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2011

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An Exploration Of The Paradigm Of Kinship Caregiving And Caregivers' Experiences With Child Welfare And Public Welfare Systems Using Critical Theory Analysis, Tara Valinchus Dejohn Jan 2011

An Exploration Of The Paradigm Of Kinship Caregiving And Caregivers' Experiences With Child Welfare And Public Welfare Systems Using Critical Theory Analysis, Tara Valinchus Dejohn

LSU Doctoral Dissertations

Kinship caregiving as a paradigm in the United States (US) is historically linked to slavery subcultural practices. Over time, dominant US systems have vacillated in demonstrating formal acknowledgement of kinship as an acceptable family unit and in availing resources to support kinship caregiving. The patterns and practices of these variations pertaining to kinship caregiving as a paradigm has received little attention despite documentation of its increased utilization in public child welfare and welfare systems. This exploratory case study responds to the paucity of knowledge regarding the systemic shifts towards the kinship caregiving paradigm and the perspectives of kinship caregivers who …

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Asians In The American Mind: How Americans View Asian Americans Politically, Nhung Kim Nguyen Jan 2011

Asians In The American Mind: How Americans View Asian Americans Politically, Nhung Kim Nguyen

LSU Doctoral Dissertations

This study explores how the general American public thinks about Asian Americans, who are a multiethnic, immigrant-dominated, fast-growing, and understudied group. Understanding Americans’ views toward Asians is important in light of the changing face of the American electorate, whose recent additions comprise largely of immigrants from Asia and Latin America, and the likelihood that Americans’ beliefs or thoughts about race and ethnicity will be altered beyond the black-white divide in U.S. politics. As an attempt to gain such understanding, the purpose of this study is to provide a systematic study of Americans’ attitudes toward Asians in terms of positive/negative evaluations …

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Surfactants And Digital Alloys For Strain Relief In Iii-Nitride Distributed Bragg Reflectors And Related Heterostructures Via Metal Organic Vapor Phase Epitaxy, Lee Ellen Rodak Jan 2011

Surfactants And Digital Alloys For Strain Relief In Iii-Nitride Distributed Bragg Reflectors And Related Heterostructures Via Metal Organic Vapor Phase Epitaxy, Lee Ellen Rodak

Graduate Theses, Dissertations, and Problem Reports (ETD)

III-Nitride based semiconductors have emerged as one of the promising materials for electronic and opto-electronic devices, including but not limited to, solid state emitters, photodetectors, and transistors. Despite commercial success, several issues ranging from material growth to device fabrication remain unresolved and continue to hinder the efficiency of these devices. One such issue includes strain management in III-Nitride heterostructures. The binary alloys in the (Al,In,Ga)N family are characterized by a large lattice and thermal mismatch which leads to defect formation and cracking within heterostructures. These defects are detrimental to device fabrication and operation. This work investigates growth based techniques to …

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Structure-Function Relationships In Poly(3-Hexylthiophene)S Formed Via Manipulation Of Oxidative Coupling Routes, Warren James Solfiell Jan 2011

Structure-Function Relationships In Poly(3-Hexylthiophene)S Formed Via Manipulation Of Oxidative Coupling Routes, Warren James Solfiell

LSU Doctoral Dissertations

This investigation focused on the analytical characterization of poly(3-hexylthiophene), a heterocyclic conducting polymer system, with an overall objective of elucidating the effects that the experimental conditions during chemical oxidation using iron(III) chloride as an oxidant impart on the structure of the resulting polymers. Poly(3-alkylthiophene)s are extensively studied materials due to their high electrical conductivities and unique optical properties that make them extremely valuable for use in contemporary technological applications and devices. Specifically, the aim of this research was to determine the dependence of structural characteristics, such as endgroups, molecular weights, and regioregularities, on the solvent employed for the reaction and …

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Effects Of Load And Gradient On Musculoskeletal Loading During Dynamic Two-Wheeled Cart Pushing And Pulling, Yun Sun Jan 2011

Effects Of Load And Gradient On Musculoskeletal Loading During Dynamic Two-Wheeled Cart Pushing And Pulling, Yun Sun

Graduate Theses, Dissertations, and Problem Reports (ETD)

