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Articles 13231 - 13260 of 20348
Full-Text Articles in Entire DC Network
Medicinal Garden In Peru, Crystal Galarza '13
Medicinal Garden In Peru, Crystal Galarza '13
Linfield Magazine
Charlotte Trowbridge '10 and Josh Ness '11 dug in and got their hands dirty when they led a binational team effort to create a medicinal garden at the ancient Chimu site of Chan Chan, Peru, last summer.
Class Notes, Linfield Magazine Staff, Laura Davis
Class Notes, Linfield Magazine Staff, Laura Davis
Linfield Magazine
News about Linfield alumni
A View From Melrose, Thomas L. Hellie
A View From Melrose, Thomas L. Hellie
Linfield Magazine
An essay by President Thomas L. Hellie: The Value of Education.
What Comes Next?, Linfield Magazine Staff
What Comes Next?, Linfield Magazine Staff
Linfield Magazine
After turning their tassels at the spring commencement ceremony, a few Linfield College graduates share their plans for the future.
Molecular Identification Of Novel Genes Associated With Atherosclerosis, Stephen R. Archacki
Molecular Identification Of Novel Genes Associated With Atherosclerosis, Stephen R. Archacki
ETD Archive
No abstract provided.
Development Of Bioanalytical Methods For Clinical Applications And Drug Screening, Xiaohan Cai
Development Of Bioanalytical Methods For Clinical Applications And Drug Screening, Xiaohan Cai
ETD Archive
In the past decade, bioanalytical method development has become an integral part of clinical diagnosis, biomarker discovery, and drug discovery and development. The new and emerged bioanalytical technologies allow the quantitative and qualitative analysis of small molecules and biomolecules with high sensitivity and specificity. Specifically, the bioanalytical methods based on LC-MS and methylation-specific PCR are well suited for detecting low-abundance metabolites, proteins, and DNA in biofluids and tissues for biomarker investigation. They offer great clinical promises for early diseases diagnosis and therapeutic interventions. Besides, the LC-MS/MS quantitative method is essential for the estimation of pharmacokinetic and toxicological properties in drug …
Academic Predictors Of Mental Health Outcomes For Children And Youth With Emotional Disturbance, John J. Callahan
Academic Predictors Of Mental Health Outcomes For Children And Youth With Emotional Disturbance, John J. Callahan
ETD Archive
Research suggests a strong correlation linking academic achievement and mental health outcomes in children with emotional disturbance (ED) (Kauffman, 2005 U.S. Department of Education, 2006). However, the exact nature of this critical relationship remains unclear. This study used a series if regression analyses and Z-Tests to investigate the predictive relationship of measures of academic achievement in determining social-emotional function over time. Examined was a sample of 261 students receiving special education and mental health services at a treatment center. Academic, mental health and demographic information was gathered from a preexisting archive. Students were assessed annually using the KTEA-II in the …
Elevating The Civic Science Literacy Of American Adults;Assessing A Renewed Citizen Science Paradigm Integrating Nonformal Outdoor Adult Education And Enhanced Experiential Learning, David Patrick Cronin
Elevating The Civic Science Literacy Of American Adults;Assessing A Renewed Citizen Science Paradigm Integrating Nonformal Outdoor Adult Education And Enhanced Experiential Learning, David Patrick Cronin
ETD Archive
America's adult populace has failed to keep pace with the rapid inundation of science-centric advancements affecting nearly every facet of personal and public life. With deficiencies in areas of science knowledge, America's adult populace is characterized as civic science illiterate. This research constructed and employed the renewed citizen science paradigm, incorporating nonformal outdoor adult education and enhanced experiential learning while maintaining the basic tenet of citizen science, towards elevating the civic science literacy of adults who volunteered to conduct scientific research towards answering important research questions posed by a science research agency. With 67 volunteers, 23 adults were purposively selected …
The Public Education Of Students With Autism Spectrum Disorders In Northeast Ohio;The Examination And Comparison Of Current Practices To The Perspective Of Parents And Professionals, Jocelyn M. Geib
ETD Archive
