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Annual Report, 2011-2012, Ammerman Center, Connecticut College

Annual Reports

No abstract provided.

Kasten V. Saint-Gobain Performance Plastics: Protecting Oral Complaints At The Expense Of Workplace Complaints, Shaun O'Donnell

Proxy

No abstract provided.

Matrixx Initiatives, Inc. V. Siracusano: Nasal Spray Decision Throws Corporations Off The Scent Of "Materiality" Definition, Marcie Brecher

Proxy

No abstract provided.

Stare Decisis And Foreign Affairs, Michael P. Van Alstine

Faculty Scholarship

This article examines whether the jurisprudential and institutional premises of the doctrine of stare decisis retain their validity in the field of foreign affairs. The proper role of the judicial branch in foreign affairs has provoked substantial scholarly debates—historical, institutional, normative—since the very founding of the republic. Precisely because of the sensitivity of the subject, the Supreme Court itself has both cautioned about the judicial branch’s comparative lack of expertise in the field and recognized a web of deference doctrines designed to protect against improvident judicial action. Notwithstanding all of this, however, neither the Supreme Court nor any scholar has …

Treating Religion Differently, Melissa Rogers

First Amendment Law Review

No abstract provided.

The Canon, 2012, Dordt College

Dordt Canon

• Cover Design by Aanna Stadem
• How Great Thou Art by Hannah DeVries
• Kiss the Rain by Aubrey Pasker
• Always, Tim Hortons by Anna Visser
• Sugar High by Kelli Durant
• Claymen by Carrie Goff
• Collection of Science Devotionals by Deborah Jude
• NYC Motion by Jordan Edens
• Untitled by Hannah DeVries
• Prairie Wind by Benjamin Hofland
• Dordt News Channel Not Real Enough, Students Say by Caroline Eckstrom
• Angles by Jordan Edens
• RUSH by Kelli Durant
• Where I'm From by Kelli Durant
• The Organ in the Cave by Carrie Goff
• Onions by Jordan Edens
• Ghosts of Grand Central Station by Aanna Stadem
• Path …

Comparison Of Three Yarrowia Lipolytica Strains For Lipase Production: Nbrc 1658, Ifo 1195, And A Local Strain, Özgür Kebabci, Ni̇lüfer Ci̇hangi̇r

Turkish Journal of Biology

Lipase production was examined with 3 strains of Yarrowia lipolytica: NBRC 1658, IFO 1195, and a local strain. All strains were obtained from Hacettepe University's Department of Food Engineering. The addition of nitrogen and carbon sources and the effects of initial pH and temperature parameters were studied. For all 3 strains, the growth temperature range was 20-40 °C, and maximum growth was determined at 30 °C. The initial pH range was 6-9 for growth and 3-6 for lipase production. Maximum growth results were detected as follows: Y. lipolytica NBRC 1658 at 30 °C and pH 8, Y. lipolytica IFO 1195 …

Anti-Inflammatory Effects Of Different Extracts From Three Salvia Species, Eli̇f Çadirci, Hali̇s Süleyman, Peri̇han Gürbüz, Ayşe Uz, Zühal Güvenalp, Lütfi̇ye Ömür Demi̇rezer

Turkish Journal of Biology

Salvia L. species have been used for the treatment of various inflammatory ailments in traditional medicine. In order to evaluate this ethnobotanical information, water, methanol, n-butanol, acetone, and chloroform extracts from 3 Salvia species (S. fruticosa, S. verticillata, and S. trichoclada) were screened for their anti-inflammatory activity using in vivo experimental models in rats. For this purpose a carrageenan-induced inflammatory paw edema model was used. All extracts demonstrated anti-inflammatory activities; however, n-butanol extract of Salvia fruticosa (syn. S. triloba), which is known as Turkish sage, was found to be the most active. It can be expected that the active flavonoids, …

Folk Medicines In The Villages Of Ilıca District (Erzurum, Turkey), Ufuk Özgen, Yusuf Kaya, Peter Houghton

Turkish Journal of Biology

The villages of Ilıca District in Erzurum Province, Turkey, were surveyed in terms of plants and animals used traditionally for medicinal purposes. Plants were compiled according to their families, botanical names, local names, usages, and applications. A total of 70 plant species belonging to 29 families are used by village people to treat a wide range of complaints, such as hemorrhoids, urinary system infections, stomach disorders, respiratory diseases, skin diseases, rheumatism, and jaundice. In addition, 3 animal species are used for the treatment of some diseases. The collected data were compared with those formerly recorded.

