Digital Commons Network^™

American Natures: The Shape Of Conflict In Environmental Law, Jedediah S. Purdy

Faculty Scholarship

There is a firestorm of political and cultural conflict around environmental issues, including, but running well beyond, climate change. Legal scholarship is in a bad position to make sense of this conflict because the field has concentrated on making sound policy recommendations to an idealized lawmaker, neglecting the deeply held and sharply clashing values that drive, or block, environmental lawmaking. This Article sets out a framework for understanding and engaging the clash of values in environmental law and, by extension, approaching the field more generally. Americans have held, and legislated based upon, four distinct ideas about why the natural world …

Inter Arma Enim Non Silent Leges, Philip C. Bobbitt

Faculty Scholarship

There is good reason to think that law and war have nothing to do with one another, and this has certainly been so for most of the lifetime of mankind. Cicero's famous observation-silent enim leges inter arma – from which I take my title, was not a novel insight when uttered in 52 B.C. and in any case was not said in the context of war, but of a prosecution for murder in the aftermath of the Roman riots of that era between the partisans of the populares and optimates. Clausewitz, however, said much the same thing when he decried …

Actin Polymerization Controls The Activation Of Multidrug Efflux At Fertilization By Translocation And Fine-Scale Positioning Of Abcb1 On Microvilli., Kristen E. Whalen, A Reitzel, A. Hamdoun

Biology Faculty Scholarship

No abstract provided.

Netrin/Dcc Signaling Guides Olfactory Sensory Axons To Their Correct Location In The Olfactory Bulb, Vanisha Lakhina, Christina L. Marcaccio, Xin Shao, Roshan A. Jain

Biology Faculty Scholarship

No abstract provided.

Moore Is Less: Why The Development Of Induced Pluripotent Stem Cells Might Radically Upend Property Law Concerning Human Tissues As We Know It, Osagie K. Obasogie, Helen Theung

Faculty Scholarship

No abstract provided.

A Note On India’S Attempt To Reconcile Diversity And Intellectual Property Issues, Srividhya Ragavan

Faculty Scholarship

For developing countries, the concept of diversity holds great promises not least because of the protection it promises for the fast depleting natural resources leading to catastrophic effect on the environment. The concept of diversity also holds great promises from a trade perspective. In reality, appropriate protection of diversity can be the solution to balance the effects of the trade regime to achieve sustainable development. The term sustainable development, as opposed to rapid pockets of development, embodies great promises for the socio-political framework in poorer nations, apart from the obvious benefit of sustainability. In fact, sustainable development, if it ensues, …

Procedural Wound Geometry And Blood Flow Generation For Medical Training Simulators, Rifat Aras, Yuzhong Shen, Jiang Li, David R. Holmes Iii (Ed.), Kenneth H. Wong (Ed.)

Electrical & Computer Engineering Faculty Publications

Efficient application of wound treatment procedures is vital in both emergency room and battle zone scenes. In order to train first responders for such situations, physical casualty simulation kits, which are composed of tens of individual items, are commonly used. Similar to any other training scenarios, computer simulations can be effective means for wound treatment training purposes. For immersive and high fidelity virtual reality applications, realistic 3D models are key components. However, creation of such models is a labor intensive process. In this paper, we propose a procedural wound geometry generation technique that parameterizes key simulation inputs to establish the …

Methamphetamine Administration Targets Multiple Immune Subsets And Induces Phenotypic Alterations Suggestive Of Immunosuppression., Robert Z. Harms, Brenda M. Morsey, Craig W. Boyer, Howard S. Fox, Nora E. Sarvetnick

Journal Articles: Regenerative Medicine

Methamphetamine (Meth) is a widely abused stimulant and its users are at increased risk for multiple infectious diseases. To determine the impact of meth on the immune system, we utilized a murine model that simulates the process of meth consumption in a typical addict. Our phenotypic analysis of leukocytes from this dose escalation model revealed that meth affected key immune subsets. Meth administration led to a decrease in abundance of natural killer (NK) cells and the remaining NK cells possessed a phenotype suggesting reduced responsiveness. Dendritic cells (DCs) and Gr-1(high) monocytes/macrophages were also decreased in abundance while Gr-1(low) monocytes/macrophages appear …

