Digital Commons Network^™

West Virginia Therapists' Knowledge Of Tarasoff-Related Court Cases, Bruce E. Clay

Theses, Dissertations and Capstones

The Tarasoff decisions regarding the duties to third parties were profoundly significant to the practice of psychology and counseling. Despite this, there have been few studies regarding the impact on these decisions on clinical practice. There are essentially three sources of data regarding the analysis of any Tarasoff-related clinical scenario. They include state statutes, court case law and the professional ethics codes. Most of the limited studies conducted have indicated serious knowledge gaps with respect to relevant state statues and the essence of the Tarasoff duties. This study evaluated West Virginia therapists’ knowledge of Tarasoff-related court cases. It was hypothesized …

A Mechanistic Study Of S-Adenosyl-L-Methionine Protection Against Acetaminophen Hepatotoxicity, James Michael Brown

Theses, Dissertations and Capstones

Acetaminophen (APAP) toxicity remains the leading cause of drug induced liver failure in the United States. The current therapy for APAP toxicity is N-acetylcysteine (NAC). NAC must be administered within eight hours of APAP overdose for maximum efficacy. That, coupled with the fact that APAP toxicity may not be overtly evident, makes an alternative therapeutic intervention worth exploring. Previous work by our laboratory has demonstrated that S-adenosyl-L-methionine (SAMe) prevents APAP toxicity when given following APAP overdose in C57Bl/6 mice at a level comparable to NAC. The focus of the current work was to examine the mechanistic aspects of this protection …

The Use Of Cerium Oxide And Curcumin Nanoparticles As Therapeutic Agents For The Treatment Of Ventricular Hypertrophy Following Pulmonary Arterial Hypertension, Madhukar Babu Kolli

Theses, Dissertations and Capstones

Pulmonary arterial hypertension (PAH) is a progressive and fatal disease characterized by inflammation, increased pulmonary vascular resistance, right ventricular failure and premature death. Monocrotaline (MCT) has been used to induce PAH in laboratory rats. Previous in vitro and in vivo work suggested that cerium oxide (CeO2)-and curcumin nanoparticles exhibit anti-inflammatory activity; however, it is unknown if these materials are effective for the treatment of PAH induced cardiac hypertrophy. To determine the efficacy of CeO2 nanoparticle treatment in preventing MCT-induced RV hypertrophy, male Sprague Dawley rats were divided into one of three groups (control, MCT, or MCT + CeO2 nanoparticle, n=6/group). …

Redox Regulation Of Differentiation In Neuroblastoma, Anne Marie Silvis

Theses, Dissertations and Capstones

Neuroblastoma is the most common extracranial solid tumor in childhood, ranking third in prevalence among infant cancers. Despite intensive therapy with surgery, radiation and chemotherapy, there is a high chance of tumor recurrence. These children are therefore given retinoids in the maintenance phase to differentiate the tumor cells and to avoid/lessen this incidence. Although 13-cis retinoic acid (13-cis RA) is currently used to treat neuroblastoma, there is much evidence supporting the prevalence of its metabolite, all-trans retinoic acid (ATRA), to be the main signaling retinoid in vivo.

The SK-N-SH neuroblastoma cell line, which is composed of three sub-types: sympatheoadrenal neuroblasts …

Hermes International, Phuong Tran

Theses, Dissertations and Capstones

Hermes International Company is the second strongest brand in luxury industry. They have spent more than 100 years to make Hermes name as famous as today. With 3,000 million euro in average revenue, Hermes has a very strong financial position and potential growth compare to other competitors. Their products are always well-designed, high quality, and fashionable. They do not make good products but extremely good ones. Hermes’ target customers are wealthy people who have high level of income and are interested in luxury items. With more than 300 stores all over the world, Hermes is working on their ways to …

Down-Regulation Of The Transcription Factor Snail In The Placentas Of Patients With Preeclampsia And In A Rat Model Of Preeclampsia, Larissa Federova, Cara Gatto-Weis, Sleiman Smaili, Nauman Khurshid, Joseph I. Shapiro M.D., Deepak Malhorta, Terrence Horrigan

Biochemistry and Microbiology

Background: Placental malfunction in preeclampsia is believed to be a consequence of aberrant differentiation of trophoblast lineages and changes in utero-placental oxygenation. The transcription factor Snail, a master regulator molecule of epithelial-mesenchymal transition in embryonic development and in cancer, is shown to be involved in trophoblast differentiation as well. Moreover, Snail can be controlled by oxidative stress and hypoxia. Therefore, we examined the expression of Snail and its downstream target, e-cadherin, in human normal term, preterm and preeclamptic placentas, and in pregnant rats that developed preeclampsia-like symptoms in the response to a 20- fold increase in sodium intake.

