Digital Commons Network^™

Encoding Of Temporal Sound Features In The Rodent Superior Paraolivary Nucleus, Richard A. Felix Ii

Graduate Theses, Dissertations, and Problem Reports (ETD)

The superior paraolivary nucleus (SPON) is a prominent cell group in the mammalian brainstem. SPON neurons are part of a monaural circuit that encodes temporal sound features in the ascending auditory pathway. Such attributes of acoustic signals are critical for speech perception in humans and likely equally as important in animal communication. While basic properties of SPON neurons have been characterized in some detail, a comprehensive examination of mechanisms that underlie their ability to precisely represent temporal information is lacking. Furthermore, little is known of how the SPON impacts its primary target, the inferior colliculus. Combinations of electrophysiological, pharmacological and …

The Depletion Of Dna Methyltransferase-1 And The Epigenetic Effects Of 5-Aza-2'Deoxycytidine (Decitabine) Are Differentially Regulated By Cell Cycle Progression, Mazin Al-Salihi, Margaret Yu, David M. Burnett, Amanda Alexander, Wolfram Samlowski, Frank A. Fitzpatrick

Faculty and Staff Publications

5-Aza-2'-deoxycytidine (decitabine) is a drug targeting the epigenetic abnormalities of tumors. The basis for its limited efficacy in solid tumors is unresolved, but may relate to their indolent growth, their p53 genotype or both. We report that the primary molecular mechanism of decitabine-depletion of DNA methyltransferase-1 following its "suicide" inactivation-is not absolutely associated with cell cycle progression in HCT 116 colon cancer cells, but is associated with their p53 genotype. Control experiments affirmed that the secondary molecular effects of decitabine on global and promoter-specific CpG methylation and MAGE-A1 mRNA expression were S-phase dependent, as expected. Secondary changes in CpG methylation …

Extrusion And Alkali Extrusion Of Corn Stover To Improve Enzyme Saccharification, Shujing Zhang

Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research

Biomass pretreatment constitutes an important part in the whole process of bioethanol production. The main goals of pretreatment include improving cellulose accessibility to enzyme, enhancing sugar yields from hemicellulose, achieving low capital and energy costs, as well as low sugar degradation and low chemical requirements. Extrusion, as a continuous and high throughput pretreatment method, requires much less chemical compared to traditional alkali pretreatment. In this research, twin-screw extrusion was evaluated for its effect with regard to promoting sugar yields from corn stover. Also, the underlying factors contributing to this improvement were examined. It was found that extrusion with no chemicals …

Effect Of The Infection With Porcine Reproductive And Respiratory Syndrome Virus On The Regulation Of Cytokines: Tumor Necrosis Factor-Alpha And Interleukin-10, Sakthivel Subramaniam

School of Veterinary and Biomedical Sciences: Dissertations, Theses, and Student Research

Porcine reproductive and respiratory syndrome virus (PRRSV) causes late-term abortion in sows and pneumonia in growing piglets. PRRSV evades the host immune response by several mechanisms, including the modulation of cytokine secretions in infected pigs, which is the subject of this dissertation. Particularly, PRRSV reduces the secretion of the pro-inflammatory cytokine, tumor necrosis factor-α (TNF-α) but increases the secretion of the anti-inflammatory cytokine interleukin-10 (IL-10). The latter effect, however, is PRRSV strain-specific. In this dissertation, we have examined mechanisms by which PRRSV regulates TNF-α and IL-10 expressions. The pathogenic strain FL12, derived from a PRRSV infectious clone, consistently suppressed TNF-α …

Role Of Porcine Reproductive And Respiratory Syndrome Virus Non-Structural Protein 1 In Viral Replications And Pathogenesis, Lalit Kumar Beura

School of Veterinary and Biomedical Sciences: Dissertations, Theses, and Student Research

Porcine reproductive and respiratory syndrome virus (PRRSV) is an infectious agent of significant concern to the global swine industry. PRRSV infection of pigs is initiated by a long viremia after which the virus enters in an extended persistent phase of 3-4 months that ultimately is resolved by the immune system. The delayed and weak host adaptive response is responsible for the protracted convalescence period. An initial sub-optimal innate immune response is postulated to be the reason behind such meager adaptive immune response. A major focus of the studies undertaken in this dissertation was to identify the viral non-structural proteins (nsps) …

Identification Of Host Proteins Required For Vesicular Stomatitis Virus Infection, Debasis Panda

