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2012

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Articles 1261 - 1290 of 19083

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Lack Of P53 Affects The Expression Of Several Brain Mitochondrial Proteins: Insights From Proteomics Into Important Pathways Regulated By P53, Ada Fiorini, Rukhsana Sultana, Eugenio Barone, Giovanna Cenini, Marzia Perluigi, Cesare Mancuso, Jian Cai, Jon B. Klein, Daret K. St. Clair, D. Allan Butterfield Nov 2012

Lack Of P53 Affects The Expression Of Several Brain Mitochondrial Proteins: Insights From Proteomics Into Important Pathways Regulated By P53, Ada Fiorini, Rukhsana Sultana, Eugenio Barone, Giovanna Cenini, Marzia Perluigi, Cesare Mancuso, Jian Cai, Jon B. Klein, Daret K. St. Clair, D. Allan Butterfield

Chemistry Faculty Publications

The tumor suppressor protein p53 has been described "as the guardian of the genome" for its crucial role in regulating the transcription of numerous genes responsible for cells cycle arrest, senescence, or apoptosis in response to various stress signals. Although p53 promotes longevity by decreasing the risk of cancer through activation of apoptosis or cellular senescence, several findings suggest that an increase of its activity may have deleterious effects leading to selected aspects of the aging phenotype and neurodegenerative diseases. There is the link between p53 and oxidative stress, the latter a crucial factor that contributes to neurodegenerative processes like …

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Using The Taylor Center To Teach Odes, Alexander Gofen Nov 2012

Using The Taylor Center To Teach Odes, Alexander Gofen

CODEE Journal

This article introduces a powerful ODE solver called the Taylor Center for PCs (http://taylorcenter.org/Gofen/) as a tool for teaching and performing numeric experiments with ODEs. The Taylor Center is an All-in-One GUI-style application for integrating ODEs by applying the modern Taylor Method (Automatic Differentiation). The Taylor Center also offers dynamic graphics (including 3D stereo vision). After a brief review of the features of the Taylor Center, we consider instructive examples of ODEs in various applications and also several particular examples illustrating intricacies of numeric integration. The article therefore continues the thesis of Borrelli and Coleman (CODEE Journal, http://www.codee.org/ref/CJ09-0157) that awareness …

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The Evolution Of Host Specificity In The Vertebrate Gut Symbiont Lactobacillus Reuteri, Steven Frese Nov 2012

The Evolution Of Host Specificity In The Vertebrate Gut Symbiont Lactobacillus Reuteri, Steven Frese

Department of Food Science and Technology: Dissertations, Theses, and Student Research

The vertebrate gut is home to one of the densest populations of life on Earth. This microbial community has a profound effect on host health, nutrition, development, behavior, and evolution. However, very little is known about how these microbes have evolved with their vertebrate hosts, how and whether they select hosts or how they remain associated with their hosts. Recent work identified Lactobacillus reuteri as an organism that is composed of host-specific sub-populations, each population associated with a different host animal. Representatives from each host-associated population were tested for their ability to colonize gnotobiotic mice, which only rodent strains could …

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Free Improvisation Information Service Over The Internet, Peter Stubley Nov 2012

Free Improvisation Information Service Over The Internet, Peter Stubley

Proceedings of the IATUL Conferences

No abstract provided.

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The Multi-Media Approach To Preservation And Presentation Of Special Collections, Jean Hofacket, Cory S. Lund Nov 2012

The Multi-Media Approach To Preservation And Presentation Of Special Collections, Jean Hofacket, Cory S. Lund

Proceedings of the IATUL Conferences

No abstract provided.

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New Media And New Library Partnerships Downunder, Gulcin Cribb, Janine Schmidt Nov 2012

New Media And New Library Partnerships Downunder, Gulcin Cribb, Janine Schmidt

Proceedings of the IATUL Conferences

No abstract provided.

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Changing Patterns Of Communication And Electronic Publishing, Arthur J. Meadows Nov 2012

Changing Patterns Of Communication And Electronic Publishing, Arthur J. Meadows

Proceedings of the IATUL Conferences

No abstract provided.

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Scholarly Communication - Historical Development And New Possibilities, Nancy Fjällbrant Nov 2012

Scholarly Communication - Historical Development And New Possibilities, Nancy Fjällbrant

Proceedings of the IATUL Conferences

No abstract provided.