Methods: Western …

Extraskeletal Effects Of Vitamin D: Potential Impact On Wv Disease Morbidity And Mortality, Franklin D. Shuler, Dana Lycans, Elias Salloum

Orthopaedics

Vitamin D is an essential nutrient and a secosteroid hormone that regulates many physiologic processes beyond calcium and bone homeostasis. These "extraskeletal" effects are impacted by the circulating levels of the storage form of vitamin D, 25-hydroxyvitamin D3. Levels of vitamin D can be detected after completing a simple 25(OH)D blood test. Vitamin D deficiency (< 30 ng/mL) is associated with a higher risk of many chronic diseases including, but not limited to, fourteen types of cancers, type 1 and 2 diabetes mellitus, obesity, cardiovascular disease, hypertension, stroke, and asthma. This article explores the association between vitamin D deficiency and the burden of chronic diseases in West Virginia.

"That's A Lotta Faith We're Putting In A Word": Language, Religion, And Heteroglossia As Oppression And Resistance In Comtemporary British Dystopian Fiction, Haley Cassandra Gambrell

MA in English Theses

Dystopian literature, in which writers imagine a chaotic, uncertain future, has become a trend in contemporary literature. Three recent British dystopian texts--Alan Moore and David Lloyd's graphic novel V for Vendetta , Patrick Ness's young adult novel The Knife of Never Letting Go , and China Miéville's detective novel The City & the City --reveal important themes of dystopian literature that transcend genre and stylistic convention. When a totalitarian regime governs the people, language and religion become commodities used by both government and citizens. First, I will explain the role of naming in establishing identity of both governing bodies and …

A Case Study Of The Impact Of The Learning Focused Schools Model On Culture In A Middle School Setting, Jonathan Fitzgerald Kay

Education Dissertations and Projects

This dissertation was designed to evaluate the impact of the Learning Focused Schools model on culture in a middle school setting. The school used in this study is a Title I school with low student achievement. The Learning Focused Schools model was implemented to provide comprehensive school reform strategies and solutions based on exemplary practices and research-based strategies. These practices and strategies focus on five areas: Planning, Curriculum, Instruction, Assessment, and School Organization. The study analyzed the effects of the Learning Focused Schools model on the school culture and how that, in turn, affects the academic achievement of the students. …

The Effect Of Education On Healthcare Personnel's Knowledge Of Lymphedema Detection And Prevention, Dolly Wilson

Nursing Theses and Capstone Projects

Secondary lymphedema (SLE) is a serious problem for many of the 2.6 million breast cancer survivors in the United States. It is estimated that 28 - 38% of breast cancer survivors develop lymphedema. The five-year incidence ranges from 43% to 94% (Armer, 2010). The purpose of this study was to evaluate the effectiveness of an education program on healthcare personnel's knowledge of the risk of and preventive measures for upper limb lymphedema in breast cancer patients. A sample of healthcare personnel (N = 32) included both trained healthcare personnel and ancillary staff who are employed in a single oncology center …

The Place To Be

Publications and Exhibits

Public life brings us together in common activity: cheering on the school sports team, enjoying Sunday dinner at a favorite restaurant, shopping at a local store. In these public spaces we conduct business, swap recipes, discuss issues of the day, relax with friends, and welcome newcomers to town. Public life knits together the diverse elements of a community and fosters a sense of civic responsibility. But longer job commutes, greater popularity of home entertainment, and online shopping mean more time spent privately and fewer opportunities to get together. To retain vitality, communities must continually nurture their traditional gathering places and …

Reviews And End Matter

BEADS: Journal of the Society of Bead Researchers

The History of Beads: From 100,000 B.C. to the Present, Revised and Expanded Edition, by Lois Sherr Dubin, and The Worldwide History of Beads, by Lois Sherr Dubin, reviewed by Margret Carey

Phoenix Rising: Narratives in Nyonya Beadwork from the Straits Settlements, by Hwei-Fe'n Cheah, reviewed by Alice Scherer

Journal: Borneo International Beads Conference 2010, Heidi Munan and Freya Martin (eds.), reviewed by Jean Nicholls

Journal: Borneo International Beads Conference 2011, Heidi Munan and Freya Martin (eds.), reviewed by Marjorie Bernbaum

African Dolls/Afrikanische Puppen: The Dulger-Collection, by Frank Jolles, reviewed by Marilee Wood

Cherished …

Heirloom Blue-Glass Melon Beads Of The Tani Tribes, Northeast India, Barbie Campbell Cole

BEADS: Journal of the Society of Bead Researchers

The Tani tribes of Arunachal Pradesh in India's remote northeast wear various heirloom necklaces including those composed of highly distinctive melon-shaped beads of wound turquoise-blue glass. These are unique to central Arunachal and were already of considerable age and very highly prized in the early 19th century. The Tanis believe their beads were made by a mythical ancestor in Tibet, but their bubbly opaque blue glass and wound method of production suggest a Chinese origin. The beads have local names which appear to link them to Tsari, one of Tibet's most important Buddhist pilgrimage sites. For centuries, the hostile animist …

Captions And Color Plates (V. 24, 2012)

BEADS: Journal of the Society of Bead Researchers

No abstract provided.

