Digital Commons Network^™

Implementing Legal Capacity Under Article 12 Of The Un Convention On The Rights Of Persons With Disabilities: The Difficult Road From Guardianship To Supported Decision-Making, Robert D. Dinerstein

Human Rights Brief

No abstract provided.

The Convention On The Rights Of Persons With Disabilities In The Post-Lisbon European Union, Jennifer W. Reiss

Human Rights Brief

No abstract provided.

The Conflict Surrounding Universal Access To Hiv/Aids Medical Treatment In South Africa, Kaila C. Randolph

Human Rights Brief

No abstract provided.

Coverage Of The 144th Period Of Sessions Of The Inter-American Commission On Human Rights, Veronica Gonzalez, Sabina Petersen, Shubra Ohri, Molly M. Hofsommer

Human Rights Brief

No abstract provided.

Opening Remarks, Claudio Grossman, Brita Sydhoff, Mohamud S. N. Said

Human Rights Brief

No abstract provided.

Civic Culture: Public Opinion And The Resurgence Of Civic Culture, Yuri Levada

Russian Culture

There has hardly been a stretch in Russian history more saturated with sweeping changes than the period between 1988-1993. Packed into this exceedingly brief historical era are the rise of "perestroika" and the fall of its illustrious leader, Mikhail Gorbachev; the collapse of the Soviet Union and the emergence in its place of 15 independent states; the August '91 communist putsch and the democrats' triumphant ascension to power; the proliferation of virulent ethnic conflicts and the recognition of the abiding need for cooperation; the bloody October '93 confrontation between the executive and legislative powers and the surprising strength that the …

Topological Theory In Bioconstructivism, John Shannon Hendrix

Architecture, Art, and Historic Preservation Faculty Publications

In the essay “Landscapes of Change: Boccioni’s Stati d’animo as a General Theory of Models,” in Assemblage 19, 1992, Sanford Kwinter proposed a number of theoretical models which could be applied to computer-generated forms in Bioconstructivism. These included topological theory, epigenesis, the epigenetic landscape, morphogenesis, catastrophe and catastrophe theory. Topological theory entails transformational events or deformations in nature which introduce discontinuities into the evolution of a system. Epigenesis entails the generation of smooth landscapes, in waves or the surface of the earth, for example, formed by complex underlying topological interactions. The epigenetic landscape is the smooth forms of relief which …

Interferon-Α Regulates Glutaminase 1 Promoter Through Stat1 Phosphorylation: Relevance To Hiv-1 Associated Neurocognitive Disorders., Lixia Zhao, Yunlong Huang, Changhai Tian, Lynn Taylor, Norman Curthoys, Yi Wang, Hamilton Vernon, Jialin C. Zheng

Journal Articles: Pharmacology & Experimental Neuroscience

HIV-1 associated neurocognitive disorders (HAND) develop during progressive HIV-1 infection and affect up to 50% of infected individuals. Activated microglia and macrophages are critical cell populations that are involved in the pathogenesis of HAND, which is specifically related to the production and release of various soluble neurotoxic factors including glutamate. In the central nervous system (CNS), glutamate is typically derived from glutamine by mitochondrial enzyme glutaminase. Our previous study has shown that glutaminase is upregulated in HIV-1 infected monocyte-derived-macrophages (MDM) and microglia. However, how HIV-1 leads to glutaminase upregulation, or how glutaminase expression is regulated in general, remains unclear. In …

Activation Of Extracellular Signal-Regulated Protein Kinase 5 Is Essential For Cystitis- And Nerve Growth Factor-Induced Calcitonin Gene-Related Peptide Expression In Sensory Neurons, Sharon Yu, Chun-Mei Xia, Li-Ya Qiao

Physiology and Biophysics Publications and Presentations

Background Cystitis causes considerable neuronal plasticity in the primary afferent pathways. The molecular mechanism and signal transduction underlying cross talk between the inflamed urinary bladder and sensory sensitization has not been investigated.