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Thaumatoporella Ladders Unraveled, Felix Schlagintweit Nov 2012

Thaumatoporella Ladders Unraveled, Felix Schlagintweit

Studia UBB Geologia

Thaumatoporella (incertae sedis) represents a widespread constituent in Middle Triassic–Cretaceous shallow-marine carbonates of the Tethyan realm and exhibit a wide morphological variability. Seemingly monostromatic cell-layers intermingled with and incorporated into bacinellid crusts (“Bacinella irregularis”) were described as Thaumatoporella bridges or ladders in the literature. This appearance of Thaumatoporella also accounted for the creation of the genus Polygonella ELLIOTT and its misleading comparison with single-layered crustose corallinacean alga, e.g., genus Lithoporella. In fact, these “ladders” belong to the roof part of thaumatoporellaceans encrusting microbial crusts that subsequently became overgrown and thus incorporated. Often a rudimentary thin basal layer …

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Characterization Of The Role Of Mitochondrial Function During Tumor Development And Muscle Wasting, Xiao Wang Nov 2012

Characterization Of The Role Of Mitochondrial Function During Tumor Development And Muscle Wasting, Xiao Wang

Open Access Dissertations

Mitochondria play important roles in multiple cellular processes including energy metabolism, cell death, and aging. Regulated energy production and utilization is critical in maintaining energy homeostasis in normal cells and functional organisms. However, mitochondria go through a series of morphological and functional alterations during carcinogenesis. The metabolic profile in transformed cells is altered to accommodate their fast proliferation, confer resistance to cell death, or facilitate metastasis. On the organism level, mitochondrial function is crucial especially in tissues that require high energy supply, such as brain and skeletal muscle. Mitochondrial dysfunction has been implied in various neurodegenerative disorders and deteriorating chronic …

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Gsu View, 2012-11-26, Office Of Marketing And Communications Nov 2012

Gsu View, 2012-11-26, Office Of Marketing And Communications

GSU View

Newsletter published by Governors State University 2007-current.

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Discovery Of Highly Potent And Selective α4β2-Nicotinic Acetylcholine Receptor (Nachr) Partial Agonists Containing An Isoxazolylpyridine Ether Scaffold That Demonstrate Antidepressant-Like Activity. Part Ii, Li Fang Yu, J. Brek Eaton, Allison Fedolak, Han Kun Zhang, Taleen Hanania, Dani Brunner, Ronald J. Lukas, Alan P. Kozikowski Nov 2012

Discovery Of Highly Potent And Selective α4β2-Nicotinic Acetylcholine Receptor (Nachr) Partial Agonists Containing An Isoxazolylpyridine Ether Scaffold That Demonstrate Antidepressant-Like Activity. Part Ii, Li Fang Yu, J. Brek Eaton, Allison Fedolak, Han Kun Zhang, Taleen Hanania, Dani Brunner, Ronald J. Lukas, Alan P. Kozikowski

Translational Neuroscience

In our continued efforts to develop α4β2-nicotinic acetylcholine receptor (nAChR) partial agonists as novel antidepressants having a unique mechanism of action, structure-activity relationship (SAR) exploration of certain isoxazolylpyridine ethers is presented. In particular, modifications to both the azetidine ring present in the starting structure 4 and its metabolically liable hydroxyl side chain substituent have been explored to improve compound druggability. The pharmacological characterization of all new compounds has been carried out using [ 3 H]epibatidine binding studies together with functional assays based on 86 Rb + ion flux measurements. We found that the deletion of the metabolically liable hydroxyl group …

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The Chanticleer, 2012-11-26, Coastal Carolina University Nov 2012

The Chanticleer, 2012-11-26, Coastal Carolina University

The Chanticleer Student Newspaper

The editorially independent student produced weekly newspaper of Coastal Carolina University.

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Current, November 26, 2012, University Of Missouri-St. Louis Nov 2012

Current, November 26, 2012, University Of Missouri-St. Louis

Current (2010s)

No abstract provided.

