Digital Commons Network^™

A Statin-Regulated Microrna Represses C-Myc Expression And Function., Apana Agha L. Takwi 1980-

Electronic Theses and Dissertations

c-Myc dysregulation is one of the most common abnormalities found in human cancer. MicroRNAs (miRNAs) are functionally intertwined with the c-Myc network as multiple miRNAs are regulated by c-Myc, while others directly suppress c-Myc expression. In this work, we identified miR-33b as a primate-specific negative regulator of c-Myc. The human miR-33b gene is located at 17pl1.2, a genomic locus frequently lost in medulloblastomas, which are pediatric brain tumors that display c-Myc overproduction. Through a small-scale screening with drugs approved by the US Food and Drug Administration (FDA), we found that lovastatin up-regulated miR-33b expression, reduced cell proliferation, and impaired c-Myc …

November 2011 News Releases, University Of Montana--Missoula. Office Of University Relations

University of Montana News Releases, 1928, 1956-present

No abstract provided.

Trails And Physical Activity: A Review, Heather A. Starnes, Philip J. Troped, David B. Klenosky, Angela M. Doehring

Kinesiology and Public Health

To provide a synthesis of research on trails and physical activity from the public health, leisure sciences, urban planning, and transportation literatures. Methods: A search of databases was conducted to identify studies published between 1980 and 2008. Results: 52 studies were identified. The majority were cross-sectional (92*%) and published after 1999 (11%). The evidence for the effects of trails on physical activity was mixed among 3 intervention and 5 correlational studies. Correlates of trail use were examined in 13 studies. Several demographic (eg, race, education, income) and environmental factors (eg, land-use mix and distance to trail) were related to trail …

Minimizing Bias In Biomass Allometry: Model Selection And Log‐Transformation Of Data, Joseph Mascaro, Creighton M. Litton, R. Flint Hughes, Amanda Uowolo, Stefan A. Schnitzer

Biological Sciences Faculty Research and Publications

Nonlinear regression is increasingly used to develop allometric equations for forest biomass estimation (i.e., as opposed to the traditional approach of log‐transformation followed by linear regression). Most statistical software packages, however, assume additive errors by default, violating a key assumption of allometric theory and possibly producing spurious models. Here, we show that such models may bias stand‐level biomass estimates by up to 100 percent in young forests, and we present an alternative nonlinear fitting approach that conforms with allometric theory.

Florida Charter Schools: The Effects Of Types And Socioeconomic Status On Academic Achievement, Reginald Thompson

Doctoral Dissertations and Projects

No Child Left Behind (NCLB) was established in 2002 with the primary goal of closing the achievement gap between low socioeconomic students and their more advantaged peers. Charter schools are a part of NCLB's school choice policy and are intended to be a form of intervention to close the achievement gap. Much research has been conducted to measure charter school student achievement compared to regular public schools. But little has been done in distinguishing the differences between charter schools and their impact on student achievement. This quantitative study identifies the different types of public charter schools in Florida using Carpenter's …

Georgia High-Stakes Testing: The Correlation Between Eighth Grade And Ninth Grade Achievement, Venita Lee Bruton

Doctoral Dissertations and Projects

Standardized tests are an education reality and an important accountability consideration in most states and school systems. Most states require standardized assessments to meet requirements of the federal No Child Left Behind Act of 2001. Changes to curriculum and instruction and to the school culture frequently occur through a school improvement process, and standardized test data are often used to inform these decisions. The school improvement process and professional development should focus on student learning, but how administrators and teachers perceive standardized testing and the ensuing data analyses is an important consideration in understanding what needs improvement and the professional …

Functional Dissection Of The Glucose Signaling Pathways That Regulate The Yeast Glucose Transporter Gene (Hxt) Repressor Rgt1, David J. Jouandot Ii, Adhiraj Roy, Jeong-Ho Kim

Faculty Publications

The yeast Rgt1 repressor is a bifunctional protein that acts as a transcriptional repressor and activator. Under glucose-limited conditions, Rgt1 induces transcriptional repression by forming a repressive complex with its corepressors Mth1 and Std1. Here, we show that Rgt1 is converted from a transcriptional repressor into an activator under high glucose conditions and this occurs through two independent but consecutive events mediated by two glucose signaling pathways: (1) disruption of the repressive complex by the Rgt2/Snf3 pathway; (2) phosphorylation of Rgt1 by the cAMP-dependent protein kinase (cAMP-PKA) pathway. Rgt1 is phosphorylated by PKA at four serine residues within its amino-terminal …

Volume 109, Number 10 - Tuesday, November 1, 2011, Saint Mary's College Of California

The Collegian

No abstract provided.

