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The Role Of Receptor Tyrosine Kinase Axl In Pancreatic Ductal Adenocarcinoma And Its Regulation By Hematopoietic Progenitor Kinase 1, Xianzhou Song

Dissertations and Theses (Open Access)

Pancreatic ductal adenocarcinoma (PDA) is one of the most aggressive malignancies with less than 5% of five year survival rate. New molecular markers and new therapeutic targets are urgently needed for patients with PDA. Oncogenic receptor tyrosine kinase Axl has been reported to be overexpressed in many types of human malignancies, including diffuse glioma, melanoma, osteosarcoma, and carcinomas of lung, colon, prostate, breast, ovary, esophagus, stomach, and kidney. However, the expression and functions of Axl in PDA are unclear. We hypothesized that Axl contributes to the development and progression of PDA. We examined Axl expression in 54 human PDA samples …

Prognostic Significance Of Xct Polymorphisms And Expression In Patients With Advanced Pancreatic Cancer Treated With Chemotherapy, Tzu-Chuan Jane Huang Md

Dissertations and Theses (Open Access)

The plasma membrane x_c^- cystine/glutamate transporter mediates cellular uptake of cystine in exchange for intracellular glutamate and is highly expressed by pancreatic cancer cells. The xCT gene, encoding the cystine-specific xCT protein subunit of x_c^-, is important in regulating intracellular glutathione (GSH) levels, critical for cancer cell protection against oxidative stress, tumor growth and resistance to chemotherapeutic agents including platinum. We examined 4 single nucleotide polymorphisms (SNPs) of the xCT gene in 269 advanced pancreatic cancer patients who received first line gemcitabine with or without cisplatin or oxaliplatin. Genotyping was performed using Taqman real-time PCR …

Plagiarism Among Applicants For Faculty Positions, Sam Harirforoosh, John B. Bossaer, Stacy D. Brown, Brooks B. Pond, Victoria P. Ramsauer, David S. Roane

ETSU Faculty Works

To the Editor. Recently, Dr. DiPiro published an article in the Journal¹ that discussed several aspects pertinent to the process of faculty recruitment, emphasizing an individual's “fit” within the culture of the hiring institution. In the present article, we discuss another aspect of “fitness” that became evident to our search committee during the 2010-2011 academic year...

In Search Of Shell Space: A Look At A Unique Sea Turtle Nesting Behavior, Mia Dawson

The Synapse: Intercollegiate science magazine

No abstract provided.

Issue 0

The Synapse: Intercollegiate science magazine

No abstract provided.

To The Brink Of Understanding, Isaac H. Mcceery

The Synapse: Intercollegiate science magazine

No abstract provided.

So That They May Model, Isaac H. Mcceery

The Synapse: Intercollegiate science magazine

No abstract provided.

Artificial Intelligence In Digital Music: Musicians Using Techology To Streamline The Creative Process, Sam Fisher

The Synapse: Intercollegiate science magazine

No abstract provided.

Kinship Between The Kingdoms: Horizontal Gene Transfer, Darrin Schultz, Ben Garfinkel

The Synapse: Intercollegiate science magazine

No abstract provided.

Its About (Geological) Time, Paris Achenbach

The Synapse: Intercollegiate science magazine

No abstract provided.

Cruzin' With Yolanda: The Life And Research Of The Biology 100 Icon

The Synapse: Intercollegiate science magazine

No abstract provided.

The Short-Term Effects Of Cortisol

The Synapse: Intercollegiate science magazine

No abstract provided.

Deterrence And Escalation In Cross-Domain Operations: Where Do Space And Cyberspace Fit?, Vincent Manzo

Strategic Forums

Warfare has become even more complicated since Richard Smoke wrote this description of escalation in 1977. The National Security Space Strategy describes space as “congested, contested, and competitive,” yet satellites underpin U.S. military and economic power. Activity in cyberspace has permeated every facet of human activity, including U.S. military operations, yet the prospects for effective cyber defenses are bleak. Many other actors depend on continued access to these domains, but not nearly as much as the United States.

Improving Flavor Of Slo: Volunteer Engagement, Motivation, And Goal Setting In Event Planning, Kendall Ann Young

Communication Studies

No abstract provided.

