Digital Commons Network^™

Feminists And Firearms: Why Are So Many Women Anti-Choice?, Lindsay K. Charles

Cardozo Journal of Equal Rights & Social Justice

The article argues that gun rights should be recognized as a feminist issue, emphasizing women's autonomy, safety, and equality. It challenges the conventional narrative that gun control aligns with feminist values, asserting that disarming women disempowers them and undermines their ability to defend themselves. The author advocates for women's right to bear arms as a means of self-defense, drawing parallels to other feminist issues like abortion, and proposes a rebuttable presumption for issuing concealed carry permits to women.

Sirtuin-Mediated Nuclear Differentiation And Programmed Degradation In Tetrahymena, Kristin M. Slade, Sydney Freggiaro, Kyle A. Cottrell, Joshua J. Smith, Emily A. Wiley

College of Health and Human Services

Background: The NAD+-dependent histone deacetylases, known as "sirtuins", participate in a variety of processes critical for single- and multi-cellular life. Recent studies have elucidated the importance of sirtuin activity in development, aging, and disease; yet, underlying mechanistic pathways are not well understood. Specific sirtuins influence chromatin structure and gene expression, but differences in their pathways as they relate to distinct chromatin functions are just beginning to emerge. To further define the range of global chromatin changes dependent on sirtuins, unique biological features of the ciliated protozoan Tetrahymena thermophila can be exploited. This system offers clear spatial and temporal separation of …

The Role Of Nck In Pancreatic Secretion, Cole Lightfoot

Honors Capstones

In the body, secretion is a vital process providing the release of many different and important macromolecular compounds. Using the pancreas as a model secretory organ, research was conducted pertaining to pancreatic exocytosis and the signal transduction system that controls it. The specific focus of the research is to better understand the role of Nck, a ubiquitous adaptor protein, in cytoskeleton reorganization and pancreatic secretion. The goal of the experiments conducted is to prove that upon stimulation of pancreatic acinar cells, Nck recruits to the secretory vesicles. Nck facilitates protein-protein interactions and acts as a regulator of cytoskeletal activation-dependent processes. …

Customs Law, Yohai Baisburd, John Boscariol, Cyndee B. Todgham Cherniak, David G. Forgue, Laura Fraedrich, Geoffrey M. Goodale, Gwendolyn Hassan, Greg Kanargelidis, Christine H. Martinez, Martin Masse, Matthew T. Mcgrath, Cortney O'Toole Morgan, Julia S. Padierna-Peralta, David Salkeld, Deep Sengupta, Christopher H. Skinner

The International Lawyer

No abstract provided.

We Could Tell You, But Then We'd Have To Kill You: How Indigenous Cultural Secrecy Impedes The Protection Of Natural Cultural Heritage In The United States, Audrey Mense

Chicago-Kent Journal of International and Comparative Law

No abstract provided.

Virtualization And Self-Organization For Utility Computing, Mehdi Saleh

Electronic Theses and Dissertations

We present an alternative paradigm for utility computing when the delivery of service is subject to binding contracts; the solution we propose is based on resource virtualization and a selfmanagement scheme. A virtual cloud aggregates set virtual machines to work in concert for the tasks specified by the service agreement. A first step for the establishment of a virtual cloud is to create a scale-free overlay network through a biased random walk; scale-free networks enjoy a set of remarkable properties such as: robustness against random failures, favorable scaling, and resilience to congestion, small diameter, and average path length. Constrains such …

The Performance And Power Impact Of Using Multiple Dram Address Mapping Schemes In Multicore Processors, Rami Jadaa

Electronic Theses and Dissertations

Lowest-level cache misses are satisfied by the main memory through a specific address mapping scheme that is hard-coded in the memory controller. A dynamic address mapping scheme technique is investigated to provide higher performance and lower power consumption, and a method to throttle memory to meet a specific power budget. Several experiments are conducted on single and multithreaded synthetic memory traces -to study extreme cases- and validate the usability of the proposed dynamic mapping scheme over the fixed one. Results show that applications’ performance varies according to the mapping scheme used, and a dynamic mapping scheme achieves up to 2x …

Tapeworms Of Elasmobranchs, Part Iii: A Monograph On The Phyllobothriidae (Platyhelminthes, Cestoda), Timothy R. Ruhnke

Bulletin of the University of Nebraska State Museum (1924–2023)