Pushing and pulling of carts are found to be associated with low back pain and shoulder complaints. It is currently unclear as to how the dynamic pushing and pulling tasks performed under different task conditions (e.g. weight, walkway gradient, direction of force application) affect the musculoskeletal loading of low back and shoulder joints. Therefore, the objective in this study was to evaluate dynamic pushing and pulling tasks to quantify their effects on the 3D musculoskeletal loading of low back and shoulder joints. Twelve male participants performed cart pushing pulling tasks along a 5° and 10° ramp by carrying loads of …

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Characterization Of Novel Akermanite:Poly-E-Caprolactone Scaffolds For Bone Tissue Engineering Aapplications Combined With Human Adipose-Derived Stem Cells, Andre S. Zanetti Jan 2011

Characterization Of Novel Akermanite:Poly-E-Caprolactone Scaffolds For Bone Tissue Engineering Aapplications Combined With Human Adipose-Derived Stem Cells, Andre S. Zanetti

LSU Doctoral Dissertations

The development of porous materials useful as scaffolds for the sustained three-dimensional (3D) growth of human adipose-derived stem cells (hASC) is of particular interest to facilitate healing after musculoskeletal injuries. In this study, a composite porous material obtained by blending akermanite with poly-e-caprolactone (PCL) is proposed as novel alternative to bone tissue regeneration. The objectives of this study are (1) to characterize the akermanite:PCL scaffold properties; (2) to investigate the in vitro osteogenic potential of hASC loaded to optimal akermanite:PCL scaffolds; (3) to assess the metabolic activity and osteogenesis of hASC loaded to optimal akermanite:PCL scaffolds post-thawing using optimal cryopreservation …

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Development And Application Of Serogroup-Independent And Serogroup-Specific Loop-Mediated Isothermal Amplification Assays For Detecting Shiga Toxin-Producing Escherichia Coli, Fei Wang Jan 2011

Development And Application Of Serogroup-Independent And Serogroup-Specific Loop-Mediated Isothermal Amplification Assays For Detecting Shiga Toxin-Producing Escherichia Coli, Fei Wang

LSU Doctoral Dissertations

Shiga toxin-producing Escherichia coli (STEC), encompassing E. coli O157:H7 and non-O157 STEC, is a significant cause of foodborne illnesses and deaths in the United States and worldwide. Shiga toxins (encoded by stx) and intimin (encoded by eae) are important virulence factors for STEC strains causing infection. Although E. coli O157:H7 remains to be the single most common STEC causing disease, the clinical importance of non-O157 STEC is on the rise worldwide. And six major serogroups (O26, O45, O103, O111, O121, and O145) accounted for over 70% of non-O157 STEC infections in the United States. Loop-mediated isothermal amplification (LAMP) is a …

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Revision And Reclassification Of The Genera Of Phalacridae (Coleoptera: Cucujoidea), Matthew Gimmel Jan 2011

Revision And Reclassification Of The Genera Of Phalacridae (Coleoptera: Cucujoidea), Matthew Gimmel

LSU Doctoral Dissertations

The family Phalacridae is monographed at the genus level using modern phylogenetic and classification methods. A morphological matrix of 106 characters and 2063 base pairs of aligned 18S rDNA sequence data were analyzed both separately and in a concatenated matrix, using maximum parsimony, Bayesian methods, and maximum likelihood. The phylogenetic hypotheses were used to construct a new subfamilial classification for the family. I recognize eight subfamilies, including two described as new: Biophytinae Guillebeau 1894, Eustilbinae Guillebeau 1892, Ochrolitinae Guillebeau 1894, Olibrinae Guillebeau 1892, Olibroporinae, subfam. nov., Olibrosominae, subfam. nov., Phaenocephalinae Matthews 1899, Phalacrinae Guillebeau 1892. Twenty-eight new generic synonymies are …

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Exploring The French Flute School In North America: An Examination Of The Pedagogical Materials Of Georges Barrère, Marcel Moyse, And René Le Roy, Sarah Kate Gearheart Jan 2011

Exploring The French Flute School In North America: An Examination Of The Pedagogical Materials Of Georges Barrère, Marcel Moyse, And René Le Roy, Sarah Kate Gearheart

LSU Doctoral Dissertations

The discussions that surround the topic of the French flute school and its approach to flute playing have yielded many conflicting assessments. Specifically, different opinions regarding who carried on the French school’s tradition of flute playing have produced different ideas about its lasting influence. At the center of this topic is a lack of clarity as to what constitutes the pedagogical approach that Paul Taffanel initiated and passed on to his flute students at the Paris Conservatory. In order to determine what this approach consists of as well as who passed it on, this study presents an examination of the …