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Late Embryogenesis Abundant Proteins Protect Human Hepatoma Cells During Acute Desiccation, Shumin Li, Nilay Chakraborty, Apurva Borcar, Michael A. Menze, Mehmet Toner, Steven C. Hand Nov 2012

Late Embryogenesis Abundant Proteins Protect Human Hepatoma Cells During Acute Desiccation, Shumin Li, Nilay Chakraborty, Apurva Borcar, Michael A. Menze, Mehmet Toner, Steven C. Hand

Faculty Research & Creative Activity

Expression of late embryogenesis abundant (LEA) proteins is highly correlated with desiccation tolerance in anhydrobiotic animals, selected land plants, and bacteria. Genes encoding two LEA proteins, one localized to the cytoplasm/nucleus (AfrLEA2) and one targeted to mitochondria (AfrLEA3m), were stably transfected into human HepG2 cells. A trehalose transporterwas used for intracellular loading of this disaccharide. Cellswere rapidly and uniformly desiccated to low water content (<0.12 g H2O/g dry weight) with a recently developed spin-drying technique. Immediately on rehydration, control cells without LEA proteins or trehalose exhibited 0% membrane integrity, comparedwith 98% in cells loaded with trehalose and expressing AfrLEA2 or AfrLEA3m; surprisingly, AfrLEA3m without trehalose conferred 94% protection. Cell proliferation across 7 d showed an 18-fold increase for cells dried with AfrLEA3m and trehalose, compared with 27-fold for nondried controls. LEA proteins dramatically enhance desiccation tolerance in mammalian cells and offer the opportunity for engineering biostability in the dried state.

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Economic Impact Of Agriculture On South Dakota, Gary Taylor Nov 2012

Economic Impact Of Agriculture On South Dakota, Gary Taylor

Economics Commentator (1972- 2016)

No abstract provided.

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Cardiovascular Reactivity In Friendships: Length Of Relationship And Frequency Of Contact As Potential Moderators, Benjamin D. Clark Nov 2012

Cardiovascular Reactivity In Friendships: Length Of Relationship And Frequency Of Contact As Potential Moderators, Benjamin D. Clark

Theses and Dissertations

Social support has been linked to positive health outcomes. Specifically, having available support from a friend may act as a buffer to the negative effects of stress on cardiovascular reactivity. Relationship quality is an important moderator of this effect. The purpose of this study was to examine how cardiovascular reactivity is affected by relationship quality within friendships and whether the length of relationship and frequency of contact may moderate the effect. 134 healthy male and female adults (and their same-sex friend) were recruited to participate. Results revealed no significant difference between subjects interacting with supportive friends compared to interacting with …

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The Art Of Legal Reasoning And The Angst Of Judging: Of Balls, Strikes, And Moments Of Truth, Timothy P. Terrell Nov 2012

The Art Of Legal Reasoning And The Angst Of Judging: Of Balls, Strikes, And Moments Of Truth, Timothy P. Terrell

Northwestern Journal of Law & Social Policy

An essay of only five short paragraphs published several years ago by the noted Harvard paleontologist Stephen Jay Gould about a controversial call by baseball umpire Babe Pinelli provides all the foundation necessary for a thorough investigation of the phenomenon of legal reasoning. The present article contrasts Gould’s analysis of a “strike” with the comment by then-Judge John Roberts at his Supreme Court confirmation hearings that he just wanted to “call [the] balls and strikes,” and through this exchange develops a new approach toward identifying—and teaching—the basic elements of sophisticated legal thinking. This article divides legal reasoning into four interrelated …

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Crow's Nest, November 26, 2012, Crow's Nest Staff Nov 2012

Crow's Nest, November 26, 2012, Crow's Nest Staff

Crow's Nest

The November 26, 2012, issue of the Crow's Nest.

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Secondary Contact And Admixture Between Independently Invading Populations Of The Western Corn Rootworm, Diabrotica Virgifera Virgifera In Europe, Gérald Bermond, Marc Ciosi, Eric Lombaert, Aurélie Blin, Marco Boriani, Lorenzo Furlan, Stefan Toepfer, Thomas Guillemaud Nov 2012

Secondary Contact And Admixture Between Independently Invading Populations Of The Western Corn Rootworm, Diabrotica Virgifera Virgifera In Europe, Gérald Bermond, Marc Ciosi, Eric Lombaert, Aurélie Blin, Marco Boriani, Lorenzo Furlan, Stefan Toepfer, Thomas Guillemaud

All Peer-Reviewed Publications

The western corn rootworm, Diabrotica virgifera virgifera (Coleoptera: Chrysomelidae), is one of the most destructive pests of corn in North America and is currently invading Europe. The two major invasive outbreaks of rootworm in Europe have occurred, in North-West Italy and in Central and South-Eastern Europe. These two outbreaks originated from independent introductions from North America. Secondary contact probably occurred in North Italy between these two outbreaks, in 2008. We used 13 microsatellite markers to conduct a population genetics study, to demonstrate that this geographic contact resulted in a zone of admixture in the Italian region of Veneto. We show …