This monograph aims to provide information on the taxonomic status of all genera associated with the tetraphyllidean family Phyllobothriidae. Full treatments of the three valid species of the type genus, Phyllobothrium, in addition to the 47 valid species of Clistobothrium, Crossobothrium, Marsupiobothrium, Monorygma, Nandocestus, Orectolobicestus, Orygmatobothrium, Paraorygmatobothrium, Ruhnkecestus, and Scyphophyllidium are provided, as is a taxonomic history of the family. Of the valid genera historically associated with the family, only Phyllobothrium is considered to be an unambiguous member of the family. The genera Bibursibothrium, Calyptrobothrium, Cardiobothrium, Clistobothrium, Crossobothrium, Doliobothrium, Flexibothrium, Marsupiobothrium, Monorygma, Nandocestus, Orectolobicestus, Orygmatobothrium, Paraorygmatobothrium, Ruhnkecestus, Scyphophyllidium …

The Impending Nuclear Disaster: Flaws In The International Counter-Proliferation Regime At Sea, Raul (Pete) Pedrozo

Loyola University Chicago International Law Review

No abstract provided.

The Destruction Of Mass Weapon Distribution: The United Nations Arms Trade Treaty & The Part America Must Play, Matthew Leavitt

Loyola University Chicago International Law Review

No abstract provided.

Death By A Thousand Cuts: Incorporating Cumulative Effects In Australia's Environment Protection And Biodiversity Conservation Act, Jessica T. Dales

Washington International Law Journal

The Environment Protection and Biodiversity Conservation Act 1999 (“EPBCA” or “the Act”) is the Australian government's keystone piece of environmental legislation. The EPBCA provides a legal framework to protect and manage nationally and internationally important flora, fauna, ecological communities, and heritage places—defined in the Act as matters of National Environmental Significance (“NES”). The Act comes into play when a proposed action has the potential to have a significant impact on a matter of national environmental significance. Although it has played a vital role in protecting Australia’s environment, the EPBCA does not explicitly address the cumulative impact of multiple actions on …

The Status In Eu Law Of International Agreements Concluded By Eu Member States, Allan Rosas

Fordham International Law Journal

This Essay will, first, provide a general discussion on the status in Union law of agreements concluded by EU Member States. Second, brief discussions will follow on the specific nature of agreements concluded between the Member States inter se as well as on the special status of agreements concluded before the Member State concerned became a member of the Union. Third, the main part of this Essay will address different categories of agreements concluded by Member States in order to provide a more refined picture of the legal relevance of such agreements for Union law. The final Section will provide …

Objective Physical Activity And Sleep Characteristic Measurements Using A Triaxial Accelerometer In Eight Year Olds, Susan Ann Harrington

Wayne State University Dissertations

Background: Secular trends demonstrate that young children are less active and sleep less. Inequity in an individual's energy balance is known to have poor health outcomes. Academic achievement, academic behavior, and weight status are proxy indicators for health and psychosocial outcomes in this study. Current guidelines in place for sleep and physical activity in childhood are the result of data collected in the form of self-reports. Quantification and qualification of physical activity dimensions and sleep characteristics are essential not only for the purpose of clearly establishing parameters but also for the intent of verifying optimal health outcomes and evaluating interventions …

The Process Of Autophagy In An In Vitro Model Of Myocardial Ischemia-Reperfusion Injury, Kadija Abounit

Wayne State University Dissertations

Autophagy has been implicated in the pathogenesis of myocardial ischemia-reperfusion (I/R) injury; however, it is not clear whether autophagy is beneficial or detrimental to cell survival. We hypothesized that autophagy is beneficial to cardiomyocytes during I/R and that the paucity of ATP may limit its occurrence. To test this hypothesis, we developed a model of ischemia (hypoxia) involving exposure of HL-1 murine atrial cardiomyocytes to two concentrations of oxygen (0.5% and 2.0%) and 2-deoxyglucose.