Results In a rat cystitis model induced by cyclophosphamide (CYP) for 48 h, the mRNA and protein levels of the excitatory neurotransmitter calcitonin gene-related peptide (CGRP) are increased in the L6 dorsal root ganglia (DRG) in response to bladder inflammation. Cystitis-induced CGRP expression in L6 DRG is triggered by endogenous nerve growth factor (NGF) because neutralization of NGF with a specific NGF antibody reverses CGRP up-regulation during cystitis. …

Mekk1-Mkk4-Jnk-Ap1 Pathway Negatively Regulates Rgs4 Expression In Colonic Smooth Muscle Cells, Yonggang Zhang, Fang Li, Shu Liu, Hong Wang, Sunila Mahavadi, Karnam S. Murthy, Kamel Khalili, Wenhui Hu

Physiology and Biophysics Publications and Presentations

Background

Regulator of G-protein Signaling 4 (RGS4) plays an important role in regulating smooth muscle contraction, cardiac development, neural plasticity and psychiatric disorder. However, the underlying regulatory mechanisms remain elusive. Our recent studies have shown that upregulation of Rgs4 by interleukin (IL)-1β is mediated by the activation of NFκB signaling and modulated by extracellular signal-regulated kinases, p38 mitogen-activated protein kinase, and phosphoinositide-3 kinase. Here we investigate the effect of the c-Jun N-terminal kinase (JNK) pathway on Rgs4 expression in rabbit colonic smooth muscle cells.

Methodology/Principal Findings

Cultured cells at first passage were treated with or without IL-1β …

Up-Regulation Of Brain-Derived Neurotrophic Factor In Primary Afferent Pathway Regulates Colon-To-Bladder Cross-Sensitization In Rat, Chun-Mei Xia, Melisa A. Gulick, Sharon Yu, John R. Grider, Karnam S. Murthy, John K. Kuemmerle, Hamid I. Akbarali

Physiology and Biophysics Publications and Presentations

Background In humans, inflammation of either the urinary bladder or the distal colon often results in sensory cross-sensitization between these organs. Limited information is known about the mechanisms underlying this clinical syndrome. Studies with animal models have demonstrated that activation of primary afferent pathways may have a role in mediating viscero-visceral cross-organ sensitization.

Methods Colonic inflammation was induced by a single dose of tri-nitrobenzene sulfonic acid (TNBS) instilled intracolonically. The histology of the colon and the urinary bladder was examined by hematoxylin and eosin (H&E) stain. The protein expression of transient receptor potential (TRP) ion channel of the vanilloid type …

Journal Of Mormon History Vol. 38, No. 2, Spring 2012

Journal of Mormon History

CONTENTS

LETTERS

--Augusta Adams Cobb Young: Priesthood Holder Connell O’Donovan, vii

PRESIDENTIAL ADDRESS

--“Not as a Stranger”: A Presbyterian Afoot in the Mormon Past William P. MacKinnon, 1

TANNER LECTURE

--Mormon Stories: A Librarian’s Perspective George A. Miles, 47

ARTICLES

--From Doctor to Disciple: Willard Richards’s Journey to Mormonism Devery S. Anderson, 67

--New Ways In: Writing Interdisciplinary Mormon History Introduction Rachel Cope, 99

--Shifting the Plot: Possibilities in Mormon Women’s History Rachel Cope, 100

--History through Liturgy: What Worship Remembers Matthew Bowman, 108

--A Shared Historicist Enterprise: Mormon History through a Literary …

Suggestive Characters: Hypnotism And Subjectivity In Blanca De Los Ríos’S Las Hijas De Don Juan (1907), Ryan A. Davis

