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2012

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Apolipoprotein E: Essential Catalyst Of The Alzheimer Amyloid Cascade, Huntington Potter, Thomas Wisniewski Jan 2012

Apolipoprotein E: Essential Catalyst Of The Alzheimer Amyloid Cascade, Huntington Potter, Thomas Wisniewski

Molecular Medicine Faculty Publications

The amyloid cascade hypothesis remains a robust model of AD neurodegeneration. However, amyloid deposits contain proteins besides Aβ, such as apolipoprotein E (apoE). Inheritance of the apoE4 allele is the strongest genetic risk factor for late-onset AD. However, there is no consensus on how different apoE isotypes contribute to AD pathogenesis. It has been hypothesized that apoE and apoE4 in particular is an amyloid catalyst or “pathological chaperone”. Alternatively it has been posited that apoE regulates Aβ clearance, with apoE4 been worse at this function compared to apoE3. These views seem fundamentally opposed. The former would indicate …

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Understanding Viral Transmission Behavior Via Protein Intrinsic Disorder Prediction: Coronaviruses, Gerard Kian-Meng Goh, A. Keith Dunker, Vladimir N. Uversky Jan 2012

Understanding Viral Transmission Behavior Via Protein Intrinsic Disorder Prediction: Coronaviruses, Gerard Kian-Meng Goh, A. Keith Dunker, Vladimir N. Uversky

Molecular Medicine Faculty Publications

Besides being a common threat to farm animals and poultry, coronavirus (CoV) was responsible for the human severe acute respiratory syndrome (SARS) epidemic in 2002–4. However, many aspects of CoV behavior, including modes of its transmission, are yet to be fully understood. We show that the amount and the peculiarities of distribution of the protein intrinsic disorder in the viral shell can be used for the efficient analysis of the behavior and transmission modes of CoV. The proposed model allows categorization of the various CoVs by the peculiarities of disorder distribution in their membrane (M) and nucleocapsid (N). This categorization …

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Conceptualizing Shari'a In The Modern State, Khaled Abou El Fadl Jan 2012

Conceptualizing Shari'a In The Modern State, Khaled Abou El Fadl

Villanova Law Review (1956 - )

THIS Article addresses the animated and evolving role that Shari'a, i.e., the system of Islamic jurisprudence collectively or generally, and Shari'a conceptions play in the contemporary world. There are various manifestations of this evolving role in the often dynamic, subtle, highly negotiated, and far from formalistic ways that Shari'a is animated in today's world. There are three main points that I will address in this Article. First is to provide some insight into the various ways that Shari'a has been manifesting in the recent revolutions sweeping through the Arabic-speaking world, while at the same time contrasting the rather curious case …

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Concerning Procedures Related To The Costs Of Impounded Animals., Colorado General Assembly Jan 2012

Concerning Procedures Related To The Costs Of Impounded Animals., Colorado General Assembly

Session Laws 2001-Present

No abstract provided.

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Concerning The Classification Of The Sales Of Certain Items Used In Agricultural Production As Wholesale Sales., Colorado General Assembly Jan 2012

Concerning The Classification Of The Sales Of Certain Items Used In Agricultural Production As Wholesale Sales., Colorado General Assembly

Session Laws 2001-Present

No abstract provided.

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Concerning A Supplemental Appropriation To The Department Of Agriculture., Colorado General Assembly Jan 2012

Concerning A Supplemental Appropriation To The Department Of Agriculture., Colorado General Assembly

Session Laws 2001-Present

No abstract provided.

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Concerning Continuation Of The State Board Of Pharmacy, And, In Connection Therewith, Implementing The Recommendations Contained In The Sunset Review And Report Regarding The Board And Recodifying The Laws Regulating Pharmacists, The Practice Of Pharmacy, And The Manufacture, Distribution, And Dispensing Of Prescription Drugs And Controlled Substances, And Making An Appropriation., Colorado General Assembly Jan 2012

Concerning Continuation Of The State Board Of Pharmacy, And, In Connection Therewith, Implementing The Recommendations Contained In The Sunset Review And Report Regarding The Board And Recodifying The Laws Regulating Pharmacists, The Practice Of Pharmacy, And The Manufacture, Distribution, And Dispensing Of Prescription Drugs And Controlled Substances, And Making An Appropriation., Colorado General Assembly

Session Laws 2001-Present

No abstract provided.