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Formation And Stabilization Of Combustion-Generated Environmentally Persistent Free Radicals On Transition Metal Oxides Supported On Silica, Eric Warren Pimentel Vejerano Jan 2011

Formation And Stabilization Of Combustion-Generated Environmentally Persistent Free Radicals On Transition Metal Oxides Supported On Silica, Eric Warren Pimentel Vejerano

LSU Doctoral Dissertations

The formation of environmentally persistent free radicals in combustion system was investigated from chemisorptions of chlorine- and hydroxy-substituted benzenes on transition metal oxide surface under post-combustion conditions. This manuscript reports the formation of EPFRs on silica particles containing 5% Fe(III)2O3, Ni(II)O, and Zn(II)O. The EPFRs are formed by the chemisorption of substituted aromatic molecular adsorbates on the metal cation center followed by electron transfer from the adsorbate to the metal ion at temperatures from 150 to 400 oC. Depending on the nature of the adsorbate and the temperature, two organic EPFRs were formed: a phenoxyl-type radical, which has a lower …

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An Aloha State Of Mind: Performing Hawaiian Cultural Identities, Kirsten E. Ogden Jan 2011

An Aloha State Of Mind: Performing Hawaiian Cultural Identities, Kirsten E. Ogden

LSU Doctoral Dissertations

There are many Hawaiian identities currently in effect. This dissertation explores several representative and contested Hawaiian identities, and how these identities develop through key performances, plays, and other representational practices by Hawaiians and by Locals. Due to its unique situation as one of only two U.S. states formerly with its own government, and as one of only two U.S. states not connected to the main land-mass of the United States, Hawaiian identity is complicated by multiple factors: sanitized historical constructions, sovereignty, intermingling ethnic identities, tourism, and reclaimed cultural practices. Additionally, Hawaiians as a native people hold a unique place in …

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Structural And Functional Insights Of Human 5-Lipoxygenase, Nathaniel Carson Gilbert Jan 2011

Structural And Functional Insights Of Human 5-Lipoxygenase, Nathaniel Carson Gilbert

LSU Doctoral Dissertations

This work describes the structure of human 5-lipoxygenase (5-LOX) (Gilbert, Bartlett et al. 2011) and the techniques required to ascertain the structure. 5-LOX is a notoriously unstable enzyme with important biological functions. The human 5-LOX has been implicated in many disease states including asthma, atherosclerosis and cancer. Part of 5-LOX biology is the inherent instability of the enzyme, which is thought to help regulate the production of its pro-inflammatory products, the leukotrienes. Our objective was stabilizing the enzyme for in vitro studies without affecting catalytic fidelity. I was able to quantitate stabilizing and destabilizing point mutations of 5-LOX by thermal …

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Droplet Motion On Miniaturized Ratchets, Jeong Tae Ok Jan 2011

Droplet Motion On Miniaturized Ratchets, Jeong Tae Ok

LSU Doctoral Dissertations

The main objective of this study is to evaluate the feasibility of using miniaturized asymmetric structures to move liquid droplets and understand the driving mechanism. We developed the fabrication process for large area topological ratchets with the period ranging from millimeter down to sub-micrometer using micromachining techniques. Non-wetting superhydrophobic surfaces were successfully fabricated using soft UV or thermal nanoimprint lithography, reactive ion etching by oxygen plasma, and chemical surface modification by fluorinated silane vapor deposition. An accurate and reproducible experimental setup equipped with high speed camera and automatic injection system was established. Image processing tools allowed us to obtain various …

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An Easy And Straightforward Route For The Synthesis Of Disubstituted Imidazoles, Debasish Bandyopadhyay, Yvette Mora, Jesus A. Trevino-Cantu, Bimal K. Banik Jan 2011

An Easy And Straightforward Route For The Synthesis Of Disubstituted Imidazoles, Debasish Bandyopadhyay, Yvette Mora, Jesus A. Trevino-Cantu, Bimal K. Banik

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

A simple and high-yielding procedure has been developed to synthesize disubstituted imidalozes using phenyl glyoxal monohydrate, ammonium acetate and aldehydes. This synthetic protocol allows the preparation of a variety of 2,4 (s)-disubstituted imidalozes without using any catalyst, expensive or sensitive reagents. A corresponding 2-aroyl-4(s) disubstituted imidalozes derivative has also been isolated as byproduct. The effects of solvents have also been studied.

