Digital Commons Network^™

Methods And Compounds For Inhibition Of Cell Death, Antonis Zervos

UCF Patents

This invention is directed to methods and compositions for inhibiting caspase-independent apoptosis. In particular, methods and compositions for inhibiting Omi/HtrA2 activity, as well as method for identifying other inhibitors of Omi/HtrA2. Also disclosed are Omi/HtrA2 specific substrates and methods for identifying other substrates of Omi/HtrA2.

Early Evidence Of San Material Culture Represented By Organic Artifacts From Border Cave, South Africa, Francesco D’Errico, Lucinda Backwell, Paola Villa

KIP Articles

Recent archaeological discoveries have revealed that pigment use, beads, engravings, and sophisticated stone and bone tools were already present in southern Africa 75,000 y ago. Many of these artifacts disappeared by 60,000 y ago, suggesting that modern behavior appeared in the past and was subsequently lost before becoming firmly established. Most archaeologists think that San hunter–gatherer cultural adaptation emerged 20,000 y ago. However, reanalysis of organic artifacts from Border Cave, South Africa, shows that the Early Later Stone Age inhabitants of this cave used notched bones for notational purposes, wooden digging sticks, bone awls, and bone points similar to those …

In Vitro Model Of Latent Mycobacterial Infection (Div I), Pappachan Kolattukudy, Jaiyanth Daniel, Chirajyoti Deb, Tatiana Sirakova

UCF Patents

A new in vitro culture model for latency of tuberculosis pathogen suitable for screening chemical libraries was developed by subjecting the pathogen to multiple stresses that the pathogen is thought to encounter in the host. When subjected to these stress factors, the pathogen develops key features characteristic of latency, drug resistance and lipid storage. Using the culture, a method to screen chemicals was developed. This method is suitable for high through put screening.

Kayleigh's Australian Adventure: A Story For Children, Diane A. Wetmore

Honors Theses

This is a children's book for upper elementary students (3rd/4th grade) as an introduction to Australian culture

Membrane Properties Involved In Calcium-Stimulated Microparticle Release From The Plasma Membranes Of S49 Lymphoma Cells, Lauryl Elizabeth Campbell

Theses and Dissertations

The mechanism of microparticle shedding from the plasma membrane of calcium-loaded cells has been investigated in erythrocytes and platelets. Recent studies have revealed the physiological and clinical importance of microparticle release from nucleated cells such as lymphocytes and endothelium. The experiments of this study were designed to address whether simple mechanisms discovered in platelets and erythrocytes also apply to the more complex nucleated cells. Four such mechanisms were addressed: potassium efflux, transbilayer phosphatidylserine migration, cytoskeleton degradation, and membrane lipid order. The rate and amount of microparticle release in the presence of a calcium ionophore, ionomycin, was assayed by light scatter …

A Signal Processing Approach For Preprocessing And 3d Analysis Of Airborne Small-Footprint Full Waveform Lidar Data, Jiaying Wu

Theses

The extraction of structural object metrics from a next generation remote sensing modality, namely waveform light detection and ranging (LiDAR), has garnered increasing interest from the remote sensing research community. However, a number of challenges need to be addressed before structural or 3D vegetation modeling can be accomplished. These include proper processing of complex, often off-nadir waveform signals, extraction of relevant waveform parameters that relate to vegetation structure, and from a quantitative modeling perspective, 3D rendering of a vegetation object from LiDAR waveforms. Three corresponding, broad research objectives therefore were addressed in this dissertation. Firstly, the raw incoming LiDAR waveform …

Validation Of Astrodynamic Formation Flying Models Against Space-Si Experiments With Prisma Satellites, Drago Matko, Tomaž Rodič, Sašo Blažič, Aleš Marsetič, Krištof Oštir, Gašper Mušič, Luka Teslić, Gregor Klančar, Marko Peljhan, David Zobavnik, Robin Larsson, Eric Clacey, Christian Svärd, Thomas Karlsson