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Concerning The Provision For Payment Of The Expenses Of The Executive, Legislative, And Judicial Departments Of The State Of Colorado, And Of Its Agencies And Institutions, For And During The Fiscal Year Beginning July 1, 2012, Except As Otherwise Noted., Colorado General Assembly Jan 2012

Concerning The Provision For Payment Of The Expenses Of The Executive, Legislative, And Judicial Departments Of The State Of Colorado, And Of Its Agencies And Institutions, For And During The Fiscal Year Beginning July 1, 2012, Except As Otherwise Noted., Colorado General Assembly

Session Laws 2001-Present

No abstract provided.

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Splendid Hybrids: The Effects Of A Tiger Beetle Hybrid Zone On Apparent Species Diversity, Mathew L. Brust, W. Wyatt Hoback, Stephen M. Spomer Jan 2012

Splendid Hybrids: The Effects Of A Tiger Beetle Hybrid Zone On Apparent Species Diversity, Mathew L. Brust, W. Wyatt Hoback, Stephen M. Spomer

Department of Entomology: Faculty Publications

Nonexpert citizen groups are being used to monitor species to track ecosystem changes; however, challenges remain for proper identification, especially among diverse groups such as beetles. Tiger beetles, Cicindela spp., have been used for biological diversity monitoring because of their diversity and the ease of recognition. The finding of an apparent hybrid zone among Cicindela denverensis Casey, Cicindela limbalis Klug, and Cicindela splendida Hentz in central Nebraska prompted a detailed study of the biogeography of this species group within Nebraska, a test of characteristics that could be used by citizen scientists, and limited breeding experiments. This study suggests that while …

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Expected Economic Potential Of Substituting Legumes For Nitrogen In Bermudagrass Pastures, Jon T. Biermacher, The Samuel Roberts Noble Foundation, Inc. Reuter, M.K. Kering, J.K. Rogers, J. Blanton Jr, John A. Guretzky, T.J. Butler Jan 2012

Expected Economic Potential Of Substituting Legumes For Nitrogen In Bermudagrass Pastures, Jon T. Biermacher, The Samuel Roberts Noble Foundation, Inc. Reuter, M.K. Kering, J.K. Rogers, J. Blanton Jr, John A. Guretzky, T.J. Butler

Department of Agronomy and Horticulture: Faculty Publications

Grazing warm-season grass pastures with stocker cattle (Bos taurus) is an important economic activity in the southern Great Plains, and substantial increases in the price of N fertilizer have negatively affected profi tability of forage producers. The goal of the study was to determine if bermudagrass [Cynodon dactylon (L.) Pers.] pastures interseeded with either annual or perennial legumes are more profitable than the conventional method of fertilizing with 112 kg N ha–1 commercial fertilizer. A completely randomized design grazing study was conducted in south-central Oklahoma during the spring and summer months of 2008, 2009, and 2010. …

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Optimizing Cover Crop Benefits With Diverse Mixtures And An Alternative Termination Method, Samuel E. Wortman, Charles A. Francis, Mark L. Bernards, Rhae A. Drijber, John L. Lindquist Jan 2012

Optimizing Cover Crop Benefits With Diverse Mixtures And An Alternative Termination Method, Samuel E. Wortman, Charles A. Francis, Mark L. Bernards, Rhae A. Drijber, John L. Lindquist

Department of Agronomy and Horticulture: Faculty Publications

Previous studies have demonstrated benefits of individual cover crop species, but the value of diverse cover crop mixtures has received less attention. The objectives of this research were to determine the effects of spring-sown cover crop mixture diversity and mechanical cover crop termination method on cover crop and/or cash crop productivity, soil moisture and N, and profitability in an organic cropping system. An experiment was conducted between 2009 and 2011 near Mead, Nebraska, United States, where mixtures of two (2CC), four (4CC), six (6CC), and eight (8CC) cover crop species, or a summer annual weed mixture were included in a …

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Concerning A Fund Consisting Of Surcharges On Insurance Premiums To Pay For Costs Associated With Criminal Prosecution Of Insurance Fraud Investigations, And, In Connection Therewith, Making An Appropriation., Colorado General Assembly Jan 2012

Concerning A Fund Consisting Of Surcharges On Insurance Premiums To Pay For Costs Associated With Criminal Prosecution Of Insurance Fraud Investigations, And, In Connection Therewith, Making An Appropriation., Colorado General Assembly

Session Laws 2001-Present

No abstract provided.

