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2011

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Influence Of Elemental Sulfur On Nutrient Uptake, Yield And Quality Of Cucumber Grown In Sandy Calcareous Soil, M.R. Motior, A.S. Abdou, F.H. Al Darwish, K.A. El-Tarabily, M.A. Awad, F. Golam, Mohd Sofian-Azirun Jan 2011

Influence Of Elemental Sulfur On Nutrient Uptake, Yield And Quality Of Cucumber Grown In Sandy Calcareous Soil, M.R. Motior, A.S. Abdou, F.H. Al Darwish, K.A. El-Tarabily, M.A. Awad, F. Golam, Mohd Sofian-Azirun

Research Publications (2011 to 2015)

This study was carried out to investigate the effect of elemental sulfur (S 0) and sulfur oxidizing bacteria (Paracoccus versutus) on nutrient uptake, yield and quality of cucumber grown in sandy calcareous soils. Both elemental sulfur powder (S 0P) and pellets of sulfur powder-Tiger 90 (S 0T) were applied at rates of 0, 1, 5 and 10 t/ha at Al Hamraneya. On the contrary, S 0P was used at rates of 0, 1, 5 and 10 t/ha combined with or without Paracoccus versutus (Pv) at Al Kuwaitat, United Arab Emirates (UAE). Higher concentrations of N, P, S, Mn and Zn …

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Influence Of Growth Stage And Variety On The Pigment Levels In Ipomoea Batatas (Sweet Potato) Leaves, S.M. Hue, A.N. Boyce, C. Somasundram Jan 2011

Influence Of Growth Stage And Variety On The Pigment Levels In Ipomoea Batatas (Sweet Potato) Leaves, S.M. Hue, A.N. Boyce, C. Somasundram

Research Publications (2011 to 2015)

The study of pigments and nutritional composition in Ipomoea batatas has been intensive, yet little studies have been conducted on their leaves. I. batatas (sweet potato) leaves which are discarded after the harvesting period can be used as a potential source of natural dye extraction due to their high level of carotenoids (particularly lutein). Selection of leaves material is dependable on factors such as leaves varieties and stages of growth developments. Variations in chlorophyll a, chlorophyll b, total carotenoids and lutein level were determined spectrophotometrically at different stages of leaves development in 6 different varieties of I. batatas leaves. Result …

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Morphological And Tissue Culture Studies Of Platycerium Coronarium, A Rare Ornamental Fern Species From Malaysia, Rosna Mat Taha, Noorma Wati Haron, Sharifah Nurashikin Wafa Jan 2011

Morphological And Tissue Culture Studies Of Platycerium Coronarium, A Rare Ornamental Fern Species From Malaysia, Rosna Mat Taha, Noorma Wati Haron, Sharifah Nurashikin Wafa

Research Publications (2011 to 2015)

The genus Platycerium consists of about 18 species, commonly found in tropical and subtropical forests. Among the different species, Platycerium coronarium, P. platylobium, P. ridleyi and P. wallichi are found in Peninsular Malaysia, and P. coronarium is considered the most attractive ornamentally. Platycerium coronarium is an epiphytic fern, bears a gigantic morphology and is native to tropical areas of South America, Africa, Southeast Asia, Australia and New Guinea. Platycerium coronarium nests on the upper branches of the tallest trees in the forest. Due to having a uniquely-shaped fronds, they are famous for ornamental purposes, where they can be found in …

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Nutritional And Socio-Economic Determinants Of Cognitive Function And Educational Achievement Of Aboriginal Schoolchildren In Rural Malaysia, H.M. Al-Mekhlafi, M.A. Mahdy, A.A. Sallam, W.A. Ariffin, A.M. Al-Mekhlafi, A.A. Amran, Johari Surin Jan 2011

Nutritional And Socio-Economic Determinants Of Cognitive Function And Educational Achievement Of Aboriginal Schoolchildren In Rural Malaysia, H.M. Al-Mekhlafi, M.A. Mahdy, A.A. Sallam, W.A. Ariffin, A.M. Al-Mekhlafi, A.A. Amran, Johari Surin

Research Publications (2011 to 2015)

