Digital Commons Network^™

Nurses Information Appraisal Within The Clinical Setting, Heather D. Carter-Templeton

Theses and Dissertations (ETD)

Information appraisal is foundational to information literacy, a necessary skill to support evidence-based practice. Little discussion in nursing literature exists regarding how nurses appraise information. If nurses lack information appraisal skills they cannot safely and effectively apply evidence in practice. Furthermore, if nurses at all levels are to engage in evidence-based practice, information appraisal in the clinical setting must be understood. The research study used an interpretive description design to define and describe the process of information appraisal in the clinical setting. Participants of this study represented a stratified purposeful sample of 44 registered nurses employed at a regional medical …

Spatial Distribution Of Obesity Among West Virginia 5th Grade Children: Analysis Of The Socioeconomic, Physical, And Personal Environment, Sherry Roper

Theses and Dissertations (ETD)

Childhood obesity defined as a body mass index (BMI) at or above the 95th percentile for children of the same age and sex, is considered an epidemic in the United States. Biology and lifestyle behaviors have been identified as important factors in the development of childhood obesity; however, researchers are beginning to place more emphasis upon the impact that continual environmental exposures have upon obesity development. Environmental risk factors associated with obesity are distributed continuously over space, yet evidence suggests that burden of risk may not be evenly dispersed across a community. West Virginia (WV), a rural Appalachian community has …

The Effects Of Pten Deletion On Cell Size And Plasticity In The Hippocampus, Margaret Sperow

Theses and Dissertations (ETD)

The tumor suppressor phosphatase and tensin homolog (PTEN) is the central negative regulator of the phosphatidylinositol 3-kinase (PI3K) -signaling pathway, which mediates diverse processes in various tissues. In the nervous system, the PI3K pathway modulates proliferation, migration, cellular size and synaptic transmission and plasticity. Neurologic abnormalities such as autism, seizures, and ataxia are associated with inherited PTEN mutations. Yet, how PTEN loss contributes to neurologic dysfunction remains unknown. PTEN loss during early development is associated with extensive deficits in neuronal migration and substantial hypotrophy of neurons and synaptic densities. However, whether its effect on synaptic transmission and plasticity is direct …

Development And Evaluation Of Nano‑Scale Systems For Targeted Delivery To Treat Liver Fibrosis, Ningning Yang

Theses and Dissertations (ETD)

Excessive deposition of ECM is the common characteristic of liver fibrosis. During hepatic fibrosis, various inflammatory cytokines are released and trigger the activation of quiescent HSCs. The activated HSCs play the major role in producing extra amount collagen. It becomes very crucial to focus on HSCs to find out therapeutics, such as inhibiting collagen synthesis, inhibiting activation to myofibroblasts, or controlling inflammation.

To control excessive collagen synthesis, one triplex forming oligonucleotides (TFO), was systemically administrated to prevent type I collagen mRNA transcription. To enhance circulation time and targeted delivery efficiency, TFO was conjugated to M6P‑HPMA and showed efficient targeted delivery …

Preclinical Pharmacology Of The Mdm2 Antagonist Nutlin-3a, Fan Zhang

Theses and Dissertations (ETD)

Nutlin-3a is an MDM2-p53 interaction antagonist that is under investigation in preclinical models for a variety of pediatric malignancies, including neuroblastoma, retinoblastoma, leukemia, and rhabdomyosarcoma. In the current research, we conducted preclinical pharmacology studies of nutlin-3a to evaluate the synergistic effect of the nutlin-3a and topotecan combination on neuroblastoma cell growth, to assess the effect of nutlin-3a on breast cancer resistance protein (BCRP), and to characterize the disposition of nutlin-3a in the mouse plasma and multiple tissues.

