Digital Commons Network^™

Implicit Social Learning In Relation To Autistic-Like Traits, Matthew Hudson, Tanja C.W. Nijboer, Tjeerd Jellema

School of Psychology

No abstract provided.

Northern Cheyenne Tribe: Traditional Law And Constitutional Reform, Sheldon C. Spotted Elk

Tribal Law Journal

This profile by Sheldon C. Spotted Elk examines the U.S. Government's infringement on the Northern Cheyenne's political sovereignty. Most significantly, this profile examines the relationship between the oral history of the Northern Cheyenne and its impact on traditional tribal governance and law. Following the Northern Cheyenne's adoption of a modern constitution, many members fought to continue living under a traditional constitution. Ultimately, the Northern Cheyenne a written IRA compatible constitution while maintaining an oral constitution. The delicate balance allows the Northern Cheyenne to address modern issues while also keeping the fundamental traditional and customary law of the tribe alive.

Mir-145 Directly Targets P70s6k1 In Cancer Cells To Inhibit Tumor Growth And Angiogenesis., Qing Xu, Ling-Zhi Liu, Xu Qian, Qi Chen, Yue Jiang, Dan Li, Lihui Lai, Bing-Hua Jiang

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

MiR-145 can regulate cell apoptosis, proliferation, neural development and stem cell differentiation. Previous studies indicate that miR-145 is downregulated in human colon cancer cells. However, the molecular mechanisms of miR-145 used to regulate colon carcinogenesis and angiogenesis remain to be clarified. Here, we show that the expression of miR-145 is downregulated in colon and ovarian cancer tissues and cell lines. MiR-145 inhibits p70S6K1 post-transcriptional expression by binding to its 3'-UTR. The angiogenic factors hypoxia-inducible factor 1 (HIF-1) and vascular endothelial growth factor (VEGF), which are downstream molecules of p70S6K1, are decreased by miR-145 overexpression. P70S6K1 rescues miR-145-suppressed HIF-1 and VEGF …

Blood-Brain Barrier Abnormalities Caused By Hiv-1 Gp120: Mechanistic And Therapeutic Implications., Jean-Pierre Louboutin, David S Strayer

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

The blood-brain barrier (BBB) is compromised in many systemic and CNS diseases, including HIV-1 infection of the brain. We studied BBB disruption caused by HIV-1 envelope glycoprotein 120 (gp120) as a model. Exposure to gp120, whether acute [by direct intra-caudate-putamen (CP) injection] or chronic [using SV(gp120), an experimental model of ongoing production of gp120] disrupted the BBB, and led to leakage of vascular contents. Gp120 was directly toxic to brain endothelial cells. Abnormalities of the BBB reflect the activity of matrix metalloproteinases (MMPs). These target laminin and attack the tight junctions between endothelial cells and BBB basal laminae. MMP-2 and …

Integrative Gene Regulatory Network Analysis Reveals Light-Induced Regional Gene Expression Phase Shift Programs In The Mouse Suprachiasmatic Nucleus., Haisun Zhu, Rajanikanth Vadigepalli, Rachel Rafferty, Gregory E Gonye, David R Weaver, James S Schwaber

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

We use the multigenic pattern of gene expression across suprachiasmatic nuclei (SCN) regions and time to understand the dynamics within the SCN in response to a circadian phase-resetting light pulse. Global gene expression studies of the SCN indicate that circadian functions like phase resetting are complex multigenic processes. While the molecular dynamics of phase resetting are not well understood, it is clear they involve a "functional gene expression program", e.g., the coordinated behavior of functionally related genes in space and time. In the present study we selected a set of 89 of these functionally related genes in order to further …

Knockdown Of Ki-67 By Dicer-Substrate Small Interfering Rna Sensitizes Bladder Cancer Cells To Curcumin-Induced Tumor Inhibition., Sivakamasundari Pichu, Swapna Krishnamoorthy, Andrei Shishkov, Bi Zhang, Peter Mccue, Biddanda C Ponnappa

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Transitional cell carcinoma (TCC) of the urinary bladder is the most common cancer of the urinary tract. Most of the TCC cases are of the superficial type and are treated with transurethral resection (TUR). However, the recurrence rate is high and the current treatments have the drawback of inducing strong systemic toxicity or cause painful cystitis. Therefore, it would be of therapeutic value to develop novel concepts and identify novel drugs for the treatment of bladder cancer. Ki-67 is a large nucleolar phosphoprotein whose expression is tightly linked to cell proliferation, and curcumin, a phytochemical derived from the rhizome Curcuma …