A community-based cross-sectional study was carried out among Aboriginal schoolchildren aged 7-12 years living in remote areas in Pos Betau, Pahang, Malaysia to investigate the potential determinants influencing the cognitive function and educational achievement of these children. Cognitive function was measured by intelligence quotient (IQ), while examination scores of selected school subjects were used in assessing educational achievement. Blood samples were collected to assess serum Fe status. All children were screened for soil-transmitted helminthes. Demographic and socio-economic data were collected using pre-tested questionnaires. Almost two-thirds (67.6 ) of the subjects had poor IQ and most of them (72.6) had insufficient …

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Nutritional Composition, Antioxidant Activities, And Antiulcer Potential Of Lentinus Squarrosulus(Mont.) Mycelia Extract, N.A.M. Omar, N. Abdullah, Umah Rani Kuppusamy, M.A. Abdulla, V. Sabaratnam Jan 2011

Nutritional Composition, Antioxidant Activities, And Antiulcer Potential Of Lentinus Squarrosulus(Mont.) Mycelia Extract, N.A.M. Omar, N. Abdullah, Umah Rani Kuppusamy, M.A. Abdulla, V. Sabaratnam

Research Publications (2011 to 2015)

Water extract of Lentinus squarrosulus mycelia was analysed for nutritional content, antioxidant capacity, and antiulcer ability. The extract contains high protein (57.6 g/100 g) and low total fat (0.5 g/100 g) and is rich in magnesium (0.4 g/100 g), potassium (3.8 g/100 g), vitamins B1 (1.42mg/100 g), and B3 (194.29 mg/100 g) with total phenolic content of 39.16 mg/100 g. The cupric reducing antioxidant capacity and 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity of the extract were A(450) of 0.20 perpendicular to 0.03 at 0.5mg/ml and IC(50) of 14.29 mg/ml, respectively. Oral feeding of L. squarrosulus extract (250 mg/kg) offered significant gastric mucosal …

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Oxidative Stress And Antioxidant Status In Primary Bone And Soft Tissue Sarcoma, F.M. Nathan, V.A. Singh, A. Dhanoa, U.D. Palanisamy Jan 2011

Oxidative Stress And Antioxidant Status In Primary Bone And Soft Tissue Sarcoma, F.M. Nathan, V.A. Singh, A. Dhanoa, U.D. Palanisamy

Research Publications (2011 to 2015)

Background: Oxidative stress is characterised by an increased level of reactive oxygen species (ROS) that disrupts the intracellular reduction-oxidation (redox) balance and has been implicated in various diseases including cancer. Malignant tumors of connective tissue or sarcomas account for approximately 1 of all cancer diagnoses in adults and around 15 of paediatric malignancies per annum. There exists no information on the alterations of oxidant/antioxidant status of sarcoma patients in literature. This study was aimed to determine the levels of oxidative stress and antioxidant defence in patients with primary bone and soft tissue sarcoma and to investigate if there exists any …

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Prevalence And Risk Factors Of Intestinal Parasitism In Rural And Remote West Malaysia, R. Ngui, S. Ishak, C. S. Chuen, R. Mahmud, Y. A. L. Lim Jan 2011

Prevalence And Risk Factors Of Intestinal Parasitism In Rural And Remote West Malaysia, R. Ngui, S. Ishak, C. S. Chuen, R. Mahmud, Y. A. L. Lim

Research Publications (2011 to 2015)

Background: Intestinal parasitic infections (IPIs) have a worldwide distribution and have been identified as one of the most significant causes of illnesses and diseases among the disadvantaged population. In Malaysia, IPIs still persist in some rural areas, and this study was conducted to determine the current epidemiological status and to identify risk factors associated with IPIs among communities residing in rural and remote areas of West Malaysia. Methods/Findings: A total of 716 participants from 8 villages were involved, comprising those from 1 to 83 years old, 550 (76.8) participants aged <= 12 years and 166 (23.2) aged >= 13 years, and 304 (42.5) male and 412 (57.5) …

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Risk Of Metabolic Syndrome Among Children Living In Metropolitan Kuala Lumpur: A Case Control Study, B.S. Wee, B.K. Poh, A. Bulgiba, M.N. Ismail, A.T. Ruzita, A.P. Hills Jan 2011

Risk Of Metabolic Syndrome Among Children Living In Metropolitan Kuala Lumpur: A Case Control Study, B.S. Wee, B.K. Poh, A. Bulgiba, M.N. Ismail, A.T. Ruzita, A.P. Hills

Research Publications (2011 to 2015)