Cabbychic, Stephanie Stroud

Communication Studies

College students are presented with new challenges as they transfer from their known world to a new one with social pressures, challenging education, and time management issues, just to name a few. Over the past decade there has been a change in the social dynamics of college students, especially as it relates to partying. As a result there is a growing demand for safe, sober and available rides home, which women in particular feel comfortable taking. This senior project and business plan will solve the need for such a service in the San Luis Obispo area as well as investigate …

Introduction To An Extract From War Of The Pews: A Personal Account Of The St. Augustine Church In New Orleans, By Rev. Jerome G. Ledoux, S.V.D., Christopher Matthews

Department of Anthropology Faculty Scholarship and Creative Works

No abstract provided.

A Qualitative Study Of The Formation And Composition Of Social Networks Among Homeless Youth, Kimberly A. Tyler, Lisa Melander

Department of Sociology: Faculty Publications

Although social networks are essential for explaining protective and risk factors among homeless youth, little is known about the formation and composition of these groups. In this study, we utilized 19 in-depth interviews with homeless youth to investigate their social network formation, role relationships, housing status, and network member functions. Our findings reveal that the formation of these networks occurred in different ways including meeting network members through others or in specific social situations. The majority of social network members were currently housed and provided various functions including instrumental and social support and protection. Responses from participants provide valuable insight …

How Institutional Context Alters Social Reproduction Dynamics: Ethnic Track Placement Patterns In The U.S. And Germany, Regina E. Werum, Tomeka Davis, Simon Cheng

Department of Sociology: Faculty Publications

How does institutional context shape the way family dynamics, especially ethnic background and parental resources, affect track placement? We contrast the track placement patterns of immigrants and ethnic majority students in two countries marked by drastic differences in the social organization of schooling. Drawing on German (GSOEP) and U.S. (NELS) data, we find that, in general, more family resources pull students from lower to higher tracks, but ethnic inequalities in these resources favor the ethnic majority groups in both countries. In addition, institutional context conditions which parental resources shape educational outcomes, and how they do so. We find that the …

Guinea Pigging In Philadelphia, Roberto Abadie

Department of Sociology: Faculty Publications

On June 16, 2001, the national press first reported the death of Ellen Roche, a healthy 24-year-old who volunteered for an asthma study at Johns Hopkins University. The story revealed that a few days into the trial she felt very sick, was discharged, and sent home. Within some hours she checked into the emergency room at a local hospital and fell into a coma. Ellen remained in this state until her death a month later. She had received $375 for participating in seven to nine sessions as an outpatient in the clinical drug study that resulted in her death.

This …

Aircraft Longitudinal Control Experiment, Dustin Schaff

Aerospace Engineering

This paper describes the design, fabrication, and analysis of an experiment that demonstrates the stability and control system characteristics of an aircraft constrained at the center of gravity in an air flow field. Given a set of basic requirements, the physical system (including the airframe, wings, tail, and mounted ball bearing) was designed, modeled, and manufactured. With the aircraft placed in front of a fan and allowed to rotate freely with the ball bearing, an angular rate sensor and servo motor to the deflect the elevator may be connected to any computer using an analog/digital Data Acquisition (DAQ) device to …

Proposals For A Scheme For Continuing Professional Development In Pakistan, Rashid Jooma

Section of Neurosurgery

No abstract provided.

Hiring And Recruitment As Rhetorical Strategies: An Analysis Of The Way Businesses Approach Graduating University Students And Influence Their Choices, Sean D. Gibson

Communication Studies

To answer the question, which rhetorical strategies are most persuasive to university graduates regarding hiring and recruitment, I surveyed three classrooms with a questionnaire that gauged university graduates attraction to three different types of rhetorical strategies. The rhetoric came from three major businesses that recruit university graduates: College Works Painting, Peace Corps, and Hewlett Packard.

Each one of these businesses uses a different type of strategy to recruit university graduates. College Works Painting uses an Experience Illusion strategy based on the premise that the company will help train university graduates to become managers and leaders in business. Peace Corps’ uses …

Sign Language Word List Comparisons: Toward A Replicable Coding And Scoring Methodology, Jason Parks

Theses and Dissertations

This study describes and evaluates a methodology for sign language word list comparisons. The purpose of this sociolinguistic research tool is to identify similarity relationships among sign language varieties by assessing similarities of lexical items. Similarities are calculated using the Levenshtein distance metric which measures the number of differences between signs.

