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Articles 13501 - 13530 of 19169
Full-Text Articles in Entire DC Network
Identification Of A Novel Regulator Of Er Stress-Induced Apoptosis, Genevieve S. Joseph
Identification Of A Novel Regulator Of Er Stress-Induced Apoptosis, Genevieve S. Joseph
Student Theses and Dissertations
The survival and development of a multicellular organism is reliant upon proper cell and organelle function, and the tight regulation of cell number. The endoplasmic reticulum (ER) is the cellular compartment where membrane and secretory pathway proteins are folded and modified for transport within or outside of the cell. When the ER becomes overwhelmed by the accumulation of unfolded or misfolded proteins, it enters a state of "ER stress" and the organelle activates the unfolded protein response (UPR) to alleviate the strain. One prominent event during ER stress and the UPR is the Ire1-mediated splicing of unspliced xbp1 (xbp1U) into …
Molecular And Functional Characterization Of Pyramidal Cell Types In The Frontal Cortex Of Mouse Brain, Prerana Shrestha
Molecular And Functional Characterization Of Pyramidal Cell Types In The Frontal Cortex Of Mouse Brain, Prerana Shrestha
Student Theses and Dissertations
Mammalian neocortex is the most complex structure in the brain. Considered the seat of executive function, the neocortex subserves diverse cognitive processes such as decision-making, motor planning, sensory discrimination and memory consolidation. The cellular heterogeneity of the neocortex makes it difficult to understand the molecular and cellular substrate of cognition during normal brain function and disease related dysfunction. A deep understanding of the contribution of the neocortex to behavior can best be achieved with reproducible access to genetically defined and functionally coherent cell populations. Using BAC modification strategy, we targeted distinct cell types in the neocortex for expressing effector molecules …
Establishment Of Introduced Reptiles Increases With The Presence And Richness Of Native Congeners, Rodrigo Barbosa Ferreira, Karen H. Beard, Stephen L. Peterson, Sharon A. Poessel, Colin M. Callahan
Establishment Of Introduced Reptiles Increases With The Presence And Richness Of Native Congeners, Rodrigo Barbosa Ferreira, Karen H. Beard, Stephen L. Peterson, Sharon A. Poessel, Colin M. Callahan
Wildland Resources Faculty Publications
Darwin proposed two contradictory hypotheses to explain the influence of congeners on the outcomes of invasion: the naturalization hypothesis, which predicts a negative relationship between the presence of congeners and invasion success, and the pre-adaptation hypothesis, which predicts a positive relationship between the presence of congeners and invasion success. Studies testing these hypotheses have shown mixed support. We tested these hypotheses using the establishment success of non-native reptiles and congener presence/absence and richness across the globe. Our results demonstrated support for the pre-adaptation hypothesis. We found that globally, both on islands and continents, establishment success was higher in the presence …
Beguiling Religion: The Bifurcations And Biopolitics Of Spirituality And Medicine, M. Therese Lysaught
Beguiling Religion: The Bifurcations And Biopolitics Of Spirituality And Medicine, M. Therese Lysaught
Institute of Pastoral Studies: Faculty Publications and Other Works
No abstract provided.
Epiphany In The Homeric Hymn To Demeter And The Odyssey, Erwin F. Cook
Epiphany In The Homeric Hymn To Demeter And The Odyssey, Erwin F. Cook
Classical Studies Faculty Research
In the following essay I investigate the Odyssey’s sustained engagement with the theme of epiphany. Within the poem’s own narrative, the central epiphanic moment is the recognition scene between Odysseus and Penelope, and it resonates powerfully with a series of other such moments throughout the poem, beginning with Athene’s epiphany to Telemakhos in Book 1. But I also hope to show that these Odyssean scenes resonate just as powerfully with Demeter’s epiphanies in the Homeric hymn to the goddess.
Medicine@Yale September/October 2012 Volume 8, Issue 4, Yale School Of Medicine Office Of Communications
Medicine@Yale September/October 2012 Volume 8, Issue 4, Yale School Of Medicine Office Of Communications
Medicine@Yale - development newsletter
Medicine@Yale : advancing biomedical science, education and health care was a print and online newsletter which published news about academics, research and philanthropy for alumni, donors, faculty, students and the general public. It was initially published 6 times a year and then changed to a quarterly schedule. The first issue came out June/Jul. 2005. The final issue was published in May/June 2022, vol. 17, issue 1. Published by Yale School of Medicine, Office of Communications.
Improving With Age, Nancy Brokaw '71
Improving With Age, Nancy Brokaw '71
News and Events (Discontinued Series)
No abstract provided.