Background: With the increasing prevalence of childhood obesity, the metabolic syndrome has been studied among children in many countries but not in Malaysia. Hence, this study aimed to compare metabolic risk factors between overweight/obese and normal weight children and to determine the influence of gender and ethnicity on the metabolic syndrome among school children aged 9 12 years in Kuala Lumpur and its metropolitan suburbs. Methods: A case control study was conducted among 402 children, comprising 193 normal-weight and 209 overweight/obese. Weight, height, waist circumference (WC) and body composition were measured, and WHO (2007) growth reference was used to categorise …

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Simultaneous Detection Of Methicillin-Resistant Staphylococcus Aureus, Acinetobacter Baumannii, Escherichia Coli, Klebsiella Pneumoniae And Pseudomonas Aeruginosa By Multiplex Pcr, Kwai Lin Thong, M.Y. Lai, Cindy Shuan Ju Teh, Kek Heng Chua Jan 2011

Simultaneous Detection Of Methicillin-Resistant Staphylococcus Aureus, Acinetobacter Baumannii, Escherichia Coli, Klebsiella Pneumoniae And Pseudomonas Aeruginosa By Multiplex Pcr, Kwai Lin Thong, M.Y. Lai, Cindy Shuan Ju Teh, Kek Heng Chua

Research Publications (2011 to 2015)

A PCR-based assay that can simultaneously detect and differentiate five different types of nosocomial bacterial pathogens was developed. Six pairs of selected primers targeting femA (132 bp) and mecA (310 bp) of methicillin-resistant Staphylococcus aureus, gltA (722 bp) of Acinetobacter baumannii, phoA (903 bp) of Escherichia coli, mdh (364 bp) of Klebsiella pneumoniae and oprL (504 bp) of Pseudomonas aeruginosa were used in this study. The conditions were optimized for the multiplex PCR to ensure specific amplification of the selected targets. Sensitivity and specificity tests were also carried out using a blind test approach on 50 bacterial cultures and resulted …

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Spasmolytic Effect Of Citral And Extracts Of Cymbopogon Citratus On Isolated Rabbit Ileum, Ramachandran Chitra Devi, Si Mui Sim, Rosnah Ismail Jan 2011

Spasmolytic Effect Of Citral And Extracts Of Cymbopogon Citratus On Isolated Rabbit Ileum, Ramachandran Chitra Devi, Si Mui Sim, Rosnah Ismail

Research Publications (2011 to 2015)

Cymbopogon citratus, commonly known as lemongrass, has been shown to have antioxidant, antimicrobial and chemo-protective properties. Citral, a monoterpenoid, is the major constituent of C. citratus that gives off a lemony scent and is postulated to be responsible for most of its actions. In addition, C. citratus has been traditionally used to treat gastrointestinal discomforts, however, the scientific evidence for this is still lacking. Thus, the aim of the present study was to investigate the effect of the extracts of various parts of C. citratus (leaves, stems and roots) and citral on the visceral smooth muscle activity of rabbit ileum. …

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Total Phenolic Contents, Antioxidant And Antimicrobial Activities Of Bruguiera Gymnorrhiza, M. Haq, W. Sani, A.B.M.S. Hossain, R.M. Taha, K.M. Monneruzzaman Jan 2011

Total Phenolic Contents, Antioxidant And Antimicrobial Activities Of Bruguiera Gymnorrhiza, M. Haq, W. Sani, A.B.M.S. Hossain, R.M. Taha, K.M. Monneruzzaman

Research Publications (2011 to 2015)

In the present work, the antioxidant and antibacterial activities of methanolic, ethanolic and chloroform crude extract of leaves and barks of Bruguiera gymnorrhiza were investigated. The antioxidant activity of the crude extracts were evaluated using the enzymatic and non enzymatic methods namely superoxide dismutase determination, reducing power assay and 2, 2-diphenyl-1-picrylhydrazil free radical scavenging assays. Folin-ciocalteu reagent method was used to estimate the amount of total phenolic compounds of the extracts. Ethanol extract of barks showed the best result in all antioxidant assays which was positively co-related with the total phenolic contents. There was no significant difference between the IC(50) …

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Nutrient Variability For Distillers Grains Plus Solubles And Dry Matter Determination Of Ethanol By-Products, C. D. Buckner, M. F. Wilken, J. R. Benton, S. J. Vanness, V. R. Bremer, T. J. Klopfenstein, P. J. Kononoff, G. E. Erickson Jan 2011