Small Satellite Conference

In this paper several astrodynamical formation flying models are assessed against the experimental results derived from the SPACE-SI formation flying experiments performed in September 2011 with the OHB Sweden developed Prisma satellites Mango and Tango. In these formation flying experiments critical manoeuvres for three types of missions were investigated with respect to in-orbit performances. The experiments included parallel flying with in track displacement demonstrating high-resolution optical dual satellite imaging and radar interferometric constellation, circumvolution as well as encircling of the target demonstrating debris observation and parallel flying with the radial displacement demonstrating fractionated spacecraft and accurate pointing of the formation. …

A Look At The Supreme Court Justices’ Individual Biases Toward Copyright Law: Prediction And Reflection On The Golan V. Holder Decision, Elizabeth F. Jackson

Intellectual Property Brief

No abstract provided.

Music As Biotech: Remixing The Ubmta For Use With Digital Samples, Adam G. Holofcener

Intellectual Property Brief

No abstract provided.

Using Mice With Conditional Deletion Of The Ifng Receptor To Identify The Cellular Targets Of Ifng During Development Of Anti-Listeria Immune Responses, Sang Hun Lee

All Theses and Dissertations (ETDs)

Host responsiveness to IFNg is critical for resolution of Listeria infection, but the identities and roles of IFNg responsive cells that initiate this process remain unclear. In this thesis, unique mice displaying conditional loss of the IFNg receptor: Ifngr1f/f mice) in different tissues have been generated and used to explore the role of this cytokine in initiating the anti-Listeria response.

Whereas Ifngr1f/f mice displayed normal cellular levels of IFNGR1 and normal resistance to Listeria infection, Vav-icre+Ifngr1f/f mice lacking IFNg responsiveness selectively in hematopoietic cells exhibited highly increased susceptibility to Listeria infection comparable to that of Ifngr1-/- mice. In contrast, Itgax-cre+ …

Cancer Biotherapy Resource, Preety Priya

Theses

`Cancer Biotherapy' - as opposed to cancer chemotherapy- is the use of macromolecular, biological agents instead of organic chemicals or drugs to treat cancer. Biotherapy is a treatment modality that blocks the growth of cancer cells by interfering with specific, targeted molecules needed for carcinogenesis and tumor growth instead of simply interfering with rapidly dividing cells as in chemotherapy1. In light to the much higher selectivity of biological agents than chemical agents for cancer cells over normal cells, there is a much less toxic side effect in biotherapy as compared to chemotherapy. As solid tumor cancer continues to be analyzed …

Murine Gammaherpesvirus 68 Lana Acts On Terminal Repeat Dna To Mediate Episome Persistence, Aline C. Habison, Chantal Beauchemin, J. Pedro Simas, Edward J. Usherwood

Dartmouth Scholarship

Murine gammaherpesvirus 68 (MHV68) ORF73 (mLANA) has sequence homology to Kaposi’s sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen (LANA). LANA acts on the KSHV terminal repeat (TR) elements to mediate KSHV episome maintenance. Disruption of mLANA expression severely reduces the ability of MHV68 to establish latent infection in mice, consistent with the possibility that mLANA mediates episome persistence. Here we assess the roles of mLANA and MHV68 TR (mTR) elements in episome persistence. mTR-associated DNA persisted as an episome in latently MHV68-infected tumor cells, demonstrating that the mTR elements can serve as a cis-acting element for MHV68 episome maintenance. In some …

Sex In Rotrou’S Theater: Performance And Disorder, Nina Ekstein

Modern Languages and Literatures Faculty Research

Sexual desire is ubiquitous in all theater. It follows that virtually all theatrical traditions struggle with the issue of the representation of that desire onstage. The French stage of the 1630s and Jean Rotrou's theater of that period in particular constitute an unusual moment of relative freedom before the imposition of the bienséances banished sexual activity from the stage. What I propose is a theatrical reading of sex in Rotrou's plays, a tripartite examination of dramatic strategy: how Rotrou foregrounds the scandalous by direct depiction of sexuality onstage; how at other moments he moves to attenuate its prurient force by …