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Microwave-Induced N-Bromosuccinimide-Mediated Novel Synthesis Of Pyrroles Via Paal-Knorr Reaction, Rosemarie Andoh-Baidoo, Roberto Danso, Sanghamitra Mukherjee, Debasish Bandyopadhyay, Bimal K. Banik Jan 2011

Microwave-Induced N-Bromosuccinimide-Mediated Novel Synthesis Of Pyrroles Via Paal-Knorr Reaction, Rosemarie Andoh-Baidoo, Roberto Danso, Sanghamitra Mukherjee, Debasish Bandyopadhyay, Bimal K. Banik

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

An expeditious rapid synthesis of N-substituted pyrroles using microwave-induced Nbromosuccinimide- mediated solventless reaction of 2,5-hexanedione and primary amine has been accomplished.

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Microwave-Induced Indium-Catalyzed Synthesis Of Pyrrole Fused With Indoline In Water, Dina Abrego, Debasish Bandyopadhyay, Bimal K. Banik Jan 2011

Microwave-Induced Indium-Catalyzed Synthesis Of Pyrrole Fused With Indoline In Water, Dina Abrego, Debasish Bandyopadhyay, Bimal K. Banik

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

An expeditious microwave-induced indium metal-catalyzed synthesis of pyrrole fused with indoline in water is developed by reacting isatin and 4-hydroxyproline.

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Microwave-Induced Bismuth Nitrate-Catalyzed Expeditious Enamination Of Β-Dicarbonyl Compounds Under Solvent-Free Conditions, Debasish Bandyopadhyay, Bimal K. Banik Jan 2011

Microwave-Induced Bismuth Nitrate-Catalyzed Expeditious Enamination Of Β-Dicarbonyl Compounds Under Solvent-Free Conditions, Debasish Bandyopadhyay, Bimal K. Banik

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

Bismuth nitrate-catalyzed, automated microwave-assisted expeditious synthesis of β- enaminones and β-enaminoesters has been carried out in an efficient manner under solvent-free condition. The reaction is general for primary, secondary (cyclic, heterocyclic and acyclic), benzylic as well as aromatic amines.

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Effects Of Leaf Excision And Sample Storage Methods On Spectral Reflectance By Foliage Of Giant Reed, Arundo Donax, Kenneth R. Summy, Jonathan Lieman, Yuridia Patricia Gandy, Adarsh Mamachen, Ashish Mamachen, John A. Goolsby, Patricia J. Moran Jan 2011

Effects Of Leaf Excision And Sample Storage Methods On Spectral Reflectance By Foliage Of Giant Reed, Arundo Donax, Kenneth R. Summy, Jonathan Lieman, Yuridia Patricia Gandy, Adarsh Mamachen, Ashish Mamachen, John A. Goolsby, Patricia J. Moran

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Research was conducted to evaluate the effects of leaf excision and sample storage methods on spectral reflectance by foliage of giant reed, Arundo donax, an invasive weed which has caused extensive damage in many areas of the Rio Grande Basin in Texas and Mexico. Within 24 hours of excision, A. donax leaves exposed to ambient laboratory conditions (room temperature under natural lighting conditions) exhibited two trends indicative of physiological stress: 1) small but significant increases in reflectance of blue and red wavelengths (400-500 nm and 600-700 nm, respectively) and 2) a substantial reduction in reflectance of near-infrared (NIR) wavelengths (700-1,100 …

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Fp-11-06 Adoption Motivations Among U.S. Parents, Elizabeth J. Ela Jan 2011

Fp-11-06 Adoption Motivations Among U.S. Parents, Elizabeth J. Ela

National Center for Family and Marriage Research Family Profiles

No abstract provided.

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Right-Wing Ecology In Germany: Assessing The Historical Legacy, Peter Staudenmaier Jan 2011

Right-Wing Ecology In Germany: Assessing The Historical Legacy, Peter Staudenmaier

History Faculty Research and Publications

No abstract provided.