The Count's Dilemma, Or, Harmony And Dissonance In Legal Language, Ian Gallacher

College of Law - Faculty Scholarship

Lawyers have had a long, but ambivalent, relationship with metaphor. Viewed by some as a mere literary device, a trick of language that "adds little of substance to an argument," metaphor is seen by others as an essential component of legal language, a rhetorical device inseparable from thought. On one thing, though, all can agree: lawyers only have words to express their thoughts, so they have an obligation to use words, whether used metaphorically or not, as exactly as possible.

This article offers a critique of the way lawyers meet this obligation when they use metaphors based in musical language. …

Talking In The Dark: Using Technology For Basic Academic Support, Ian Gallacher

College of Law - Faculty Scholarship

No abstract provided.

Law And Legal Theory In The History Of Corporate Responsibility: Corporate Personhood, Lyman P.Q. Johnson

Scholarly Articles

This paper, part of a larger scholarly project, addresses one of four areas – i.e., the emergence of corporate personhood – where, historically, law has both influenced and mirrored cultural expectations concerning corporate responsibility. The other areas (treated elsewhere) are corporate purpose, corporate regulation, and corporate governance. Corporate personhood is a subject of longstanding and recurring interest that, notwithstanding it has been a settled concept since the 19th century, continues to vex and excite, as seen in the U. S. Supreme Court’s splintered 5-4 decision in the 2010 case of Citizens United v. Federal Election Commission. The decades-long debates about …

Categories, Tiers Of Review, And The Roiling Sea Of Free Speech Doctrine And Principle: A Methodological Critique Of United States V. Alvarez, Rodney A. Smolla

Scholarly Articles

None available.

Honor As Property, Johanna E. Bond

Scholarly Articles

This Article is the first to use a property lens to explore the social construction of honor within legal systems around the world. The Article makes the claim that the law in many countries has implicitly treated honor as a form of property and has made legal and social allowances for men who seek to reclaim honor property through violence. The Article expands the boundaries of the existing scholarship concerning honor-related violence by exploring the intersections between social constructions of honor and social constructions of property. Using a property lens to analyze the relationship between honor, patriarchal control, and law …

Carrots And Sticks, From President Obama’S Solyndra And Beyond, Paul Boudreaux

Washington and Lee Journal of Energy, Climate, and the Environment

No abstract provided.

El Tratado De Libre Comercio Entre Centroamérica, República Dominicana Y Estados Unidos (Cafta-Dr) Y El Desarrollo Desigual, Mary Finley-Brook

Geography and the Environment Faculty Publications

This paper utilizes geographical and interdisciplinary approaches to analyze changes in human-environment interactions following the Dominican Republic-Central American Free Trade Agreement (DR-CAFTA). It documents spatially and socially uneven patterns of transnational, national and local production and exchange. Negative ecological and social repercussions concentrate among marginalized groups while benefits accrue to regional elite and foreign corporations. Findings from Costa Rica, the Dominican Repblic and Nicaragua build from 2009 and 2010 fieldwork involving interviews with state officials, industry representatives and civil society. Media coverage, governmental and nongovernmental reports, industry data and scholarly articles supplement field sources and demonstrate transitions in Guatemala, Honduras …

Center For Grassland Studies, Winter-Spring 2012, Volume 18, No. 1

Center for Grassland Studies: Newsletters

Tracking Trout Lilies: Hybridization, Species Boundaries, and Conservation in the Genus Erythronium

From the Director

Corn Residue: Nebraska’s Great Forage Resource

CGS Associates

Baenziger: Ag Challenges to Feed the World Are Unprecedented

Program Shaping Up for 2012 Nebraska Grazing Conference

Call for Papers: 5th National Conference on Grazing Lands

2012 Nebraska Range Shortcourse

Resources

Wildland Fire In Ecosystems Effects Of Fire On Cultural Resources And Archaeology, Krista Deal, Leaonard Debano, Michael L. Elliot, Charles Haecker, Ann Trinkle Jones, Roger Kelly, Kristine M. Lee, Daniel F. Mccarthy, Elizabeth Oster, Trisha Rude, Samantha M. Ruscava-Barz, Kevin C. Ryan, Nelson Siefkin, Rebecca S. Timmons, John R. Welch