Securities Class Actions Against Foreign Issuers, Merritt B. Fox

Faculty Scholarship

This Article addresses the fundamental question of whether, as a matter of good policy, it is ever appropriate that a foreign issuer be subject to the U.S. fraud-on-the-market private damages class action liability regime, and, if so, by what kinds of claimants and under what circumstances. The bulk of payouts under the U.S. securities laws arise out of fraud-on-the-market class actions – actions against issuers on behalf of secondary market purchasers of their shares for trading losses suffered as a result of issuer misstatements in violation of Rule 10b-5. In the first decade of this century, foreign issuers became frequent …

A Leopard’S Tail: The Life And Work Of Alice Nderitu Of Kenya, Stephanie Chiu

Kroc IPJ Research and Resources

In the following pages, you will find narrative stories about a Woman PeaceMaker, along with additional information to provide a deep understanding of a contemporary conflict and one person’s journey within it. These complementary components include a brief biography of the peacemaker, a historical summary of the conflict, a timeline integrating political developments in the country with personal history of the peacemaker, a question-and-answer transcript of select interviews, and a table of best practices in peacebuilding as demonstrated and reflected on by the peacemaker during her time at the Joan B. Kroc Institute for Peace & Justice.

A commissioner in …

A Cognitive Theory Of The Aesthetic Experience, Gianluca Consoli

Contemporary Aesthetics (Journal Archive)

This paper aims at naturalizing the aesthetic experience on the basis of cognitive sciences. In traditional philosophical aesthetics, the aesthetic experience requires a specific attitude and a characteristic work of imagination. Today, cognitive sciences offer a rich set of empirically corroborated concepts useful in explaining these notions in naturalistic terms. This paper extends these concepts to explain how the aesthetic experience is integrated and how it affords knowledge.

Not The Power To Destroy: An Effects Theory Of The Tax Power, Neil S. Siegel, Robert D. Cooter

Faculty Scholarship

The Supreme Court’s “new federalism” decisions impose modest limits on the regulatory authority of Congress under the Commerce Clause. According to those decisions, the Commerce Clause empowers Congress to use penalties to regulate interstate commerce, but not to regulate noncommercial conduct. What prevents Congress from penalizing non-commercial conduct by calling a penalty a tax and invoking the Taxing Clause? The only obstacle is the distinction between a penalty and a tax for purposes of Article I, Section 8. In National Federation of Independent Business v. Sebelius (NFIB), the Court considered whether the minimum coverage provision in the Patient …

The Liberty Of Free Riders: The Minimum Coverage Provision, Mill’S “Harm Principle,” And American Social Morality, Jedediah Purdy, Neil S. Siegel

Faculty Scholarship

In this Article, the authors show that cost-shifting and adverse selection problems link the federalism dimension of the debate over the Affordable Care Act to the doctrinally separate and suppressed individual rights dimension. As the scope of these free-rider problems justifies federal power to require individuals to obtain health insurance coverage, so the very existence of the free-rider problems illuminates the difficulty of arguing directly — as opposed to indirectly through the Commerce Clause — that the minimum coverage provision infringes individual liberty. The interdependence between some people’s decisions to forgo insurance and the well-being of other people means that …

Sorrell V. Ims Health And The End Of The Constitutional Double Standard, Ernest A. Young

Faculty Scholarship

No abstract provided.

Not Your Parents' Law Library: A Tale Of Two Academic Law Libraries, Julian Aiken, Femi Cadmus, Fred Shapiro

Faculty Scholarship

As academic law libraries continue to face the inevitability of a rapidly changing landscape which includes a new breed of digital users with sophisticated technological needs, it remains to be seen what libraries will look like in years to come. It is certain that libraries as we know them today will have changed, but to what extent? An ability to remain adaptable and to anticipate the evolving needs of users in a dynamic environment will continue to be key for libraries to remain relevant, and even to survive, in the 21st century; vital to this endeavor will also be an …

Slavery In The United States: Persons Or Property?, Paul Finkelman

Faculty Scholarship

No abstract provided.

Interpretive Contestation And Legal Correctness, Matthew D. Adler

Faculty Scholarship

No abstract provided.

