Digital Commons Network^™

Nrt1 And Tna1-Independent Export Of Nad+ Precursor Vitamins Promotes Nad+ Homeostasis And Allows Engineering Of Vitamin Production, Peter Belenky, Rebecca Stebbins, Katrina L. Bogan, Charles R. Evans, Charles Brenner

Dartmouth Scholarship

NAD⁺ is both a co-enzyme for hydride transfer enzymes and a substrate of sirtuins and other NAD⁺ consuming enzymes. NAD⁺ biosynthesis is required for two different regimens that extend lifespan in yeast. NAD⁺ is synthesized from tryptophan and the three vitamin precursors of NAD⁺: nicotinic acid, nicotinamide and nicotinamide riboside. Supplementation of yeast cells with NAD⁺ precursors increases intracellular NAD⁺ levels and extends replicative lifespan. Here we show that both nicotinamide riboside and nicotinic acid are not only vitamins but are also exported metabolites. We found that the deletion of the nicotinamide …

Plex, Jon-Phillip Sheridan

Theses and Dissertations

This thesis explores the evolution of my practice as it developed over my two years of graduate school. I entered school interested in the built environment and how structures helped create subjectivity and provided sites for material and phenomenological transformations. Early in graduate school, I developed a photography series that investigated these issues. However, an awareness of a conversation occurring in the larger art world that questioned the efficacy of photography drove me to consider ways to extend my practice into sculpture and installation. Over the next two semesters, I developed my ideas of light, form and structure into video …

Kenyon Collegiate - May 11, 2011

Kenyon Collegiate

No abstract provided.

Residence Time Distributions In Surface Transient Storage Zones In Streams: Estimation Via Signal Deconvolution, Michael N. Gooseff, David A. Benson, Martin A. Biggs, Mitchell Weaver, Wilfred M. Wollheim, Bruce J. Peterson, Charles S. Hopkinson

Faculty Publications

Little is known about the impact of surface transient storage (STS) zones on reach‐scale transport and the fate of dissolved nutrients in streams. Exchange with these locations may influence the rates of nutrient cycling often observed in whole‐stream tracer experiments, particularly because they are sites of organic matter collection and lower flow velocities than those observed in the thalweg. We performed a conservative stream tracer experiment (slug of dissolved NaCl) in the Ipswich River in northeastern Massachusetts and collected solute tracer data both in the thalweg and adjacent STS zones at three locations in a fifth‐order reach. Tracer time series …

Influenza And Bacterial Coinfections In The 20th Century, Xuan-Yi Wang, Paul E. Kilgore, Kyung Ah Lim, Song-Mei Wang, Jeongseok Lee, Wei Deng, Mei-Qi Mo, Batmunkh Nyambat, Jing-Chen Ma, Michael O. Favorov, John D. Clemens

Department of Pharmacy Practice

To help understand the potential impact of bacterial coinfection during pandemic influenza periods, we undertook a far-reaching review of the existing literature to gain insights into the interaction of influenza and bacterial pathogens. Reports published between 1950 and 2006 were identified from scientific citation databases using standardized search terms. Study outcomes related to coinfection were subjected to a pooled analysis. Coinfection with influenza and bacterial pathogens occurred more frequently in pandemic compared with seasonal influenza periods. The most common bacterial coinfections with influenza virus were due to S. pneumoniae, H. influenzae, Staphylococcus spp., and Streptococcus spp. …

Staff Council Student Success Committee Meeting, 5/10/2011, Unm Staff Council

UNM Staff Council

No abstract provided.