Nutrient Variability For Distillers Grains Plus Solubles And Dry Matter Determination Of Ethanol By-Products, C. D. Buckner, M. F. Wilken, J. R. Benton, S. J. Vanness, V. R. Bremer, T. J. Klopfenstein, P. J. Kononoff, G. E. Erickson

Department of Animal Science: Faculty Publications

Three experiments were conducted to evaluate nutrient content and DM determination methods of dry milling byproducts. In Exp. 1, nutrient composition was determined for wet distillers grains plus solubles (WDGS) and modified distillers grains plus solubles (MDGS) from 6 ethanol plants with 10 samples collected per day, across 5 d, and sampling was repeated over 4 separate months. Mean composition was 31.0% CP, 11.9% fat, 0.84% P, and 0.77% S (DM basis). Coefficients of variation for DM content were greater for some plants than others, and variation occurred within and across days. Variability was small for CP and P, whereas …

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University Of New Hampshire Undergraduate Course Catalog, 2011-2012, University Of New Hampshire Jan 2011

University Of New Hampshire Undergraduate Course Catalog, 2011-2012, University Of New Hampshire

Undergraduate Catalog

No abstract provided.

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Obesity-Mediated Inflammatory Microenvironment Stimulates Osteoclastogenesis And Bone Loss In Mice, Ganesh V. Halade, Amina El Jamali, Paul J. Williams, Roberto J. Fajardo, Gabriel Fernandes Jan 2011

Obesity-Mediated Inflammatory Microenvironment Stimulates Osteoclastogenesis And Bone Loss In Mice, Ganesh V. Halade, Amina El Jamali, Paul J. Williams, Roberto J. Fajardo, Gabriel Fernandes

Internal Medicine Faculty Publications

Clinical evidence indicates that fat is inversely proportional to bone mass in elderly obese women. However, it remains unclear whether obesity accelerates bone loss. In this report we present evidence that increased visceral fat leads to inflammation and subsequent bone loss in 12-month-old C57BL/6J mice that were fed 10% corn oil (CO)-based diet and a control lab chow (LC) for 6. months. As expected from our previous work, CO-fed mice demonstrated increased visceral fat and enhanced total body fat mass compared to LC. The adipocyte-specific PPARγ and bone marrow (BM) adiposity were increased in CO-fed mice. In correlation with those …

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Uri Undergraduate And Graduate Course Catalog 2011-2012, University Of Rhode Island Jan 2011

Uri Undergraduate And Graduate Course Catalog 2011-2012, University Of Rhode Island

URI Course Catalogs Archive

This is a digitized, downloadable version of the University of Rhode Island course catalog.

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Wireless Telesurveillance System For Detecting Dementia, William D. Kearns, James L. Fozard, Vilis O. Nams, Jeffrey D. Craighead Jan 2011

Wireless Telesurveillance System For Detecting Dementia, William D. Kearns, James L. Fozard, Vilis O. Nams, Jeffrey D. Craighead

Rehabilitation and Mental Health Counseling Faculty Publications

Objective We hypothesized path tortuosity (an index of casual locomotor variability) measured by a movement telesurveillance system would be suitable for assisted living facility residents clinically diagnosed with dementia. Background We examined the relationship of dementia to path tortuosity and to movement speed and path length variability, both of which increase in dementia. Methods Daytime movements of 25 elders (19 female; 14 with dementia; average age 80.6) were monitored for 30 days using radio transponders measuring location with a maximum accuracy of 20 cm. After 30 days, the Mini Mental State Exam (MMSE) and Revised Algase Wandering Scale-Community Version (RAWS-CV) …

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Reconciling The Right To Food And Trade Liberalization: Developing Country Opportunities, Lily Endean Nierenberg Jan 2011

Reconciling The Right To Food And Trade Liberalization: Developing Country Opportunities, Lily Endean Nierenberg

Minnesota Journal of International Law, Vols 1-28:1 (1992-2019)

No abstract provided.