Decimonónica

In July of 1906, Blanco y negro published a brief story by Blanca de los Ríos entitled “Metempsicosis: De las ‘memorias’ del doctor Hipnos,” which dramatizes the ominous dangers of hypnotism.¹ In the story, a medical student, driven by his obsession for Susana, pays a traveling hypnotizer to “infundir mi alma en [el] cuerpo [de Alberto de San Andrés],” Susana’s husband (“Metempsicosis” 51). His subsequent confession to Susana about his actions precipitates her death, which in turn causes the student to go insane. In the final lines of the story, Hipnos reflects on the tragic outcome and the perils …

De Noches, Tempestades Y Olas: La Experiencia De Lo Sublime En E. Echeverría, J. M. Heredia Y J. E. Caro, María Elena Campero

Decimonónica

El siglo XIX hereda gracias a los aportes de Immanuel Kant uno de los giros más importantes para la posteridad: el viraje del objeto al sujeto. La imposibilidad de conocer las cosas en sí lleva a Kant a plantear la necesidad de centrarse en el sujeto y en la posibilidad que ofrecen los sentidos del ser humano para aprehender el mundo circundante. Este énfasis y reflexión en torno al “yo” también se cristaliza en la poesía decimonónica donde el sujeto se afirma en tanto tal a partir de su pugna, de su enfrentamiento con un “otro.” De allí la importancia …

José Martí Y Rubén Darío Ante La Anexión De Los Territorios Indígenas En Argentina Y Nicaragua, Jorge Camacho

Decimonónica

El siglo XIX marcó el triunfo del liberalismo en Hispanoamérica, pero este triunfo no fue compartido por igual por todos los grupos étnicos. Después de las guerras de independencia, los liberales hispanoamericanos propusieron medidas que les fueron muy adversas a los indígenas. Legislaron sus territorios sobre las márgenes ficticias que había dejado el antiguo poder colonial y llevaron a cabo una serie de reformas que terminaron despojándolos de sus tierras y reduciéndolos a la miseria. Entre las medidas que propusieron figuraban el cultivo intensivo de los terrenos ociosos o que pertenecían a estas comunidades; el blanqueamiento de la población a …

“After The Apple”: Female Sexuality In The Writings Of Emilia Pardo Bazán, Susan Walter

Decimonónica

The Biblical story of creation in which Adam and Eve are deceived by the serpent is recognized widely as one of the foundational stories of Western culture. The story’s importance is asserted by many scholars, including Elaine Pagels in her groundbreaking study Adam, Eve and the Serpent: “[T]he biblical creation story, like the creation stories of other cultures, communicates social and religious values and presents them as if they were universally valid” (xx). In this same study Pagels suggests that Christians have interpreted the story of “Genesis” in various ways over the centuries, finding in it important teachings about …

Andalusia’S Cultural Spirit And The Historical Ballads Of Romancero Gitano, Nelson Orringer

Decimonónica

Though praised by its author for its unity, Lorca’s Romancero gitano seemingly ends in disarray (Obras 3: 339).¹ The final three ballads appear arbitrarily grouped under the rubric, Romances históricos. First, Martirio de Santa Olalla embellishes the martyrdom of fourth-century Saint Eulalia in Roman-ruled Mérida; next, Burla de Don Pedro a caballo parodies the cycle of fourteenth-century Pedro the Cruel; finally, Thamar y Amnón lyrically revisits the incest of 2 Samuel 13: 1. What unites the three, other than remote temporal settings, and what makes them historical ballads? C. Marcilly unconvincingly interprets the Don Pedro ballad as …

Wildlife, Water Quality, And The Public Trust Doctrine: A Means Of Enforcing Agricultural Nonpoint Source Pollution Management Plans, Veronique Jarrell-King

Villanova Environmental Law Journal (1991 - )

No abstract provided.

