Digital Commons Network^™

Composition And Christology, Brian Leftow

Faith and Philosophy: Journal of the Society of Christian Philosophers

No abstract provided.

Filamin A Is A Phosphorylation Target Of Membrane But Not Cytosolic Adenylyl Cyclase Activity, Sarah L. Sayner, Ron Balczon, Dara W. Frank, Dermot M. F. Cooper, Troy Stevens

University Faculty and Staff Publications

Transmembrane adenylyl cyclase (AC) generates a cAMP pool within the subplasma membrane compartment that strengthens the endothelial cell barrier. This cAMP signal is steered toward effectors that promote junctional integrity and is inactivated before it accesses microtubules, where the cAMP signal causes phosphorylation of tau, leading to microtubule disassembly and barrier disruption. During infection, Pseudomonas aeruginosa uses a type III secretion system to inject a soluble AC, ExoY, into the cytosol of pulmonary microvascular endothelial cells. ExoY generates a cAMP signal that disrupts the endothelial cell barrier. We tested the hypothesis that this ExoY-dependent cAMP signal causes phosphorylation of tau, …

Russia In The Arctic, Stephen J. Blank Dr.

Books, Monographs & Collaborative Studies

The Arctic has returned with a vengeance as an area of international contention. Beginning in 2007, Russia has continued to make aggressive moves and claims regarding territory in the Arctic Ocean. These moves undoubtedly have been prompted by global climate change and the importance of energy, with which Russia believes the Arctic is lavishly supplied. These moves apparently were intended to compel other Arctic states, like Norway, to come to terms with Russia. Nonetheless, the tendency to invoke military and security issues and instruments in this region of the world continues apace. These essays, taken from SSI's 2010 conference on …

The New Aztecs: Ritual And Restraint In Contemporary Western Military Operations, Zhivan Alach Dr.

Books, Monographs & Collaborative Studies

The Western way of war has come full circle. After centuries of evolution toward increased totality and brutality, it has turned back once again to the ritualistic and restrained methods of primitive warfare. Largely, this has been due to an interaction between the perceived lack of utility in contemporary warfare, developing humanitarian public opinion, and increasing professionalism among militaries. The significance of these evolutionary trends in the way that the West engages in modern warfare is that they are potentially dangerous, and they include the possibility that the West will be unprepared for a future foe whose defeat requires more …

Speaking Rate Effects On Normal Aspects Of Articulation: Outcomes And Issues, Jeffrey J. Berry

Speech Pathology and Audiology Faculty Research and Publications

The articulatory effects of speaking rate have been a point of focus for a substantial literature in speech science. The normal aspects of speaking rate variation have influenced theories and models of speech production and perception in the literature pertaining to both normal and disordered speech. While the body of literature pertaining to the articulatory effects of speaking rate change is reasonably large, few speaker-general outcomes have emerged. The purpose of this paper is to review outcomes of the existing literature and address problems related to the study of speaking rate that may be germane to the recurring theme that …

Environmental History Of A Closed-Basin Lake In The Us Great Plains: Diatom Response To Variations In Groundwater Flow Regimes Over The Last 8500 Cal. Yr Bp, William O. Hobbs, Sherilyn C. Fritz, Jeffery R. Stone, Joseph J. Donovan, Eric C. Grimm, James E. Almendinger

Department of Earth and Atmospheric Sciences: Faculty Publications

Sediment records from closed-basin lakes in the Northern Great Plains (NGP) of North America have contributed significantly to our understanding of regional paleoclimatology. A high-resolution (near decadal) fossil diatom record from Kettle Lake, ND, USA that spans the last 8500 cal. yr BP is interpreted in concert with percent abundance of aragonite in the sediment as an independent proxy of groundwater flow to the lake (and thus lake water level). Kettle Lake has been relatively fresh for the majority of the Holocene, likely because of the coarse substrata and a strong connection to the underlying aquifer. Interpretation of diatom assemblages …

The Collaborative Colorado– Nebraska Unmanned Aircraft System Experiment, Adam L. Houston, Brian Argrow, Jack Elston, Jamie Lahowetz, Eric W. Frew, Patrick C. Kennedy

