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Analysis Of Endocrine Disrupting Compounds In Wastewater Treatment Plants: A Perspective Of Trans-Boundary Waterborne Pollution, Roberto De La Torre

Open Access Theses & Dissertations

Recent decades have brought an increasing concern of potential adverse human and ecological health effects resulting from Endocrine Disruptor Compounds (EDCs). In particular from new emerging compounds such as natural estrogens (e.g., 17©¬-estradiol, estrone), synthetic estrogens (e.g., 17Â¥á-ethynylestradiol), bisphenol A (BPA), nonylphenol ethoxylates (NPEOS), and nonylphenol (NP). These chemicals which are also known as organic wastewater contaminants are released directly to the environment after passing through wastewater treatment plants (WWTPs), which often are not designed to remove them from the effluent. The occurrence of the aforementioned compounds in surface water is becoming of increasing concern worldwide, and has led to …

Hemispheric Asymmetry Of The Affective Priming Effect, David R. Herring

Open Access Theses & Dissertations

The present study examined the role of prime strength on the lateralized affective priming effect. Participants were presented unilateral primes (i.e., either to the left or right visual field) and then made evaluative decisions on centrally presented targets. Across both experiments, the affective congruity effect occurred for high, but not low, arousing primes. In Experiment 1, when stimuli were primes or targets but not both, the affective priming effect occurred in the right visual field (left hemisphere) for high arousing primes. However in Experiment 2, when stimuli were presented as both primes and targets receiving repeated parafoveal and foveal exposure …

The Energy Landscape Analysis Of Cancer Mutations In Protein Kinases, Anshuman Dixit, Gennady M. Verkhivker

Mathematics, Physics, and Computer Science Faculty Articles and Research

The growing interest in quantifying the molecular basis of protein kinase activation and allosteric regulation by cancer mutations has fueled computational studies of allosteric signaling in protein kinases. In the present study, we combined computer simulations and the energy landscape analysis of protein kinases to characterize the interplay between oncogenic mutations and locally frustrated sites as important catalysts of allostetric kinase activation. While structurally rigid kinase core constitutes a minimally frustrated hub of the catalytic domain, locally frustrated residue clusters, whose interaction networks are not energetically optimized, are prone to dynamic modulation and could enable allosteric conformational transitions. The results …

Identifying Factors That Increase The Likelihood For Alcohol-Induced Blackouts In The Prepartying Context, Joseph W. Labrie, Justin F. Hummer, Shannon Kenney, Andrew Lac, Eric Pedersen

Heads Up!

The present study examined risk factors related to “blacking out” (e.g., temporary periods of memory loss during drinking) during preparty drinking events (i.e., pregaming, predrinking). Participants were students from two universities on the West Coast who reported past month prepartying (N = 2,546) in online surveys administered in the fall of 2008. Among these students, 25% (n = 636) reported blacking out during at least one occasion in which they prepartied in the past month. A logistic regression model underscored that Greek student affiliation, family history of alcohol abuse, frequency of prepartying, and both playing drinking games and …

Ovarian Hormones, Aging And Stress On Hippocampal Synaptic Plasticity, Michael R. Foy

Psychological Science Faculty Works

The ovarian steroid hormones estradiol and progesterone regulate a wide variety of non-reproductive functions in the central nervous system by interacting with molecular and cellular processes. A growing literature from studies using rodent models suggests that 17β-estradiol, the most potent of the biologically relevant estrogens, enhances synaptic transmission and the magnitude of long-term potentiation recorded from in vitro hippocampal slices. In contrast, progesterone has been shown to decrease synaptic transmission and reduce hippocampal long-term potentiation in this model system. Hippocampal long-term depression, another form of synaptic plasticity, occurs more prominently in slices from aged rats. A decrease in long-term potentiation …

Heavy Episodic Drinking On College Campuses: Does Changing The Legal Drinking Age Make A Difference?, Jawaid W. Rasul, Robert G. Rommel, Geoffrey M. Jacquez, Ben G. Fitzpatrick, Azmy S. Ackleh, Neal Simonsen, Richard Scribner