Emotional Regulation And Judicial Behavior, Terry A. Maroney

Vanderbilt Law School Faculty Publications

Judges are human and experience emotion when hearing cases, though the standard account of judging long has denied that fact. In the post-Realist era it is possible to acknowledge that judges have emotional reactions to their work, yet our legal culture continues to insist that a good judge firmly puts those reactions aside. Thus, we expect judges to regulate their emotions, either by preventing emotion’s emergence or by walling off its influence. But judges are given precisely no direction as to how to engage in emotional regulation.
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/="/">This Article proposes a model for judicial emotion regulation that goes …

Lymphotoxin-Beta Receptor Blockade Reduces Cxcl13 In Lacrimal Glands And Improves Corneal Integrity In The Nod Model Of Sjögren's Syndrome, Roy A. Fava, Susan M. Kennedy, Sheryl G. Wood, Anne I. Bolstad, Jadwiga Bienkowska, Adrian Papandile, John A. Kelly

Dartmouth Scholarship

In Sjögren's syndrome, keratoconjunctivitis sicca (dry eye) is associated with infiltration of lacrimal glands by leukocytes and consequent losses of tear-fluid production and the integrity of the ocular surface. We investigated the effect of blockade of the lymphotoxin-beta receptor (LTBR) pathway on lacrimal-gland pathology in the NOD mouse model of Sjögren's syndrome.

Do "Iron Curtains" Happen More Than Once?, Dr. William Yoder

Occasional Papers on Religion in Eastern Europe

"Two separations significant for World Christendom commemorated their 50th birthdays on 13 August: the construction of the Berlin Wall and the splitting up of the “All-Union Council of Evangelical Christians-Baptists”. On 18 August, in one of two major Russian-language commentaries on the second event, Moscow’s Mikhail Cherenkov celebrated in the news service “Protestant” the maverick and courageous spirit of the underground, “Initiativniki” Baptist movement. He described them as a “mighty spiritual” and “radical reformist” movement and exclaimed: No one could have expected that an “anti-church directive” put out by the All-Union Council could “invoke such massive resistance on the local-church …

Prevention Of Vessel-Source Marine Pollution: A Note On The Challenges And Prospects For Chinese Practice Under International Law, Nengye Liu, Frank Maes

Research Collection Yong Pung How School Of Law

This article examines China’s domestic legal regime for the prevention of vessel sourcepollution. It pays special attention to the recently adopted Regulation on Preventionand Control of Marine Pollution from Vessels. Potential challenges and emerging issuesthat China has to confront are addressed, including: application of the legislation todisputed sea areas between China and its neighbors, freedom of navigation in theexclusive economic zone, reduction of emission from ships, and prevention of invasivespecies from ballast water.

Analysis Of Binding Site Hot Spots On The Surface Of Ras Gtpase, Greg Buhrman, Casey O'Connor, Brandon Zerbe, Bradley M. Kearney, Raeanne Napoleon, Elizaveta A. Kovrigina, Sandor Vajda, Dima Kozakov, Evgenii L. Kovrigin, Carla Mattos

Chemistry Faculty Research and Publications

We have recently discovered an allosteric switch in Ras, bringing an additional level of complexity to this GTPase whose mutants are involved in nearly 30% of cancers. Upon activation of the allosteric switch, there is a shift in helix 3/loop 7 associated with a disorder to order transition in the active site. Here, we use a combination of multiple solvent crystal structures and computational solvent mapping (FTMap) to determine binding site hot spots in the “off” and “on” allosteric states of the GTP-bound form of H-Ras. Thirteen sites are revealed, expanding possible target sites for ligand binding well beyond the …

Laws For Learning In An Age Of Acceleration, John O. Mcginnis

William & Mary Law Review

No abstract provided.

Globalization And Structure, Julian Ku, John Yoo

William & Mary Law Review

No abstract provided.