Hypoxia, irrespective of the oxygen concentration, caused a dramatic drop in cellular ATP and an increase in the phosphorylation of AMPK (an indication of energy starvation),. …

Boys' Masculinities In Three Adventure Physical Education Classes, Amy Tischler

Wayne State University Dissertations

The diminished state of youth health in the United States has been a rising concern over the past few decades (Fahlman, Dake, McCaughtry, & Martin, 2008; Krebs, Baker, & Greer, 2003). Headlines across the nation declare that children in the United States are getting heavier and most point to a lack of physical activity as the cause (Wechsler et al., 2004). Understanding adventure physical education might help to create physical education programs that captivate students so much so that they look forward to participating rather than enacting task avoidance strategies. In fact, physical education might empower students to be physically …

Mechanisms Of Alpha]-Synuclein-Induced Neurodegenertaion In Parkinson's Disease And Stroke, Cherine Belal

Electronic Theses and Dissertations

Parkinson’s disease (PD) is a debilitating neurodegenerative disorder affecting one million Americans. Despite its social and economic impact, the pathological cascades that lead to neuron dysfunction and degeneration in PD are poorly understood. Endoplasmic reticulum (ER) stress has been implicated as an initiator or contributing factor in neurodegenerative diseases including PD. The ER is an organelle central to protein folding and intracellular Ca2+ homeostasis. Perturbations of these functions result in ER stress and upregulation of ER stress proteins, of which some have been implicated in counteracting ER stress-induced cell death. The mechanisms that lead to ER stress and how ER …

Social Support And Health Outcomes In Adolescents Experiencing Homelessness And Poverty: A Test Of The Main Effect And Stress-Buffering Hypotheses, Danijela Zlatevski

Wayne State University Dissertations

The health benefit and stress-buffering effects of social support were examined. Homeless (N=250) and housed (N=148) adolescents were assessed in adolescence and again in early adulthood, providing longitudinal data to help understand how these social constructs may change and influence health. The study was designed to test Cohen and Wills (1985) main effect and stress-buffering hypotheses. Current findings provide some support for the main effect hypothesis and some more limited support for the stress-buffering effect of perceived social support on mental health. Specifically, a main effect was found at baseline for network social support on number of substance abuse symptoms. …

Racial/Cultural Identity Development In Foster Children Placed In Transracial Foster Homes, Vanessa Brooks Herd

Wayne State University Dissertations

This qualitative study was designed to identify how racial and cultural identity is developed and maintained in foster children who are placed in foster homes racially and culturally different than they are. The research questions included how the foster care system addresses racial identity issues and how foster parents assign meaning to the transracial foster care experience. Another area of interest was the preparation by the foster care system for foster parents to manage issues of racial identity. The pre-training curriculum for foster parents was subjected to a content analysis.

Effect Of Dimethylarginine Dimethylaminohydrolase In The Development Of Salt Sensitivity, Samar Abdulla Nasser

Wayne State University Dissertations

Salt sensitivity is associated with a rise in blood pressure (BP) occurring during sodium loading and/or a fall in BP during sodium restriction that exceeds random fluctuations in BP. Salt sensitivity is more common in African American than Caucasian hypertensives and is also present, in normotensive African Americans. The mechanism or mechanisms resulting in salt-sensitive hypertension are multiple and include both activation of the renin angiotensin system via increases in angiotensin II and reductions in the endogenous vasodilator, nitric oxide (NO). An important means of NO downregulation is through asymmetric dimethylarginine (ADMA), an endogenous NO inhibitor, which is largely metabolized …

Molecular Details Of The Mitochondrial Iron Sulfur Cluster Assembly Pathway, Swati Rawat

Wayne State University Dissertations

MOLECULAR DETAILS OF THE MITOCHONDRIAL IRON SULFUR CLUSTER ASSEMBLY PATHWAY

Iron-sulfur clusters are an important class of prosthetic group involved in electron transfer, enzyme catalysis, and regulation of gene expression. Their biosynthesis requires complex machinery located within the mitochondrion since free iron and sulfide are extremely toxic to the cell. Defects in this pathway results in several diseases such as Friedreich's Ataxia (FRDA), Sideroblastic Anemia and ISCU Myopathy. Therefore molecular details of the biogenesis pathway will provide deep insight in the pathway and treatment options for these diseases. FRDA is caused by deficiency of a single protein called as `Frataxin'. …

Chemical Synthesis Of Peptides And Peptide Thioesters, Indrajeet Sharma

Wayne State University Dissertations

This dissertation describes investigations toward the development of a new chemistry for the block synthesis of peptides and peptidyl thioesters. A direct approach for the Fmoc-SPPS of peptidyl thioesters is also delineated in this thesis.

In the first part of chapter one, the difficulty and importance of chemical synthesis of peptides is explained, and a brief survey of available methods is given. The second part of chapter one presents the challenges inherent in the synthesis of peptidyl thioesters by Fmoc-SPPS.

The second chapter outlines the investigations conducted towards the development of a new chemistry for epimerization-free block synthesis of peptides …

The Researcher Rat's Culture And Ease Of Access To The Publication Lever: Implications For The Patentability Of University Scientific Research, Joshua R. Nightingale

West Virginia Law Review

No abstract provided.