Activating the p53 pathway might offer a new therapy for neuroblastoma. In the first part of the study, we assessed the effect of …

Using Geographical Information Systems To Investigate Spatial Patterns In Fossils Of Tapirus Polkenis From The Gray Fossil Site, Washington County, Tennessee, Winn Addison Ketchum

Electronic Theses and Dissertations

Discovered in 2000, the Gray Fossil Site provides a snapshot of the flora and fauna that lived during late Miocene to early Pliocene time in eastern Tennessee. These fossils occur in sediments consisting of fine-grained clays and sands of lacustrine origin, which were deposited after multiple sinkholes formed in the underlying Knox Group basement carbonates. Three-dimensional nearest neighbor analysis has been applied to fossils of Tapirus polkensis, characterizing the spatial patterns exhibited. These analyses determined the importance of taphonomic and depositional processes that occurred during the sites formation. Six characteristics were analyzed, four at the bone level including carnivore …

Effect Of Gender On The Association Of Single-Nucleotide Polymorphisms With Bipolar Disorder, Jerald Eric Mullersman

Electronic Theses and Dissertations

Bipolar disorder is a relatively common form of mental illness that depends strongly on genetic inheritance for expression. The author of this study has sought to evaluate whether the gender of subjects influences which genetic variants are associated with the disease. A portion of the cases from a previously published study were analyzed using PLINK software and the association of single-nucleotide polymorphisms was evaluated separately for all cases, for female subjects alone, and for male subjects alone. The results obtained for male subjects alone reached higher levels of statistical significance than when both genders were evaluated together or when female …

Feeding Practices Of Mothers In The Gobi Desert Of Mongolia, Julie F. Tate

Electronic Theses and Dissertations

The diets of Mongolia infants are deficient in vitamins and minerals and complementary foods are introduced too early. Breastfeeding is the best source of nutrition for infants until 6 months of age. A survey of 50 Mongolian mothers with children under the age of 5 in the town of Sainshand, Dornogobi, was conducted in July 2011. Mongolian infants are among the highest percent of infants in the world who are exclusively breastfed for the first 6 months of their lives, thus providing them with excellent nutrition. However, complementary feedings and supplements are not appropriately used or understood. Therefore, the diets …

Real Leadership And The U.S. Army: Overcoming A Failure Of Imagination To Conduct Adaptive Work, John B. Richardson Colonel

Books, Monographs & Collaborative Studies

This monograph begins with a case study that provides a means for analyzing the complexity of organizational leadership in the contemporary security environment. As such, it presents a high stakes problem-set that required an operational adaptation by a cavalry squadron conducting combat operations in Baghdad. This problematic reality triggered the struggle to find a creative response to a very deadly problem, while cultural norms served as barriers that prevented the rejection of previously accepted solutions that had proven successful in the past, even though those successful solutions no longer fit in the context of the reality of the present. The …

Organizational Change In The Russian Airborne Forces: The Lessons Of The Georgian Conflict, Rod Thornton Dr.

Books, Monographs & Collaborative Studies

This monograph considers the recent history of organizational change in the Russian Airborne Forces (VDV). In particular, it looks at how the VDV has changed since the end of Russia’s conflict with Georgia in 2008. The VDV, a force much admired in Russian media and society has, in fact, escaped fairly lightly during the comprehensive reform of the Russian Army more generally over the last few years. In large part this has been down to the personality of the current head of the VDV, Lieutenant-General Vladimir Shamanov. Close to Prime Minister Vladimir Putin, Shamanov--a "maverick"--has used his political connections to …

The Saudi-Iranian Rivalry And The Future Of Middle East Security, W. Andrew Terrill Dr.

Books, Monographs & Collaborative Studies

Saudi Arabia and Iran have often behaved as serious rivals for influence in the Middle East and especially the Gulf area since at least Iran’s 1979 Islamic Revolution and the 1980-88 Iran-Iraq War. While both nations define themselves as Islamic, the differences between their foreign policies could hardly be more dramatic. In most respects, Saudi Arabia is a regional status quo power, while Iran often seeks revolutionary change throughout the Gulf area and the wider Middle East with varying degrees of intensity. Saudi Arabia also has strong ties with Western nations, while Iran views the United States as its most …

Salud Y Saludos: The E-News Of The College Of Health Sciences, College Of Health Sciences

College of Health Sciences

Monthly e-news of the College of Health Sciences

A Preliminary Exploration Of Breakthrough Thinking Preferences Of Ice Hockey Players, Bonnie A. Doliszny