The Dermatan Sulfate Proteoglycan Decorin Modulates Α2Β1 Integrin And The Vimentin Intermediate Filament System During Collagen Synthesis., Oliver Jungmann, Katerina Nikolovska, Christian Stock, Jan-Niklas Schulz, Beate Eckes, Christoph Riethmüller, Rick T Owens, Renato V Iozzo, Daniela G Seidler

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Decorin, a small leucine-rich proteoglycan harboring a dermatan sulfate chain at its N-terminus, is involved in regulating matrix organization and cell signaling. Loss of the dermatan sulfate of decorin leads to an Ehlers-Danlos syndrome characterized by delayed wound healing. Decorin-null (Dcn(-/-)) mice display a phenotype similar to that of EDS patients. The fibrillar collagen phenotype of Dcn(-/-) mice could be rescued in vitro by decorin but not with decorin lacking the glycosaminoglycan chain. We utilized a 3D cell culture model to investigate the impact of the altered extracellular matrix on Dcn(-/-) fibroblasts. Using 2D gel electrophoresis followed by mass spectrometry, …

Decorin Protein Core Affects The Global Gene Expression Profile Of The Tumor Microenvironment In A Triple-Negative Orthotopic Breast Carcinoma Xenograft Model., Simone Buraschi, Thomas Neill, Rick T Owens, Leonardo A Iniguez, George Purkins, Rajanikanth Vadigepalli, Barry Evans, Liliana Schaefer, Stephen C Peiper, Zi-Xuan Wang, Renato V Iozzo

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Decorin, a member of the small leucine-rich proteoglycan gene family, exists and functions wholly within the tumor microenvironment to suppress tumorigenesis by directly targeting and antagonizing multiple receptor tyrosine kinases, such as the EGFR and Met. This leads to potent and sustained signal attenuation, growth arrest, and angiostasis. We thus sought to evaluate the tumoricidal benefits of systemic decorin on a triple-negative orthotopic breast carcinoma xenograft model. To this end, we employed a novel high-density mixed expression array capable of differentiating and simultaneously measuring gene signatures of both Mus musculus (stromal) and Homo sapiens (epithelial) tissue origins. We found that …

Temporal Changes In Innate Immune Signals In A Rat Model Of Alcohol Withdrawal In Emotional And Cardiorespiratory Homeostatic Nuclei., Kate Freeman, Anthony Brureau, Rajanikanth Vadigepalli, Mary M Staehle, Melanie M Brureau, Gregory E Gonye, Jan B Hoek, D Craig Hooper, James S Schwaber

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

BACKGROUND: Chronic alcohol use changes the brain's inflammatory state. However, there is little work examining the progression of the cytokine response during alcohol withdrawal, a period of profound autonomic and emotional upset. This study examines the inflammatory response in the central nucleus of the amygdala (CeA) and dorsal vagal complex (DVC), brain regions neuroanatomically associated with affective and cardiorespiratory regulation in an in vivo rat model of withdrawal following a single chronic exposure.

METHODS: For qRT-PCR studies, we measured the expression of TNF-α, NOS-2, Ccl2 (MCP-1), MHC II invariant chain CD74, and the TNF receptor Tnfrsf1a in CeA and DVC …

Conversion From Enzyme-Inducing Antiepileptic Drugs To Topiramate: Effects On Lipids And C-Reactive Protein., Scott Mintzer, Christopher T Skidmore, Sara J Rankin, Inna Chervoneva, Edward Pequinot, David M Capuzzi, Michael R Sperling

Department of Neurology Faculty Papers

PURPOSE: We previously demonstrated that converting patients from the enzyme-inducers phenytoin or carbamazepine to the non-inducers levetiracetam or lamotrigine reduces serum lipids and C-reactive protein (CRP). We sought to determine if the same changes would occur when patients were switched to topiramate, which has shown some evidence of enzyme induction at high doses. We also examined the effects of drug switch on low-density lipoprotein (LDL) particle concentration.