Mathematics, Statistics and Data Science Faculty Works

This article extends the compartmental model previously developed by Scribner et al. in the context of college drinking to a mathematical model of the consequences of lowering the legal drinking age. Method: Using data available from 32 U.S. campuses, the analyses separate underage and legal age drinking groups into an eight-compartment model with different alcohol availability (wetness) for the underage and legal age groups. The model evaluates the likelihood that underage students will incorrectly perceive normative drinking levels to be higher than they actually are (i.e., misperception) and adjust their drinking accordingly by varying the interaction between underage students in …

Outreach And Citizen Engagement In The Winnicut River Watershed: A Participatory Action Study, Jillan Scahill Farrell

Master's Theses and Capstones

Recently, citizen initiated watershed management has seen a rise in popularity. Citizen watershed groups have been created across the country especially in New England. These groups advocate for protections and responsible watershed-wide management. Each watershed contains a certain set of unique ecological, social, regulatory and problem situations and therefore each watershed organization requires a full mapping process of the policy and social process as well as the ecological and problem situation before engaging the citizens. This research explores the Winnicut River watershed in southeastern New Hampshire. Covering three communities and representing a subwatershed of the Great Bay coastal watershed this …

Short Peptides As Inhibitors Of Amyloid Aggregation, Bradley Neddenriep, Anastasia Calciano, Daniel Conti, Erin Sauve, Marissa Paterson, Edward Bruno, David A. Moffet

Chemistry and Biochemistry Faculty Works

The misfolding and aggregation of proteins into amyloid has been linked to a variety of age-related diseases. Aggregation of proteins, such as Aβ in Alzheimer's disease and Islet Amyloid Polypeptide (IAPP, amylin) in type 2 diabetes, appears to lead to the formation of toxic assemblies. These assemblies range in size from small oligomers (2-8 proteins) to large fibrils (thousands of proteins). It remains unclear how these amyloidogenic proteins misfold and form toxic species, but growing evidence suggests that inhibiting the aggregation of these proteins could slow, if not prevent altogether, the progression of these diseases. We describe the use of …

The Down Low And The Sexuality Of Race, Brad E. Stone

Philosophy Faculty Works

There has been much interest in the phenomenon called "the Down Low," in which "otherwise heterosexual" African American men have sex with other black men. This essay explores the biopolitics at play in the media’s curiosity about the Down Low. The Down Low serves as a critical, transgressive heterotopia that reveals the codetermination of racism, sexism, and heterosexism in black male sexuality.

Philosophy And Theology: Notes On Fetal Interventions, Christopher Kaczor

Philosophy Faculty Works

In the article, the author discusses the issues involving the ethics of fetal surgery. He cites the works of scholars Frank A. Chervenak and Laurence B. McCullough on the ethical questions on fetal surgery. The positions of such pro-abortion individuals as Peter Singer, Michael Tooley and David Boonin on the issue of fetal homicide are also cited.

Relationships Between Physiological Characteristics And Trace Metal Body Burdens Of Banded Garden Spiders Argiope Trifasciata (Araneae, Araneidae), Martina Ramirez, Jeremy Mccallum, James M. Landry, Viviana A. Vallin, Sarah H. Fukui, Heidi E. Gergus, Jaclyn D. Torres, Charisse L. Sy

Biology Faculty Works

Banded garden spiders (Argiope trifasciata) were collected at the Ballona Wetlands, a metal contaminated salt marsh. The relationship between spider body size and individual metal loads was investigated. Biochemical markers were identified in spider fecal material and found to correlate to body metal levels. Body metal dry weight concentrations of Cd, Cr, Cu, Zn and total metals in female A. trifasciata exhibited distinct patterns of spatial and annual variation during 2006 and 2007. Spider body size was homogeneous across sites in both years, while increased Cd and Cr concentrations were sometimes associated with a reduction in spider size, though the …

Urbanization, Water Quality, And The Regulated Landscape, Dave Owen

University of Colorado Law Review

Watershed scientists frequently describe urbanization as a primary cause of water quality degradation, and recent studies conclude that even in lightly-developed watersheds, urbanization often precludes attainment of water quality standards. This Article considers legal responses to this pervasive problem. It explains why traditional legal measures have been ineffective, and it evaluates several recent innovations piloted in the northeastern United States. These innovations are potentially applicable across the nation. Specifically, the innovations involve using impervious cover total maximum daily loads, residual designation authority, and collective permitting to expand, intensify, and modify regulatory control of urban stormwater. More generally, the innovations involve …