Factors Controlling Macondo Oil Biodegraqdation On A Rapidly Eroding Coastal Headlands Beach, Marilany G. Urbano

LSU Master's Theses

Fourchon Beach, located along the southeast Louisiana coast, was affected by the oil leaking from the British Petroleum’s Deepwater Horizon Oil rig explosion in 2010. The oil, labeled MC252 oil, came ashore in a stable emulsion form, contaminating the sand, salt pan, marsh and mangroves along the beach. A unique oil form, labeled SSRB (small surface residue ball) was formed from the MC252 oil and a combination of environmental factors. The SSRB is an aggregate of sand and emulsified oil, and forms a large portion of the oil still present on the supratidal zone of Fourchon Beach. SSRBs have not …

Instability In A Generalized Keller–Segel Model, Patrick De Leenheer, Jay Gopalakrishnan, Erica Zuhr

Mathematics and Statistics Faculty Publications and Presentations

We present a generalized Keller–Segel model where an arbitrary number of chemical compounds react, some of which are produced by a species, and one of which is a chemoattractant for the species. To investigate the stability of homogeneous stationary states of this generalized model, we consider the eigenvalues of a linearized system. We are able to reduce this infinite dimensional eigenproblem to a parametrized finite dimensional eigenproblem. By matrix theoretic tools, we then provide easily verifiable sufficient conditions for destabilizing the homogeneous stationary states. In particular, one of the sufficient conditions is that the chemotactic feedback is sufficiently strong. Although …

Second Things First: What Free Speech Can And Can’T Say About Guns, Joseph Blocher

Faculty Scholarship

Professor Blocher responds to Gregory Magarian’s article on the implications of the First Amendment for the Second.

Homosexuality And The Bible: What Is At Stake In The Current Debate, Richard M. Davidson

Faculty Publications

The sexual distinction between male and female is fundamental to what it means to be human. Humankind-in-fellowship as male and female is fundamental to what it means to be in the image of God.

Self-Reported Stress And Posttraumatic Growth Following The Transition To Motherhood : Investigating The Role Of Social Support And Self-Efficacy, Jillian M. Millar

Theses: Doctorates and Masters

The onset of parenthood signifies a transition point in a person’s life, which requires adaptation to a variety of changes and is often considered a time of great stress and great joy. Posttraumatic growth (PTG) or positive psychological outcomes can be experienced as a result of an individual’s struggles with highly stressful or challenging life events, such as the birth of a child. The current research explores the relationship between PTG and the transition to motherhood. Two studies investigated women’s retrospective perceptions of PTG regarding their first experience of parenthood. Study One employed a quantitative methodology to examine the extent …

Mutant P63 Causes Defective Expansion Of Ectodermal Progenitor Cells And Impaired Fgf Signalling In Aec Syndrome, Giustina Ferone, Helen A. Thomason, Dario Antonini, Rosa L De, Bing Hu, Marica Gemei, Huiqing Zhou, Raffaele Ambrosio, David P. Rice, Dario Acampora, Bokhoven H Van, Vecchio L Del, Maranke I. Koster, Gianluca Tadini, Bradley Spencer-Dene, M Dixon, J Dixon, Caterina Missero

Peninsula Dental School

No abstract provided.

Reflective Practice For Marine Planning: A Case Study Of Marine Nature-Based Tourism Partnerships, Claire Kelly, Stephen Essex, Gillian Glegg

School of Geography, Earth and Environmental Sciences

An essential component of ecosystem-based approaches in coastal zone management and the emerging field of marine planning are partnerships and collaborations between a range of multi-sector organisations and individuals. Ensuring that partnerships are effective is a priority for those responsible for planning and management in coastal and marine environments. Current partnership evaluation approaches, however, tend to view effectiveness as the cumulative end result of a set of variables acting in a linear process at a specific point in time. Given that governance and participation are acknowledged as non-linear and multifaceted processes, more reflective and nuanced approaches that take account of …

High Metabolic Potential May Contribute To The Success Of St131 Uropathogenic Escherichia Coli., Tarek M. Gibreel, Andrew R. Dodgson, John Cheesbrough, Frederick J. Bolton, Andrew J. Fox, Mathew Upton