METHODS: We converted 13 patients from phenytoin or carbamazepine monotherapy to topiramate monotherapy (most at doses of 100-150 mg/day). Fasting lipids, including LDL particle concentration, and CRP were obtained before and ≥6 weeks …

Thermosensitive Magnetic Nanoparticles For Self-Controlled Hyperthermia Cancer Treatment, Karen S. Martirosyan

Physics & Astronomy Faculty Publications

Magnetic nanoparticles show remarkable phenomena such as superparamagnetism, high field irreversibility and high saturation magnetization [1]. The study of magnetic nanoparticles has been a very active research field due to many important applications such as drug delivery, imaging and hyperthermia cancer treatment [2]. Hyperthermia has been used for many years to treat a wide variety of tumors in patients and used as well as an adjunct to cancer radiotherapy or chemotherapy [3,4]. Its use is based on the fact that tumor cells are more sensitive to temperature in the range of 42–45°C (which yields necrosis, coagulation, or carbonization) than normal …

The Impact Of Kenya National Library Services (Knls), Kisumu Provincial Mobile Library Services On Education In Kisumu County,Kenya., James Macharia Tutu

Library Philosophy and Practice (e-journal)

The purpose of this study was to establish the impact of KNLS Kisumu provincial mobile library services on education in Kisumu County. Qualitative research approach was used to conduct the study. Interviews were used to collect data and data was analysed qualitatively. Ten schools were sampled for the study, six secondary schools and four primary schools. Personnel working with KNLS Kisumu provincial mobile library services and teachers in sampled schools were interviewed. The study established that the impact of KNLS Kisumu provincial mobile library services on education in Kisumu County was positive. The study recommends the diversification of the mobile …

Title Vii Works - That's Why We Don't Like It, Chuck Henson

Faculty Publications

In response to the universal belief that Title VII of the Civil Rights Act of 1964 is not fulfilling its purpose, this Article presents a different perspective on the reality of this federal employment discrimination law. Title VII is fulfilling the purpose of the Congress that created it. The purpose was not the eradication of all discrimination in employment. The purpose was to balance the prohibition of the most obvious forms of discrimination with the preservation of as much employer decision-making latitude as possible. Moreover, the seminal Supreme Court decision, McDonnell Douglas v. Green, accurately implemented this balance. This Article …

Structural And Molecular Pathology Of The Atrium In Boxer Arrhythmogenic Cardiomyopathy, Jorge Luis Vila

LSU Master's Theses

Arrhythmogenic cardiomyopathy (AC), also known as arrhythmogenic right ventricular cardiomyopathy (ARVC), is a disease characterized by fatty or fibro-fatty myocardial replacement, predominantly in the right ventricle and to a lower extent the left ventricle. It is recognized as a disease affecting the cardiac intercalated disc. Clinically, it is associated with ventricular arrhythmias, although atrial arrhythmias and atrial histopathological changes characteristic of AC have occasionally been reported. The full extent of atrial involvement in AC has not been investigated. Therefore, we aimed to apply histopathology, immunochemical detection, immunolocalization and transmission electron microscopy (TEM) techniques to characterize the distribution of desmosomal and …

Natural Disasters, Brittany Beth Barr

Graduate Student Theses, Dissertations, & Professional Papers

Six stories.

Real Live Girls And Other Stories, Emily Karen Jones

Graduate Student Theses, Dissertations, & Professional Papers

This is a collection of short stories.

The Use Of Motion Capture And 2d Animation In The Making Of "If At First...", Kyle Formella

Research Papers

No abstract provided.

Annual Variation In Timing, Orientation And Effects Of Weather On Jefferson Salamander (Ambystoma Jeffersonianum) And Spotted Salamander (Ambystoma Maculatum) Movements In Central Kentucky, Christopher James St. Andre

Online Theses and Dissertations

Annual variation in temporal and spatial patterns of amphibian migration and dispersal are poorly understood. To address this issue, a circular drift fence was installed around an ephemeral pond at the Central Kentucky Wildlife Management Area, Madison County, Kentucky. The pond was checked daily for salamander movements from 17 January 2010 to 26 September 2010 and from 26 January 2011 to 3 August 2011, which corresponded to the activity season. Weather variables examined in relation to amphibian movements included barometric pressure, cumulative precipitation, temperature and relative humidity. Several species used the ephemeral pond during the study but few successfully reproduced. …