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Dekalb Farmers' Market : Assessing Factors That Impact Participation And Developing Nutrition Information Materials Based On Market's Produce, Anna Wells Jan 2011

Dekalb Farmers' Market : Assessing Factors That Impact Participation And Developing Nutrition Information Materials Based On Market's Produce, Anna Wells

Honors Capstones

I worked with Re:New DeKalb, the organization that coordinates the DeKalb Farmers’ Market. The purpose of the project was to provide Re:New DeKalb with information and fliers that they could use to improve and promote the market. My project had two parts. The first part of the project was a survey that I created for community members to complete. After receiving Institutional Review Board approval, the survey was posted online and an e-mail was sent out through Re:New DeKalb. The survey asked questions to determine demographics of market patrons and non- patrons and their opinions and suggestions for the market. …

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Philanthropy, Community, And Grant Writing, Katie Haft Jan 2011

Philanthropy, Community, And Grant Writing, Katie Haft

Honors Capstones

The Child Development Lab at Northern Illinois University has had a history of helping Bachelor degree candidates receive their diplomas with the completion of the internship/practicum at their lab. While using their facilities as research for multiple classes, it was discovered that they were in need of new playground materials. It was decided something would be done to help gain financial funding for this project. Multiple sources were considered and using a grant database to find a grant suitable for the lab’s needs proved to be the best idea. After the attendance of grant application training, an interview with the …

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Nutrient Removal From Urban Stormwater Using Floating Treatment Wetland System, Md Kamrul Islam Jan 2011

Nutrient Removal From Urban Stormwater Using Floating Treatment Wetland System, Md Kamrul Islam

Electronic Theses and Dissertations

Despite the technology advancement, degradation of water quality due to stormwater continues to be a significant threat to the water and ecosystems due to the exponential growth of industries and agricultural enterprises that discharge stormwater. These anthropogenic activities are the sources of high nitrogen and phosphorus quantities in stormwater, which is responsible for eutrophication phenomena and deterioration of public health. Floating Treatment Wetlands (FTWs) are a potential solution to this problem. Both microcosm and mesocosm level studies were conducted for the effective removal of nutrients in stormwater wet detention ponds with different sorption media under varying nutrient concentrations and weather …

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Bayesian Model Selection For Classification With Possibly Large Number Of Groups, Justin Kyle Davis Jan 2011

Bayesian Model Selection For Classification With Possibly Large Number Of Groups, Justin Kyle Davis

Electronic Theses and Dissertations

The purpose of the present dissertation is to study model selection techniques which are specifically designed for classification of high-dimensional data with a large number of classes. To the best of our knowledge, this problem has never been studied in depth previously. We assume that the number of components p is much larger than the number of samples n, and that only few of those p components are useful for subsequent classification. In what follows, we introduce two Bayesian models which use two different approaches to the problem: one which discards components which have “almost constant” values (Model 1) and …

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Commencement Program (June 2011), Csusb Jan 2011

Commencement Program (June 2011), Csusb

CSUSB Commencement Programs

No abstract provided.

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Systematic Study Of Gene Functions For Morphological Chain Formation In Streptococcus Sanguinis, Karra Evans Jan 2011

Systematic Study Of Gene Functions For Morphological Chain Formation In Streptococcus Sanguinis, Karra Evans

Theses and Dissertations

Streptococcus sanguinis is a gram-positive facultative anaerobe that is indigenous to the oral cavity and a primary colonizer of the oral cavity. It serves as a tether for the attachment of several oral bacteria that colonize the tooth surface, form dental plaque, and cause periodontal disease. Previous experiments with streptococcal strains have suggested that cellular chain morphology of streptococci may influence the competitiveness, susceptibility to phagocytosis, acidurance, and aggregation of the bacterium. The purpose of this study was to systematically determine gene functions that contribute to cellular chain length morphology in the SK36 strain of S. sanguinis. Gene functions for …

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High Resolution Hybrid Mass Spectrometry For The Determination Of Marine Biotoxins, Azaspiracids, And Their Biotransformation Products., Zuzana Skrabakova Jan 2011

High Resolution Hybrid Mass Spectrometry For The Determination Of Marine Biotoxins, Azaspiracids, And Their Biotransformation Products., Zuzana Skrabakova

Theses

Azaspiracids (AZAs), polyether marine toxins, are produced by marine microalgae and accumulate in filter-feeding bivalve molluscs, such as mussels, clams, oysters and scallops, while grazing on phytoplankton, from which they derive nutrition. Although being discovered quite recently, AZAs have caused several human intoxication events and thus became a problem for health authorities and shellfish industries. The rapid development of highly sensitive liquid chromatography multiple tandem mass spectrometry (LC-MS/MS, LC-MS") methods enabled the identification of numerous AZA analogues and added to the control of shellfish contamination. Tandem mass spectrometry techniques, while being highly selective and sensitive for determination of AZAs in …