Rethinking Parental Incarceration, Sarah Abramowicz

University of Colorado Law Review

Recent changes in sentencing law, in the wake of cases interpreting Blakely v. Washington and United States v. Booker, have raised the possibility that courts sentencing parents may take children's interests into account more extensively than had previously been permissible. Now is thus an opportune time to reevaluate the merits of considering children's interests when sentencing parents. This Article uses the perspective of family law to offer a new rationale for, and a new approach to, taking children's interests into account when sentencing their parents. It does so by bringing out the connection between the debate over parental incarceration and …

Prenatal Programming Of Human Neurological Function, Curt A. Sandman, Elyssia Poggi Davis, Claudia Buss, Laura M. Glynn

Psychology Faculty Articles and Research

The human placenta expresses the genes for proopiomelanocortin and the major stress hormone, corticotropin-releasing hormone (CRH), profoundly altering the "fight or flight" stress system in mother and fetus. As pregnancy progresses, the levels of these stress hormones, including maternal cortisol, increase dramatically. These endocrine changes are important for fetal maturation, but if the levels are altered (e.g., in response to stress), they influence (program) the fetal nervous system with long-term consequences. The evidence indicates that fetal exposure to elevated levels of stress hormones (i) delays fetal nervous system maturation, (ii) restricts the neuromuscular development and alters the stress response of …

Natural Product Inhibitors Of Rhodesain : The Major Cysteine Protease Of Trypanosoma Brucei, Ifedayo Victor Ogungbe

Dissertations

No abstract provided.

Traveling Wave Fronts For A Diffusive Competition Model With Time Delay, Yinshu Wu

Dissertations

No abstract provided.

Fast Localized Wavefront Correction Using Area-Mapped Phase-Shift Interferometry, Gunnsteinn Hall, Gabriel C. Spalding, Paul J. Campagnola, John G. White, Kevin W. Eliceiri

Physics Faculty Scholarship

No abstract provided.

Not Of Woman Born: A Scientific Fantasy, Jennifer S. Hendricks

Case Western Reserve Law Review

No abstract provided.

Armstrong Atlantic State University 2011 Fact Book, Armstrong State University

Armstrong Office of Institutional Research: Armstrong Fact Books (Archived)

No abstract provided.

Physical Transport And Chemical Behavior Of Dispersed Oil, James R. Payne, C. J. Beegle-Krause

Coastal Response Research Center

During response operations, scientific information is provided to decision makers, such as the Federal On-Scene Coordinator (FOSC), state and federal trustees, and the public. The decision to use chemical dispersants during a response is made among all these parties, and during the Deepwater Horizon (DWH) oil spill the dispersant discussion included both surface and subsurface application of chemical dispersants. This paper is intended to provide perspective on research needs considered pre- and post-DWH oil spill related to response modeling and data collection needs for decision support of dispersant application and its potential effects. Given time constraints for implementing models and …

The Selfish Patent, Bratislov Stankovic, Mirjana Stankovic

Journal of Law, Technology, & the Internet

No abstract provided.

“At Night, I Cross Behind The Enemy Lines”: Reaching The Negotiating Table In The Age Of Fast Communication, Cesar Rebellon

The University Dialogue

No abstract provided.

Reaching Disagreement, David R. Hiley

The University Dialogue

No abstract provided.