This study examined the perceptions of professionals and parents of children with autism regarding quality indicators of successful educational practices in Northeast Ohio and compared this information to current literature trends. The study used questionnaires and interviews to look at these topics and compare them to the perceptions of stakeholders. Results indicate that stakeholder perceptions are similar to those promoted in the literature. Parents and professionals perceived methodology based interventions that are individualized and delivered by highly trained and qualified personnel to be the most important components of an educational program for students with autism. Barriers to delivering these services …
Role Of The Thrombospondin - Cd36 - Histidine Rich Glycoprotein Pathway In Tumor Growth And Angiogenesis, James Scott Hale
Role Of The Thrombospondin - Cd36 - Histidine Rich Glycoprotein Pathway In Tumor Growth And Angiogenesis, James Scott Hale
ETD Archive
Cancer is typically thought of as an uncommon disease, in which solid tumors require a blood supply in order to grow and metastasize. Interestingly, upon autopsy a large portion of elderly individuals display numerous non-vascularized lesions throughout their bodies. Thus, the angiogenic switch in the development of cancer presents an important therapeutic target. Previous work by our laboratory has established an interaction between CD36, Histidine Rich Glycoprotein (HRGP) and Thrombospondin 1 (TSP-1) in the modulation of angiogenesis. Briefly, endothelial cell receptor CD36 interaction with soluble or cell bound TSP-1 leads to the induction of an apoptotic signaling cascade in vascular …
Common Factors That African American Adults Attribute To Their Graduation From A Predominantly African American Midwestern School District: A Case Study, Adriennie Yvette Hatten
Common Factors That African American Adults Attribute To Their Graduation From A Predominantly African American Midwestern School District: A Case Study, Adriennie Yvette Hatten
ETD Archive
This qualitative research study examines the reflections of African American adults on their high school journey to graduation in the late 20th Century from one Midwestern public school district where African- American students represented the majority of the student body. The particular emphasis of this study was to identify common factors that the participants perceive as critical to their own high school graduation, as the measure of academic success and lifelong learning. This dissertation addresses two research questions through the methodology of narrative inquiry: 1) what are the experiences of the African American adults who were educated in the same …
Glia Specific Innate Responses And Their Influence On Murine Coronavirus Inducedencephalomyelitis, Parul Kapil
Glia Specific Innate Responses And Their Influence On Murine Coronavirus Inducedencephalomyelitis, Parul Kapil
ETD Archive
No abstract provided.
Capillary Gradient Chromatofocusing-Mass Spectrometry;A Sensitive Approach For Protein Analysis, James Anthony Hribar
Capillary Gradient Chromatofocusing-Mass Spectrometry;A Sensitive Approach For Protein Analysis, James Anthony Hribar
ETD Archive
Gradient chromatofocusing-mass spectrometry is a new technique for protein analysis recently introduced by our research group. Capable of separating and identifying proteins according to pI values and molecular weight, gradient chromatofocusing-mass spectrometry has been achieved by integrating a new ion-exchange chromatography technique called gradient chromatofocusing with a newly discovered buffer system that promotes mass spectrometry detection. Differing from traditional ion-exchange chromatography techniques, gradient chromatofocusing employs specific low molecular weight, volatile buffer components that are introduced onto an ion-exchange HPLC column by programming a binary gradient pumping system to deliver the correct proportions of acidic mobile phase to overcome buffering of …
Design Of An Implant For First Metatarsophalangeal Joint Hemiarthroplasty, Atul Kumar
Design Of An Implant For First Metatarsophalangeal Joint Hemiarthroplasty, Atul Kumar
ETD Archive
Osteoarthritis (OA) is the most common form of arthritis and it affects 27 million US adults. OA disease involves all of the tissues of the diarthrodial joint and ultimately, may lead to softening, ulceration, loss of articular cartilage, sclerosis and polished appearance of the subchondral bone, osteophytes, and subchondral cysts. The first metatarsophalangeal joint (MTPJ1) is affected in up to 42 cases of OA. Besides osteoarthritis, other conditions such as rheumatoid arthritis and gout also affect the MTPJ1. Involvement of MTPJ1 with these conditions invariably leads to deformed toe such as hallux valgus and hallux rigidus. Over 150 surgical techniques …
Development Of Quantitative Lc-Ms/Ms Methods For The Pharmacological Studies Of Anti-Cancer Drugs, Lan Li
Development Of Quantitative Lc-Ms/Ms Methods For The Pharmacological Studies Of Anti-Cancer Drugs, Lan Li