The Discourses Of Energy And Environmental Security In The Debate Over Offshore Oil Drilling Policy In Florida, Emily Joyce Martens

Open Access Theses

Amid growing concern over access to sufficient and cheap energy resources, on March 31, 2010 the Obama Administration announced the opening of new exploratory and drilling sites for oil within the United States Outer Continental Shelf. The announcement concerning the Outer Continental Shelf Oil and Gas Strategy came only three weeks before the BP oil spill in the Gulf of Mexico that marked an unprecedented economic and environmental disaster. Though the concern over offshore drilling, especially regarding regulation and environmental impact, has increased in the wake of the oil disaster, the general debate regarding offshore oil drilling has been a …

Rip1 And Fadd's Role In Innate Immunity, Jinhee Hyun

Open Access Dissertations

Rapid production of type I Interferon is pivotal to initiate cellular antiviral host defense and adaptive immunity. In order to facilitate innate immune processes, a cell harbors pattern recognition receptors (PRRs) which sense distinctive forms of pathogen associated molecular patterns (PAMPs). For example, Toll like receptors (TLRs) and RIG-I like receptors (RLRs) were discovered as PRRs for pathogen derived molecules and the production of type I Interferon (IFN). To induce type I IFN, several transcription factors such as nuclear factor-kappaB (NF-ĸB), interferon regulatory factor 3 (IRF3), interferon regulatory factor 7 (IRF7), and activating protein-1 (AP-1) need to be stimulated through …

Evidence For Opsin-Based Photosensitivity In Coral Larvae, Benjamin M. Mason

Open Access Dissertations

Photosensitive behaviors and circadian rhythms are well documented in reef-building corals and their larvae, yet photoreceptive structures and opsins have not been described in these organisms. Here I provide evidence for red sensitivity in several species of coral larvae. Behavioral experiments with two Caribbean corals, Porites astreoides and Acropora palmata demonstrated that larvae settle and metamorphose at a greater frequency on red substrata than on similar substrata of other colors. Attachment to red substrata was not observed when larvae were maintained in the dark, suggesting that red sensitivity was responsible for the observed behavior. Extracellular recordings confirm photosensitivity and indicate …

Fluorescent Particles Comprising Nanoscale Zno Layer And Exhibiting Cell-Specific Toxicity, Hua Wang, Denise Wingett, Kevin Feris, Madhusudan R. Kongara, Alex Punnoose

Boise State Patents

Multifunctional "smart" nanostructures are disclosed that include fluorescein isothiocyanate (FITC)-encapsulated SiO₂ core-shell particles with a nanoscale ZnO finishing layer, wherein an outer ZnO layer is formed on the SiO₂-FITC core. These ~200 nm sized particles showed promise toward cell imaging and cellular uptake studies using the bacterium Escherichia coli and Jurkat cancer cells, respectively. The FITC encapsulated ZnO particles demonstrated excellent selectivity in preferentially killing Jurkat cancer cells with minimal toxicity to normal primary immune cells (18% and 75% viability remaining, respectively, after exposure to 60 μg/mL) and inhibited the growth of both gram-positive and gram-negative bacteria …

The Werewolf Pride Movement: A Step Back From Queer Medieval Tradition, Caitlin B. Giacopasi

Theses

No abstract provided.

Cal Poly Marine Biology Professor Named 2011 Fulbright Arctic Chair, Public Affairs Office

Press Releases

No abstract provided.

Strengthening Africa’S Contributions To Child Development Research: Introduction, Kofi Marfo, Alan Pence, Robert A. Levine, Sarah Levine

Institute for Human Development, East Africa

The articles in this Special Section are based on contributions to an SRCD-sponsored invitational conference held in Victoria, Canada, in February 2009. This introductory article establishes the rationale for focusing on Africa as part of an effort to advance a more inclusive science of child development, provides a brief overview of the thrust of the other articles in the section, describes 2 research capacity-building initiatives that emerged from the conference, and concludes with reflective perspectives on conceptual and methodological considerations for a future African child development field.

A Celebration Of Faculty Scholarship - 2011, Dean's Office, College Of The Holy Cross

Annual Bibliography of Faculty Publications

A listing of the scholarly and creative works produced by the faculty of the College of the Holy Cross. It includes articles, book chapters, productions, exhibitions, grants and reviews reported for the 2010-2011 academic year.

Method For Detecting An Unknown Contaminant Concentration In A Substance, Yanbin Li, Xiao-Li Su

Patents Granted

A method for determining a concentration of a contaminant in a first sample is described. The method includes producing the first sample, adding a plurality of immuno-beads to a test substance; exposing a crystal microbalance immunosensor to the first sample; determining a change in a first motional resistance of the crystal microbalance immunosensor following exposure to the first sample (Delta R1); and determining the concentration of the contaminant in the first sample according to Delta R1.