Law's Slow Violence: A Review Of Rob Nixon's "Slow Violence And The Environmentalism Of The Poor" (Hup, 2010), Dayna Nadine Scott
Law's Slow Violence: A Review Of Rob Nixon's "Slow Violence And The Environmentalism Of The Poor" (Hup, 2010), Dayna Nadine Scott
Comparative Research in Law & Political Economy
With gripping urgency, Rob Nixon’s book "Slow Violence and the Environmentalism of the Poor" seeks to reveal the “occluded relationships” between transnational economic actors and the things that tie them to particular places, such as labour, land, resources and commodity dynamics. He brings into view the bodies caught in the middle – those that have been raced and erased, made invisible, and wiped away -- by exposing the violence perpetrated against them across time and space. Nixon’s work is a broad synthesis of a seemingly disparate set of literatures in post-colonial studies, eco-criticism and literary studies. His arresting narrative engages …
Oppression, Suppression, And Injustice: A Critical Evaluation Of The Grievance Procedure In The Federal Public Service, Grant Lopatriello
Oppression, Suppression, And Injustice: A Critical Evaluation Of The Grievance Procedure In The Federal Public Service, Grant Lopatriello
Comparative Research in Law & Political Economy
For nearly half a century, the Government of Canada has been administering a grievance system widely-criticized for its complexity and ineffectiveness. This criticism is due, in no small part, to the government’s unique and untenable role — that of both employer and administrative decision-maker. The Public Service Labour Relations Act (PSLRA) establishes this role and effectively confers an unparalleled level of authority upon management to dispose of employee-centred grievances. Likewise, it triggers management’s obligation to attend to grievances fairly and in accordance with the principles of natural justice. However, because the grievance system derives from the private sector — a …
Indeterminacy And Balance: A Path To A Wholesome Corporate Law, Fenner L. Stewart Jr.
Indeterminacy And Balance: A Path To A Wholesome Corporate Law, Fenner L. Stewart Jr.
Comparative Research in Law & Political Economy
This article argues that corporate legal scholarship needs to focus primarily upon the indeterminacy of essentialist theories about the corporation. This will result in greater pluralism, since no essentialist legal theory would become heavily privileged over any other. When such a balance is created between theories, a robust debate can occur where no ideas are raised to the status of being “undiscussable preferences” and no essentialist theory is off the table before the debate begins. This would lead to fewer consensuses but more complexity than presently exists within corporate legal discourse, helping to immunize the law from the sort of …
Transnational Business Governance Interactions: Conceptualization And Framework For Analysis, Burkard Eberlein, Kenneth W. Abbott, Julia Black, Errol Meidinger
Transnational Business Governance Interactions: Conceptualization And Framework For Analysis, Burkard Eberlein, Kenneth W. Abbott, Julia Black, Errol Meidinger
Comparative Research in Law & Political Economy
This article demonstrates the value of studying interactions in transnational business governance (TBG) and proposes an analytical framework for that purpose. The number of TBG schemes involving non-state authority to govern business conduct across borders has vastly expanded in a wide range of issue areas. As TBG initiatives proliferate, they increasingly interact with one another, and with state-based and other normative regimes. The key challenge is to understand the implications of TBG interactions for regulatory capacity and performance – the most fruitful initial focus – and ultimately for the impacts of regulation on social and environmental problems. To gain purchase …
Problems And Variations In Hospitality Administration Programs Across Illinois, Gina Defano
Problems And Variations In Hospitality Administration Programs Across Illinois, Gina Defano
Honors Capstones
The title of my project is Problems and Variations in Hospitality Administration Programs Across Illinois. The purpose of this study is to determine the strengths and weaknesses of Northern Illinois University’s (NIU) Hospitality Administration program in comparison to the other hospitality programs in Illinois. The goal of this study is to find out what is missing from our program. What do stronger programs have that we don’t? Why is our enrollment not as high as we would like it to be? Are other programs offering more beneficial courses? To answer these questions, I researched the 40 hospitality programs in Illinois. …
Role Of Hoga And Sskb Protein Kinases In Mycotoxin Production In The Filamentous Fungus Aspergillus Nidulans, Lauren Jurkowski
Role Of Hoga And Sskb Protein Kinases In Mycotoxin Production In The Filamentous Fungus Aspergillus Nidulans, Lauren Jurkowski
Honors Capstones
Aspergillus nidulans is a filamentous fungus that is often used as a model organism in genetics and molecular biology studies. The species has a well- characterized life-cycle and its genome has been sequenced. Aspergillus species are commonly found in the environment. Some species can cause health problems in humans. Some Aspergillus species produce aflatoxin, a toxic compound that causes acute necrosis, cirrhosis, and carcinoma of the liver in some animal species and can potentially cause similar symptoms in humans (Center for Integrated Fungal Research, 2005). A. nidulans produces the carcinogenic mycotoxin sterigmatocystin (ST), a precursor in the aflatoxin biosynthetic pathway …