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Vitamin D Deficiency And Sun Avoidance Among University Students At Abu Dhabi, United Arab Emirates, Fatme Al Anouti, Justin Thomas, Laila Abdel-Wareth, Jaishen Rajah, William B. Grant, Afrozul Haq Jan 2011

Vitamin D Deficiency And Sun Avoidance Among University Students At Abu Dhabi, United Arab Emirates, Fatme Al Anouti, Justin Thomas, Laila Abdel-Wareth, Jaishen Rajah, William B. Grant, Afrozul Haq

All Works

This study offers evidence that vitamin D deficiency could be a major public health burden among young Emirati adults, mostly because of sun deprivation in a sun-blessed country. This study included a random sample of 138 females and 70 males tested for serum 25-hydroxyvitamin D [25(OH)D] status. To further evaluate the predictors of vitamin D status in this population, the study examined diet, obesity and sun exposure. In summer, the mean serum 25(OH)D concentration for females was 20.9 ± 14.9 nmol/L, whereas that for males was 27.3 ± 15.7 nmol/L. Females scored significantly higher than males on the sun avoidance …

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The Effect Of The Release Of A Thermal Stressor On Bluegill (Lepomis Macrochirus) Morphology And Physiology, Jessica Eagar Jan 2011

The Effect Of The Release Of A Thermal Stressor On Bluegill (Lepomis Macrochirus) Morphology And Physiology, Jessica Eagar

All ETDs from UAB

Temperature is considered a very important abiotic factor in fish communities. An increase in water temperature, as is found with the use of nuclear production reactors, can act as a stressor in aquatic systems. The P-reactor, operational from 1954-1988, on the Savannah River Site near Aiken, South Carolina, utilized the Par Pond Reservoir System as part of its cooling mechanisms. During reactor operation, heated effluents were displaced into Pond C, causing the water to be heated to around 45° C. Fischer (1994) found that the bluegill population had adapted with changes to their morphology and physiology. The bluegill from the …

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Role Of The Cardiomyocyte Circadian Clock In Modulating Myocardial Physiology And Pathophysiology, David Joseph Durgan Jan 2011

Role Of The Cardiomyocyte Circadian Clock In Modulating Myocardial Physiology And Pathophysiology, David Joseph Durgan

All ETDs from UAB

It is well established that multiple parameters of cardiovascular physiology and pathophysiology exhibit diurnal variations. For example, human heart rate and blood pressure peak during the morning and trough in the evening. Similarly, there is a morning prevalence for the onset of multiple adverse cardiovascular events, including myocardial ischemia, arrhythmias, and sudden cardiac death. Traditionally these rhythms have been attributed to rhythms in neurohumoral stimulation. However recent identification of the circadian clock mechanism in cardiovascular relevant cell types, including the cardiomyocyte, has prompted investigation into its role in modulating myocardial physiology and pathophysiology over the course of the day. Preliminary …

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From Brown To Bakke: Race Change And The Birmingham City Schools, 1963-1983, Johnmark Allen Edwards Jan 2011

From Brown To Bakke: Race Change And The Birmingham City Schools, 1963-1983, Johnmark Allen Edwards

All ETDs from UAB

When in 1954 the US Supreme Court declared that "separate but equal" was inherently not equal, every segregated school system in America was supposed to desegregate. This was easier said than done, and more successful in some systems than others. Here is a case study of that episode in American history focused on Birmingham, Alabama. This city's tumultuous road to educational desegregation unfolded in four phases: non-compliance (1954-1963), incremental desegregation (1963-1967), "freedom of choice" (1967-1970) and zoned integration (1970-1983). In this context, the thesis has three objectives: first, to explore how people of Birmingham - black and white, male and …

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The Role Of The Classical Nf-Kb Pathway In Hsc Self-Renewal And Acute Myeloid Leukemia, Robert Jason Flynn Jan 2011

The Role Of The Classical Nf-Kb Pathway In Hsc Self-Renewal And Acute Myeloid Leukemia, Robert Jason Flynn

All ETDs from UAB

Acute myeloid leukemia (AML) comprises approximately 25% of newly diagnosed cases of leukemia each year. The constitutive activation of the classical NF-κB signaling pathway has been observed in up to 70% of AML cases, and could be due to mutations upstream involving the PI3K-Akt cascade, which is also constitutively active in a majority of cases. In mice, constitutive activation of Akt either through deletion of the negative regulator of PI3K-Akt, PTEN, or by expression of Myr-Akt induces rapid stem cell loss along with a lethal, transplantable myeloproliferative disorder and AML. These studies show that constitutive Akt and NF-κB signaling distinguish …

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Occupational Stress In Veterinary Support Staff, Sandra Morales Foster Jan 2011