School of Veterinary and Biomedical Sciences: Dissertations, Theses, and Student Research

Viruses usurp host cell pathways for different stages of their infection. Understanding virus-host interaction will be invaluable to elucidate molecular mechanisms of virus infection and to identify drug targets. In order to identify such critical cellular genes in vesicular stomatitis virus (VSV, a model non-segmented negative strand RNA virus) infection, we developed a stable cell line constitutively expressing replication proteins of VSV. Attempts to establish a cell line replicating a sub-genomic replicon was not successful because of induction of interferon response by replication of viral genomic analog. Subsequently, we used siRNA technology and conducted a genome-wide siRNA screen in HeLa …

Disease And Insect Resistance And Quality Characterization Of Six Cimmyt Synthetic Hexaploid Wheats, Kayse Onweller

Department of Agronomy and Horticulture: Dissertations, Theses, and Student Research

The germplasm sources of common wheat (Triticum aestivum L.) are eroded by selection pressures applied by plant breeders and the disappearance of landraces. The erosion causes a loss of potentially useful resistance genes, among other agronomic and quality genes. Continuously changing pathogen races and insect biotypes affecting the Great Plains requires identification of new sources of resistance. Synthetic hexaploid wheats (SHWs), T. turgidum (BBAA) x T. tauschii (DD) hybridizations, offer ways to utilize resistances trapped in the diploid and tetraploid ancestors of common wheat. Six SHWs were assayed for resistance to a variety of fungal diseases, viruses, and aphids …

Remarkable Features Of The Hotdog-Fold Thioesterases Involved In Phylloquinone (Vitamin K1) Biosynthesis, Joshua R. Widhalm

Department of Agronomy and Horticulture: Dissertations, Theses, and Student Research

Phylloquinone (vitamin K₁) is a bipartite molecule, consisting of a naphthoquinone ring attached to a phytyl side chain, that is synthesized by plants and certain cyanobacteria to serve as an electron carrier in photosystem I. The coupling of the ring and isoprenyl moieties relies on the cleavage of the CoA-thioester linkage with 1,4-dihydroxy-2- naphthoate (DHNA). It has long been a mystery if this hydrolysis is an enzymatic or chemical process. Using comparative genomics, protein biochemistry, genetics and metabolic profiling, we identified a cyanobacterial thioesterase responsible for the in vivo hydrolysis of DHNA-CoA. This enzyme bears a signature domain …

Identification Of Ssr Markers Associated With Height Using Pool-Based Genome-Wide Association Mapping In Sorghum, Paul W. Bible, Yi-Hong Wang, Rasiah Loganantharaj, Hari D. Upadhyaya

Computer Science Faculty publications

Sorghum has been proposed as a potential energy crop. However, it has been traditionally bred for grain yield and forage quality, not traits related to bioenergy production. To develop tools for genetic improvement of bioenergy-related traits such as height, genetic markers associated with these traits have first to be identified. Association mapping has been extensively used in humans and in some crop plants for this purpose. However, genome-wide association mapping using the whole association panel is costly and time-consuming. A variation of this method called pool-based genome-wide association mapping has been extensively used in humans. In this variation, pools of …

Is There A Relationship Between Positive Behavior Supports And Student Achievement?, Todd Edward Boucher

Dissertations

The purpose of this study was to determine whether a relationship exists between a school’s behavior program and student achievement. This study explored the many facets of school behavior plans from across the state of Mississippi and compared the responses of high school principals to the schools’ U.S. history standardized test scores.

School discipline has become an issue that schools find themselves dealing with on a daily basis. While school discipline issues are not new to the educational arena, the way in which some schools are handling them is changing. Some of the changes are as a result of changes …

Transport Of A Soft Cargo On A Nanoscale Ratchet, Umut A. Gurkan

Faculty Scholarship

No abstract provided.

2010-2011 Fy Annual Report, Tennessee. Department Of Safety & Homeland Security.

Annual Report

No abstract provided.

