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Quantifying The Effects Of Nicotine And Nitroglycerin On The Microvasculature, Macdale Elwin

Yale Medicine Thesis Digital Library

Abstract

Nicotine can stimulate both sympathetic and parasympathetic ganglionic cells depending on which ganglionic cells of the ANS it is able to access. This study involved the transdermal delivery of low doses of nicotine and nitroglycerin to the forehead and finger microvasculature so as to test the hypothesis that, although both drugs will cause vasodilation at the forehead, the nature of the dilation will differ as a consequence of their different sites of action within the neuro-microvascular pathways. With IRB approval, the local effects of transdermal nitroglycerin and nicotine were investigated on the forehead and finger of 10 healthy volunteers …

Collateral Damage: The History Of United States Case Law On Today's Military Hunger Strike Doctrine, Adrian Mora

Yale Medicine Thesis Digital Library

HYPOTHESIS/AIMS: In the Global War on Terror (GWOT), hunger strikes by detainees in Guantanamo Bay, Cuba have been managed by military physicians through force feedings. This thesis answers the question of how did the United States justify its current practice of force feeding prisoners against prevailing medical ethics? The author hypothesizes that U.S. case law history of approximately 1979 to 1997 enabled the current military doctrine to force feed international detainees in GWOT.

METHODS: A qualitative and comprehensive review of the relevant literature was undertaken. The sources used for conclusive analysis included press releases, ethics commentary, law reviews, medical association …

Investigating Contributions Of Langerhans Cells To The Epidermal Oxidative Stress Response, Debra Smith

Yale Medicine Thesis Digital Library

INVESTIGATING THE CONTRIBUTIONS OF LANGERHANS CELLS TO THE EPIDERMAL OXIDATIVE STRESS RESPONSE. Debra A. Smith, Julia Lewis, Renata Filler, Kseniya Golubets, Michael Girardi. Department of Dermatology, Yale University, School of Medicine, New Haven, CT.

Langerhans cells (LC) play an essential role in the development of skin cancer in a chemical carcinogenesis mouse model. To elucidate the mechanism of this effect, LC-deficient (Langerin-dipheria toxin A or human Langerin-diphtheria toxin receptor transgenic) mouse epidermis was compared to normal littermate controls (NLC) to assess whether levels of oxidative stress or DNA damage are affected by LC. Groups of mice were treated with either …

Is Aggressive Mediastinal Control Needed After Neoadjuvant Therapy For Distal Esophagus Carcinomas?, Chantae Sullivan

Yale Medicine Thesis Digital Library

The pattern of recurrence after neoadjuvant chemoradiotherapy followed by transhiatal esophagectomy with limited mediastinal lymphadenectomy among 73 patients with carcinoma of the distal esophagus, gastroesophageal junction (GEJ) and/or gastric cardia, was investigated in this retrospective study. Results indicate that among the 30 patients with recurrence, distant sites (n = 24) were more common than local sites (n = 6) and this difference was statistically significant (P = 0.001). Lungs and liver were the most common sites of first recurrence, 51%, while mediastinal nodes were the sites of first recurrence in 6% of cases. Twenty patients (27.4%) had pathologic complete response, …

Enemy Of The People: The Need For Congress To Pass The Clean Water Restoration Act, Cathryn Henn

Florida A & M University Law Review

No abstract provided.

Biodiversity Assessment Of Tetranychid Mites In Kenya And The Conservation Hotspots Of Tanzania, Faith Jebet Toroitich

All PhD Dissertations

The aims of this study were to develop a detailed record of the tetranychid mites of Kenya and Tanzania, to assess the diversity of tetranychid mites in the east African biodiversity hotspots and to determine female characters that can be used to identify the species of the economically important Tetranychus species found in these countries. The genetic diversity of the most abundant Tetranychus species (Tetranychus evansi Baker & Pritchard) was also assessed. The Tetranychidae (Acari) contain some of the most important pest species of phytophagous mites worldwide. Out of the almost 1,300 species in this family, 256 species are known …

Development Of A Fungal Based-Product For The Control Of Western Flower Thrips Frankliniella Occidentalis (Pergande), Niassy Saliou

All PhD Dissertations

The Western Flower Thrips (WFT) Frankliniella occidentalis (Pergande) is a major constraint to many cultivated crops in the world, causing important economical yield losses. They cause direct damage on plants and contribute exclusively in the propagation of tospovirus to plant. Thrips control is essentially based on the use of synthetic chemical pesticides; however most thrips species including Foccidentalis are resistant to a wide group of chemical pesticides. Hence there is the need to develop alternative strategies that are environmentally friendly. Entomopathogenic fungi are among the options being considered as a promising alternative for F. occidentalis management. The aim of this …

Ohio Northern University Catalog, 2011-2012, Ohio Northern University

University Catalogs

No abstract provided.