Department of Earth and Atmospheric Sciences: Faculty Publications

Unmanned aircraft (UA) can provide observations of atmospheric phenomena that are either difficult or impossible to obtain with existing platforms. It is for this reason that facilitating the maturation of this relatively new technology has become a high priority in the atmospheric sciences. This position is reflected in the 2007 National Research Council Decadal Survey, which states that unmanned aircraft technology “should be increasingly factored into the nation’s strategic plan for Earth science” (National Research Council 2007, p. 14). Moreover, the fiscal year 2008 budget for the National Oceanic and Atmospheric Administration (NOAA) featured an increased investment in unmanned aircraft …

Polyanhydride Microparticles Enhance Dendritic Cell Antigen Presentation And Activation, Maria P. Torres, Jennifer H. Wilson-Welder, Senja K. Lopac, Yashdeep Phanse, Brenda Carillo-Conde, Amanda E. Ramer-Tait, Bryan H. Bellaire, Michael J. Wannemeuhler, Balaji Narasimhan

Department of Food Science and Technology: Faculty Publications

The present studies were designed to evaluate the adjuvant activity of polyanhydride microparticles prepared in the absence of additional stabilizers, excipients, or immune modulators. Microparticles composed of varying ratios of either 1,6-bis(p-carboxyphenoxy)hexane (CPH) and sebacic acid (SA) or 1,8-bis(p-carboxyphenoxy)-3,6-dioxaoctane (CPTEG) and CPH were added to in vitro cultures of bone marrow-derived dendritic cells (DCs). Microparticles were efficiently and rapidly phagocytosed by DCs in the absence of opsonization and without centrifugation or agitation. Within 2 h, internalized particles were rapidly localized to an acidic, phagolysosomal compartment. By 48 h, only a minor reduction in microparticle size was …

Generation Of A Kupffer Cell-Evading Adenovirus For Systemic And Liver-Directed Gene Transfer, Reeti Khare, Shannon M. May, Francesco Vetrini, Eric A. Weaver, Donna Palmer, Amanda Rosewell, Nathan Grove, Philip Ng, Michael A. Barry

Nebraska Center for Virology: Faculty Publications

As much as 90% of an intravenously (i.v.) injected dose of adenovirus serotype 5 (Ad5) is absorbed and destroyed by liver Kupffer cells. Viruses that escape these cells can then transduce hepatocytes after binding factor X (FX). Given that interactions with FX and Kupffer cells are thought to occur on the Ad5 hexon protein, we replaced its exposed hypervariable regions (HVR) with those from Ad6. When tested in vivo in BALB/c mice and in hamsters, the Ad5/6 chimera mediated >10 times higher transduction in the liver. This effect was not due to changes in FX binding. Rather, Ad5/6 appeared to …

Environmental And Taxonomic Bacterial Diversity Of Anaerobic Uranium(Iv) Bio-Oxidation, Karrie A. Weber, J. Cameron Thrash, J. Ian Van Trump, Laurie A. Achenbach, John D. Coates

School of Biological Sciences: Faculty Publications

Microorganisms in diverse terrestrial surface and subsurface environments can anaerobically catalyze the oxidative dissolution of uraninite. While a limited quantity (~5 to 12 μmol liter^-1) of uranium is oxidatively dissolved in pure culture studies, the metabolism is coupled to electron transport, providing the potential of uraninite to support indigenous microbial populations and to solubilize uranium.

Supplementary files (zip folder) attached (below).

Humic Acid-Oxidizing, Nitrate-Reducing Bacteria In Agricultural Soils, J. Ian Van Trump, Kelly C. Wrighton, J. Cameron Thrash, Karrie A. Weber, Gary L. Andersen, John D. Coates

School of Biological Sciences: Faculty Publications

This study demonstrates the prevalence, phylogenetic diversity, and physiology of nitrate-reducing microorganisms capable of utilizing reduced humic acids (HA) as electron donors in agricultural soils. Most probable number (MPN) enumeration of agricultural soils revealed large populations (10⁴ to 10⁶ cells g^-1 soil) of microorganisms capable of reducing nitrate while oxidizing the reduced HA analog 2,6-anthrahydroquinone disulfonate (AH₂DS) to its corresponding quinone. Nitratedependent HA-oxidizing organisms isolated from agricultural soils were phylogenetically diverse and included members of the Alphaproteobacteria, Betaproteobacteria, and Gammaproteobacteria. Advective up-flow columns inoculated with corn plot soil and amended with reduced …