Meeting Sanford Meisner: An Investigation Of The Origins, Development, And Practical Application Of The Meisner Technique, Mandy Butler

Theses and Dissertations

The Sanford Meisner Technique is among the most mysterious and misunderstood approaches to the craft of acting. Very often, it is taught poorly, incompletely, or even dangerously. Through the exploration of Meisner’s private life, as well as a detailed analysis of his system, this work aims to dispel some of the common misconceptions which plague the Technique and its most fervent supporters. After being made privy to his biography, readers will be taken through Meisner’s foundational exercises, beginning at the first phase of Repetition and ending with the introduction of text. In addition to the descriptions of student responsibilities, the …

Using Polymer Ligand Films For Rapid Radiochemical Analyses, Crystal L. Tulley-Cordova

Water Resources Professional Project Reports

Existing procedures for radiochemical analysis of environmental samples involves extensive laboratory preparation requiring chemical separations that are time consuming, and labor intensive to remove interferences and impurities associated with the sample matrix. Technology developed in this project reduces turnaround time, labor and supplies needed to examine radionuclides in water samples. The thin film technique can be used as a screening method. A solution including an extractive ligand and polymer are used to create a thin film to concentrate radionuclides from solution. In this project, several ligands, polymers, solvents, thin film types, and extraction procedures were examined. The polymer ligand thin …

Erosion Potential Of The Main Branch Of The Piedras Marcadas Watershed, Petroglyph National Monument, New Mexico, Elaine S. Brouillard

Water Resources Professional Project Reports

The Piedras Marcadas Watershed covers approximately 6 square miles west of the Rio Grande in Albuquerque, New Mexico. This watershed is semi-arid and has arroyos, ephemeral streams that empty into a retaining dam. During the fall of 1998, eleven erosion pins and bridges were placed to record the sediment eroded or aggraded. The erosion pins recorded erosion in a range of 0.05 to 4 mm erosion and aggradation of 2 to 10 mm. The erosion bridges recorded erosion in a range of 3 to 9 mm and 1.5 to 10.7 mm ranges of aggradation. Two modified universal soil loss equations …

Complete Genome Sequence Of Mycoplasma Suis And Insights Into Its Biology And Adaption To An Erythrocyte Niche, Ana Ms Guimaraes, Andrea P. Santos, Phillip Sanmiguel, Thomas Walter, Jorge Timenetsky, Joanne Messick

Department of Comparative Pathobiology Faculty Publications

Mycoplasma suis, the causative agent of porcine infectious anemia, has never been cultured in vitro and mechanisms by which it causes disease are poorly understood. Thus, the objective herein was to use whole genome sequencing and analysis of M. suis to define pathogenicity mechanisms and biochemical pathways. M. suis was harvested from the blood of an experimentally infected pig. Following DNA extraction and construction of a paired end library, whole-genome sequencing was performed using GS-FLX (454) and Titanium chemistry. Reads on paired-end constructs were assembled using GS De Novo Assembler and gaps closed by primer walking; assembly was validated by …

Cord Blood Collection In Pregnant Women For Stem Cell Research, Irene Carr Phd

Dissertations

Umbilical cord blood (UCB) stem cells form commonly banked types of human tissue. Confusion remains about sources of stem cells and their use. Birth is a once in a lifetime opportunity with 74 million births per year in the world and four million occur in the United States. Cord blood contains hematopoietic stem cells and pluripotent mesenchymal cells (Moise, 2005). There is a surge of interest in the clinical use and research investigation of umbilical cord blood for transplantation and regenerative medicine. Clinicians need increased awareness and education of options for private versus public donation and banking of cord blood …

Effects Of Tethering A Multistate Folding Protein To A Surface, Shuai Wei, Thomas A. Knotts Iv

Faculty Publications

Protein/surface interactions are important in a variety of fields and devices, yet fundamental understanding of the relevant phenomena remains fragmented due to resolution limitations of experimental techniques. Molecular simulation has provided useful answers, but such studies have focused on proteins that fold through a two-state process. This study uses simulation to show how surfaces can affect proteins which fold through a multistate process by investigating the folding mechanism of lysozyme (PDB ID: 7LZM). The results demonstrate that in the bulk 7LZM folds through a process with four stable states: the folded state, the unfolded state, and two stable intermediates. The …