Creative Studies Graduate Student Master's Theses

The purpose of this study was to conduct a preliminary exploration of creative-thinking preferences of ice hockey players. FourSight: The Breakthrough Thinking Profile is an assessment designed to assist individuals and teams to better understand their approach to problem solving through creative thinking. This qualitative study explored the application of FourSight to a New England Preparatory school ice hockey team identifying if the cognitive and creative preferences translate into on ice behavior. Triangulated data from real game performances, coaching analysis and individual player interviews were gathered to answer the following questions:

Do creative process preferences exist among ice hockey …

Mapping Injustice: The World Is Witness, Place-Framing, And The Politics Of Viewing On Google Earth, Joshua P. Ewalt

Department of Communication Studies: Faculty Publications

Working from assumptions that inequality is often spatially informed, a set of interactive cartographies has recently proliferated on Google Earth. In this essay, I analyze one of those interactive cartographies: The World is Witness produced by the United States Holocaust Memorial Museum (USHMM). I read the map as an organizational rhetoric that frames place as "embedded injustice." I also argue that thorough analysis of the framing of local place on Google Earth must inherently question whether the map can create a disruption in the viewing subject. While the map presents vital information on excruciatingly despicable acts of injustice, and the …

Homologous Recombination In Nannochloropsis: A Powerful Tool In An Industrially Relevant Alga, Donald P. Weeks

Department of Biochemistry: Faculty Publications

The availability of facile methods for targeted gene knockout and gene replacement based on homologous recombination in bacteria and yeast systems has driven rapid progress in understanding many of the complex metabolic and regulatory networks in prokaryotic and eukaryotic cells. The lack of such tools in other organisms is a major impediment to progress both in fundamental research and in research that is directed toward practical economic and societal outcomes. For example, the current goal to replace fossil fuels with renewable energy sources produced by plants and algae is hampered in both the short term and the long term by …

Morphine Potentiates Neuropathogenesis Of Siv Infection In Rhesus Macaques, Sirosh M. Bokhari, Ramakrishna Hedge, Shannon Callen, Honghong Yao, Istvan Adany, Qingsheng Li, Zhuang Li, David Pinson, Hung-Wen Yeh, Paul D. Cheney, Shilpa Buch

Qingsheng Li Publications

Despite the advent of antiretroviral therapy, complications of HIV-1 infection with concurrent drug abuse are an emerging problem. Opiates are well-known to modulate immune responses by preventing the development of cell-mediated immune responses. Their effect on the pathogenesis of HIV-1 infection however, remains controversial. Using the Simian Immunodeficiency Virus/ macaque model of HIV pathogenesis, we sought to explore the impact of morphine on disease progression and pathogenesis. Sixteen Rhesus macaques were divided into 2 groups; 4 were administered saline and twelve others morphine routinely. Both groups of animals were then inoculated with SIVmacR71/17E and followed longitudinally for disease pathogenesis. The …

Cancer Stem Cells. From Characterization To Therapeutic Implications., Nehad M. Alajez

Saudi Medical Journal

The cancer stem cell (CSC), or alternatively referred to as the tumor initiating cell (TIC) model, proposes that human cancers are organized in a hierarchical structure with the CSC at the apex. Cancer stem cells are functionally defined by their ability to self-renew, and to recapitulate the hierarchy of the original tumor from which they were derived. Emerging data from the literature suggest that CSCs might be the fraction within the tumor that resists conventional therapies; hence, the CSC paradigm provides new insight into tumor progression and relapse. Herein, we provide literature review of the CSC model, with emphasis on …

Expression Of Alkaline Phosphatase In Immortalized Murine Cementoblasts In Response To Compression-Force., Ye Tian, Lan Huang, Yong-Wen Guo, Li Cao, Ya-Ting Wang, Hui Xu, Ding Bai