Rollins College Catalog 2011, Rollins College

College of Liberal Arts Catalogs

No abstract provided.

Environmental Factors Affecting Settlement Of Quagga Mussel (Dreissena Rostriformis Bugensis) Veligers In Lake Mead, Nevada-Arizona, Usa, Dong Chen, Shawn Gerstenberger, Sara Ann Mueting, Wai Hing Wong

Environmental & Global Health Faculty Research

Environmental factors that can affect the settlement rate of quagga mussel veligers include flow velocity, water temperature, pH, dissolved oxygen (DO), conductivity, total organic carbon (TOC), and the surface roughness of monitoring substrates. In the present study, six artificial substrates, Acrylonitrile Butadiene Styrene (ABS) plastic, High Density Polyethylene (HDPE) plastic, Concrete Underlayment Board (CUB), aluminum, stainless steel and fiberglass, were used to monitor the settlement of quagga mussel veligers at different water depths in Lake Mead, Nevada-Arizona, USA. Considering the hierarchical data structure of observed mussel densities, we investigated the relationship between mussel settlement on monitoring substrates and the surrounding …

Quagga Mussels In The Western United States: Monitoring And Management, Wai Hing Wong, Shawn Gerstenberger

Environmental & Global Health Faculty Research

Dreissenid mussels including zebra mussel (Dreissena polymorpha Pallas, 1771), originating from the Ponto-Caspian area, and quagga mussel (Dreissena rostriformis bugensis Andrusov, 1897), originating from the mouths of the Rivers Southern Bug and Dnieper are both species native to Eastern Europe, which were accidently introduced into the Laurentian Great Lakes in North America in the 1980s in ballast water (Carlton 2008; Van der Velde et al 2010). Dreissenid mussels have created severe ecological, recreational and economic impacts on many systems because they are biofoulers and efficient ecological engineers that filter large quantities of water. Examples of these wide-ranging impacts are discussed …

Refereed Articles Or Books Published During 2010-2011, College Of Arts & Sciences

SHU Faculty Publications

This is a bibliography of faculty scholarship from the College of Arts and Sciences at Sacred Heart University during the academic year 2010-2011.

Decomposing The Intergenerational Disparity In Income And Obesity, Qi Zhang, Buhong Zheng, Ning Zhang, Youfa Wang

Community & Environmental Health Faculty Publications

Intergenerational disparity in income and health violates the norm of equal opportunity and deserves the attention of researchers and policy makers. To understand changes in intergenerational disparity, we created the intergenerational mobility index (IMI), which can simultaneously measure changes in income rankings and in health outcomes across two generations. We selected obesity as one health outcome to illustrate the application of IMI due to its severe health and financial consequences for society and the significant changes in the distribution of obesity across income groups. Although obesity has increased in all income groups in the last four decades, higher income groups …

Factors Influencing The Ecology Of Greater Sage-Grouse On The Bear Lake Valley, Utah- Idaho Current Research Progress And Future Research Plans, C. Cardinal, Terry A. Messmer

Wildland Resources Faculty Publications

No abstract provided.

Contemporary And Historical Separation Of Transequatorial Migration Between Genetically Distinct Seabird Populations, M J. Rayner, M E. Hauber, T E. Steeves, H A. Lawrence, D R. Thompson, P M. Sagar, S J. Bury, R A. Phillips, T J. Landers, L Ranjard, Scott A. Shaffer

Faculty Publications, Biological Sciences

Pelagic seabirds are highly mobile, reducing the likelihood of allopatric speciation where disruption of gene flow between populations is caused by physically insurmountable, extrinsic barriers. Spatial segregation during the non-breeding season appears to provide an intrinsic barrier to gene flow among seabird populations that otherwise occupy nearby or overlapping regions during breeding, but how this is achieved remains unclear. Here we show that the two genetically distinct populations of Cook's petrel (Pterodroma cookii) exhibit transequatorial separation of non-breeding ranges at contemporary (ca. 2–3 yrs) and historical (ca. 100 yrs) time scales. Segregation during the non-breeding season per se appears as …