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Evaluation Of Monoclonal Antibody–Based Immunohistochemistry For The Detection Of European And North American Porcine Reproductive And Respiratory Syndrome Virus And A Comparison With In Situ Hybridization And Reverse Transcription Polymerase Chain Reaction, Kiwon Han, Hwi Won Seo, Yeonsu Oh, Ikjae Kang, Changhoon Park, Sang Hoon Kang, Sung-Hoon Kim, Bog-Hieu Lee, Byung Joon Kwon, Chanhee Chae Jan 2012

Evaluation Of Monoclonal Antibody–Based Immunohistochemistry For The Detection Of European And North American Porcine Reproductive And Respiratory Syndrome Virus And A Comparison With In Situ Hybridization And Reverse Transcription Polymerase Chain Reaction, Kiwon Han, Hwi Won Seo, Yeonsu Oh, Ikjae Kang, Changhoon Park, Sang Hoon Kang, Sung-Hoon Kim, Bog-Hieu Lee, Byung Joon Kwon, Chanhee Chae

Nebraska Center for Virology: Faculty Publications

The objective of the present study was to compare the ability of 2 monoclonal antibodies (mAbs; SDOW17 and SR30) to detect types 1 and 2 Porcine reproductive and respiratory syndrome virus (PRRSV) in formalin-fixed, paraffin-embedded (FFPE) lung tissues by immunohistochemistry (IHC) and to compare the immunohistochemical results with in situ hybridization (ISH) and reverse transcription nested polymerase chain reaction (RT-nPCR) detection techniques. Lungs from 30 experimentally infected pigs (15 pigs with each genotype of PRRSV) and 20 naturally infected pigs (10 pigs with each genotype of PRRSV) with types 1 and 2 PRRSV, respectively, were used for the IHC, ISH, …

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Siv Infection Induces Accumulation Of Plasmacytoid Dendritic Cells In The Gut Mucosa, R. Keith Reeves, Tristan I. Evans, Jacqueline Gillis, Fay E. Wong, Guobin Kang, Qingsheng Li, R. Paul Johnson Jan 2012

Siv Infection Induces Accumulation Of Plasmacytoid Dendritic Cells In The Gut Mucosa, R. Keith Reeves, Tristan I. Evans, Jacqueline Gillis, Fay E. Wong, Guobin Kang, Qingsheng Li, R. Paul Johnson

Nebraska Center for Virology: Faculty Publications

Multiple studies suggest that plasmacytoid dendritic cells (pDCs) are depleted and dysfunctional during human immunodeficiency virus/simian immunodeficiency virus (HIV/SIV) infection, but little is known about pDCs in the gut—the primary site of virus replication. Here, we show that during SIV infection, pDCs were reduced 3-fold in the circulation and significantly upregulated the gut-homing marker α4β7, but were increased 4-fold in rectal biopsies of infected compared to naive macaques. These data revise the understanding of pDC immunobiology during SIV infection, indicating that pDCs are not necessarily depleted, but instead may traffic to and accumulate in the gut mucosa.

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Economic Impact Of Canada-United States Regulatory Convergence: From The Canada-United States Auto Pact To The North American Free Trade Agreement And Beyond, The, Wilbur Leatherberry, Meera Fickling, Maureen Irish Jan 2012

Economic Impact Of Canada-United States Regulatory Convergence: From The Canada-United States Auto Pact To The North American Free Trade Agreement And Beyond, The, Wilbur Leatherberry, Meera Fickling, Maureen Irish

Canada-United States Law Journal

No abstract provided.

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Food Safety In Canada And The United States, Robert Strassfeld, Stephanie Lariviere, Cyndee Todgham Cherniak Jan 2012

Food Safety In Canada And The United States, Robert Strassfeld, Stephanie Lariviere, Cyndee Todgham Cherniak

Canada-United States Law Journal

No abstract provided.

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Towards Sustainable Consumption And Production In North America: Building Legitimacy Through Roles And Responsibilities In A Beyond Compliance Operating Environment, Stefanie Bowles Jan 2012

Towards Sustainable Consumption And Production In North America: Building Legitimacy Through Roles And Responsibilities In A Beyond Compliance Operating Environment, Stefanie Bowles

Canada-United States Law Journal

No abstract provided.

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Partnership For Regional Prosperity And Global Peace, A, Davis Robinson, John Negroponte Amb. Jan 2012

Partnership For Regional Prosperity And Global Peace, A, Davis Robinson, John Negroponte Amb.