ETD Archive
In the development of anti-cancer drugs, it is essential to study the pharmacological profiles of the drugs. Among the analytical tools utilized in the pharmacological studies, LC-MS/MS has gained increased popularity due to its unequivocal sensitivity and specificity, as well as the ability of handling a wide variety of compounds with relatively simple sample preparation procedures. In this work, a brief review on the method rational, instrumentations, analytical method validation, and work flow of the method development was included. The processes of LC-MS/MS method development for the pharmacological studies of three anti-cancer drugs (i.e., methoxyamine, fludarabine, and 6-benzylthioinosine) were illustrated. …
Female Adolescent Body Image And Success At School: A Grounded Theory Approach To Creation Of Administrative Best Practice, Erin K. Murphy
Female Adolescent Body Image And Success At School: A Grounded Theory Approach To Creation Of Administrative Best Practice, Erin K. Murphy
ETD Archive
At present, school administrators do not have necessary information to create a school environment where teenage girls unhappy with their bodies can experience success at school. This research surrounds three research questions: 1. How do adolescent girls' definitions of their bodies relate to their perception of their high school's climate? 2. How does the manner in which adolescent female girls define their bodies relate to their success in school? 3. What is the nature of adolescent girls' and high school administrators' perceptions of how adolescent girls' body image influences administrative practice? Four school administrators and ten high school girls were …
Influences Of Environmental Variability, Genetics And Plant Size On Variation In Sexual And Clonal Reproduction And Allocation Of Resources In Three Wetland Plant Species, Ann M. Nicholls
ETD Archive
Optimal Partitioning Theory (OPT) states organisms will give more resources to structures and functions that enhance fitness. OPT can be applied to reproduction in clonal plants, which allocate resources between two modes of reproduction--sexual through fruits and clonal through spacers and ramets. In nutrient rich environments, clonal growth allows offspring to stay in beneficial surroundings, while in nutrient poor conditions, sexual reproduction can allow escape and generation of new, potentially more fit offspring. I tested this hypothesis by comparing clonal and sexual reproductive allocation in Penthorum sedoides under differing nutrient levels over two generations. Genotypic and environmental influences on reproductive …
Development Of A Muscle Force Optimization Algorithm To Improve Center Of Pressure During Simulated Walking, Lawrence Dean Noble
Development Of A Muscle Force Optimization Algorithm To Improve Center Of Pressure During Simulated Walking, Lawrence Dean Noble
ETD Archive
The Universal Musculoskeletal Simulator (UMS) was developed at the Cleveland Clinic to facilitate general purpose orthopaedic research that allows investigators to study the in vitro forces applied to bones, tendons and ligaments during simulated exercise of cadaver joint systems. In its original state, the UMS hardware consisted of a rotopod (a specialized hexapod robot), a single rotary tendon actuator and custom LabVIEW software for coordinated control and operation of the system. The focus of this work was to 1) enhance the UMS with a multi-tendon actuator system, 2) develop a muscle force optimization algorithm and evaluate it with a static …
Novel Translational Regulation Of The Proapoptotic Bcl2 Member Puma And Its Role During Skeletal Myoblast Apoptosis, Atossa Shaltouki
Novel Translational Regulation Of The Proapoptotic Bcl2 Member Puma And Its Role During Skeletal Myoblast Apoptosis, Atossa Shaltouki
ETD Archive
Differentiation and apoptosis are coordinately regulated in skeletal myoblasts. During the process of skeletal myoblast differentiation, our lab has determined that roughly 30 of myoblasts undergo apoptosis rather than differentiation. Further, we have reported that cytochrome C is released, and that the expression level of the pro-apoptotic Bcl2 family member PUMA is elevated, when 23A2 myoblasts are cultured in DM. Our long-term goal is to identify targets for manipulation that would abrogate this apoptosis without affecting differentiation. These findings could be significant to the study of myoblast transfer as a therapeutic approach. The goals of this dissertation are to: 1- …
Three Essays On Innovation And Regional Economic Development, Jon R. Shelton
Three Essays On Innovation And Regional Economic Development, Jon R. Shelton
ETD Archive