Commentary: Selecting Synaptic Partners: Grasping The Role Of Unc- 6/Netrin, Q L. Ch'ng

Faculty Publications, Biological Sciences

Forming synaptic connections of the appropriate strength between specific neurons is crucial for constructing neural circuits to control behavior. A recent paper in Neural Development describes the use of a synapse-specific label in Caenorhabditis elegans to implicate local UNC-6/netrin signaling in this developmental process. Thus, as well as their well known roles in cell migration and axon guidance, UNC-6/netrin signals distinguish an appropriate synaptic partner from other potential targets.

Speciation, Luminescence, And Alkaline Fluorescence Quenching Of 4-(2-Methylbutyl)Aminodipicolinic Acid (H2mebadpa), Gilles Muller, A. J. Ingram, A. G. Dunpal, R. Dipietro

Faculty Publications, Chemistry

4-(2-Methylbutyl)aminodipicolinic acid (H2MEBADPA) has been synthesized and fully characterized in terms of aqueous phase protonation constants (pKa's) and photophysical measurements. The pKa's were determined by spectrophotometric titrations, utilizing a fully sealed titration system. Photophysical measurements consisted of room temperature fluorescence and frozen solution phosphorescence as well as quantum yield determinations at various pH, which showed that only fully deprotonated MEBADPA2– is appreciably emissive. The fluorescence of MEBADPA2– has been determined to be quenched by hydroxide and methoxide anions, most likely through base-catalyzed excited-state tautomerism or proton transfer. This quenching phenomenon has been quantitatively explored through steady-state and time-resolved fluorescence measurements. …

Assessing The Long-Term Effects Of The Bp Deepwater Horizon Oil Spill On Marine Mammals In The Gulf Of Mexico: A Statement Of Research Needs

United States Marine Mammal Commission

Assessing the Long-term Effects of the BP Deepwater Horizon Oil Spill on Marine Mammals in the Gulf of Mexico: A Statement of Research Needs

Ua12/13 2011 Sustainability Report [Western Kentucky University], Wku Office Of Sustainability, Christian Ryan-Downing

Sustainability Publications and Resources

AASHE is an association of colleges and universities that are working to create a sustainable future. AASHE’s mission is to empower higher education to lead the sustainability transformation. The organization provides resources, professional development and a network of support to enable institutions of higher education to model and advance sustainability in everything they do, from governance and operations to education and research. For more information about AASHE, visit www.aashe.org.

In early 2010, Western Kentucky University became a charter member of the Association for the Advancement of Sustainability in Higher Education’s Sustainability Tracking, Assessment and Rating System (STARS). STARS® is a …

Age-Associated Alterations In The F344xbn Rat Heart And The Efficacy Of Chronic Acetaminophen Ingestion As A Therapeutic Approach, Sunil K. Kakarla

Theses, Dissertations and Capstones

Despite advances in therapeutic and diagnostic strategies cardiovascular disease still remains the leading cause of death in older people. Recent studies suggest that age- related elevations in oxidative stress are associated with increases in cardiac apoptosis and compensatory hypertrophy of the remaining cardiomyocytes. Acetaminophen has been shown to exhibit cardioprotective effects following ischemia-reperfusion injury by acting as an antioxidant. Here, we investigate the molecular mechanisms underlying aging associated cardiac remodeling in male F344XBN rats and examine the efficacy of chronic acetaminophen ingestion as a therapeutic approach.

Aging in male F344XBN rats is characterized by a significant increase in heart size, …

Ua1d Wku University Wide Personnel File, Wku Archives

WKU Archives Collection Inventories

Personnel files from all WKU departments opened 30 years after separation from the university or upon death. The records include information regarding education, awards and honors, and correspondence. Clippings and other materials from former biographical vertical files have also been added to many folders.

Note: Employment dates noted in the catalog are for reference purposes and should be confirmed by referring to records in the collection.

