Digital Commons Network^™

Mouse Versus Rat: Profound Differences In Meiotic Regulation At The Level Of The Isolated Oocyte, Stephen M. Downs

Biological Sciences Faculty Research and Publications

Cumulus cell-enclosed oocytes (CEO), denuded oocytes (DO), or dissected follicles were obtained 44–48 hr after priming immature mice (20–23 days old) with 5 IU or immature rats (25–27 days old) with 12.5 IU of equine chorionic gonadotropin, and exposed to a variety of culture conditions. Mouse oocytes were more effectively maintained in meiotic arrest by hypoxanthine, dbcAMP, IBMX, milrinone, and 8-Br-cGMP. Atrial natriuretic peptide, a guanylate cyclase activator, suppressed maturation in CEO from both species, but mycophenolic acid reversed IBMX-maintained meiotic arrest in mouse CEO with little activity in rat CEO. IBMX-arrested mouse, but not rat, CEO were induced to …

Framed By Privilege: Perpetuating And Resisting White Supremacy In White, Middle-Class Parenting, Kelly Brianne Baldwin

College of Education Theses and Dissertations

Parenting is a primary site for the socialization of young children, including socialization around issues of race and racism. Giving careful attention to the implications of a socially privileged racial status, this study draws on the personal narratives of three White, middle-class, heterosexual mothers living in Chicago to improve understanding of White, middle-class parenting around issues of race and racism and to critically examine the ways parenting practices relate to larger social Discourses in the United States that perpetuate or disrupt White supremacy. When parenting around issues of race and racism, mothers adherent to White supremacy typically abandoned parenting strategies …

Improving The Fda Approval Process, Mark Van Der Laan, Anup Malani, Oliver Van Der Bembom

Coase-Sandor Institute for Law & Economics Research Paper Series

The FDA employs an average-patient standard when reviewing drugs: it approves a drug only if is safe and effective for the average patient in a clinical trial. It is common, however, for patients to respond differently to a drug. Therefore, the average-patient standard can reject a drug that benefits certain patient subgroups (false negative) and even approval a drug that harms other patient subgroups (false positives). These errors increase the cost of drug development – and thus health care – by wasting research on unproductive or unapproved drugs. The reason why the FDA sticks with an average patient standard is …

No Longer Mine: An Extensive Look At The Environmental Protection Agency’S Veto Of The Section 404 Permit Held By The Spruce No. 1 Mine, Amy Oxley

Southern Illinois University Law Journal

Under section 404(c) of the Clean Water Act, the Environmental Protection Agency (EPA) has the power to veto permits for the discharge of fill or dredged materials issued by the U.S. Army Corps of Engineers.  This veto power can only be used if the discharge will have unacceptable adverse effects on water supplies, aquatic life, wildlife, or recreational areas.  The EPA’s use of its veto power is rare and is usually invoked before a section 404 permit has been issued.  The recent veto of a section 404 permit for the Spruce No. 1 Mine in Logan County, West Virginia, by …

Managing Water Rights Using Fishing Rights As A Model, Shelley Ross Saxer

Marquette Law Review

None

Through The Looking Glass: Understanding Social Science Norms For Analyzing International Investment Law, Susan Franck, Calvin Garbin, Jenna Perkins

Scholarly Articles in Law Reviews & Journals

When social science methods are being employed in a new context — such as the assessment of international investment law — there is value in exploring the underlying assumptions and normative baselines of the enterprise. This article and response address critiques about the methodology of an article in the Harvard International Law Journal by: (1) describing the value of social science in international investment law; (2) replicating the research using new methodologies to conduct more than 20 new tests that were still unable to ascertain the existence of a reliable relationship between development status and outcomes on the basis of …

A Fig For Your Philosophy And Great Knowledge In The Sciences: Observation, Deception, Scientific Fraud And Social Authority In The Antebellum Museum, Jeff Nagle , '12