Immigrant Non-Profit Organizations: How Do They Serve Their Constituencies?, Gustavo A. Amaya

Research Papers

Immigration has become one of the most important topics in the United States. According to the Census Bureau (2011), Hispanics are officially the largest minority group in the nation. This has a direct impact on new legislation and federal, state and local government decision making. The consequences of these actions directly influence the way public administrators do their job. To better understand the changes and its consequences, all these levels of government must understand the situation and all factors involved to the best of their capabilities. This research paper explores the services a group of Mexican immigrant non-profit organizations provide …

Executive Committee - Agenda, 5/10/2011, Academic Senate

Academic Senate Agendas

No abstract provided.

Role Of Mutations In The Essential Light Chain (Elc) Of Myosin In Familial Hypertrophic Cardiomyopathy (Fhc), Alexander Raytman

Open Access Theses

Force generation and the ability of the heart muscle to contract and correspondingly to beat depends upon multiple interactions between myosin and actin-tropomyosin-troponin, the key proteins of the contractile apparatus. The myosin molecule consists of two heavy chains and two types of light chains, two essential (ELC) and two regulatory (RLC) light chains. We hypothesize that mutations in myosin ELC may affect the ability of myosin to bind to actin, thus producing structurally and/or functionally abnormal sarcomeres effecting heart muscle contraction and relaxation. We believe that this pathological process underlies the basis of Familial Hypertrophic Cardiomyopathy (FHC), a genetic disorder …

Volumetric Analysis Of Brain Mri For Alzheimer’S Disease, Qian Shen

Open Access Dissertations

Alzheimer’s disease (AD), the most common cause of dementia in the elderly, is a gradually progressive degenerative neurological disorder that is characterized by increasing cognitive impairment, characteristic degenerative pathology and brain atrophy. Studies have shown that the progression of AD pathology in the brain develops in a predictable pattern and the pathological changes that take place in brain begin at the microscopic level long before the first signs of memory loss. Structural Magnetic Resonance Imaging (MRI), which has exceptional soft tissue contrast and detailed resolution, is the best way to noninvasively examine changes which occur early in the course of …

Profile Of Class Of 2011 Shows Promise, Winthrop University

Winthrop News 2011

• The Class of 2011 graduated May 7 from Winthrop and departed with many hopes and dreams. Here are some of their stories.

Adaptive Clinical Trial Designs With Pre-Specified Rules For Modifying The Sample Size: Understanding Efficient Types Of Adaptation, Gregory P. Levin, Sarah C. Emerson, Scott S. Emerson

UW Biostatistics Working Paper Series

Methods allowing unplanned adaptations to the sample size based on the interim estimate of treatment effect do not base inference on the minimal sufficient statistic and suffer losses in efficiency when compared to group sequential designs [1, 2, 3]. However, when adaptive sampling plans are completely pre-specified at the design stage of the trial, investigators can proceed with frequentist inference based on the minimal sufficient statistic at the analysis stage. In the context of two general settings where different optimality criteria govern the choice of clinical trial design, we quantify the relative costs and benefits of a variety of fixed …

Capillary Climb Dynamics In The Limits Of Prevailing Capillary And Gravity Force, B. Bijeljic, B. Markicevic, Homayun K. Navaz

Mechanical Engineering Publications

The dynamics of capillary climb of a wetting liquid into a porous medium that is opposed by gravity force is studied numerically. We use the capillary network model, in which an actual porous medium is represented as a network of pores and throats, each following a predefined size distribution function. The liquid potential in the pores along the liquid interface within the network is calculated as a result of capillary and gravity forces. The solution is general, and accounts for changes in the climbing height and climbing velocity. The numerical results for the capillary climb reveal that there are at …

May 9th 2011, Csusb

Coyote Chronicle (1984-)

No abstract provided.

The Statesman, V. 54, I. 29, Stony Brook University

Stony Brook Statesman-Sucolian

v. 54, i. 29