Evaluation Of Water Transport In Pemfc Gas Diffusion Layers Using Image Analysis, Michael Daino

Theses

Liquid water transport through the gas diffusion layer (GDL) of a proton exchange membrane fuel cell (PEMFC) was investigated through three interrelated studies utilizing the tools of image processing. First, a new framework and model for the digital generation and characterization of the microstructure of GDL materials with localized binder and polytetrafluoroethylene (PTFE) distributions were developed using 3D morphological imaging processing. The new generation technique closely mimics manufacturing processes and produces realistic 3D phase-differentiated digital microstructures in a cost- and time- effective manner. The generated distributions of hydrophobic (PTFE) and hydrophilic (carbon) regions representative of commercial GDL materials provides water …

Bone Morphogenetic Protein Inhibition Promotes Neurological Recovery After Intraventricular Hemorrhage, Krishna Dummula, Govindaiah Vinukonda, Philip Chu, Yiping Xing, Furong Hu, Sabrina Mailk, Anna Csiszar, Caroline Chua, Peter Mouton, Robert J. Kayton, Joshua C. Brumberg, Rashmi Bansal, Praveen Ballabh

Publications and Research

Intraventricular hemorrhage (IVH) results in neural cell death and white matter injury in premature infants. No therapeutic strategy is currently available against this disorder. Bone morphogenetic protein (BMP) signaling suppresses oligodendrocyte development through basic-helix-loop-helix (bHLH) transcription factors and promotes astrocytosis. Therefore, we hypothesized that IVH in premature newborns initiates degeneration and maturation arrest of oligodendrocyte lineage and that BMP inhibition alleviates hypomyelination, gliosis, and motor impairment in the survivors of IVH. To test the hypotheses, a rabbit model of IVH was used in which premature rabbit pups (E29) are treated with intraperitoneal glycerol at 2 hours of age to induce …

Qualitative Analysis To A Nonlinear System, Pengcheng Xiao

Theses and Dissertations - UTB/UTPA

In this thesis, we first present a qualitative analysis to a nonlinear system under certain parametric conditions. Then for a special case, we make a series of variable transformation and apply the Prelle-Singer Method to find the first integrals of the simplified equations without complicated calculations. Through the inverse transformations we get the first integrals of the original equation. Finally, we use the same Prelle-Singer method to get the first integral for an extended nonlinear system.

Monitoring Atrazine-Degrading And Atrazine-Tolerant Bacterial Populations In Lower Rio Grande Valley Agricultural Canals Using Quantitative-Pcr And Internal Atza Primers, Ibdanelo Cortez

Theses and Dissertations - UTB/UTPA

The research hypothesis was that atrazine-degrading bacteria would be detectable during the planting and rainy seasons with their populations dissipating during non-planting and dry seasons in 2010-2011. Atrazine concentration was detected in March, May, June and August for all canals with June having the highest average concentration of 0.77ppb. Gene atzA abundance was detected from June through August with July samples having the highest gene abundance of 250.6 (pg). Tolerant bacterial densities were detectable from March through June. Atrazine concentration and population abundance were not statistically different during planting and non-planting, rainy and dry seasons, although there was a trend …

Galantamine-Induced Tremulous Jaw Movements In Rats: Reversal With Adenosine A2a Antagonists, Chelsea Elizabeth Leser

Honors Scholar Theses

Alzheimer's disease is the most common neurdegenerative disorder, affecting millions of people worldwide. The underlying etiology of Alzheimer's disease, however, is such that treatment is difficult.

Researchers have linked a decrease in the transmission of the neurotransmitter acetylcholine to the cognitive deficits seen in Alzheimer's disease. Recent drug therapies have focused on using drugs that block the action of the enzyme, acetylcholinesterase, that breaks down acetylcholine. However, these drugs, known as acetylcholinesterase inhibitors, have been found to produce side effects that have the same characteristics as Parkinson's disease, the second most common neurodegenerative disorder. In this study, the acetylcholinesterase inhibitor, …

Post-Adoption Contact Between Siblings: Is "Avoidance Of Harm" The Right Standard For New Jersey Siblings Adopted From Foster Care Parents?, Kristen L. Settlemire

Seton Hall Journal of Legislation and Public Policy

No abstract provided.

Aiding Conservation Of The Federally Threatened Scutellaria Montana (Lamiaceae, Large-Flowered Skullcap) Through Abundance Monitoring And Transplantation Studies, Heather Mae Kile

Masters Theses and Doctoral Dissertations

Scutellaria montana Chapm. (large-flowered skullcap) is a federally threatened species endemic to Georgia and Tennessee. This thesis presents conservation work on this species through abundance monitoring at a single site in Catoosa County, Georgia, and transplantation experiments at two sites located in Hamilton County, Tennessee, and Catoosa County, Georgia. Plants naturally occurring in the fixed plots surveyed over seven years had an overall stable growth status, though relatively low floral induction and seedlings. Transplantation revealed influences of abiotic and biotic factors. One transplantation site was fenced to prevent human trampling and apparently discouraged vertebrate grazing, resulting in dramatic flower number …

Dissolved And Colloidal Element Transport Through The Coastal Transition Zone, Moo Joon Shim

Dissertations

There are several factors (e.g., hurricanes, floodplain, and anthropogenic sources) that could modify trace element behavior through the coastal transition zone (CTZ). However, there is still a lack of information about these variables in affecting trace elements in the CTZ. For this study, water samples were collected in the Pearl River (PR), Bay of St. Louis (BSL), and the Mississippi River plume to study the effects of these factors on trace element.