Forest Dynamics Of Two Multi-Aged Hemlock-Mixed Mesophytic Forests In The Northern Cumberland Plateau, Kentucky, Kacie Lee Tackett

Online Theses and Dissertations

Tsuga canadensis (eastern hemlock) is a foundation species that performs a unique ecological role within the Appalachian mixed mesophytic forest of the eastern United States. However, the non-native hemlock woolly adelgid (HWA; Adelges tsugae Annand), a novel invasive colonizer, is significantly altering the natural processes within T. canadensis ecosystems. Few studies have documented T. canadensis forests before, during, and after HWA infestation. This study documented the pre-HWA conditions of two old hemlock-mixed mesophytic forests in eastern Kentucky by examining the composition, T. canadensis crown health, stand structure, age structure, and disturbance history. Rock Creek Research Natural Area (RCRNA) is a …

Nocturnal Habitat Selection During Spring Migration By American Woodcock (Scolopax Minor) In Central Kentucky, Andrew K. Newman

Online Theses and Dissertations

American woodcock (Scolopax minor) have experienced long-term population declines due to habitat loss. While significant research has occurred on breeding and wintering grounds, little is known about spring migratory ecology. This study assessed nocturnal roosting habitat of American woodcock through the use of night spotlighting techniques. The study was conducted on the Blue Grass Army Depot and the Central Kentucky Wildlife Management Area, both located in Madison County, Kentucky. A total of 84 field, 421 ha, of four habitat types, burned, grazed, hayed, old/fallow, were searched for woodcock. Roost sites were marked and the vegetation of each site was compared …

Effect Of Predator Type, Season, Brood Size, And West Nile Virus Infection On The Nest Defense Behavior Of Male And Female Eastern Bluebirds, Kayde Lynn Gilbert

Online Theses and Dissertations

The intensity of nest defense by birds can be influenced by many factors, including a parent's sex, brood size, stage of breeding season, type of predator, and physical condition. Because previous studies have produced conflicting results concerning the effects of these factors on the nest defense behavior of birds, additional studies are needed to better clarify how and why such factors influence behavior. No one to date has examined the possible effect of a viral infection on avian nest defense behavior. Thus, my objectives were to determine the effect of adult sex, brood size, stage of the breeding season, predator …

A Dietary Study Of Big Brown (Eptesicus Fuscus) And Northern Bats (Myotis Septentrionalis) In Western Kentucky, Sarah Elizabeth Asher

Online Theses and Dissertations

Knowledge is lacking regarding the dietary habits of northern (Myotis septentrionalis) and big brown bats (Eptesicus fuscus) in Kentucky. The objective of this study was to determine the prey items consumed by both species at three sites in western Kentucky. Totals of 103 fecal pellet samples from northern bats and 36 fecal pellet samples from big brown bats were collected in 2003 and 2004. Overall prey items found within the samples collected for both species indicated their diets were similar (Sorensen's coefficient; S_S= 0.72); with the most common insect orders being Coleoptera, Lepidoptera, and …

The Black Gum Well, Carolyn Ruth Pennington

Online Theses and Dissertations

The writing of the novel as a creative thesis in American literature was a special project approved by the English department of Eastern Kentucky University. Beyond the university's departmental requirements in the course of study for a a Master of English in American literature, I did an independent study of creative writing texts recommended by the creative writing department at Easter Kentucky University. I attended three summer workshops at the Hindman Settlement School Writer's Workshop, Hindman, Kentucky, with classes under professors/authors Robert Morgan, Gurney Norman, Lee Smith and other noted others. My undergraduate study of the English novel and my …

The Effectiveness Of Homeland Security Training For Rural Communities: A Comparative Analysis Of Web-Based And Instructor-Led Training Delivery, Ryan K. Baggett

Online Theses and Dissertations

The development of advanced training technologies such as Web Based Training (WBT), coupled with the proliferation of computer and Internet availability, has increased training opportunities for rural communities. This advancement is critical to meeting the training needs of emergency response personnel in rural communities who routinely face the challenge of providing continuous services to their community with limited resources. Despite the perceived convenience of WBT for emergency responders, little research has been conducted in homeland security on the knowledge acquisition of those who are trained using an electronic medium as compared to those in a traditional, Instructor-Led Training (ILT) delivery. …