Saudi Medical Journal

OBJECTIVES: To determine the effect of compression-force on the expression of alkaline phosphatase (ALP), and ALP activity in cementoblasts. METHODS: We performed this study in the State Key Laboratory of Oral Diseases, West China Stomatology Hospital, Sichuan University, Chengdu, Sichuan, China from October to December 2010. We exposed murine immortalized cementoblasts (OCCM-30) to 2000-ustrain compression-force at a frequency of 0.5 Hz for 1, 3, 6, 12, and 24 hours. We assayed the cellular ALP activity after the treatments. We used real-time polymerase chain reaction (RT-PCR) and western blot to examine the gene and protein expression of ALP in the OCCM-30 …

Serum Hyaluronic Acid Level Does Not Reliably Differentiate Minimal And Significant Liver Disease In Chronic Hepatitis C., Shoukat A. Arain, Sultan A. Meo, Qamar Jamal

Saudi Medical Journal

OBJECTIVES: To evaluate the predictive value of hyaluronic acid (HA) for the assessment of liver fibrosis and inflammation in chronic hepatitis C (CHC). METHODS: This cross-sectional study was conducted at Ziauddin University, Karachi, Pakistan from June 2006 to July 2010. Ninety-eight CHC patients, 52 (53%) males, and 46 (47%) females, with an age range of 20-60 years (mean 36.0±10.5) were recruited. Liver fibrosis was staged on a 5-point scale, F0 to F4, and inflammation was graded on a 4-point scale, A0 to A3. Patients were divided into minimal (F<2 and A<2) and significant (F>/=2 or A>/=2) overall disease groups. The HA was measured …

Plasma Total Antioxidant Capacity And Its Related Factors In Iranian Pregnant Women., Zatollah Asemi, Shima Jazayeri, Mohammad Najafi, Mansoreh Samimi, Zohreh Tabasi, Farzad Shidfar, Abbas Rahimi-Foroushani, Vahid Mofid

Saudi Medical Journal

OBJECTIVES: To determine the plasma total antioxidant capacity (TAC) and its related factors in pregnant Iranian women attending maternity clinics. METHODS: In a cross-sectional study carried out in Naghavi Maternity Clinic, Shaheed Beheshti Specialty and Subspecialty Polyclinic and 10 antenatal centers, affiliated to Kashan University of Medical Sciences, Kashan, Iran, we determined the plasma TAC and its related factors including maternal age, weight, and body mass index (BMI) at the beginning, thirteenth, and twenty-first to twenty-fourth weeks of pregnancy, and gestational age at the twenty-first to twenty-fourth weeks of pregnancy in 137 primigravid pregnant women, 18-30 years old from October …

The Burden Of Ischemic Heart Disease At A Major Cardiac Center In Central Saudi Arabia., Ahmed M. Osman, Mohammed S. Alsultan, Meshal A. Al-Mutairi

Saudi Medical Journal

OBJECTIVES: To estimate the direct medical costs associated with ischemic heart disease (IHD) at Prince Sultan Cardiac Center (PSCC) in Riyadh, Saudi Arabia. METHODS: This is a prevalence-based prospective observational cost of illness study conducted in PSCC, Riyadh, Kingdom of Saudi Arabia between April and June 2009. All patients diagnosed or suspected of having IHD at admission were included. They were followed up until discharge, or performing coronary artery bypass graft (CABG), or changing diagnosis. Clinical data were extracted from the patients9 computerized database, and combined with the unit cost of services to calculate costs. RESULTS: A total of 205 …

Assessment Of Quality Of Life In Patients With Type 2 Diabetes Mellitus In Oman., Masoud Y. Al-Maskari, Ali O. Al-Shookri, Samir H. Al-Adawi, Khor G. Lin

Saudi Medical Journal

OBJECTIVES: To measure quality of life of type 2 diabetes patients in Oman, and examine which patients9 socio-demographic and diabetes-related clinical characteristics are associated with better quality of life. METHODS: This cross-sectional study of 200 diabetic subjects was conducted in Sultan Qaboos University Hospital, Al-Khod, Oman between April and September 2009. A short form of the diabetes quality of life questionnaire (DQoL) was used to elicit indices of quality of life on subjects (n=200) seeking consultation at the diabetic outpatient clinic. Socio-demographic variables, body mass index (kg/m) and clinical parameters relevant for the diagnosis of type 2 diabetes, including glycated …