A possible effect of Hurricane Katrina on water quality was examined in the East Pearl River (EPR). Hurricane Katrina could have resulted in increased inputs of organic matter …

Latent Growth Modeling Of A Nutrition And Physical Activity Intervention, Alicia Dea Sample

Dissertations

The health, economic, and social impacts of physical inactivity and unhealthy dietary patterns are quite significant and evidenced by the fact that only 3-4% of American adults follow all the dietary advice recommended by the Dietary Guidelines for Americans (DGA; Kohatsu, Robinson, & Torner, 2004), and specific subpopulations, including the rural South, are affected even more drastically (McCabe-Sellers et al., 2007). Furthermore, the majority of the people in the United States do not currently meet recommended amounts of physical activity (PA) and have not since the mid 1980s (U.S. Department of Health and Human Services [USDHHS], 2008). To address the …

Self-Repairable Polymeric Networks: Synthesis And Network Design, Biswajit Ghosh

Dissertations

This dissertation describes the design, synthesis and development of a new class of polymeric networks that exhibit self-repairing properties under UV exposure. It consists of two parts: (a) modification and synthesis of oxetane (OXE), and oxolane (OXO) substituted chitosan (CHI) macromonomer, and (b) design, and synthesis of self-repairing polyurethane (PUR) networks consisting of modified chitosan. Unmodified CHI consisting of acetamide (-NHCOCH₃), primary hydroxyl (-OH), and amine (-NH₂) functional groups were reacted with OXE or OXO compounds under basic conditions in order to substitute the 1° –OH groups, and at the same time, convert -NHCOCH₃ functionalities …

The Relations Among Laterality, Cortisol, And Approach-Avoidance Behavior In Garnett's Bushbaby (Otolemur Garnettii), David Burton Hanbury

Dissertations

Many studies to date have demonstrated that approach and avoidance behaviors are processed asymmetrically in the brain and may be reflected in measures such as handedness. The purpose of this study was to extend work in primates on this topic to Garnett’s bushbaby, a prosimian species. Furthermore, to determine whether measures in addition to handedness relate to approach-avoidance behavior, lateralized differences in tympanic membrane temperature were assessed. Cortisol measures were also obtained to determine whether it was related approach-avoidance behavior and handedness. Eleven captive-born Garnett’s bushbabies (Otolemur garnettii) were evaluated for handedness and responsiveness to novelty. Moreover, the …

Precision Synthesis Of Functional Materials Via Raft Polymerization And Click-Type Chemical Reactions, Joel Diez Flores

Dissertations

The need to tailor polymeric architectures with specific physico-chemical properties via the simplest, cleanest, and most efficient synthetic route possible has become the ultimate goal in polymer synthesis. Recent progress in macromolecular science, such as the discoveries of controlled/“living” free radical polymerization (CRP) methods, has brought about synthetic capabilities to prepare (co)polymers with advanced topologies, predetermined molecular weights, narrow molecular weight distributions, and precisely located functional groups. In addition, the establishment of click chemistry has redefined the selected few highly efficient chemical reactions that become highly useful in post-polymerization modification strategies. Hence, the ability to make well-defined topologies afforded by …

An Electrophysiological Investigation Of The Cognitive Processes Underlying Provoked Aggression In Humans, Jennifer Renee Fanning

Dissertations

Recently, the event-related potential (ERP) technique has been applied to questions of social information processing. Several studies have examined standard and social information processing variables in aggressive individuals, but little is known about the neurophysiological processes that take place in real-time during an aggressive encounter. In this study, 48 men and women high and low in aggression history exchanged noise blasts of varying intensity with a (fictitious) opponent in a modified version of a well-validated laboratory-controlled behavioral measure of aggression, the Taylor Reaction-time Task (Taylor, 1967), while ERPs were simultaneously being recorded at scalp sites. Mixed model ANOVAs were used …