Canada-United States Law Journal

No abstract provided.

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Trust, In So Many Words, Birgit Matthiesen Jan 2012

Trust, In So Many Words, Birgit Matthiesen

Canada-United States Law Journal

No abstract provided.

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Just Places: Creating A Space For Place In Environmental Justice, Damayanti Banergee Jan 2012

Just Places: Creating A Space For Place In Environmental Justice, Damayanti Banergee

Societies Without Borders

This paper explores how discourses on sense of place and cultural heritage inform environmental justice conflicts. I argue that while economic distribution remains the overarching frame within environmental justice scholarship, cultural entitlement concerns are rarely discussed in the literature. I argue that environmental justice scholarship can draw upon place and cultural research to explore how cultural entitlement claims can be incorporated in environmental justice. I draw upon place literature to propose a three-dimensional typology of place. I call these three dimensions – political place, cultural place, and moral place. The proposed typology allows us to examine how discourses of place …

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The Collaborative Dialogue Panel: Changing The Model Of The Professional Sociology Conference, Kenneth A. Gould Jan 2012

The Collaborative Dialogue Panel: Changing The Model Of The Professional Sociology Conference, Kenneth A. Gould

Societies Without Borders

The emergence of Sociologists Without Borders opened up new opportunities for social justice oriented intellectual engagement and collaboration. Given the opportunity to re-imagine the structure and function of professional conferences, a number of us who were focused on issues of environmental justice as a human right came together in 2006 to challenge the traditional model of serial paper presentations at panel sessions. The collaborative dialogue panel brings together sociologists focused on a specific social problem or issue, and asks them to work together to generate questions and answers in a public forum in dialogue with each other and with others …

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Of Tools And Houses: Sociologists Without Borders And The Aaas Science And Human Rights Coalition, Bruce K. Friesen, Mark Frezzo, Brian K. Gran Jan 2012

Of Tools And Houses: Sociologists Without Borders And The Aaas Science And Human Rights Coalition, Bruce K. Friesen, Mark Frezzo, Brian K. Gran

Societies Without Borders

Sociologists Without Borders (SSF) has played a key role in the Science and Human Rights Coalition (SHRC) of the American Association for the Advancement of Science. This Coalition, which consists of nearly fifty scientific organizations, seeks to advance the human right to benefit from scientific progress and its application. This article critically evaluates SSF’s role in the SHRC. After providing background on the work, organization, and objectives of the Coalition, this article then elaborates on how sociologists, particularly representatives of the American Sociological Association and SSF, have collaborated with other scientists on various projects designed to implement this human right. …

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Nature, Society And Social Change, Michael Briguglio Jan 2012

Nature, Society And Social Change, Michael Briguglio

Societies Without Borders

Environmental destruction has become an everyday reality in the contemporary world. Major concerns are being put forward regarding the dangers to the environment in general and to human societies in particular, with strong focus currently being put on climate change. Sociology has an important role to play in the analysis of environmental problems. The interaction between nature and society can be analysed through the concept of overdetermination. At the same time, the social construction on environmental problems is imperative for environmental issues to reach the agenda. An active environmental sociology which is as much concerned with analysis as it is …

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Deterritorialization, Pure War, And The Consequences Of Indian Captivity In Transnational Colonial Discourse, Billy J. Stratton Jan 2012

Deterritorialization, Pure War, And The Consequences Of Indian Captivity In Transnational Colonial Discourse, Billy J. Stratton

English and Literary Arts: Faculty Scholarship

The genre of the captivity narrative has operated as a vital circuit for transnational colonial discourse since its inception. Throughout the age of discovery, accounts of the captivity became an indispensible means of connecting the European metropole to foreign lands in Asia and Africa, as well as North and South America. The development of the Indian captivity narrative within the Atlantic context functioned as an effective tool for the dissemination of knowledge concerning the New World and its Indigenous inhabitants. In this essay, I examine some of the ways in which the captivity narrative functions as a colonial apparatus vital …

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Simulation Visualization Rhetoric And It's Practical Implications, D'An Knowles Ball, Andrew J. Collins Jan 2012

Simulation Visualization Rhetoric And It's Practical Implications, D'An Knowles Ball, Andrew J. Collins