The Accession Insight And Patent Infringement Remedies, Peter Lee

Michigan Law Review

What is the appropriate allocation of rights and obligations when one party, without authorization, substantially improves the property of another? According to the doctrine of accession, a good faith improver may take title to such improved property, subject to compensating the original owner for the value of the source materials. While shifting title to a converter seems like a remarkable remedy, this outcome merely underscores the equitable nature of accession, which aims for fair allocation of property rights and compensation between two parties who both have plausible claims to an improved asset. This Article draws upon accession-a physical property doctrine …

Linking Fruit Traits To Variation In Predispersal Vertebrate Seed Predation, Insect Seed Predation, And Pathogen Attack, Noelle G. Beckman, Helene C. Muller-Landau

Biology Faculty Publications

The importance of vertebrates, invertebrates, and pathogens for plant communities has long been recognized, but their absolute and relative importance in early recruitment of multiple coexisting tropical plant species has not been quantified. Further, little is known about the relationship of fruit traits to seed mortality due to natural enemies in tropical plants. To investigate the influences of vertebrates, invertebrates, and pathogens on reproduction of seven canopy plant species varying in fruit traits, we quantified reductions in fruit development and seed germination due to vertebrates, invertebrates, and fungal pathogens through experimental removal of these enemies using canopy exclosures, insecticide, and …

A Different Kind Of Quarterback, Jerry Charles Guyden

Publications and Research

I am not big on celebrations, nor do I accept many invitations to receive awards. There is much work to be done, and the reward is in the doing. I learned this lesson early from my parents, Martha and Robert Guyden. However, I am humbled that anyone would even mention my name in association with E. E. Just. I, like he, was born into a segregated America, and somehow we both found biology. I think Just's life story instigates a discussion on diversity in science, as well it should. However, after reading Tyrone Hayes' (2010 E. E. Just Award recipient) …

Infertility, M. Therese Lysaught

Institute of Pastoral Studies: Faculty Publications and Other Works

No abstract provided.

Neutron Imaging And Applications: A Reference For The Imaging Community, Edmund Perfect, Chu-Lin Cheng, Peter Lehmann

Civil Engineering Faculty Publications

No abstract provided.

Cirt Newsletter--November 2011, Center For Instruction & Research Technology (Cirt)

CIRT News

This issue contains:

Faculty Spotlight: Finding and Presenting Images with ARTStor

Using Peer Instruction To Boost Student Engagement And Promote Learning

Upcoming Events

Digital Thinking: Uses for Video in Scholarship

Changes to the Online ISQ Process

New Poster Templates

Best Practices Online: Blogs

Blackboard News

iTunes U in Blackboard

New Faculty Bio Tool

App Review: ShowMe

News from ITS: December Outages and New Student E-mail

New in CIRT: Changes to Equipment Checkout Procedures

Reactivity Of Acyclic (Pentadienyl)Iron(1+) Cations: Synthetic Studies Directed Toward The Frondosins, Do W. Lee, Rajesh K. Pandey, Sergey V. Lindeman, William A. Donaldson

Chemistry Faculty Research and Publications

A short, 4-step route to the scaffold of frondosin A and B is reported. The [1-methoxycarbonyl-5-(2′,5′-dimethoxyphenyl)pentadienyl]Fe(CO)₃⁺ cation was prepared in two steps from (methyl 6-oxo-2,4-hexadienoate)Fe(CO)₃. Reaction of this cation with isopropenyl Grignard or cyclohexenyllithium reagents affords (2-alkenyl-5-aryl-1-methoxycarbonyl-3-pentene-1,5-diyl)Fe(CO)₃ along with other addition products. Oxidative decomplexation of these (pentenediyl)iron complexes, utilizing CuCl₂, affords 6-aryl-3-methoxycarbonyl-1,4-cycloheptadienes via the presumed intermediacy of a cis-divinylcyclopropane.

Removal Of 2,4-Dichlorophenoxyacetic Acid By Calcined Zn–Al–Zr Layered Double Hydroxide, Allen Chaparadza, Jeanne Hossenlopp

Chemistry Faculty Research and Publications

The adsorption equilibrium, kinetics, and thermodynamics of removal of 2,4-dichlorophenoxy-acetic acid (2,4-D) from aqueous solutions by a calcined Zn–Al layered double hydroxide incorporated with Zr⁴⁺ were studied with respect to time, temperature, pH, and initial 2,4-D concentration. Zr⁴⁺ incorporation into the LDH was used to enhance 2,4-D uptake by creating higher positive charges and surface/layer modification of the adsorbent. The LDH was capable of removing up to 98% of 2,4-D from 5 to 400 ppm aqueous at adsorbent dosages of 500 and 5000 mg L⁻¹. The adsorption was described by a Langmuir-type isotherm. The percentage 2,4-D …