Senior Theses, Projects, and Awards

There is an increasingly sophisticated literature on the role played by museums in reaffirming social norms of examination in the antebellum United States. This literature has largely focused on the way museums presented this knowledge to the public, not how audiences reacted to claims of scientific authority. Popular reaction to pseudoscientific claims demonstrated to the public in the scientific context of museums, in this case Charles Redheffer's 1812 perpetual motion device and P. T. Barnum's Fejee Mermaid, shed light on the close relationship between early popular scientific observation and ways of judging authenticity and deception in the commercial and social …

Reduced Cardioprotective Action Of Adiponectin In High-Fat Diet-Induced Type Ii Diabetic Mice And Its Underlying Mechanisms., Wei Yi, Yang Sun, Erhe Gao, Xufeng Wei, Wayne Bond Lau, Qijun Zheng, Yajing Wang, Yuexing Yuan, Xiaoliang Wang, Ling Tao, Rong Li, Walter Koch, Xin-Liang Ma

Department of Emergency Medicine Faculty Papers

Diabetes exacerbates ischemic heart disease morbidity and mortality via incompletely understood mechanisms. Although adiponectin (APN) reduces myocardial ischemia/reperfusion (MI/R) injury in nondiabetic animals, whether APN's cardioprotective actions are altered in diabetes, a pathologic condition with endogenously reduced APN, has never been investigated. High-fat diet (HD)-induced diabetic mice and normal diet (ND) controls were subjected to MI via coronary artery ligation, and given vehicle or APN globular domain (gAPN, 2 μg/g) 10 min before reperfusion. Compared to ND mice (where gAPN exerted pronounced cardioprotection), HD mice manifested greater MI/R injury, and a tripled gAPN dose was requisite to achieve cardioprotective extent …

Linked By Water, Linked By Blood: Madrid Ditch No. 2 In Cucharas, Colorado, 1884–1903, Virginia Sanchez

New Mexico Historical Review

No abstract provided.

Mcnair Messenger- Fall 2011, Mcnair Staff

McNair Messenger

McNair Scholars Program

Parents' Influence On Child Social Self-Efficacy And Social Cognition, Denise Marie Gardner

Master's Theses (2009 -)

No abstract provided.

Acculturation, Cultural Values, And Latino Parental Beliefs About The Etiology Of Adhd, Kathryn E. Lawton

Master's Theses (2009 -)

Attention-Deficit/Hyperactivity Disorder (ADHD) is one of the most prevalent mental health disorders of childhood, but despite the availability of several evidence-based interventions, Latino children are more likely than non-minority children to have an unmet need for services related to ADHD. Because parental beliefs about the etiology of ADHD likely influence which services are sought, more research is needed to examine this aspect of help-seeking behavior in order to address the unmet need among Latino families. Specifically, research needs to focus on cultural factors that likely influence parental beliefs about the etiology of child behavior problems. Thus, the goal of the …

Nmr And Computational Studies Of Nad(P)(H) Cofactor Binding, Junghwa Kim

Master's Theses (2009 -)

Tuberculosis (TB) is one of the most dangerous diseases in a sense of spread method. According W.H.O., one third of world population has this disease and annual one of these infected people spreads 10 -15 people unintentionally. To protect human from this bacterial, the unique feature of mycrobacterial [sic] TB was studied previously. The unique cell wall, peptidoglycan, has high content of DAP (diaminopimelic acid). The disruption of synthesis DAP results in cell death due to instability of cell wall. One way to inhibiting synthesis of DAP is to modify cofactor which acts with dehydrogenase. To do that the study …

Database Methods For Copy Number Variant Analysis Of One Hundred Disease Associated Genes In Human Congenital Heart Disease, Maureen E. Tuffnell

Master's Theses (2009 -)

Human genetic variation occurs more commonly than was recognized after the completion of the Human Genome Sequencing Project in 2003. Submicroscopic human DNA analysis has revealed copy number variation (CNV) as the deletion or duplication of a genomic region potentially affecting gene dosage. Advanced genetic research now includes the study of CNVs in diseased subject groups compared to in house controls or online published datasets of control CNV data. Research labs choose from different bioinformatic algorithms to make the copy number calls. Solutions for further processing the copy number data into quantifiable form require collaboration with data analysts and include …