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The Serotonin Transporter Gene Linked Polymorphic Region Is Associated With The Behavioral Response To Repeated Stress Exposure In Infant Rhesus Macaques, Simona Spinelli, Melanie L. Schwandt, Stephen G. Lindell, Markus Heilig, Stephen J. Suomi, James Dee Higley, David Goldman, Christina S. Barr Nov 2012

The Serotonin Transporter Gene Linked Polymorphic Region Is Associated With The Behavioral Response To Repeated Stress Exposure In Infant Rhesus Macaques, Simona Spinelli, Melanie L. Schwandt, Stephen G. Lindell, Markus Heilig, Stephen J. Suomi, James Dee Higley, David Goldman, Christina S. Barr

Faculty Publications

The short allele of the serotonin transporter linked polymorphic region (5-HTTLPR) moderates the effects of stress on vulnerability to mood and anxiety disorders. The mechanism by which this occurs may relate to differential sensitivity to stressful life events. Here we explored whether 5- HTTLPR and sex affected behavioral responses to repeated maternal separation in infant rhesus macaques. Behaviors were collected during the acute (Day 1) and the chronic (Days 2–4) phases of the separation, and the effects of duration of separation (acute vs. chronic), genotype (long/long vs. short allele), and sex (male vs. female) on behavioral responses were analyzed across …

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Farmers Nat. Bank V. Green River Dairy, Llc Amicus Brief Dckt. 40101 Nov 2012

Farmers Nat. Bank V. Green River Dairy, Llc Amicus Brief Dckt. 40101

Idaho Supreme Court Records & Briefs, All

No abstract provided.

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Sinusoidal Endothelial Dysfunction In Non-Alcoholic Fatty Liver Disease., Sandhya Lakshmi Gopalakrishnan Nov 2012

Sinusoidal Endothelial Dysfunction In Non-Alcoholic Fatty Liver Disease., Sandhya Lakshmi Gopalakrishnan

Department of Biochemistry: Dissertations, Theses, and Student Research

Non-alcoholic fatty liver disease (NAFLD) is an asymptomatic increasingly common disorder that affects liver metabolism and is often the precursor for liver pathologies such as fibrosis, cirrhosis and hepato-cellular carcinoma. The liver sinusoidal endothelial cells act as a liver sieve by allowing macromolecules and chylomicrons to traverse through their fenestrations (sieve plates) to hepatocytes. Since liver sinusoidal endothelial cells (LSEC) regulate serum derived macromolecular exposure to hepatocytes, we asked what role LSEC could play in the pathogenesis of NAFLD. To investigate the early events of NAFLD we used a rat model (Sprague-Dawley) in which animals were maintained on standard and …

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Investigating The Tolerance Response Of Early Vegetative Stage Soybeans To Aphis Glycines Matsumura, Lia Da Silva Marchi Nov 2012

Investigating The Tolerance Response Of Early Vegetative Stage Soybeans To Aphis Glycines Matsumura, Lia Da Silva Marchi

Department of Entomology: Dissertations, Theses, and Student Research

The objectives of this research were to evaluate the impact of soybean aphid (Aphis glycines Matsumura) feeding on the yield response of V1, V3, and R1 KS4202 soybean plants and examine the effect of soybean aphid feeding on peroxidase activity in V1 and V3 KS4202 plants. KS4202 plants infested during the early vegetative stages (VC, VE and V1) were identified as highly susceptible based upon plant damage and stunting of the plants. In contrast, V3, V4, and V5 stage KS4202 soybeans were classified as moderately resistant. In the yield response study, V1, V3 and R1 plants had aphid numbers …

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Evidence Of Transmission Of Escherichia Coli O157:H7 To The Tissues Or Phyllo-Plane Of Wheat, From Contaminated Soil, Seeds Or Water, Bismarck Antonio Martinez Nov 2012

Evidence Of Transmission Of Escherichia Coli O157:H7 To The Tissues Or Phyllo-Plane Of Wheat, From Contaminated Soil, Seeds Or Water, Bismarck Antonio Martinez

Department of Food Science and Technology: Dissertations, Theses, and Student Research