Utep Magazine: The University Of Texas At El Paso, Utep University Communications

UTEP Magazine

Centennial Legacy: The New University Mace Captures UTEP's Rich History as Well as Its Highly Promising Future, From Its Beginnings as Texas' First Mining School in 1914 to Today's Competitive Research University Serving a 21st Century Student Demographic.

Annual Report (2012): Statistical Report And Physician Referral Guide, Lehigh Valley Health Network

LVHN Annual & Statistical Reports

No abstract provided.

Financial Literacy And Numerical Ability: Keys To Better Mortgage Outcomes, Singapore Management University

Perspectives@SMU

While mortgage credit expansion had lead to a rapid increase of home ownership in the US, the reversal of home prices beginning in 2006 resulted in a substantial increase in mortgage delinquencies and an explosion in outright defaults. Its devastating impact on the associated mortgage backed securities led the US and the world to its worst financial and macroeconomic crisis since the Great Depression, with its deleterious effects still felt today.

Enhanced Nrf2 Activity Worsens Insulin Resistance, Impairs Lipid Accumulation In Adipose Tissue, And Increases Hepatic Steatosis In Leptin-Deficient Mice, Jialin Xu, Supriya R. Kulkarni, Ajay C. Donepudi, Vijay R. More, Angela L. Slitt

Biomedical and Pharmaceutical Sciences Faculty Publications

The study herein determined the role of nuclear factor erythoid 2–related factor 2 (Nrf2) in the pathogenesis of hepatic steatosis, insulin resistance, obesity, and type 2 diabetes. Lep^ob/ob-Keap1-knockdown (KD) mice, which have increased Nrf2 activity, were generated. Markers of obesity and type 2 diabetes were measured in C57Bl/6J, Keap1-KD, Lep^ob/ob, and Lep^ob/ob-Keap1-KD mice. Lep^ob/ob-Keap1-KD mice exhibited less lipid accumulation, smaller adipocytes, decreased food intake, and reduced lipogenic gene expression. Enhanced Nrf2 activity impaired insulin signaling, prolonged hyperglycemia in response to glucose challenge, and induced insulin resistance in Lep^ob/ob background. Nrf2 augmented …

Division Of Research And Economic Development Annual Report For Fy2012, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

Annual report for the Division of Research and Economic Development of the University of Rhode Island for the year 2011-2012.

Includes statistics of project proposals, expenditures, URI Foundation Awards, previous annual report summaries and awards received by individual academic and administrative departments.

Division Of Research And Economic Development Monthly Report For January 2012, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For September 2012, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For February-March 2012, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For October 2012, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For May-June 2012, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For April 2012, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For November 2012, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For December 2012, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Division Of Research And Economic Development Monthly Report For July - October 2012, Uri Division Of Research And Economic Development

Reports (Research and Economic Development)

The monthly reports include statistics for project proposals and awards received by individual academic and administrative departments at the University of Rhode Island.

Effect Of Hla Dr Epitope De-Immunization Of Factor Viii In Vitro And In Vivo, Leonard Moise, Chang Song, William D. Martin, Ryan Tassone, Anne S. De Groot, David W. Scott

Institute for Immunology and Informatics Faculty Publications

T cell-dependent development of anti-Factor VIII (FVIII) antibodies that neutralize FVIII activity is a major obstacle to replacement therapy in hemophilia A. To create a less immunogenic therapeutic protein, recombinant FVIII can be modified to reduce HLA binding of epitopes based on predicted anchoring residues. Here, we used immunoinformatic tools to identify C2 domain HLA DR epitopes and predict site-specific mutations that reduce immunogenicity. Epitope peptides corresponding to original and modified sequences were validated in HLA binding assays and in immunizations of hemophilic E16 mice, DR3 and DR4 mice and DR3 × E16 mice. Consistent with immunoinformatic predictions, original epitopes …