Occupational Stress In Veterinary Support Staff, Sandra Morales Foster

All ETDs from UAB

OCCUPATIONAL STRESS IN VETERINARY SUPPORT STAFF Sandra Morales Foster DOCTOR OF PUBLIC HEALTH ABSTRACT Limited information exists about veterinary support staff and the occupational stressors of this workforce. Concern for workers in occupations of high or prolonged stress such as caregivers in hospitals and emergency situations has been noted in many studies. Occupational stress can cause harmful physical and emotional outcomes when the homeostatic balance is upset. This study explored occupational stress, health status, and coping strategies of veterinary support staff. A mixed-method collected quantitative and qualitative data. Demographic information and three validated instruments were ad-ministered using a web-based survey; …

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The Study Of Intracellular Signaling Pathways In Schizophrenia, Adam Funk Jan 2011

The Study Of Intracellular Signaling Pathways In Schizophrenia, Adam Funk

All ETDs from UAB

INTRACELLULAR SIGNALING AND INTEGRATION ABNORMALITIES IN SCHIZOPHRENIA Adam J. Funk DEPARTMENT OF NEUROBIOLOGY ABSTRACT The pathophysiology of schizophrenia is complex and diverse, with many classes of receptors, neurotransmitters, and brain regions implicated in this illness. The many hypotheses proposed have yet to fully explain the heterogeneity of the genetic, postmor-tem, and clinical evidence. It is the goal of this dissertation to integrate the current hy-potheses of schizophrenia into a unified hypothesis of abnormal intracellular signaling and signal integration. Inconsistencies in genetic and postmortem findings suggest that the development of schizophrenia is multifaceted, and the heterogeneity of symptoms supports the hypothesis …

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An Evaluation Of Dietary Lipids On Growth Performance In The Sea Urchin, Lytechinus Variegatus (Echinodermata: Echinoidea), Victoria K. Gibbs Jan 2011

An Evaluation Of Dietary Lipids On Growth Performance In The Sea Urchin, Lytechinus Variegatus (Echinodermata: Echinoidea), Victoria K. Gibbs

All ETDs from UAB

Sea urchin fisheries are declining across the world, and sea urchin aquaculture will be an important alternative to wild-caught fisheries. A significant aspect of a successful sea urchin culture operation is the formulation of nutritionally-complete diets with the potential to support optimal growth and health to sea urchins at different life stages. Due to the ecological variety of sea urchin species, the inclusion level and source of the various macronutrients and micronutrients needed for a complete diet must be carefully considered for each sea urchin species. Lytechinus variegatus is an echinoid species commonly found in the northern Gulf of Mexico, …

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Human Cytomegalovirus Ul97 Kinase Activity Modifies Cell Cycle Checkpoint Regulators, Rachel Brooke Gill Jan 2011

Human Cytomegalovirus Ul97 Kinase Activity Modifies Cell Cycle Checkpoint Regulators, Rachel Brooke Gill

All ETDs from UAB

Human cytomegalovirus (CMV) infection results in destructive infections in neonates and immunocompromised individuals. Being the primary congenital infection in the United States, it can often result in permanent neurological deficits in infants. The current therapies for CMV infections all target the viral DNA polymerase and also have dose-limiting toxicities. Isolates resistant to ganciclovir (GCV), the therapy of choice, can sometimes overwhelm immunocompromised hosts. Better therapies for this infection are required. The CMV UL97 kinase is a key enzyme in the treatment of CMV infection because it phosphorylates GCV. Additionally, maribavir (MBV) specifically inhibits UL97 kinase activity and inhibits viral replication. …

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Oxidative Stress And Xanthine Oxidase In Acute And Chronic Cardiac Volume Overload In Rats, James Douglas Gladden Jan 2011

Oxidative Stress And Xanthine Oxidase In Acute And Chronic Cardiac Volume Overload In Rats, James Douglas Gladden

All ETDs from UAB

Mechanisms of left ventricular dysfunction in cardiac volume overload (VO) are not well understood and there is no medical therapy. Cardiac VO is marked by eccentric remodeling and contractile dysfunction ultimately resulting in cardiac failure. Oxidative stress is implicated in the pathophysiology of heart failure and recent evidence suggests xanthine oxidase (XO) plays a role in VO. To study VO, we used a rat model of aortocaval fistula (ACF). ACF results in early diastolic stress on the left ventricle (LV) and recapitulates the progressive nature of heart failure with contractile function being initially maintained and then depressed by 6 weeks. …

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