School of Biomedical Sciences

Uropathogenic Escherichia coli (UPEC) is the predominant cause of urinary tract infection in both hospital and community settings. The recent emergence of multidrug-resistant clones like the O25b:H4-ST131 lineage represents a significant threat to health, and numerous studies have explored the virulence potential of these organisms. Members of the ST131 clone have been described as having variable carriage of key virulence factors, and it has been suggested that additional unidentified factors contribute to virulence. Here we demonstrated that ST131 isolates have high metabolic potential and biochemical profiles that distinguish them from isolates of many other sequence types (STs). A collection of …

Antimicrobial Peptides As Therapeutic Agents., Mathew Upton, Paul Cotter, John Tagg

School of Biomedical Sciences

No abstract provided.

Huntington's Disease And Its Therapeutic Target Genes: A Global Functional Profile Based On The Hd Research Crossroads Database, Ravi Kiran R. Kalathur, Miguel A. Hernández-Prieto, Matthias E. Futschik

School of Biomedical Sciences

Abstract Background Huntington’s disease (HD) is a fatal progressive neurodegenerative disorder caused by the expansion of the polyglutamine repeat region in the huntingtin gene. Although the disease is triggered by the mutation of a single gene, intensive research has linked numerous other genes to its pathogenesis. To obtain a systematic overview of these genes, which may serve as therapeutic targets, CHDI Foundation has recently established the HD Research Crossroads database. With currently over 800 cataloged genes, this web-based resource constitutes the most extensive curation of genes relevant to HD. It provides us with an unprecedented opportunity to survey molecular mechanisms …

Osteochondral Tissue Engineering: Scaffolds, Stem Cells And Applications., Patcharakamon Nooeaid, Vehid Salih, Justus P. Beier, Aldo R. Boccaccini

Peninsula Dental School

Osteochondral tissue engineering has shown an increasing development to provide suitable strategies for the regeneration of damaged cartilage and underlying subchondral bone tissue. For reasons of the limitation in the capacity of articular cartilage to self-repair, it is essential to develop approaches based on suitable scaffolds made of appropriate engineered biomaterials. The combination of biodegradable polymers and bioactive ceramics in a variety of composite structures is promising in this area, whereby the fabrication methods, associated cells and signalling factors determine the success of the strategies. The objective of this review is to present and discuss approaches being proposed in osteochondral …

Contribution Of Spores To The Ability Of Clostridium Difficile To Adhere To Surfaces, Lovleen Tina Joshi, Daniel S. Phillips, Catrin F. Williams, Abdullah Alyousef, Les Baillie

Peninsula Dental School

ABSTRACT Clostridium difficile is the commonest cause of hospital-acquired infection in the United Kingdom. We characterized the abilities of 21 clinical isolates to form spores; to adhere to inorganic and organic surfaces, including stainless steel and human adenocarcinoma cells; and to germinate. The composition of culture media had a significant effect on spore formation, as significantly more spores were produced in brain heart infusion broth (Student's t test; P = 0.018). The spore surface relative hydrophobicity (RH) varied markedly (14 to 77%) and was correlated with the ability to adhere to stainless steel. We observed no correlation between the ribotype …

The Effect Of Geographical Scale Of Sampling On Dna Barcoding., Johannes Bergsten, David T. Bilton, Tomochika Fujisawa, Miranda Elliott, Michael T. Monaghan, Michael Balke, Lars Hendrich, Joja Geijer, Jan Herrmann, Garth N. Foster, Ignacio Ribera, Anders N. Nilsson, Timothy G. Barraclough, Alfried P. Vogler

School of Biological and Marine Sciences

Eight years after DNA barcoding was formally proposed on a large scale, CO1 sequences are rapidly accumulating from around the world. While studies to date have mostly targeted local or regional species assemblages, the recent launch of the global iBOL project (International Barcode of Life), highlights the need to understand the effects of geographical scale on Barcoding's goals. Sampling has been central in the debate on DNA Barcoding, but the effect of the geographical scale of sampling has not yet been thoroughly and explicitly tested with empirical data. Here, we present a CO1 data set of aquatic predaceous diving beetles …