An Enzymatic Treatment Of Soil-Bound Prions Effectively Inhibits Replication, Samuel Saunders, Jason C. Bartz, Kurt C. Vercauteren, Shannon L. Bartelt-Hunt

Department of Civil and Environmental Engineering: Faculty Publications

Chronic wasting disease (CWD) and scrapie can be transmitted through indirect environmental routes, possibly via soil, and a practical decontamination strategy for prion-contaminated soil is currently unavailable. In the laboratory, an enzymatic treatment under environmentally relevant conditions (22°C, pH 7.4) can degrade soil-bound PrPSc below the limits of Western blot detection. We developed and used a quantitative serial protein misfolding cyclic amplification (PMCA) protocol to characterize the amplification efficiency of treated soil samples relative to controls of known infectious titer. Our results suggest large (104- to >106-fold) decreases in soil-bound prion infectivity following enzyme treatment, demonstrating that a mild enzymatic …

A Meta-Analysis On Rituximab Combined Chop Chemotherapy For Non-Hodgkin Lymphoma In China., Siyuan Hou, Wei Yang

Saudi Medical Journal

OBJECTIVES: To evaluate the curative effect of Rituximab combined CHOP chemotherapy in patients with non-Hodgkin lymphoma in China. METHODS: We conducted this study in the Affiliated Shengjing Hospital of China Medical University, Shenyang, China between June and December 2010. We used the systematic review method of The Cochrane Collaboration to collect randomized controlled trials (RCTs) of Rituximab combined CHOP chemotherapy for non-Hodgkin lymphoma by computer databases during the period 2004-2009. RESULTS: Seven trials involving 357 patients were retrieved. The complete remission rate of Rituximab combined CHOP chemotherapy was higher than that of CHOP chemotherapy alone (odds ratio = 3.02, 95% …

Hypolipidemic Effects Of Alismatis Rhizome On Lipid Profile In Mice Fed High-Fat Diet., Hong Dan, Juan Wu, Min Peng, Xuefeng Hu, Chengwu Song, Zhiwen Zhou, Shanggong Yu, Nianbai Fang

Saudi Medical Journal

OBJECTIVES: To investigate the effect of Alismatis rhizome (AR) extract on lipid profile in mice fed high-fat diet. METHODS: The study was performed in Key Laboratory of Chinese Medicine Resource and Compound Prescription (Hubei University of Chinese Medicine), Ministry of Education, Wuhan, China, between December 2009 and June 2010. Forty male Kunming mice (8-week-old) were randomly divided into 4 groups and were treated for 4 weeks: Group 1: normal control, Group 2: high-fat control, Group 3: positive control and Group 4: AR 2.26 g/kg. The hypolipidemic effects of AR were evaluated by serum lipids, liver lipids, and reverse transcriptase polymerase …

The Arabic Version Of The Modified Dental Anxiety Scale. Psychometrics And Normative Data For 15-16 Year Olds., Suha B. Abu-Ghazaleh, Lamis D. Rajab, Hawazen N. Sonbol, Ahmad K. Aljafari, Rawan F. Elkarmi, Gerry Humphris

Saudi Medical Journal

OBJECTIVES: To prepare an Arabic version of the Modified Dental Anxiety Scale (MDAS) and provide normative information including evidence to support the validity of the measure. METHODS: The MDAS was translated into Arabic and back-translated into English. Data collection took place in Amman, Jordan from March 2009 to March 2010. One thousand and six hundred two 10th grade students took part in the study (15-16 years of age) sampled from 32 schools. Questionnaire consisted not only of the MDAS, but also (i) a single global question on dental anxiety to test concurrent validity, (ii) a question on helplessness in the …

The Preparation And Characterisation Of Silver Nanomaterials And Their Application In Sensing Techniques, Aoife Power

Doctoral

In this work the impact of nanomaterial, specifically silver nanostructures, on sensing techniques is investigated. The work can be divided in to three sections, preparation and characterisation of silver nanoparticles, their application as a nanocomposite based chemiresistor humidity sensing device and finally their application within the surface enhanced (resonance) Raman spectroscopy, SE(R)RS, technique. In the first study silver nanoparticles were prepared as aqueous colloidal dispersions. The colloids were of either a defined diameter (average diameter ~ 20 nm) with high silver loading or lower loaded colloids of tuneable morphology and hence optical properties. In a subsequent study the high load …

A Real-Time Risk Assessment Tool Supporting Wildland Fire Decisionmaking, David E. Calkin, Matthew P. Thompson, Mark A. Finney, Kevin D. Hyde