Engineering Management & Systems Engineering Faculty Publications

Modeling and simulation has moved far beyond simple data representation into the world of visual communication over the past 15 years; ultimately, the acceptance of M&S within mainstream science and society will depend on the results that are produced visually. A simulation’s function is of primary importance to its end result, but it cannot be denied that the discipline of M&S now prizes fancy graphics to communicate. Rhetorical methodological decisions have the greatest impact on the end user, and considerations that bring visual rhetoric to modeling and simulation should be examined as a necessity to application. This paper will expose …

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Leaving The Fda Behind: Pharmaceutical Outsourcing And Drug Safety, Chenglin Liu Jan 2012

Leaving The Fda Behind: Pharmaceutical Outsourcing And Drug Safety, Chenglin Liu

Faculty Articles

During the 2008 heparin crisis, a tainted blood-thinning drug imported from China caused the deaths of at least eighty people in the United States. However, despite the Food and Drug Administration’s (“FDA”) reactive measures, the American regulatory framework for drug safety remains largely unchanged. Currently, about 80% of active pharmaceutical ingredients, 40% of finished drugs, and 50% of all medical devices used in the United States are imported from over 100 countries. With the growth of product outsourcing, pharmaceutical companies in the United States have stopped manufacturing many essential medicines. Nevertheless, the FDA’s foreign inspections have lagged. It would take …

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Financial Literacy And Numerical Ability: Keys To Better Mortgage Outcomes, Knowledge@Smu Jan 2012

Financial Literacy And Numerical Ability: Keys To Better Mortgage Outcomes, Knowledge@Smu

Knowledge@SMU

The US mortgage crisis and its dire after effects have highlighted the criticality of financial literacy. And while most people would have picked up fundamental mathematical principles in schools, not everyone appreciates how arithmetic translates within the complex world of finance. Yet, given what has transpired with the subprime crisis, is it important for borrowers to appreciate complicated financial concepts before taking up a loan? A study of the US mortgage market, presented at a SMU School of Economics Seminar Series, provides some clues as it uncovers links between basic numerical skills and financial fate.

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Clinical Evaluation Of Novel Methods For Extending Microneedle Pore Lifetime, Nicole K. Brogden Jan 2012

Clinical Evaluation Of Novel Methods For Extending Microneedle Pore Lifetime, Nicole K. Brogden

Theses and Dissertations--Pharmacy

Microneedles are a minimally invasive method for delivering drugs through the impermeable skin layers, and have been used to deliver a variety of compounds including macromolecules, vaccines, and naltrexone. Microneedles can be applied to the skin once, creating micropores that allow for drug delivery into the underlying circulation from a drug formulation. The utility of this technique, however, is blunted by rapid micropore closure. This research project sought to: 1) characterize micropore lifetime and re-sealing kinetics, and 2) prolong micropore lifetime via inhibition of the skin’s barrier restoration processes. Impedance spectroscopy was used as a surrogate technique in animals and …

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The Two-Component Signal Transduction System Arlrs Regulates Staphylococcus Epidermidis Biofilm Formation In An Ica-Dependent Manner, Yang Wu, Jiaxue Wang, Tao Xu, Jingran Liu, Wenqi Yu, Qiang Lou, Tao Zhu, Nianan He, Haijing Ben, Jian Hu, Friedrich Götz, Di Qu Jan 2012

The Two-Component Signal Transduction System Arlrs Regulates Staphylococcus Epidermidis Biofilm Formation In An Ica-Dependent Manner, Yang Wu, Jiaxue Wang, Tao Xu, Jingran Liu, Wenqi Yu, Qiang Lou, Tao Zhu, Nianan He, Haijing Ben, Jian Hu, Friedrich Götz, Di Qu

Molecular Biosciences Faculty Publications

Due to its ability to form biofilms on medical devices, Staphylococcus epidermidis has emerged as a major pathogen of nosocomial infections. In this study, we investigated the role of the two-component signal transduction system ArlRS in regulating S. epidermidis biofilm formation. An ArlRS-deficient mutant, WW06, was constructed using S. epidermidis strain 1457 as a parental strain. Although the growth curve of WW06 was similar to that of SE1457, the mutant strain was unable to form biofilms in vitro. In a rabbit subcutaneous infection model, sterile disks made of polymeric materials were implanted subcutaneously followed with inoculation of WW06 or SE1457. …

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A New Light On Elias Hicks, Stephen W. Angell Jan 2012

A New Light On Elias Hicks, Stephen W. Angell

Quaker Religious Thought

No abstract provided.

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