Effects Of Chronic Variable Stress Across Developmental Stages In Mice, Sheryl Jayne Stevens

Master's Theses (2009 -)

Posttraumatic Stress Disorder (PTSD) is a response to trauma exposure that involves a number of symptoms that can be highly impairing to affected individuals. Only a subset of those exposed to traumatic events will develop the disorder, which is conceptualized as developing via conditional fear. Research into factors predisposing for PTSD is needed. Furthermore, little work has been done to investigate predisposing factors in children more specifically. This research tests the effects of stress exposure on subsequent fear learning, across developmental stages in mice, as a model for PTSD. Juvenile and adult male mice were exposed to chronic variable stress …

Unraveled Fall 2011, Southern Adventist University

Unraveled - School of Education and Psychology Newsletter

The Fall 2011 issue of Unraveled contains articles on first-year teachers, the Psychology Honor Society, the transition from Summerour to Herin Hall, spotlights on new faculty, and a profile on outdoor emergency services.

Columns Fall 2011, Southern Adventist University

Alumni Newsletter

Features the article "Special Section: President’s Report". The full report that President Gordon Bietz presented to the Southern Union Conference constituency meeting, held in Atlanta this September.

Talking To Yourself: Garfield Minus Garfield As An Introduction To Techno-Companionship, Andy Engel

Reconstruction: Studies in Contemporary Culture

[First paragraph]

A year ago while surfing the Internet, I came across a website called Garfield Minus Garfield (GMG), operated by artist/businessman Dan Walsh. Walsh received notoriety for his adaptations of the popular Garfield comic strip in which he removed its title character [1]. This act results in Garfield’s human counterpart, Jon Arbuckle, alone and talking to himself in the now empty space of the strip. A radical transformation occurs because of Garfield’s deletion that serves to emphasize the crucial role Jon and Garfield’s relationship plays in our perception of the world within the strip. Walsh begins the site with …

Canada Goose Crop Damage Abatement In South Dakota, Troy M. Radtke, Charles D. Dieter

Natural Resource Management Faculty Publications

Canada geese (Branta canadensis) can cause considerable damage to crops during summer when geese are flightless. We evaluated the effectiveness of a program designed to alleviate crop damage on soybeans by Canada geese in South Dakota, USA. The applications of electric fences, feeding stations, and propane cannons reduced the area of crop damage by 90% in 2006 and 80% in 2007, but the timing was important. Fields where abatement practices were applied early in the growing season had less damage than fields where they were applied later. Abatement practices that were properly applied as soon as damage started …

Nitrogen Acquisition By Annual And Perennial Grass Seedlings: Testing The Roles Of Performance And Plasticity To Explain Plant Invasion, A. J. Leffler, T. A. Monaco, J. J. James

Natural Resource Management Faculty Publications

Differences in resource acquisition between native and exotic plants is one hypothesis to explain invasive plant success. Mechanisms include greater resource acquisition rates and greater plasticity in resource acquisition by invasive exotic species compared to non-invasive natives. We assess the support for these mechanisms by comparing nitrate acquisition and growth of invasive annual and perennial grass seedlings in western North America. Two invasive exotic grasses (Bromus tectorum and Taeniatherum caput-medusae) and three perennial native and exotic grasses (Pseudoroegneria spicata, Elymus elymoides, and Agropyron cristatum) were grown at various temperatures typical of autumn and springtime when resource are abundant and dominance …

Functional And Epigenetic Studies Reveal Multistep Differentiation And Plasticity Of In Vitro-Generated And In Vivo-Derived Follicular T Helper Cells, Paul W. Bible, Kristina T. Lu, Yuka Kanno, Jennifer L. Cannons, Robin Handon, Et Al.