In this study, the methodology was refined for optimal efficiency through an analysis of: which parameters of a sign should be compared, which values should be included in each parameter value inventory, and which items should be used in the word list. As a result of the study, I …

Space Makers Or Space Cadets Exploring Children's Perceptions Of Space And Place In The Context Of A Dublin Primary School, A Loxley, B O'Leary, Sj Minton

School of Psychology

This paper discusses two interconnected themes: (1) the variegated role of space in primary school architecture; and (2), the perception of this space as a lived phenomenon from the perspective of pupils. In this context, space is not seen as being synonymous with the physical properties of a school (although this does exert an influence), but as an 'active ingredient' through which a particular social order is produced and sustained. Echoing the work of Lefebvre's (1991) triadic conceptualisation of space, Markus's (1993) meshing of architecture and power (via Foucault, 1991a, 1991b), certain extensions of ecological/ecosystemic theories of child and adolescent …

Exploring Factors Affecting Persistence Of First-Year Student Success At The University Of The District Of Columbia, Twyla L. Jones

Graduate Theses, Dissertations, and Problem Reports (ETD)

This study examined four elements within the university environment that may provide a connection to the success of students' initial year on campus. The four elements are: freshman orientation course; academic advising and interaction with an advisor; involvement in student organizations, clubs, and athletics; and utilization of the university counseling center.;This study was based upon a survey administered during the months of March through May 2010 that examined the four areas of the university environment and the extent to which each student participated in each area. The population was 200 first-year students who had entered the university during the fall …

Characterization Of The Pharmacological Effects Of Digitoxin On Lung Epithelial Cells, Hosam Abdelmonaim Elbaz

Graduate Theses, Dissertations, and Problem Reports (ETD)

Lung diseases (excluding cancer) account for 9% of all disease related mortalities while lung cancer accounts for 30% of cancer related mortalities. Therapeutic maneuvers, as surgery are usually unfeasible given the extreme vitality of the lung. Developing novel therapeutic alternatives for lung cancer requires a thorough understanding on the lung epithelial cell behavior following exposure to drugs. The goal of this dissertation was to examine how molecular and cellular characteristics, such as morphology and cell viability, of lung cancer cells will be altered upon exposure to digitoxin, a cardiac glycosides (CGs) and a digitoxin synthetic analog. CGs are a large …

Gis Assisted Problem Analysis Of Trail Erosion In Monongahela National Forest, Steven J. Storck

Graduate Theses, Dissertations, and Problem Reports (ETD)

This research investigates the frequency and patterns of trail erosion on purposefully selected natural surface trails in Monongahela National Forest. Trail erosion is considered a non-self-limiting process which degrades trail beds making them unattractive, difficult to travel on, and has the potential to impact local streams with the introduction of silt. Recreation ecology research delineates factors which influence the rate of erosion on a trail into three broad categories: recreational use, environmental conditions, and managerial actions. This study tests the relationship of variables from each of these categories to the local patterns of erosion. Three sampling strategies are used to …

Hyperreal Battlefields: Individual Action And The Composition Of Enemy In Call Of Duty: Modern Warfare 1 & 2, Jeffrey Allen Yeager

Graduate Theses, Dissertations, and Problem Reports (ETD)

Speculative fictions present us with stories that ask the question "what if?" In the past decades there has been a noticeable increase in the amount of speculative fiction in Western popular media. War-themed video games represent one of the most popular interactive texts that have embraced the speculative fiction genre. There is a multitude of research that examines non-fiction war games and those based loosely on some actual or historical conflict. This research diverges from that path by analyzing the narrative and structure of a series of fictional war games set in the modern era. The game presents a narrative …

Exploration Of Stream Habitat Spatial Modeling; Using Geographically Weighted Regression, Ordinary Least Squares Regression, And Natural Neighbor Interpolation To Model Depth, Flow, And Benthic Substrate In Streams, Kenneth R. Sheehan

Graduate Theses, Dissertations, and Problem Reports (ETD)

Assessment and modeling of stream habitat are integral to understanding streams and the biota within them. In the past several decades, assessment sophistication of ecologic systems increased due to analysis power afforded by gains in computing capability. Spatial data analysis methodology grew alongside computing power and incorporated spatial qualities of ecological data, thereby providing new insights. New methods like geographically weighted regression (GWR) and more established methods like interpolation are now being used in ecological studies to guide assessments and management decisions. However, their accuracy and utility for analysis of stream habitat data have not been fully explored. To clarify …

Ananias Walks Home, Bob De Smith

Pro Rege

No abstract provided.