Teaching Tolerance, Leslie P. Cousens, Federico Mingozzi, Sander Van Der Marel, Yan Su, Richard Garman, Valerie Ferreira, William Martin, David W. Scott, Anne S. De Groot

Institute for Immunology and Informatics Faculty Publications

Babies born with Pompe disease require life-long treatment with enzyme-replacement therapy (ERT). Despite the human origin of the therapy, recombinant human lysosomal acid α glucosidase (GAA, rhGAA), ERT unfortunately leads to the development of high titers of anti-rhGAA antibody, decreased effectiveness of ERT, and a fatal outcome for a significant number of children who have Pompe disease. The severity of disease, anti-drug antibody (ADA) development, and the consequences thereof are directly related to the degree of the enzyme deficiency. Babies born with a complete deficiency GAA are said to have cross-reactive immunologic material (CRIM)–negative Pompe disease and are highly likely …

Research & Innovation For 2011-2012, University Of Rhode Island

Publications (Research and Economic Development)

The 2011-2012 issue of Research & Innovation, a periodical focused on research at the University of Rhode Island.

Toothbrush Contamination: A Review Of The Literature, Michelle R. Frazelle, Cindy L. Munro

School of Nursing Publications

Toothbrushes are commonly used in hospital settings and may harbor potentially harmful microorganisms. A peer-reviewed literature review was conducted to evaluate the cumulative state of knowledge related to toothbrush contamination and its possible role in disease transmission. A systematic review was conducted on adult human subjects through three distinct searches. The review resulted in seven experimental and three descriptive studies which identified multiple concepts related to toothbrush contamination to include contamination, methods for decontamination, storage, design, and environmental factors. The selected studies found that toothbrushes of healthy and oral diseased adults become contaminated with pathogenic bacteria from the dental plaque, …

Blockade Of Electron Transport At The Onset Of Reperfusion Decreases Cardiac Injury In Aged Hearts By Protecting The Inner Mitochondrial Membrane, Qun Chen, Thomas Ross, Ying Hu, Edward J. Lesnefsky

Internal Medicine Publications

Myocardial injury is increased in the aged heart following ischemia-reperfusion (ISC-REP) compared to adult hearts. Intervention at REP with ischemic postconditioning decreases injury in the adult heart by attenuating mitochondrial driven cell injury. Unfortunately, postconditioning is ineffective in aged hearts. Blockade of electron transport at the onset of REP with the reversible inhibitor amobarbital (AMO) decreases injury in adult hearts. We tested if AMO treatment at REP protects the aged heart via preservation of mitochondrial integrity. Buffer-perfused elderly Fischer 344 24 mo. rat hearts underwent 25 min global ISC and 30 min REP. AMO (2.5 mM) or vehicle was given …

Interactions Between Bile Acids And Nuclear Receptors And Their Effects On Lipid Metabolism And Liver Diseases, David Q.-H. Wang, Brent A. Neuschwander-Tetri, Piero Portincasa, William M. Pandak

Internal Medicine Publications

In this special issue of Journal of Lipids, we acknowledge the contributions by several experts offering timely perspectives on the complex interactions between bile acids and nuclear receptors (NRs) on lipid metabolism and liver diseases at different levels and contexts in the body.

NRs are found within the interior of cells and are defined as ligand-activated transcriptional regulators of several key aspects of body physiology and pathophysiology. NRs regulate gene transcription through interaction with cellular coactivators and corepressors. In the liver, NRs play a key role in a large variety of metabolic processes such as cholesterol, bile acid, fatty acid, …

Posttransplant Metabolic Syndrome, M. Shadab Siddiqui, Richard K. Sterling

Internal Medicine Publications

Metabolic syndrome (MS) is a cluster of metabolic derangements associated with insulin resistance and an increased risk of cardiovascular mortality. MS has become a major health concern worldwide and is considered to be the etiology of the current epidemic of diabetes and cardiovascular disease. In addition to cardiovascular disease, the presence of MS is also closely associated with other comorbidities including nonalcoholic fatty liver disease (NAFLD). The prevalence of MS in patients with cirrhosis and end-stage liver disease is not well established and difficult to ascertain. Following liver transplant, the prevalence of MS is estimated to be 44–58%. The main …