Enabling Gpu Acceleration With Messaging Middleware, Randall E. Duran, Li Zhang, Tom Hayhurst

Research Collection School Of Computing and Information Systems

Graphics processing units (GPUs) offer great potential for accelerating processing for a wide range of scientific and business applications. However, complexities associated with using GPU technology have limited its use in applications. This paper reviews earlier approaches improving GPU accessibility, and explores how integration with middleware messaging technologies can further improve the accessibility and usability of GPU-enabled platforms. The results of a proof-of-concept integration between an open-source messaging middleware platform and a general-purpose GPU platform using the CUDA framework are presented. Additional applications of this technique are identified and discussed as potential areas for further research.

Montana Kaimin, November 1, 2011, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.

Methodological Gravitism, Muhammad Zaman

The Qualitative Report

In this paper the author presents the case of the exchange marriage system to delineate a model of methodological gravitism. Such a model is not a deviation from or alteration to the existing qualitative research approaches. I have adopted culturally specific methodology to investigate spouse selection in line with the Grounded Theory Method. This approach, indeed, suggests the unification of methodological individualism, collectivism, and the social positioning of the actor to study the complex and intricately intertwined networks of relatedness.

Gait Verification Using Knee Acceleration Signals, L. W. Hang, C. Y. Hong, C. W. Yen, D. J. Chang, Mark L. Nagurka

Mechanical Engineering Faculty Research and Publications

A novel gait recognition method for biometric applications is proposed. The approach has the following distinct features. First, gait patterns are determined via knee acceleration signals, circumventing difficulties associated with conventional vision-based gait recognition methods. Second, an automatic procedure to extract gait features from acceleration signals is developed that employs a multiple-template classification method. Consequently, the proposed approach can adjust the sensitivity and specificity of the gait recognition system with great flexibility. Experimental results from 35 subjects demonstrate the potential of the approach for successful recognition. By setting sensitivity to be 0.95 and 0.90, the resulting specificity ranges from 1 …

How Risk Averse Farmers On Sensitive Environmental Land Respond To Dedicated Energy Crop, Kent D. Rupp

Research Papers

This study will analyze farmers and landowners of the Clear Creek Watershed in Iowa. Their willingness to accept switchgrass will be collected by a 2010 Clear Creek Land Use survey administered to the local area watershed farmers and landowners. The literature review of this will look at the current ethanol industry in Iowa, the Clear Creek Watershed's environmental health, and some of the willingness to accept factors (of biomass production) for farmers and landowners. A multiple regression was conducted on three possible predictors of the willingness to accept payment levels. Overall, the predictor values of age, education level, and farm …

Tracking Development Of The Corpus Callosum In Fetal And Early Postnatal Baboons Using Magnetic Resonance Imaging, Kimberley A. Phillips, P. Kochunov

Psychology Faculty Research

Although the maturation of the corpus callosum (CC) can serve as a sensitive marker for normative antenatal and postnatal brain development, little is known about its development across this critical period. While high-resolution magnetic resonance imaging can provide an opportunity to examine normative brain development in humans, concerns remain over the exposure of developing fetuses to non-essential imaging. Nonhuman primates can provide a valuable model for normative brain maturation. Baboons share several important developmental characteristics with humans, including a highly orchestrated pattern of cerebral development. Developmental changes in total CC area and its subdivisions were examined across the antenatal (weeks …

Investigating The Roles Of Ndj1 And Tid1 In Crossover Assurance In Saccharomyces Cerevisiae, Rianna Knowles

Master's Theses

Meiosis is the specialized process of cell division utilized during gametogenesis in all sexually reproducing eukaryotes, which consists of one round of DNA replication followed by two rounds of chromosome segregation and results in four haploid cells. Crossovers between homologous chromosomes promote proper alignment and segregation of chromosomes during meiosis.

Crossover interference is a genetic phenomenon in which crossovers are non-randomly placed along chromosomes. Crossover assurance ensures that every homologous chromosome pair obtains at least one crossover during Prophase I. Crossovers physically connect homologous pairs, allowing spindle fibers to attach and separate homologs properly. However, some organisms have shown an …