Co-Cultures Of Pseudomonas Aeruginosa And Roseobacter Denitrificans Reveal Shifts In Gene Expression Levels Compared To Solo Cultures, Crystal A. Conway, Nwadiuto Esiobu, Jose V. Lopez

Marine & Environmental Sciences Faculty Articles

Consistent biosynthesis of desired secondary metabolites (SMs) from pure microbial cultures is often unreliable. In a proof-ofprinciple study to induce SM gene expression and production, we describe mixed “co-culturing” conditions and monitoring of messages via quantitative real-time PCR (qPCR). Gene expression of model bacterial strains (Pseudomonas aeruginosa PAO1 and Roseobacter denitrificans Och114) was analyzed in pure solo and mixed cocultures to infer the effects of interspecies interactions on gene expression in vitro, Two P. aeruginosa genes (PhzH coding for portions of the phenazine antibiotic pathway leading to pyocyanin (PCN) and the RhdA gene for thiosulfate: cyanide sulfurtransferase …

A Secondary Science Teacher’S Beliefs About Environmental Education And Its Relationship With The Classroom Practices, Salima Begum

Professional Development Centre, Gilgit

Global environmental issues are increasing due to the rapid developments in science and technology. To address these environmental issues there is a need to create awareness about environmental education among the masses. This can only be possible through teachers and teacher educators. It is assumed that science teachers are teaching environmental concepts as scientific facts, without creating awareness about environmental education. The ultimate purpose of this study was to explore the beliefs of a secondary science teacher about environmental education and how his stated beliefs matched with his classroom practices. The study was conducted in one of the co-operative schools …

The Construction Of Belief : Reflections On The Thought Of Mohammed Arkoun, Abdou Filali-Ansari, Aziz Esmail

Independent Volumes

Mohammed Arkoun was one of the most prominent and influential Arab intellectuals of his day. During a career spanning more than thirty years, he was revered as an outstanding research scholar, a bold critic of the theoretical tensions embedded within Islamic studies and an outspoken public figure, upholding political, social and cultural modernism.

This festschrift honours Mohammed Arkoun’s scholarship, bringing together the contributions of eleven distinguished scholars of history, religious studies and philosophy. It offers a comprehensive selection of critical engagements with Arkoun’s work, reflecting on his considerable influence on contemporary thinking about Islam and its ideological, philosophical and theological …

Full Issue, Number 35, Spring 2012

Intersections

No abstract provided.

Cultivating Transformative Responsible Dialogue: Community Of Moral Deliberation And Lutheran Higher Education, Per Anderson

Intersections

No abstract provided.

Full Issue, Number 36, Fall 2012

Intersections

No abstract provided.

A Traveler's Manifesto For Navigating The Creation, Ann Pederson

Intersections

No abstract provided.

A Lutheran Ethic Of Environmental Stewardship, Jim Martin-Schramm

Intersections

No abstract provided.

Sustaining Sustainability, Baird Tipson

Intersections

No abstract provided.

Medicine@Yale March 2012 Volume 8, Issue 1, Yale School Of Medicine Office Of Communications

Medicine@Yale - development newsletter

Medicine@Yale : advancing biomedical science, education and health care was a print and online newsletter which published news about academics, research and philanthropy for alumni, donors, faculty, students and the general public. It was initially published 6 times a year and then changed to a quarterly schedule. The first issue came out June/Jul. 2005. The final issue was published in May/June 2022, vol. 17, issue 1. Published by Yale School of Medicine, Office of Communications.

Delaware Dissolves The Glue Of Capitalism: Exonerating From Claims Of Incompetence Those Who Manage Other People's Money, Daniel S. Kleinberger

Faculty Scholarship

Delaware law is the leading source of non-federal law governing U.S. business organizations. Over the past 25 years that law has tilted further and further toward insulating individuals who manage business firms from any liability to the firms’ owners based on claims of misconduct. These developments have occurred both in corporate law and the law of unincorporated organizations.

Although often described as consistent with market principles, these developments actually undercut the proper functioning of a market system. Effective competition among firms does not require a “dog eat dog” mentality within firms. Managerial responsibility is a prerequisite to healthy firms, which …

Annual Report Of The Town Officers Of The Town Of Jefferson, Nh For The Year Ending December 31, 2011., Jefferson Town Representatives

Jefferson, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.