Gut Microbiome Composition Is Linked To Whole Grain-Induced Immunological Improvements, Ines Martinez, James M. Lattimer, Kelcie L. Hubach, Jennifer A. Case, Junyi Yang, Casey G. Weber, Julie A. Louk, Devin J. Rose, Gayaneh Kyureghian, Daniel A. Peterson, Mark D. Haub, Jens Walter

Food for Health: Publications

The involvement of the gut microbiota in metabolic disorders, and the ability of whole grains to affect both host metabolism and gut microbial ecology, suggest that some benefits of whole grains are mediated through their effects on the gut microbiome. Nutritional studies that assess the effect of whole grains on both the gut microbiome and human physiology are needed. We conducted a randomized cross-over trial with four-week treatments in which 28 healthy humans consumed a daily dose of 60 g of whole-grain barley (WGB), brown rice (BR), or an equal mixture of the two (BR+WGB), and characterized their impact on …

Role Of Glutathione In Lung Retention Of 99mtc-Hexamethylpropyleneamine Oxime In Two Unique Rat Models Of Hyperoxic Lung Injury, Said H. Audi, David L. Roerig, Steven Thomas Haworth, Anne V. Clough

Biomedical Engineering Faculty Research and Publications

Rat exposure to 60% O₂ for 7 days (hyper-60) or to >95% O₂ for 2 days followed by a 24-hour in room air (hyper-95R) confers susceptibility or tolerance, respectively, of the otherwise lethal effects of subsequent exposure to 100% O₂. The objective of this study was to determine if lung retention of the radiopharmaceutical agent ^99mTc-HMPAO (hexamethylpropyleneamine oxime) is differentially altered in hyper-60 and hyper-95R rats. Tissue retention of HMPAO is dependent on intracellular content of the antioxidant glutathione (GSH) and mitochondrial function. HMPAO was injected i.v. in anesthetized rats and planar images were acquired. …

Acts And Work, Theology Of Work Project, Aaron Kuecker

Theology of Work Project

1. Introduction to Acts
2. The Beginning of God's New World (Acts 1-4)
   • A Community with a Mission (Act 1:6)
   • An Orienting Vocation for the Kingdom of God (Acts 1:8)
   • An Orienting Identity as God's Kingdom Witnesses in Daily Life (Acts 2:1-41)
   • An Orienting Community that Practices the Ways of God's Kingdom (Acts 2:42-47; 4:32-38)
     • The Economics of Radical Generosity (Acts 2:45; 4:34-35)
     • The Holy Spirit Empowers Radical Generosity With Every Kind of Resource (Acts 2:42-47; 4:32-38)
     • A Just Community Is a Witness to the World (Acts 2:47; 6:7)
3. A Clash of Kingdoms: Community and Power (Acts 5-7)
   • Ananias and Sapphira: A …

Sbe Notícias, Ano 7, No. 235, August 11, 2012, Marcelo A. Rasteiro, Delci K. Ishida, Agatha Matsumoto

SBE Notícias

Chamada de artigos para edição especial da Revista Espeleo-Tema; Nossa história; Abertas inscrições para o 16º Congresso Internacional de Espeleologia (16º ICS); UIS apresenta seu novo site; Café mais caro do mundo vem de grãos em fezes de animal; Turismo religioso na Pedra da Gruta Santa em Catuné MG; Curso Espeleoresgate 2012; Novas espécies de invertebrados são encontrados em gruta a mais de 2000 metros de profundidade; Confirmada a liminar que impede dano a caverna em Conceição do Mato Dentro; Globo Reporter visita cavernas na Eslovênia; Identificadas no Peru pessoas com possível imunidade à raiva; 46ºCBG terá excursão ao Vale …

Passive Treatment For Removal Of Metal And Organic Contaminants From Runoff And Effluent At Confined Disposal Facilities, Damarys Acevedo-Acevedo

Theses and Dissertations

A passive treatment alternative for the removal of metal and organic contaminants from runoff and effluent in CDFs was evaluated in this study. Activated carbon impregnated curtains have been used for different remediation projects; however, very little research has been conducted to understand its sorption behavior, breakthrough time, and exhaustion time of contaminants under high flow rates characteristic of CDF runoff and effluent. The major objectives of this study were to evaluate the efficiency of the curtain in removing contaminants from a synthetic effluent in a flow through regime and estimate the expected life of the curtains. Equilibrium tests, batch …

