards Understanding Merleau-Ponty's Post-Kantian Transcendental Philosophy, Arsalan Memon

Electronic Theses and Dissertations Archive

Merleau-Ponty is typically known for his account of embodiment or what it means to be a body. In the dissertation, Iargue that what Merleau-Ponty means by a body has not been adequately understood because the framework in which it must be understood is either ignored or inadequately interpreted. My central interpretive thesis is that Merleau-Ponty's notion of a body must be understood within a transcendental framework. To substantiate the central interpretive thesis, in Chapter 1, I examine Merleau-Ponty's proposal for a post-Kantian transcendental philosophy with which The Structure of Behavior ends. I maintain that at the basis of this proposal …

E Pluribus Unum? The Full Faith And Credit Clause And Meaningful Recognition Of Out-Of-State Adoptions, Pamela K. Terry

Fordham Law Review

No abstract provided.

Getting To “Exempt!”: Putting The Rubber Stamp On Section 501(C)(3)’S Political Activity Prohibition, Michael Fresco

Fordham Law Review

No abstract provided.

Whither Fairness? In Search Of A Jurisdictional Test After J. Mcintyre Machinery V. Nicastro, Peter R. Bryce

Fordham Law Review

No abstract provided.

Law Firms, Global Capital, And The Sociological Imagination, Christine Parker, Tanina Rostain

Fordham Law Review

No abstract provided.

The Desire Called Dystopia, Lisa Brawley

Criticism

Review of Planet of Slums by Mike Davis. (London: Verso, 2006. Pp. 228. $24.00 cloth, $16.25 paper.)

The Sweet Allure Of Theory, Helen Petrovsky

Criticism

Review of Profanations by Giorgio Agamben, trans. Jeff Fort. New York: Zone Books, 2007. Pp. 100. $25.95 cloth.

Try Anything, Todd Carmody, Heather K. Love

Criticism

Conference Review “Anxiety, Urgency, Outrage, Hope . . . A Conference on Political Feeling.” Franke Institute for the Humanities, University of Chicago, October 19–20, 2007

A Case Study Of Turkey Point Nuclear Generating Station: Perception And Power In Environmental Assessment, Tara E. Dolan

Open Access Theses

The Turkey Point Nuclear Generating Station (TPNGS) is a nuclear power plant situated on the shores of Biscayne Bay, FL. The fringing mangrove shoreline of Biscayne Bay provides essential habitat for a variety of ecologically and commercially important species of fish. There is concern among stakeholders that proposed expansion at TPNGS may pose environmental risks. The goal of this thesis was to investigate current status of knowledge of environmental risk to the nearshore fish communities inhabiting the mangroves adjacent to TPNGS. Specific objectives included: 1) examining perception of environmental risk from TPNGS by stakeholder groups in the environmental regulatory arena; …

Artifacts And Commingled Skeletal Remains From A Well On The Medical College Of Virginia Campus: Appendices, Douglas W. Owsley, Karin Bruwelheide, Merry Outlaw, Richard L. Jantz

Office of the President Documents

This is a report prepared by Douglas W. Owsley and Karin Bruwelheide, Department of Anthropology, National Museum of Natural History, Smithsonian Institution in fulfillment of the Contract Agreement between the Smithsonian Institution. The objectives of this report included identification and documentation of the bones and artifacts recovered from the well, establishing the temporal context, and interpreting the relationship of the materials to the site’s use and history as an early medical school in the city of Richmond. This report has three main sections: a review of the archival history of the school as it related to the use of the …

Murine Gut Microbiota Is Defined By Host Genetics And Modulates Variation Of Metabolic Traits, Autumn M. Mcknite, Maria Elisa Perez-Munoz, Lu Lu, Evan G. Williams, Simon Brewer, Penelope A. Andreux, John W. M. Bastiaansen, Xusheng Wang, Stephen D. Kachman, Johan Auwerx, Robert W. Williams, Andrew K. Benson, Daniel A. Peterson, Daniel C. Ciobanu

Department of Statistics: Faculty Publications

The gastrointestinal tract harbors a complex and diverse microbiota that has an important role in host metabolism. Microbial diversity is influenced by a combination of environmental and host genetic factors and is associated with several polygenic diseases. In this study we combined next-generation sequencing, genetic mapping, and a set of physiological traits of the BXD mouse population to explore genetic factors that explain differences in gut microbiota and its impact on metabolic traits. Molecular profiling of the gut microbiota revealed important quantitative differences in microbial composition among BXD strains. These differences in gut microbial composition are influenced by host-genetics, which …

06/18/2012 Obituary Records, Hawaii Obituaries

Obituaries

List of Obituaries for individuals who passed away on 06/18/2012. Scroll down to see the names and obituary description.

The Impact Of Place Attachment On Land Succession Of Nebraska Agriculturists, Shari Kunert

School of Natural Resources: Dissertations, Theses, and Student Research

Many Nebraska agriculturists rely on small family farms for their livelihood. The farm is their source of income and may be an important inheritance for their family when they retire or die. Land succession planning is a process to allow landowners to pass farmland on to the next generation without incurring a potentially debilitating tax liability for the heirs. The purpose of this study is to determine the influence of place attachment on land succession planning of Nebraska agriculturists. This comparative research, mixed methods in nature, involves Nebraska agriculturists who have a land succession plan and Nebraska agriculturists who do …

Analysis Of Periapical Biopsies Submitted For Histopathological Evaluation: A Retrospective Study, Abdullah I. Alqaied

Master's Theses

Apical periodontitis is the most common pathological process in the periapical region. Disciplined clinical and radiographic evaluations and appropriate diagnostic tests can detect lesions related to apical periodontitis. Aside from this, lesions mimicking pulp-related pathology but unrelated to pulpal infection and necrosis are occasionally discovered in the periapical region. The objective of this study was two-fold: (1) to determine the prevalence of diverse periapically located pathological entities, and (2) to apply that information to evaluate the rationale for routine submission of surgically obtained tissue for histological examination and diagnosis. Methods: A 5-year retrospective analysis of pathology reports from the UCONN …

Cofactor Molecules Maintain Infectious Conformation And Restrict Strain Properties In Purified Prions, Nathan R. Deleault, Daniel J. Walsh, Justin R. Piro, Fei Wang, Xinhe Wang, Jiyan Ma, Judy R. Rees, Surachai Supattapone

Dartmouth Scholarship

No abstract provided.

Five Nuclear Loci Resolve The Polyploid History Of Switchgrass (Panicum Virgatum L.) And Relatives, Jimmy Triplett, Yunjing Wang, Jinshun Zhong, Elizabeth Kellogg

Biology Department Faculty Works

Polyploidy poses challenges for phylogenetic reconstruction because of the need to identify and distinguish between homoeologous loci. This can be addressed by use of low copy nuclear markers. Panicum s.s. is a genus of about 100 species in the grass tribe Paniceae, subfamily Panicoideae, and is divided into five sections. Many of the species are known to be polyploids. The most well-known of the Panicum polyploids are switchgrass (Panicum virgatum) and common or Proso millet (P. miliaceum). Switchgrass is in section Virgata, along with P. tricholaenoides, P. amarum, and P. amarulum, whereas P. miliaceum is in sect. Panicum. We have …