The first essay develops a typology that identifies the multiple pathways, functions and operations where innovation can occur in a firm's internal business cycle based upon the extant literature that includes both technological and non-technological activities. This is an important step toward developing a comprehensive strategy for a regional economy and provides a common platform for the discussion of innovation among academics and practitioners.The typology adds to the existing knowledge of how innovation works in organizations by describing the pathways, business functions and operations in a firm's internal-business-process the business strategies used to advance innovation to the market and the …
A Rat Model Of Sleep Deprivation Prior To Traumatic Brain Injury, Steve G. Soehnlen
A Rat Model Of Sleep Deprivation Prior To Traumatic Brain Injury, Steve G. Soehnlen
ETD Archive
Traumatic Brain Injury (TBI) has been called the "signature injury" of U.S. soldiers in Iraq and Afghanistan. Soldiers undergo a variety of stressors during their tours of duty that could complicate recovery from TBI, one of which is sleep deprivation (SD). In this study, we sought to create a rat model exploring the effects of prior REM sleep deprivation (RSD) on recovery from TBI-induced sensorimotor and cognitive deficits. Rats were deprived of REM sleep before they underwent a controlled cortical impact (CCI) to mimic a TBI. Forelimb sensorimotor function, hindlimb motor function, forelimb motor function, and spatial learning were assessed …
Quantification Of Scenedesmus Dimorphus Growth And Substrate Kinetics For Continuous Photobioreactor Design, Daniela Ribita
Quantification Of Scenedesmus Dimorphus Growth And Substrate Kinetics For Continuous Photobioreactor Design, Daniela Ribita
ETD Archive
Increasing gas prices, limited fossil fuel resources and U.S. dependence on foreign oil make research in alternative fuels a priority. The feasibility of producing fuels from microalgae is economically dependent on improvements in lipid productivity by the algae. The research presented here focuses on the development of a mathematical model to describe the biomass and lipid productivity in a continuously-operated photobioreactor (PBR) system. Five different cell lysing methods were evaluated for the purpose of improving the methods of analysis of lipid synthesis. The two most promising methods were found to be mortar and pestle and organic solvent cell fractionation methods. …
But What Does This Have To Do With Science?: Building The Case For Engineering In K-12, Micah Maranda Arafah
But What Does This Have To Do With Science?: Building The Case For Engineering In K-12, Micah Maranda Arafah
ETD Archive
A national push for reform in STEM K-12 education and a raised focus on including engineering in the classroom have emphasized the necessity for specific professional development opportunities for teachers. These programs are available however, they are typically very expensive and consequently inaccessible to most educators in the public school sector. The Engineering Education Summer Conference (EESC) is a three day professional development conference for K-12 teachers interested in using engineering in their classrooms and is funded primarily by the University Transportation Center at Cleveland State University. Its goals are to debunk biases of engineers and engineering, provide resources and …
Dietary Supplement Wastewater Treatment By Biological Methods, Xiangting Hou
Dietary Supplement Wastewater Treatment By Biological Methods, Xiangting Hou
ETD Archive
Dietary supplements, pre-mixed meal like Slim Fast, are part of most people's lives. Since dietary supplements have a high order of complex sugars, low-fat milk, and all kinds of nutrients, they bring hazards to the environment if discharged to water bodies without any proper treatment. Therefore, wastewater from dietary supplement gains much more attention at the present time. Dietary supplement wastewater contains amounts of organic compounds which may be bio- friendly and non-toxic. Biological treatment shows its strong advantages in dealing with this kind of wastewater.In this research, four kinds of Live Liquid Micro-organisms (LLMO) were used as the sources …
Electrocoagulation/Flotation Treatment Of Synthetic Surface Water, Sampath Gunukula
Electrocoagulation/Flotation Treatment Of Synthetic Surface Water, Sampath Gunukula
ETD Archive
Rainfall generated surface runoff water could contaminate groundwater through transportation of suspended solids and organic matter in to the aquifer. Surface runoff water composition mainly depends on soil amendment. Surface runoff mainly contains clay, minerals, organic and inorganic matter, total dissolved lead, zinc. ECF technology presents an alternative for the removal of total suspended solids, turbidity, and organic matter from generated surface runoff water. This research presents development of bench scale ECF unit for the treatment of synthetic surface water. Experiments were conducted in a 10 liter Plexiglas unit provided with two aluminum electrodes, one serving as cathode, and other …