Escherichia coli O157:H7 is a human pathogen that can cause a wide spectrum of disease symptoms, such as bloody diarrhea, hemorrhagic colitis, and hemolytic uremic syndrome (HUS). Escherichia coli O157:H7 illness are mainly associated with undercooked beef; however, in recent years outbreaks have been linked to fresh produce such as spinach, lettuce, and sprouts. In 2009, flour was implicated as a contamination source in the consumption of raw cookie dough resulting in 77 illness-cases. The objective of this research was to determine the possible route of transmission of E. coli O157:H7 into the phyllo-plane of wheat using contaminated seed, soil …

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Anna Kijanowska, Piano: An Homage To Szymanowski, Department Of Music, University Of Richmond Nov 2012

Anna Kijanowska, Piano: An Homage To Szymanowski, Department Of Music, University Of Richmond

Music Department Concert Programs

No abstract provided.

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The Bg News November 26, 2012, Bowling Green State University Nov 2012

The Bg News November 26, 2012, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. November 26, 2012. Volume 103-Issue 42.

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Late Embryogenesis Abundant Proteins Protect Human Hepatoma Cells During Acute Desiccation., Shumin Li, Nilay Chakraborty, Apurva Borcar, Michael Menze, Mehmet Toner, Steven Hand Nov 2012

Late Embryogenesis Abundant Proteins Protect Human Hepatoma Cells During Acute Desiccation., Shumin Li, Nilay Chakraborty, Apurva Borcar, Michael Menze, Mehmet Toner, Steven Hand

Faculty and Staff Scholarship

Expression of late embryogenesis abundant (LEA) proteins is highly correlated with desiccation tolerance in anhydrobiotic animals, selected land plants, and bacteria. Genes encoding two LEA proteins, one localized to the cytoplasm/nucleus (AfrLEA2) and one targeted to mitochondria (AfrLEA3m), were stably transfected into human HepG2 cells. A trehalose transporterwas used for intracellular loading of this disaccharide. Cellswere rapidly and uniformly desiccated to low water content (< 0.12 g H2O/g dry weight) with a recently developed spin-drying technique. Immediately on rehydration, control cells without LEA proteins or trehalose exhibited 0% membrane integrity, comparedwith 98% in cells loaded with trehalose and expressing AfrLEA2 or AfrLEA3m; surprisingly, AfrLEA3m without trehalose conferred 94% protection. Cell proliferation across 7 d showed an 18-fold increase for cells dried with AfrLEA3m and trehalose, compared with 27-fold for nondried controls. LEA proteins dramatically enhance desiccation tolerance in mammalian cells and offer the opportunity for engineering biostability in the dried state.

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The ‘Slow-Growth-High-Mortality’ Hypothesis: How Plant Species, Leaf Quality, And The Third Trophic Level Contribute To The Mortality Of Two Common Leaf-Tying Microlepidopteran Herbivores, Kirk Lee Barnett Nov 2012

The ‘Slow-Growth-High-Mortality’ Hypothesis: How Plant Species, Leaf Quality, And The Third Trophic Level Contribute To The Mortality Of Two Common Leaf-Tying Microlepidopteran Herbivores, Kirk Lee Barnett

Theses

I investigated how the survivorship, abundance, and development of two common microlepidoteran leaf-tiers on four species of oak change in response to leaf quality and exposure to the third trophic level, and used those results to validate predictions under the slow-growth-high-mortality hypothesis. In chapter 1, I begin with a review of the literature by examining the components of plant traits that contribute to the success of insect herbivores and how plants can alter both defensive compounds and nutritional quality in order to deter herbivory. I then describe how changes in leaf quality and defense can be overcome by insect herbivores, …

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Preliminary Checklist Of Lichens Reported From Wyoming, Dorothy E. Tuthill Nov 2012

Preliminary Checklist Of Lichens Reported From Wyoming, Dorothy E. Tuthill

Monographs of the Western North American Naturalist

Although lichens are a common feature in Wyoming, there has been no attempt to compile a statewide list of species since 1900. A number of surveys have been conducted in the state, especially in Yellowstone National Park and other federally managed parks and forests, though little attention has been given to lower-elevation regions of the state. The literature search conducted for this project yielded nearly 800 species names, which number was reduced to 608 currently accepted taxa. Collection locations and references are provided for each taxon, as are global ranks (conservation status, from NatureServe.org), and a brief discussion of some …

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