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Purification, Characterisation And Applications Of A Cloned Staphylococcal Bacteriophage Lysin For The Control Of Multi-Drug Resistant Staphylococcus Aureus Including Mrsa, Mark Fenton Jan 2011

Purification, Characterisation And Applications Of A Cloned Staphylococcal Bacteriophage Lysin For The Control Of Multi-Drug Resistant Staphylococcus Aureus Including Mrsa, Mark Fenton

Theses

The work presented in this thesis focuses on the purification, characterisation and practical applications of an anti-staphylococcal lysin (LysK) and its single-domain truncated derivative (CHAPk) against pathogenic staphylococci including meticillin resistant Staphylococcus aureus (MRSA). Both proteins were purified to greater than 90% homogeneity. Affinity chromatography was applied as the optimum method for LysK purification and ion-exchange chromatography was successfully applied to CHAPk. The lytic spectrum of LysK was investigated by zymogram analysis where the enzyme exhibited strong activity against a range of staphylococci regardless of their origin, sequence type (ST) or antibiotic resistant profile. This analysis …

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Acidosis, Preeya Leelahakul Jan 2011

Acidosis, Preeya Leelahakul

Asian Medical Journal and Alternative Medicine

No abstract provided.

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Relationship Between Parents And Their Adolescent Children’S Cardiorespiratory Fitness Levels, Jamie L. Maxwell Jan 2011

Relationship Between Parents And Their Adolescent Children’S Cardiorespiratory Fitness Levels, Jamie L. Maxwell

Graduate Research Papers

The main objective of this research was to examine the relationship between the CRF levels of Grundy Center's High School students and their parents. Based on the study results, recommendations were made regarding the enhancement of CRF among adolescents and their parents. The recommendations were also presented to the school system in an effort to improve the overall health of the Grundy Center School District.

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Winter Commencement, December 18, 2011, Eastern Michigan University Jan 2011

Winter Commencement, December 18, 2011, Eastern Michigan University

Commencement Programs and Materials

No abstract provided.

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Mesalamine-Induced Myocarditis And Coronary Vasculitis In A Pediatric Ulcerative Colitis Patient: A Case Report, Elimarys Perez-Colon, Gul H. Dadlani, Ivan Wilmot, Michelle Miller Jan 2011

Mesalamine-Induced Myocarditis And Coronary Vasculitis In A Pediatric Ulcerative Colitis Patient: A Case Report, Elimarys Perez-Colon, Gul H. Dadlani, Ivan Wilmot, Michelle Miller

Pediatrics Faculty Publications

Mesalamine-containing products are often a first-line treatment for ulcerative colitis. Severe adverse reactions to these products, including cardiovascular toxicity, are rarely seen in pediatric patients. We present a case of a 16-year-old boy with ulcerative colitis treated with Asacol, a mesalamine-containing product, who developed sudden onset chest pain after four weeks on therapy. Serial electrocardiograms showed nonspecific ST segment changes, an echocardiogram showed mildly decreased left ventricular systolic function with mild to moderate left ventricular dilation and coronary ectasia, and his troponins were elevated. Following Asacol discontinuation, his chest pain resolved, troponins were trending towards normal, left ventricular systolic function …

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Isoniazid-Induced Severe Hepatotoxicity: An Infrequent But Preventable Cause Of Liver Failure In Children Treated For Latent Tuberculosis Infection, Dan Desrochers, Regino P. González-Peralta, Daniel T. Mcclenathan, Michael J. Wilsey Jr, Allah Haafiz Jan 2011

Isoniazid-Induced Severe Hepatotoxicity: An Infrequent But Preventable Cause Of Liver Failure In Children Treated For Latent Tuberculosis Infection, Dan Desrochers, Regino P. González-Peralta, Daniel T. Mcclenathan, Michael J. Wilsey Jr, Allah Haafiz

Pediatrics Faculty Publications

Isoniazid (INH) monotherapy has gained widespread acceptance as an efficacious therapy for latent tuberculosis infection (LTBI) especially in low-prevalence settings. Although INH related hepatotoxicity is well recognized, progression to severe liver dysfunction requiring care at a transplant center remains unpredictable. We report the management of a five year-old girl who developed progressive liver failure due to INH prophylaxis. This highlights the potential severity of INH related hepatic injury and underscores the significance of vigilant clinical monitoring throughout the duration of the therapy in children.

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