Four-Toed Salamander (Hemidactylium Scutatum) Nest Site Characteristics In Natural And Constructed Wetlands In Eastern Kentucky, Susan Kay King

Online Theses and Dissertations

Forested freshwater wetlands have undergone loss and alteration more than other types of wetlands. Wetland creation has slowed wetland losses, but many created wetlands do not functionally replace natural wetlands. Plant and animal communities and wetland drying cycles often differ between natural and constructed wetlands. It is important to understand what specific habitat characteristics differ between natural and constructed wetlands and what impact these differences might have on the animal assemblages. Having restrictive habitat requirements makes the four-toed salamander a good candidate for study. The objectives of this study were to understand four-toed salamander (Hemidactylium scutatum) nesting ecology …

The Process Of Colonial Adaptation: English Responses To The 1692 Earthquake At Port Royal, Jamaica, Julie Yates Matlock

Online Theses and Dissertations

This research investigates how colonists adapted to their new tropical environment after a destructive earthquake occurred in Jamaica on June 7, 1692. This earthquake killed approximately two thousand people and destroyed half of the bustling harbor town of Port Royal. The earthquake dramatically changed the landscape of England's most successful Caribbean town and affected the colonists.

Historian Richard Dunn contended that colonists did not adapt to their tropical environment for at least a century after first inhabiting the Caribbean. This study argues against Dunn's theory in that the earthquake served as a catalyst in accelerating the colonists' rate of adaptation …

The Influence Of Tail Autotomy On Avoidance Of Chemical Alarm Cues In Northern Zigzag Salamanders, Plethodon Dorsalis, Ivan Thomas Moberly

Online Theses and Dissertations

The morphology and behavior of most species are influenced by predator-prey interactions. To avoid microhabitats that pose an increased predation risk salamanders may use predator avoidance. Salamanders detect chemical alarm cues via the vomeronasal organ and their avoidance of the chemical cues is based upon the apparent associated risk. The objective of this study was to better understand predator avoidance by means of chemical alarm cues in northern zigzag salamanders, Plethodon dorsalis. Adult salamanders were placed into Petri dishes with a choice between treated substrate (filter paper treated with chemical cues) or untreated substrate (filter paper treated with distilled water). …

Population Distribution And Demographics Of Smallmouth Bass (Micropterus Dolomieu) In Silver Creek, Madison County, Kentucky, Justin Daniel Basham

Online Theses and Dissertations

The objective of this study was to determine the population distribution and demographics of smallmouth bass Micropterus dolomieu in Silver Creek, Madison Co, KY. The stream was electro-shocked at 19 locations during the Fall of 2011 and Spring of 2012. At each stream site width (m), depth (m), flow (m/s), and percentage of substrate type pool, riffle, run was recorded across transects as the microhabitat. Kentucky Division of Water's rapid habitat assessment was used to assess the habitat within the stream and the riparian vegetation surrounding the stream. The majority of smallmouth bass collected in Silver Creek were collected in …

Forgotten Victims: A Qualitative Study Of Familial And Intimate Partner Abuse Of Male-To-Female Transgender Individuals In Central Kentucky, Allison Brooke Willingham

Online Theses and Dissertations

Previous research on intimate partner and familial abuse has focused on easily identifiable social institutions, such as "homosexual couple" or "mother/daughter." However, transgender individuals do not always fit into the binary social definitions ascribed to family relationships. Little research has provided insight into cycles of familial and intimate partner verbal or physical abuse in the lives of transgender individuals. The efforts that have been made have shocking results and demonstrate a need for further and more in-depth research. The primary purpose of this research is to gain a rich understanding of the social dynamics affecting the lives of transgender individuals …

The Development Of Old-Growth Structural Characteristics In Second-Growth Forests Of The Cumberland Plateau, Kentucky, U.S.A., Robert James Scheff

Online Theses and Dissertations

Prior to Euro-American colonization beginning in the late 1700s and subsequent periods of land conversion and intensive resource extraction, most forest on the Cumberland Plateau in Kentucky would have existed in a state meeting one or more of the definitions of old-growth forest in use today. However, many recovering, mature forests currently exist that might be redeveloping old-growth structure and function. To assess the development of old-growth forest characteristics in second-growth forests, 70 - 90 year old (young) and 140 - 160 year old (old) hardwood forests in the Daniel Boone National Forest were examined for a suite of structural …