Computer Science Faculty publications

Follicular T helper (Tfh) cells provide critical help to B cells for germinal center (GC) formation. Mutations affecting SLAM-associated protein (SAP) prevent GC formation because of defective T cell-B cell interactions, yet effects on Tfh cell differentiation remain unclear. We describe the in vitro differentiation of functionally competent “Tfh-like” cells that expressed interleukin-21, Tfh cell markers, and Bcl6 and rescued GC formation in SAP-deficient hosts better than other T helper (Th) cells. SAP-deficient Tfh-like cells appeared virtually indistinguishable from wild-type, yet failed to support GCs in vivo. Interestingly, both Tfh-like and in vivo-derived Tfh cells could produce effector cytokines in …

Association Mining In Database Machine, Jindou Jiao

Master's Projects

Association rule is wildly used in most of the data mining technologies. Apriori algorithm is the fundamental association rule mining algorithm. FP-growth tree algorithm improves the performance by reduce the generation of the frequent item sets. Simplex algorithm is a advanced FP-growth algorithm by using bitmap structure with the simplex concept in geometry. The bitmap structure implementation is particular designed for storing the data in database machines to support parallel computing the association rule mining.

An Economic Approach To The Ecological Issues Of Urban Stormwater Runoff: A Case Study Of The Allen Creek Watershed In Monroe County, New York, Kelly Hellman

Theses

Urban stormwater runoff is excess runoff created by increased imperviousness in an urbanized watershed and can have significant impacts on both water quantity and quality. Natural communities and human communities are faced with damages that occur as a result of the change in the type and magnitude of stormwater runoff flows, including but not limited to increased flooding and degradation of natural aquatic systems. Therefore, from both an economic and ecological perspective, it is important that urban planners effectively manage excess stormwater runoff. This paper details the development of an ecological-economic model that can be used to guide urban planners …

A Search For Mri Diffusion Coefficient Standards, Hongmei Yuan

Theses

Diffusion coefficients (D) can be readily measured by nuclear magnetic resonance (NMR) spectroscopy and magnetic resonance imaging (MRI) instruments. Operators of these instruments often utilize standards with known diffusion coefficients to rapidly and conveniently test the performance of the NMR or MRI system to measure diffusion. A variety of these standards have been proposed in the scientific literature. This thesis describes a diffusion standard based on water constrained by container geometry, specifically water between tightly packed, parallel glass fiber filaments. The restricted diffusion of water in this environment gives a diffusion coefficient which is selectable by the choice of data …

Seeking Connection: An English Educator Speaks Across A Disciplinary Contact Zone, Janet Alsup

Department of English Faculty Publications

No abstract provided.

News From Hope College, Volume 43.2: October, 2011, Hope College

News from Hope College

No abstract provided.

The Social Nature Of Male Suicide: A New Analytic Model, Daniel Coleman, John T. Casey

School of Social Work Faculty Publications and Presentations

Suicide is one of the leading causes of male mortality. In nearly every country in the world, more males than females end their life by suicide. Previous research indicates male-specific risk factors include social factors such as being unmarried, low income, and unemployment. An analytic model of male suicide is developed, proposing that the traditional male gender role creates a culturally-conditioned narrowing of perceived options and cognitive rigidity when under stress that increases male suicide risk. Suicide prevention and intervention require recognition of the role of high traditional masculinity, situating individual explanations within a broader social context. Based on this …

Gene And Environment Interaction In Familial Suicidal Behavior. A Single Family With 4 Committed Suicides., Habibolah Khazaie, Leeba Rezaie, Reza Alibakhshi, David C. Schwebel

Saudi Medical Journal

Family history of suicide is among the strongest predictors of suicide risk. From the context of gene by environment interactions, this manuscript presents a case study of the M family, which experienced 4 committed suicides within a short time period. Over the course of 5 years, the father and 3 sons committed suicide. Suicidal ideations developed in several other members of the family. The family9s suicide risk appears to have stemmed from both environmental and genetic factors, and likely from an interactive effect between both. Environmental factors included low level of education, opium dependency among male family members, unemployment, and …

Philosophy And Theology: Notes On The Violinist Analogy, Christopher Kaczor

Philosophy Faculty Works

No abstract provided.

Fall 2011, ‘Meet’ Our 2011 International Affairs Faculty, Center For International Education

UNH International Educator Newsletter

No abstract provided.