Degradation Of Dispersants And Dispersed Oil, Kenneth Lee

Coastal Response Research Center

Chemical oil dispersants are proprietary mixtures of surfactants and solvents which are directly applied to a spill in order to reduce the natural attractive forces of the oil. When oil treated with dispersants is exposed to mixing energy, typically from wind and wave action, it is broken up into small droplets which may then become entrained in the water column (Li et al., 2009a; Li et al., 2009b; Li, 2008; Lunel, 1995). Many of these droplets are small enough to be neutrally buoyant, and therefore, advection and diffusion forces dilute the plume and transport the droplets far from the site …

Oil Dispersants And Human Health Effects, James P. Fabisiak, Bernard Goldstein

Coastal Response Research Center

The explosion and subsequent blowout of the Deepwater Horizon (DWH) offshore drilling rig on April 20, 2010, led to the largest accidental offshore oil spill since the advent of the petroleum industry, dwarfed only by the deliberate release of crude oil by Iraqi forces during the Persian Gulf War. Over the time until the well was capped on July 15, approximately 200 million gallons of oil spilled into the Gulf of Mexico from the ocean floor beneath the well site located approximately 50 miles off the coast of Louisiana. For perspective, this amount is nearly 20 times the amount of …

Shifting Patterns Of Natural Variation In The Nuclear Genome Of Caenorhabditis Elegans, Eleanne Solorzano, Kazufusa Okamoto, Pushpa Datla, Way Sung, R. D. Bergeron, W. Kelley Thomas

Hubbard Center for Genome Studies (HCGS)

Background: Genome wide analysis of variation within a species can reveal the evolution of fundamental biological processes such as mutation, recombination, and natural selection. We compare genome wide sequence differences between two independent isolates of the nematode Caenorhabditis elegans (CB4856 and CB4858) and the reference genome (N2). Results: The base substitution pattern when comparing N2 against CB4858 reveals a transition over transversion bias (1.32:1) that is not present in CB4856. In CB4856, there is a significant bias in the direction of base substitution. The frequency of A or T bases in N2 that are G or C bases in CB4856 …

Dispersants And Risk Communication, Ed Levine, J. Steven Picou

Coastal Response Research Center

Risk communications is a research area of the social sciences which is closely associated with human dimensions and external communications. External communications, traditionally in the purview of public affairs, may have multiple purposes including influencing public beliefs, opinions, and judgments about the incident.

There are many approaches toward risk communications. Some of them focus on improving the way external communications about risks are conducted, e.g., developing better messages, and some focus on the content of risk communications, that is, sharing technical information to support the assessment of the potential for risks.

Quantifying Agonist Activity At G Protein-Coupled Receptors, Frederick J. Ehlert, Hinako Suga, Michael T. Griffin

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

When an agonist activates a population of G protein-coupled receptors (GPCRs), it elicits a signaling pathway that culminates in the response of the cell or tissue. This process can be analyzed at the level of a single receptor, a population of receptors, or a downstream response. Here we describe how to analyze the downstream response to obtain an estimate of the agonist affinity constant for the active state of single receptors.

Receptors behave as quantal switches that alternate between active and inactive states (Figure 1). The active state interacts with specific G proteins or other signaling partners. In the absence …

Diversity And Distributon Of Vibrio Parahaemolyticus, A Bacterioplankton Species Of Concern For Human Health, In Rhode Island, Annie M. Cox

Open Access Dissertations

Vibrio parahaemolyticus, a naturally occurring bacterium in coastal marine environments, can cause a severe gastrointestinal illness in humans when contaminated raw or undercooked seafood is consumed. Because of their potential for human illness, V. parahaemolyticus pose a threat to aquaculture through loss of business due to unfavorable publicity. Very little is known about V. parahaemolyticus in Narragansett Bay (Rhode Island); the only recently published study found a low concentration of total V. parahaemolyticus in Narragansett Bay water in the 1980s, and no pathogenic (Kanagawa-positive) strains were isolated. Thus far, illnesses due to V. parahaemolyticus in Rhode Island and the …

Modified Chromenes As Precursors To Taar Regulators, Jonathan Lehmann, Matthew Hart

Student Summer Scholars Manuscripts

200 million people worldwide are living with a thyroid disorder related to a hormonal imbalance. Symptoms of this imbalance include deviations from normal heart rates and metabolic rates. A chemical messenger known as T3 has been shown to raise cardiac and metabolic rates, but this takes place on a timescale of hours. However, recent discoveries have revealed that a different thyroid hormone known as T1AM is capable of affecting some of these same physiological conditions in a matter of minutes. T1AM is a potent, selective agonist for the Trace Amine Associated Receptor (TAAR). Several studies have probed the structural basis …