Molecular And Biochemical Characterization Of Oleate- And Glycerol-3-Phosphate-Regulated Signaling In Plants, Mihir Kumar Mandal
Molecular And Biochemical Characterization Of Oleate- And Glycerol-3-Phosphate-Regulated Signaling In Plants, Mihir Kumar Mandal
Theses and Dissertations--Plant Pathology
Oleic acid (18:1), a monounsaturated fatty acid (FA), is synthesized upon desaturation of stearic acid (18:0) and this reaction is catalyzed by the plastidal enzyme stearoyl-acyl carrier protein-desaturase (SACPD). A mutation in the SSI2/FAB2 encoded SACPD lowers 18:1 levels, which correlates with induction of various resistance (R) genes and increased resistance to pathogens. Genetic and molecular studies have identified several suppressors of ssi2 which restore altered defense signaling either by normalizing 18:1 levels or by affecting function(s) of a downstream component. Characterization of one such ssi2 suppressor mutant showed that it is required downstream of low 18:1-mediated constitutive …
Access To Award Winning Literature For Children With Disabilities, Kristina Kelzer
Access To Award Winning Literature For Children With Disabilities, Kristina Kelzer
Honors Capstones
Historically, Newbery Medal and Honor books have had high readability levels unsuitable for early elementary students and those with reading disabilities. This project calculated Newbery readability levels 2007 to the present and explored use of Caldecott Medal and Honor books from that same time period and their “picturebooks” format to determine readability levels and whether they possess qualities to facilitate foundational reading skills. The Scholastic Book Wizard was utilized to find Lexile reading levels for all books reported on the awards’ websites. Results indicated Newbery books aim at older audiences, and Caldecott books serve a larger, more representative population within …
Disabled By Solitude: The Convention On The Rights Of Persons With Disabilities And Its Impact On The Use Of Supermax Solitary Confinement, Kathryn D. Demarco
Disabled By Solitude: The Convention On The Rights Of Persons With Disabilities And Its Impact On The Use Of Supermax Solitary Confinement, Kathryn D. Demarco
University of Miami Law Review
No abstract provided.
Access Management: Balancing Public And Private Rights In The Modern "Commons" Of The Roadway, Michael L. Stokes
Access Management: Balancing Public And Private Rights In The Modern "Commons" Of The Roadway, Michael L. Stokes
Cleveland State Law Review
This Article will begin by examining how the concept of a right of access to an abutting roadway developed and how courts treated early efforts to regulate roadway access for public welfare and safety. Next, we will see how public authorities began to comprehend the differences between mobility and land access and to perceive the conflict between traffic volume, traffic speed, and frequent driveways and intersections. This new knowledge led to the adoption of statewide permit-based programs to manage access to roadways using criteria calibrated to match each road’s function in the continuum between access and mobility. We will identify …
Constitutional Cases And The Four Cardinal Virtues, R. George Wright
Constitutional Cases And The Four Cardinal Virtues, R. George Wright
Cleveland State Law Review
In addressing constitutional cases, judges face no shortage of legal rules, tests, principles, doctrines, and policies upon which to draw. In those cases, the challenge is assumed to be to identify and apply the most relevant such legal rules, tests, principles, doctrines, and policies. An accompanying judicial opinion tries to articulate this process, partly to legitimize the outcome, partly to provide guidance, and perhaps partly for purposes of civic education and inspiration. This Article recommends a somewhat different approach to constitutional adjudication. Specifically, this Article recommends supplementing the above standard forms of constitutional adjudication with appropriate and legitimate attention to …
Talking Chalk: Defacing The First Amendment In The Public Forum, Marie Failinger
Talking Chalk: Defacing The First Amendment In The Public Forum, Marie Failinger
Faculty Scholarship
This article examines the surprising outcomes of cases challenging arrests of protesters for chalking sidewalks in public forums, and argues that courts have been careless in analyzing these blanket prohibitions under the time, place and manner doctrine.
Medical Decision Making By And On Behalf Of Adolescents: Reconsidering First Principles, B. Jessie Hill
Medical Decision Making By And On Behalf Of Adolescents: Reconsidering First Principles, B. Jessie Hill
Journal of Health Care Law and Policy
No abstract provided.
The Inherent Uncertainty Of Risk Assessment: How Pesticide Residue Tolerances Fall Short On Safety, Matthew Standeven
The Inherent Uncertainty Of Risk Assessment: How Pesticide Residue Tolerances Fall Short On Safety, Matthew Standeven
Journal of Health Care Law and Policy
No abstract provided.
Incentivizing The Utilization Of Pharmacogenomics In Drug Development, Valerie Gutmann Koch
Incentivizing The Utilization Of Pharmacogenomics In Drug Development, Valerie Gutmann Koch
Journal of Health Care Law and Policy
No abstract provided.