Joint Fire Science Program Synthesis Reports

This state-of-knowledge review provides a synthesis of the effects of fire on cultural resources, which can be used by fire managers, cultural resource (CR) specialists, and archaeologists to more effectively manage wildland vegetation, fuels, and fire. The goal of the volume is twofold: (1) to provide cultural resource/archaeological professionals and policy makers with a primer on fuels, fire behavior, and fire effects to enable them to work more effectively with the fire management community to protect resources during fuels treatment and restoration projects and wildfire suppression activities; and (2) to provide fire and land management professionals and policy makers with …

Research Perspectives On The Public And Fire Management: A Synthesis Of Current Social Science On Eight Essential Questions, Sarah M. Mccaffrey, Christine S. Olsen

Joint Fire Science Program Synthesis Reports

As part of a Joint Fire Science Program project, a team of social scientists reviewed existing fire social science literature to develop a targeted synthesis of scientific knowledge on the following questions: 1. What is the public’s understanding of fire’s role in the ecosystem? 2. Who are trusted sources of information about fire? 3. What are the public’s views of fuels reduction methods, and how do those views vary depending on citizens’ location in the wildland-urban interface or elsewhere? 4. What is the public’s understanding of smoke effects on human health, and what shapes the public’s tolerance for smoke? 5. …

Diversified Farming Systems: An Agroecological, Systems-Based Alternative To Modern Industrial Agriculture, Claire Kremen, Alastair Iles, Christopher M. Bacon

Environmental Studies and Sciences

This Special Issue on Diversified Farming Systems is motivated by a desire to understand how agriculture designed according to whole systems, agroecological principles can contribute to creating a more sustainable, socially just, and secure global food system. We first define Diversified Farming Systems (DFS) as farming practices and landscapes that intentionally include functional biodiversity at multiple spatial and/or temporal scales in order to maintain ecosystem services that provide critical inputs to agriculture, such as soil fertility, pest and disease control, water use efficiency, and pollination. We explore to what extent DFS overlap or are differentiated from existing concepts such as …

Food Security And Smallholder Coffee Production: Current Issues And Future Directions, Martha Caswell, V. Ernesto Méndez,, Christopher M. Bacon

Environmental Studies and Sciences

In recent years, there has been growing discussion within the specialty coffee industry about the preva- lence of seasonal food insecurity in coffee growing communities. The idea that coffee producers lack re- sources to feed themselves and their families flies in the face of Fair Trade and other sustainable coffee ini- tiatives, which were designed to ensure a viable livelihood and improved conditions for small-scale coffee farmers around the world. Though these certifications represent an important step toward delivering better prices to farmers, they are inadequate tools to stand alone against the formidable and entrenched barriers faced by this population. …

Redefining Chronic Toxoplasmosis: A T Cell Exhaustion Perspective, Rajarshi Bhadra, Imtiaz A. Khan

Microbiology, Immunology, and Tropical Medicine Faculty Publications

No abstract provided.

The Adjuvanticity Of An O. Volvulus-Derived Rov-Asp-1 Protein In Mice Using Sequential Vaccinations And In Non-Human Primates, Jing Wang, Nancy Trichoche, Lanying Du, Meredith Hunter, Bin Zhan, Gaddam Goud, Elizabeth S. Didier, Jing Liu, Lu Lu, Preston A. Marx, Shibo Jiang, Sara Lustigman

Microbiology, Immunology, and Tropical Medicine Faculty Publications

Adjuvants potentiate antigen-specific protective immune responses and can be key elements promoting vaccine effectiveness. We previously reported that the Onchocerca volvulusrecombinant protein rOv-ASP-1 can induce activation and maturation of naïve human DCs and therefore could be used as an innate adjuvant to promote balanced Th1 and Th2 responses to bystander vaccine antigens in mice. With a few vaccine antigens, it also promoted a Th1-biased response based on pronounced induction of Th1-associated IgG2a and IgG2b antibody responses and the upregulated production of Th1 cytokines, including IL-2, IFN-γ, TNF-α and IL-6. However, because it is a protein, the r …

Neglected Tropical Diseases As Hidden Causes Of Cardiovascular Disease, Yasmin Moolani, Gene Bukhman, Peter J. Hotez

Microbiology, Immunology, and Tropical Medicine Faculty Publications

No abstract provided.

Cell-Free Circulating Mirna Biomarkers In Cancer., Meng-Hsuan Mo, Liang Chen, Yebo Fu, Wendy Wang, Sidney W. Fu

Microbiology, Immunology, and Tropical Medicine Faculty Publications

Considerable attention and an enormous amount of resources have been dedicated to cancer biomarker discovery and validation. However, there are still a limited number of useful biomarkers available for clinical use. An ideal biomarker should be easily assayed with minimally invasive medical procedures but possess high sensitivity and specificity. Commonly used circulating biomarkers are proteins in serum, most of which require labor-intensive analysis hindered by low sensitivity in early tumor detection. Since the deregulation of microRNA (miRNA) is associated with cancer development and progression, profiling of circulating miRNAs has been used in a number of studies to identify novel minimally …