Aberrant Placental Immune Parameters In The Feline Immunodeficiency Virus (Fiv)-Infected Cat Suggest Virus-Induced Changes In Leukocyte Function, Lyndon Bart Chumbley

Theses and Dissertations

Regulatory T cells (Tregs), interleukin 17-producing T helper cells (Th17 cells), and other immune cells play important roles in the maintenance of pregnancy, and their function is impacted by HIV infection. I hypothesized that FIV-infection may likewise alter placental T cell gene expression causing aberrant immune function and compromised pregnancy. The purpose of this project was to evaluate the expression placental immunomodulators related to Treg and Th17 cell function in the FIV-infected cat model. Gene expression was quantified in placenta and serum using quantitative PCR and ELISA, respectively. Abnormal expression of cytokines was frequently associated with infection and fetal nonviability, …

Commencement Convocation Exercises - August 2012, Prairie View A&M University

Commencement and Convocation Exercises

No abstract provided.

Feature-Based Uncertainty Visualization, Keqin Wu

Theses and Dissertations

While uncertainty in scientific data attracts an increasing research interest in the visualization community, two critical issues remain insufficiently studied: (1) visualizing the impact of the uncertainty of a data set on its features and (2) interactively exploring 3D or large 2D data sets with uncertainties. In this study, a suite of feature-based techniques is developed to address these issues. First, a framework of feature-level uncertainty visualization is presented to study the uncertainty of the features in scalar and vector data. The uncertainty in the number and locations of features such as sinks or sources of vector fields are referred …

Mechanical Properties Of Porcine Muscle In Compression And Tension With Microstructural Analysis, Renee Brook Pietsch

Theses and Dissertations

A need exists for a more robust method of evaluating musculoskeletal injuries resulting from impact conditions, particularly blasts. Computational modeling is a promising method of achieving this goal. The accuracy of a model depends on high quality mechanical properties for each component. This study examined the mechanical properties of porcine muscle along with structure property relationships. Fresh muscle was tested in compression and tension at strain rates of 0.1 s-1, 0.01 s-1, and 0.001 s-1. Viscoelastic properties were observed including strain rate dependency, stress state dependency, anisotropy, relaxation, and hysteresis. Image analysis was conducted in compression on controls, 30% strain, …

Identifying Factors And Quantifying Their Impact On Transportation Costs Of Pre-Processes Biomass, Daniela Sofia Gonzales

Theses and Dissertations

This research presents a rail transportation cost analysis of bulk agricultural commodities (such as grain and wood chips) with similar characteristics as pre-processed biomass. This study analyzes the cost factors that affect rail pricing for shipments of bulk-commodities (such as grain) from the Midwest to various regions in the US using regression analysis theories. The rail cost equations developed from the regression analysis were used to compare the trade-offs that exist between truck, rail and barge transportation of pre-processed biomass.

Micromechanical Analysis Of Cells From Hyperelastosis Cutis (Hc) Affected And Carrier Horses, Kenyatta Shanika Williams Washington

Theses and Dissertations

Equine hyperelastosis cutis (HC or HERDA), a connective tissue disorder in American Quarter Horses, results in hyperelastic skin with poor wound healing. Similar conditions are found in many species and all forms display decreased skin tensile strength. Fibroblasts produce collagen and elastin fibers, forming networks, providing the dermis with strength, and elasticity. This study aims to carry out a 3-part evaluation between horse skin fibroblast (cells from horses affected with HERDA, cells from horses that are carriers of HERDA (recessive HERDA gene), and cells from horses that are normal (neither affected or carriers of HERDA); Studies include: 1. Cell proliferation …

A Computational Study Of Diesel And Biodiesel Combustion And Nox Formation In A Light-Duty Compression Ignition Engine, Zihan Wang