A Cfd Model Of Mixing In A Microfludic Device For Space Medicine Technology, Terri Lynn Mckay
A Cfd Model Of Mixing In A Microfludic Device For Space Medicine Technology, Terri Lynn Mckay
ETD Archive
The DNA Medicine Institute (DMI) is currently developing a device to be used for blood analysis to satisfy the unique requirements of space medicine applications. A key component of that device is the micromixer, which will ensure mixing and dilution of reagents utilized for detection assays. As part of the device design process, the micromixer was modeled, and the mixing characteristics were analyzed and compared to experimental data. The experimental data was based on a top-view of the system and, lacking data throughout the fluid domain, could not provide the insight into the mixing process that modeling could readily provide. …
An Assessment Of Viable Habitat For Blanding's Turtle (Emydodidea Blandingii) In The State Of Ohio Using Gis And Remote Sensing, Bradley M. Poynter
An Assessment Of Viable Habitat For Blanding's Turtle (Emydodidea Blandingii) In The State Of Ohio Using Gis And Remote Sensing, Bradley M. Poynter
ETD Archive
The Blanding's Turtle (Emydoidea blandingii) has received threatened status in the State of Ohio in 2010. The goal of this study is to provide information that can be used in conservation management to locate suitable habitat for conservation of the species as well as potential repatriation or trans location sites. Wetland Inventory and Land Use/Land Cover maps were combined with aerial photography to evaluate regions located in Ohio's Lake Erie Drainage Basin that would meet the essential requirements of the turtles life history by quantitative methods used in Geographic Information Systems (GIS) and Remote Sensing programs. This study identified suitable …
Examining Whether Social Factors Affect Listeners Sensitivity To Talker-Specific Information During Their Online Perception Of Spoken Words, Jessica L. Newell
Examining Whether Social Factors Affect Listeners Sensitivity To Talker-Specific Information During Their Online Perception Of Spoken Words, Jessica L. Newell
ETD Archive
McLennan and Luce (2005) found no significant cost associated with changing which talker produced a particular word from the first block of trials to the second (no talker effects) when participants responded relatively quickly (easy lexical decision), and that talker effects emerged when participants responded relatively slowly (hard lexical decision). In a lexical decision task, participants hear words and nonwords and reaction times to correct responses are measured. In the current study, we examined whether social factors would lead to talker effects in an easy lexical decision task. In Experiment 1, participants were told that they have a chance to …
The Parasympathetic Nervous System In Human Heart Failure, Jessica A. French
The Parasympathetic Nervous System In Human Heart Failure, Jessica A. French
ETD Archive
Heart failure (HF) affects 5.8 million Americans and is characterized by an inability of the heart to pump blood throughout the body. In a non-diseased state, the sympathetic (SNS) and parasympathetic nervous systems (PNS) innervate the heart to regulate rate and force of contraction. Actions of the PNS on the cardiovascular system are mediated via the vagus nerve, releasing acetylcholine which binds muscarinic receptors on cardiomyocytes. The SNS has been found to be overstimulated in HF, with the role of the PNS in HF unclear. We hypothesized that the PNS is dysregulated in HF, resulting in a change of muscarinic …
Treatment Of Co-Morbid Chronic Pain And Substance Use Disorders, Lisa Ellison
Treatment Of Co-Morbid Chronic Pain And Substance Use Disorders, Lisa Ellison
ETD Archive
Chronic pain affects approximately 15 of the adult population with substance use disorders (SUDS) estimated to co-occur in 15 to 28 of the chronic pain population. When these two disorders co-occur, there can be multiple implications for the affected individuals as well as numerous complications for treatment. This study examined the outcomes and program completion rates of two groups of chronic pain SUDS patients who had followed different treatment paths after their admission to the Cleveland Clinic's Chronic pain rehabilitation program (CC-CPRP). Prior to June of 2009, pre-identified chronic pain SUDS patients were advised to complete a separate chemical dependency …