Wonder - Chapter 7 Of "Faithful Teaching: Values And Themes For Teaching, Learning, And Leading Purposeful And Principled Education", Ken Badley
Faculty Publications - College of Education
No abstract provided.
Hormonal And Pheromonal Effects Of 20-Hydroxyecdysone In The American Lobster, Homarus Americanus, Michael W. Sipala
Hormonal And Pheromonal Effects Of 20-Hydroxyecdysone In The American Lobster, Homarus Americanus, Michael W. Sipala
Open Access Dissertations
20-hydroxyecdysone (20E), the active principle of the molting hormone in the American lobster has significant effects on the animals’ agonistic behavior and has been shown to influence the outcome of agonistic interactions. Animals injected with 20E are significantly more aggressive than saline-injected control animals, and premolt animals, which have high circulating levels of 20E in their hemolymph, are more successful than intermolt animals in agonistic interactions. 20E has been shown to act as an internal modulator of neuromuscular physiology: there is an increase in the amplitude of excitatory post-synaptic potentials in the claw opener muscle and a decrease of them …
Kenyon College Alumni Bulletin - Winter 2012
Kenyon College Alumni Bulletin - Winter 2012
Kenyon College Alumni Bulletin
No abstract provided.
Newer Agents In Antiplatelet Therapy: A Review., Jennifer Yeung, Michael Holinstat
Newer Agents In Antiplatelet Therapy: A Review., Jennifer Yeung, Michael Holinstat
Cardeza Foundation for Hematologic Research
Antiplatelet therapy remains the mainstay in preventing aberrant platelet activation in pathophysiological conditions such as myocardial infarction, ischemia, and stroke. Although there has been significant advancement in antiplatelet therapeutic approaches, aspirin still remains the gold standard treatment in the clinical setting. Limitations in safety, efficacy, and tolerability have precluded many of the antiplatelet inhibitors from use in patients. Unforeseen incidences of increased bleeding risk and recurrent arterial thrombosis observed in patients have hampered the development of superior next generation antiplatelet therapies. The pharmacokinetic and pharmacodynamic profiles have also limited the effectiveness of a number of antiplatelet inhibitors currently in use …
Anoxia Tolerance During Vertebrate Development - Insights From Studies On The Annual Killifish Austrofundulus Limnaeus, Jason E. Podrabsky, Claire L. Riggs, Jeffrey M. Duerr
Anoxia Tolerance During Vertebrate Development - Insights From Studies On The Annual Killifish Austrofundulus Limnaeus, Jason E. Podrabsky, Claire L. Riggs, Jeffrey M. Duerr
Faculty Publications - Department of Biological & Molecular Science
No abstract provided.
The Dangers Of The Underprivileged Ethicist: Revising The Rules Of Evidence After The Bioethics Revolution, Jacob M. Appel
The Dangers Of The Underprivileged Ethicist: Revising The Rules Of Evidence After The Bioethics Revolution, Jacob M. Appel
New Mexico Law Review
No abstract provided.
Development Of Gelatin Microbubble Based Plga Scaffold For Application In Bone Tissue Engineering, Krishna M. Shah
Development Of Gelatin Microbubble Based Plga Scaffold For Application In Bone Tissue Engineering, Krishna M. Shah
Bioengineering Theses - Archive
The overall goal of the study was to develop a delivery system for a potential bone tissue engineering application focusing on fabrication of gelatin microbubble (MB) based PLGA scaffolds capable of recruiting Mesenchymal stem cells (MSCs) and delivering bioactive molecules. Challenges associated with inefficient use of stem cells, scaffolding techniques and poor understanding of the role of growth factors hinders the success of tissue engineering strategies. A major challenge with the use of autologous stem cells is its low proliferation and migratory capacity. Our lab previously established that using a biomaterial implant, autologous MSCs can be directed and recruited in …
Increasing Lipophilicity Of Redox Active Ruthenium Complexes As A Means To Enhance Cytotoxicity And Reduce Animal Toxicity, Nagham Alatrash
Increasing Lipophilicity Of Redox Active Ruthenium Complexes As A Means To Enhance Cytotoxicity And Reduce Animal Toxicity, Nagham Alatrash
Chemistry & Biochemistry Theses - Archive
The dinuclear and monomeric ruthenium(II) polypyridyl complexes [(phen)2Ru(tatpp)Ru(phen)2]Cl4 (P) and monomer [(phen)2Ru(tatpp)]Cl2 (MP) are promising candidates for anticancer drug development in terms of the observed anti-tumor activity in mouse models. These complexes contain the redox-active tatpp bridging ligand which seems to be the critical component for biological activity. Ruthenium complexes containing the tatpp ligand have been shown to cleave DNA with an inverse dependence on the [O2], exhibit selective and good cytotoxicity towards a number of cultured malignant cell lines, and have tolerable acute toxicity in mice. Significantly, the animal toxicity of P and MP is significantly less than simple …