Visual Rhetoric And The Promotion Of Scientific Ideas: The Strange Case Of The Prion, Carol Reeves

Scholarship and Professional Work - LAS

In the field that investigates infectious brain diseases such as mad cow disease, the verbal and visual packaging of scientific visuals associated with identifying the agent, prion, its processes, and structure served the community ritual of establishing belief in a highly unorthodox phenomenon. Visual promotion fed into cultural expectations of single agents and simple processes, even though the actual agency and disease process have proven highly complex and perhaps unknowable.

Positive Selection Shaped The Convergent Evolution Of Independently Expanded Kallikrein Subfamilies Expressed In Mouse And Rat Saliva Proteomes, Robert C. Karn, Christina M. Laukaitis

Scholarship and Professional Work - LAS

We performed proteomics studies of salivas from the genome mouse (C57BL/6 strain) and the genome rat (BN/SsNHsd/Mcwi strain). Our goal was to identify salivary proteins with one or more of three characteristics that may indicate that they have been involved in adaptation: 1) rapid expansion of their gene families; 2) footprints of positive selection; and/or 3) sex-limited expression. The results of our proteomics studies allow direct comparison of the proteins expressed and their levels between the sexes of the two rodent species. Twelve members of the Mus musculus species-specific kallikrein subfamily Klk1b showed sex-limited expression in the mouse saliva proteomes. …

Singular And General Causal Relations: A Mechanist Perspective, Stuart Glennan

Scholarship and Professional Work - LAS

My aim in this paper is to make a case for the singularist view from the perspective of a mechanical theory of causation (Glennan 1996, 1997, 2010, forthcoming), and to explain what, from this perspective, causal generalizations mean, and what role they play within the mechanical theory.

Robots, Rights And Religion, James F. Mcgrath

Scholarship and Professional Work - LAS

If there is one area in which science fiction has failed to quickly become historical fact, it is in the field of artificial intelligence (A.I.). While some continue to prophesy that machine minds that are indistinguishable from human ones are just around the corner, many others in the field have become far more skeptical. All the while, there have been at least a few who have consistently found the whole idea problematic for reasons unrelated to our technical abilities, in particular the implications A.I. seems to have for our understanding of human personhood. For example, in his 1993 book The …

2011 Otterbein Football Game Day Program, Otterbein University

Football Programs

No abstract provided.

Current Status And Future Directions Of Research In Complex Signaling, Eileen Hebets

Eileen Hebets Publications

The term ‘complex signaling’ reflects a recent scientific focus on the multiple elements frequently incorporated into animal signals (reviewed in Candolin, 2003; Hebets and Papaj, 2005; Partan and Marler, 2005; Bro-Jorgensen, 2010). It embodies a new appreciation that signals used in communication are regularly composed of numerous components and that each component may individually vary in a number of ways. For example, signal components may vary in their time or mechanism of production, in the efficacy of their transmission, and/or in their mechanism of reception, among others. Employing the term ‘complex signaling’ reminds us of the need to maintain a …

The Texas Caver, Volume 57, No. 1, January - March 2011, Mark Alman

The Texas Caver

Contents: Akumal, Quintana Roo, Mexico Trip Report — 2010 - Troop 366 Explores Caves of Colorado Bend State Park - Government Canyon Karst Project 2010 Update - Jogging Thru Gypsum—Jester Cave Trip - Honeycreek! - Carbon Dioxide and Low Oxygen in Texas Caves - Girl Scouts Invade Colorado Bend State Park, Saturday, January 22nd! - TSA Spring Convention—April 1st to 3rd at Fort Clark Springs - On Rope - April 2nd at the TSA Convention. - Cave Conservation and Restoration Workshop at Cave Without a Name

Angler Survey Of The Connecticut River, Justin P. Davis

EEB Articles

The Connecticut River is the largest and most diverse inland fishery resource in the State of Connecticut. Significant improvements in water quality over the past 30 years have led to progressive increases in recreational use, presumably increasing fishing pressure on some species and possibly decreasing overall fishing quality. To address this concern, the Inland Fisheries Division (IFD) of the Connecticut Department of Energy and Environmental Protection (CT DEEP) conducted an angler survey on the entire portion of the Connecticut River within the state during March-October of 2008-09. The survey used a similar design as a smaller-scale survey of the river’s …