Circadian Rhythm And Vigorous Activity: Do They Make A Difference In Executive Function?, Janie Sue Ryland

Dissertations

PL 107-110, the No Child Left Behind Act of 2001, a federally mandated accountability system based on standards, attendance, and dropout rates has forced educational leaders to explore new avenues of student improvement. Research suggests that all three factors are impacted by scheduling preferences that are relative to time of day. The aim of this study was to extend evidence of executive function as it is impacted by time of day and diurnal preference when exposed to vigorous exercise conditions. Data were collected from a sample that included 100 sixth graders (60 females and 40 males) during the spring semester …

The Relationship Between Response To Intervention Implementation And Student Achievement, Carla Moran Mccaleb

Dissertations

The purpose of this study was to determine if there was a relationship between Response to Intervention (RTI) implementation and student achievement in reading. The study used primary data derived from the winter STAR reading diagnostic screener collected from third, fourth and fifth grade students in the RTI process. These scores were then compared to the archival data collected in the fall STAR reading diagnostic screener from the same students.

Paired-tests were performed in order to determine if there was a relationship between RTI implementation and student achievement in reading. The study sample represented in this investigation was 125 students …

The Impact Of Shrimp Farming On Mangrove Ecosystems And Local Livelihoods Along The Pacific Coast Of Ecuador, Stuart Edward Hamilton

Dissertations

This manuscript examines the expansion of Ecuador’s shrimp aquaculture industry since 1970 and the implications of this expansion on coastal residents’ food security and livelihood options. Shrimp aquaculture expanded from essentially nothing in 1970; to account for 26% of all Ecuadorian private exports by 1998. The rapid expansion of shrimp aquaculture in Ecuador’s estuaries has caused a fundamental shift in livelihoods among those who live and work in the immediate vicinity of the newly created shrimp farms. This research not only details the important land use change that has occurred within Ecuador’s estuaries during the transition from mangrove estuary to …

The Black Plumb Line: Re-Evaluating Race And Africanist Images In Non-Black Authored American Texts, Lashondra Vanessa Robinson

Dissertations

This study evaluates Africanisms (representations of racialized or ethnicized blackness) within three contemporary non-black authors’ texts: Jewish American Saul Bellow’s novel Henderson the Rain King, white southerner Melinda Haynes’ novel Mother of Pearl, and Nyurican poet Victor Hernández Cruz’s works “Mesa Blanca” and “White Table.” Though not entirely unproblematic, each selection somehow redefines black identity and agency to challenge denigrated representations of Africanist people and culture. In the process, each author subverts faulty components of American myths of racial purity, particularly stratifying black-white dualisms that promote whiteness, racial supremacy, and resulting undue privilege. This study also traces how Bellow, Haynes …

Extracellular Atp Acts On P2y2 Purinergic Receptors To Facilitate Hiv-1 Infection, Claire Séror, Marie-Therese Melki, Frederic Subra, Syed Qasim Raza, Marlene Bras, Hela Saïdi, Roberta Nardacci, Laurent Voisin, Audrey Paoletti, Frederic Law, Isabelle Martins, Alessandra Amendola, Ali A. Abdul-Sater, Fabiola Ciccosanti, Olivier Delelis, Florence Niedergang, Sylvain Thierry, Najwane Said-Sadier, Christophe Lamaze, Didier Métivier, Jerome Estaquier, Gian Maria Fimia, Laura Falasca, Rita Casetti, Nazanine Modjtahedi, Jean M. Kanellopoulos, Jean-Francois Mouscadet, David M. Ojcius, Mauro Piacentini, Marie-Lise Gougeon, Guido Kroemer, Jean-Luc Perfetini

All Dugoni School of Dentistry Faculty Articles

Extracellular adenosine triphosphate (ATP) can activate purinergic receptors of the plasma membrane and modulate multiple cellular functions. We report that ATP is released from HIV-1 target cells through pannexin-1 channels upon interaction between the HIV-1 envelope protein and specific target cell receptors. Extracellular ATP then acts on purinergic receptors, including P2Y2, to activate proline-rich tyrosine kinase 2 (Pyk2) kinase and transient plasma membrane depolarization, which in turn stimulate fusion between Env-expressing membranes and membranes containing CD4 plus appropriate chemokine co-receptors. Inhibition of any of the constituents of this cascade (pannexin-1, ATP, P2Y2, and Pyk2) impairs the replication of HIV-1 mutant …