Identification Of Genes Involved In Hematopoietic Stem Cell Differentiation And Leukemia Differentiation And Leukemia, Jasjeet Bhullar

Theses, Dissertations and Capstones

Hematopoiesis is maintained by a proper balance between self renewal and multipotent differentiation of the hematopoietic stem cells (HSC). Acute myelogenous leukemia (AML) is characterized by the blockage in the differentiation of HSC, while self renewal and proliferation is preserved. It is important to understand the mechanisms involved in the inhibition of hematopoietic differentiation and maintenance of the HSC state in order to develop better therapies for AML. In these studies I have explored the role of Hsp90, omega-3 fatty acids and YB-1 in hematopoietic differentiation. EML, a hematopoietic precursor cell line, was used as a model for the hematopoietic …

Altered Regulation Of Mitogen-Activated Protein Kinases And Glut4 Expression In Skeletal Muscle, Liver, Heart And Kidney Of Obese Zucker Rat, Sudarsanam Kundla

Theses, Dissertations and Capstones

Metabolic syndrome is characterized by insulin resistance and hyperglycemia. The molecular mechanism(s) underlying this alteration in skeletal muscle, liver, kidneys and heart in metabolic syndrome patients are presently unclear. Recent data have demonstrated that the p38and extracellular-signal-regulated kinases (ERK 1/2) - mitogen-activated protein kinase (MAPK) proteins may be involved in the regulation of (Glucose transporter type 4) GLUT4 expression levels. Other data have suggested that miRNA may also play a role. Purpose: The purpose of this study is to compare the tissue content, phosphorylation of protein kinases (AKT), p38, c-JUN Nterminal kinase(JNK), ERK1/2, GLUT4 and transcriptional factor Myocyte enhancer factor-2 …

Predicting Bison Migration Out Of Yellowstone National Park Using Bayesian Models, Chris Geremia, P. J. White, Rick L. Wallen, Fred G. R. Watson, John J. Treanor, John Borkowski, Christopher S. Potter, Robert L. Crabtree

School of Natural Sciences Faculty Publications and Presentations

Long distance migrations by ungulate species often surpass the boundaries of preservation areas where conflicts with various publics lead to management actions that can threaten populations. We chose the partially migratory bison (Bison bison) population in Yellowstone National Park as an example of integrating science into management policies to better conserve migratory ungulates. Approximately 60% of these bison have been exposed to bovine brucellosis and thousands of migrants exiting the park boundary have been culled during the past two decades to reduce the risk of disease transmission to cattle. Data were assimilated using models representing competing hypotheses of bison migration …

Carbon Fluxes In Ecosystems Of Yellowstone National Park Predicted From Remote Sensing Data And Simulation Modeling, Christopher Potter, Steven Klooster, Robert Crabtree, Shengli Huang, Peggy Gross, Vanessa Genovese

School of Natural Sciences Faculty Publications and Presentations

Background: A simulation model based on remote sensing data for spatial vegetation properties has been used to estimate ecosystem carbon fluxes across Yellowstone National Park (YNP). The CASA (Carnegie Ames Stanford Approach) model was applied at a regional scale to estimate seasonal and annual carbon fluxes as net primary production (NPP) and soil respiration components. Predicted net ecosystem production (NEP) flux of CO2 is estimated from the model for carbon sinks and sources over multi-year periods that varied in climate and (wildfire) disturbance histories. Monthly Enhanced Vegetation Index (EVI) image coverages from the NASA Moderate Resolution Imaging Spectroradiometer (MODIS) instrument …

Ua64/2 The Challenge: Magazine Of The Center For Gifted Studies (No. 26, Winter 2011), Center For Gifted Studies, Tracy Inman Editor

Gifted Studies Publications

No abstract provided.

Ua23 Spirit Of Engagement 2011, Aurelia Spaulding, Alive Center, Western Kentucky University

ALIVE Center Publications

No abstract provided.

The Idealist Discourse Of Legal Professionalism In Maryland: Delineating The Omissions And Eloquent Silences As A Progressive Critique, Kez U. Gabriel

University of Baltimore Law Forum

No abstract provided.

Chapter 66: Making Small Steps Towards Permanency For Dependent Children, Kendra Bertschy

McGeorge Law Review

No abstract provided.

Three Approaches To Law And Culture, Menachem Mautner

Cornell Law Review

No abstract provided.