United States Department of Agriculture, Forest Service / University of Nebraska-Lincoln: Faculty Publications

Development of appropriate management strategies for escaped wildland fires is complex. Fire managers need the ability to identify, in real time, the likelihood that wildfire will affect valuable developed and natural resources (e.g., private structures, public infrastructure, and natural and cultural resources). These determinations help guide where and when aggressive suppression is required to protect values and when fire may be allowed to burn to enhance ecosystem conditions. This article describes the primary components of the Wildland Fire Decision Support System (WFDSS), a geospatial decision support system developed by the US Forest Service. WFDSS provides state-of-the-art wildfire risk analysis, decision …

Managing An Invasion: Effective Measures To Control Wild Pigs, Bill Hamrick, Tyler A. Campbell, Billy Higginbotham, Steven Lapidge

United States Department of Agriculture Wildlife Services: Staff Publications

A few years back, wild pigs ran mostly unchecked on Ossabaw Island, a 25,000-acre barrier island of maritime forests and marshlands just off the coast of Savannah, Georgia. Pigs wreaked havoc on island wildlife, feasting on the eggs of snowy plovers and eating turtle hatchlings as they made their way from the beaches to the water. Managers estimated that hogs were depredating over 30 percent of Ossabaw Island’s sea turtle nests each year (Mississippi State University 2011). Something had to be done.

In 2001, the Georgia Department of Natural Resources launched the Wild Pig Removal Program on Ossabaw Island, an …

Serum Igf-1 Concentrations Change With Soy And Seaweed Supplements In Healthy Postmenopausal American Women, Jane Teas, Mohammad R. Irhimeh, Susan Druker, Thomas G. Hurley, James R. Hébert, Todd M. Savarese, Mindy S. Kurzer

Faculty Publications

Insulin-like growth factor 1 (IGF-1) is an anabolic hormone important for growth and development. However, high-circulating serum concentrations in adults are associated with increased risk of postmenopausal breast cancer. Nutritional status and specific foods influence serum IGF-1 concentrations. Breast cancer incidence is typically low in Asian countries where soy is commonly consumed. Paradoxically, soy supplement trials in American women have reported significant increases in IGF-1. Seaweed also is consumed regularly in Asian countries where breast cancer risk is low. We investigated the possibility that seaweed could modify soy-associated increases in IGF-1 in American women. Thirty healthy postmenopausal women (mean age …

Health Science, Saint Mary's College Of California

Undergraduate Academic Catalog

No abstract provided.

Environmental And Earth Science, Saint Mary's College Of California

Undergraduate Academic Catalog

No abstract provided.

2+2 Pre-Nursing Program, Saint Mary's College Of California

Undergraduate Academic Catalog

No abstract provided.

Biology, Saint Mary's College Of California

Undergraduate Academic Catalog

No abstract provided.

Anthropology, Saint Mary's College Of California

Undergraduate Academic Catalog

No abstract provided.

Economics, Saint Mary's College Of California

Undergraduate Academic Catalog

No abstract provided.

January Term, Saint Mary's College Of California

Undergraduate Academic Catalog

No abstract provided.

Mathematics And Computer Science, Saint Mary's College Of California

Undergraduate Academic Catalog

No abstract provided.

Psychology, Saint Mary's College Of California

Undergraduate Academic Catalog

No abstract provided.

Sociology, Saint Mary's College Of California

Undergraduate Academic Catalog

No abstract provided.

Transport Of Trace Elements In Runoff From Unamended And Pond‐Ash Amended Feedlot Surfaces, Jason R. Vogel, John E. Gilley, Gary L. Cottrell, Brian L. Woodbury, Elaine D. Berry, Roger Eigenberg

Department of Agricultural and Biological Systems Engineering: Faculty Publications

The use of pond ash (fly ash that has been placed in evaporative ponds for storage and subsequently dewatered) for feedlot surfaces provides a drier environment for livestock and furnishes economic benefits. However, pond ash is known to have high concentrations of trace elements, and the runoff water‐quality effects of feedlot surfaces amended with pond ash are not well defined. For this study, two experimental units (plots) were established in eight feedlot pens. Four of the pens contained unamended soil surfaces, and the remaining four pens had pond‐ash amended surfaces. Before each test, unconsolidated surface material was removed from four …