Vitiligo-Epidemiological Study Of 4134 Patients At The National Center For Vitiligo And Psoriasis In Central Saudi Arabia., Ahmed Alissa, Abdulla Al Eisa, Rozeena Huma, Sajeev Mulekar

Saudi Medical Journal

OBJECTIVES: To assess the clinical patterns, epidemiological profile of vitiligo, and its awareness among Saudi nationals. METHODS: A retrospective study was conducted among Saudi nationals with a confirmed diagnosis of vitiligo presenting to the National Center for Vitiligo and Psoriasis, Riyadh, Saudi Arabia, from August 2002 to August 2006 using a retrospective questionnaire based on the history and medical records of patients. RESULTS: Of the 4134 cases, 53.5% were females. The mean age of onset of vitiligo was 17.4 years. Vitiligo vulgaris was the most common type in 42.3% of cases, 90.5% had no associated autoimmune conditions. The family history …

Research Productivity Among Faculty Members At Medical And Health Schools In Saudi Arabia. Prevalence, Obstacles, And Associated Factors., Saad A. Alghanim, Rashid M. Alhamali

Saudi Medical Journal

OBJECTIVES: To identify the prevalence, factors and obstacles affecting research productivity among academic staff at medical and health colleges in the Kingdom of Saudi Arabia. METHODS: This cross-sectional survey employed self-administered questionnaires to collect data on faculty members9 profile, research activities, and obstacles impeding research productivity. The questionnaires were distributed randomly to 500 faculty members, of which 389 (77.8%) completed the questionnaire at 10 medical and health colleges during January to April 2011. The data were analyzed and presented in a descriptive fashion. RESULTS: Only 150 (38.6%) respondents reported published work in the past 2 years. Of these, 80% indicated …

Genotoxicity And Cytotoxicity Of Ovine Collagen On Human Dermal Fibroblasts., Fauzi M. Busra, Shiplu R. Chowdhury, Aminuddin B. Saim, Ruszymah B. Idrus

Saudi Medical Journal

No abstract provided.

Bacillus Calmette-Guerins Vaccination At Birth Causing Tuberculous Granulomatous Lymphadenitis, Mahmood D. Al-Mendalawi

Saudi Medical Journal

No abstract provided.

Comparison Of The Effects Of Sedation And General Anesthesia In Surgically Assisted Rapid Palatal Expansion, Yong H. Kim, Sang Y. Jeon, Jae H. Park, Ji H. Choe

Saudi Medical Journal

No abstract provided.

Drug Susceptibility Pattern Of Mycobacterium Tuberculosis Isolates Against Conventional Anti-Tuberculosis Drugs In Dhaka, Bangladesh., Mahmood D. Al-Mendalawi, Murad Hossain

Saudi Medical Journal

No abstract provided.

An Evaluation Of Neuroplasticity And Behavior After Deep Brain Stimulation Of The Nucleus Accumbens In An Animal Model Of Depression., Steven M Falowski, Ashwini Sharan, Beverly A S Reyes, Carl Sikkema, Patricia Szot, Elisabeth J Van Bockstaele

Department of Neurosurgery Faculty Papers

BACKGROUND: Recent interest has demonstrated the nucleus accumbens (NAcc) as a potential target for the treatment of depression with deep brain stimulation (DBS).

OBJECTIVE: To demonstrate that DBS of the NAcc is an effective treatment modality for depression and that chemical and structural changes associated with these behavioral changes are markers of neuroplasticity.

METHODS: A deep brain stimulator was placed in the NAcc of male Wistar-Kyoto rats. Groups were divided into sham (no stimulation), intermittent (3 h/d for 2 weeks), or continuous (constant stimulation for 2 weeks). Exploratory and anxietylike behaviors were evaluated with the open-field test before and after …

Borderplex Economic Outlook: 2011-2013, Thomas M. Fullerton Jr., Adam G. Walke

Border Region Modeling Project

No abstract provided.