Theses and Dissertations

Diesel and biodiesel combustion in a light duty compression ignition engine were simulated during a closed cycle, using a commercial computational fluid dynamics (CFD) code, CONVERGE. The corresponding computational domain was constructed for the engine based on combustion chamber geometry and compression ratio measurements. Submodels were calibrated for simulation. The results were able to capture the experimental pressure and apparent heat release rate trends for both fuels over a range of engine loads and fuel injection timings. NOx emissions trends were captured for diesel, while under-predicted for biodiesel. The NOx trends were also analyzed based on the thermal NO mechanism. …

Remote Sensing Of Cyanobacteria In Turbid Productive Waters, Sachidananda Mishra

Theses and Dissertations

Cyanobacterial algal bloom is a major water quality issue in inland lakes, reservoirs, and estuarine environments because of its scum and bad odor forming and toxin producing abilities. Health risks from cyanobacterial toxin can vary from skin irritations to fever, intestinal problems, and neurological disorders. Terminations of blooms also cause oxygen depletion leading to hypoxia and widespread fish kills. Adding to the problem, many species of cyanobacteria produce odorous compounds such as geosmin and 2-methylisoborneol (MIB) that cause “earthy-muddy” and “musty” odor in drinking water, which is also a serious issue in aquaculture and drinking water industry. Therefore continuous monitoring …

Physical Activity And Fruit And Vegetable Consumption Habits In College Student Smokers, Social Smokers, And Nonsmokers, Timothy Chad Murphy

Theses and Dissertations

Smoking, physical activity, and insufficient fruit and vegetable consumption have been linked to increased instances of coronary heart disease, stroke, peripheral vascular disease, chronic obstructive lung disease, type 2 diabetes, osteoporosis, depression, hypertension, numerous cancers, and complications surrounding blood pressure and blood cholesterol. In the United States approximately 22% of college students have smoked at least one cigarette in the past 30 days; 70-85% are not meeting recommended levels of physical activity; and 75% are not consuming recommended levels of fruits and vegetables. The purpose of this study was to investigate differences in physical activity and fruit and vegetable consumption …

Potential Of Great Egrets To Be Vectors For The Transmission Of S Virulent Strain Of Aeromonas Hydrophila Between Channel Catfish Culture Pond, Madison Mccall Jubirt

Theses and Dissertations

Aeromonas hydrophila is a Gram-negative, rod shaped, facultative anaerobic bacterium that is ubiquitous to freshwater and slightly brackish aquatic environments and can cause infections in fish, humans, reptiles, and avian species. Recent severe outbreaks of disease in catfish aquaculture have been associated with a highly virulent Aeromonas hydrophila strain (VAH) that is genetically distinct from less virulent strains. Given that A. hydrophila is known to infect birds, we hypothesized that fish eating birds may serve as a reservoir for VAH and spread the pathogen by flying to uninfected ponds. Great Egrets were used in this transmission model because these wading …

Multi-Scale Den-Site Selection By American Black Bears In Mississippi, Brittany Winchester Waller

Theses and Dissertations

Dens are a critical component of black bear (Ursus americanus) habitat, yet scale-dependent den-site selection has received limited attention. Natural and anthropogenic factors (e.g., vegetation, roads) may also influence bear den-site selection. I quantified black bear denning chronology and den use and evaluated multi-scale den-site selection in Mississippi, USA during 2005–2011. Females entered dens earlier than males and emerged later; multiple den use by both sexes in a single winter was common. I recorded equal numbers of tree and ground dens, with ground dens at higher elevations surrounded by dense vegetation. Chronology and other denning characteristics of bears in Mississippi …

Degree Of Pyritization And Methylmercury Analysis, Weeks Bay Alabama, Henry A. Stauffenberg

Theses and Dissertations

Methylmercury (MeHg) production is magnified in the natural environment by geochemical influxes and an active sulfate reducing bacteria community. It has been found that the presence of sulfides, excess nutrients, and the type of depositional environment (normal marine or euxinic) greatly influences MeHg production and degree of pyritization (DOP). The aim of this research is to investigate a possible connection between MeHg accumulation and the DOP in Weeks Bay sediment. Collected sediment samples have confirmed a significant presence of total reduced sulfides, inorganic mercury, reactive iron, and total organic carbon. Pyritization results indicate a normal marine environment and, of the …