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Effects Of Single Nucleotide Polymorphisms In The Human Holocarboxylase Synthetase Gene On Catalytic Activity, Shingo Esaki

Department of Nutrition and Health Sciences: Dissertations, Theses, and Student Research

Holocarboxylase synthetase (HCS) catalyzes the covalent binding of biotin to carboxylases and histones in eukaryotic cells. Biotinylated carboxylases play essential roles in the metabolism of fatty acids, amino acids, and glucose; biotinylated histones play essential roles in gene regulation and genome stability. HCS null individuals are not viable whereas HCS deficiency is linked to developmental delays and phenotypes such as short life span and low stress resistance. Greater than 2,500 single nucleotide polymorphisms (SNPs) have been reported for HCS, but the biological importance of these polymorphisms is unknown. We hypothesized that some of these SNPs impair catalytic activity and that …

The Transformation Of China’S Agriculture System And Its Impact On Southeast Asia, Phoebe Mingxuan Luo, John A. Donaldson, Qian Forrest Zhang

Research Collection School of Social Sciences

The increased role for agribusiness and larger scale production in China’s agricultural system is limited by China’s severe lack of arable land. The Household Responsibility System provides farmers a measure of power, hampering agribusiness from acquiring land needed for expansion. Some Chinese companies have sought cheaper and often more accessible land in nearby regions, including Southeast Asia. While such investments have the potential to deliver benefits, including increased productivity, structural constraints such as weak land ownership and environmental laws, highly unequal distribution of land and underdevelopment of peasant organizations prevent many poorer farmers from benefiting from these investments.

Nutrición Y Actividad Fisica En Los Niños De Monteverde: Un Estudio Exploratorio [Powerpoint], August 2011, Simone Green, James Shuford, Coralia Vázquez-Otero, Melissa Whitney

Monteverde Institute: Culture, Community, and Health

This study assesses objective levels of children's physical activity as well as children's subjective perceptions of nutritional knowledge and physical activity in the Monteverde zone.

Child Nutrition And Physical Activity In The Monteverde Zone: An Exploratory Study [Powerpoint], August 2011, Simone Green, James Shuford, Coralia Vázquez-Otero, Melissa Whitney

Monteverde Institute: Culture, Community, and Health

This study assesses objective levels of children's physical activity as well as children's subjective perceptions of nutritional knowledge and physical activity in the Monteverde zone.

Embryonic Development Of The Grass Shrimp, Palaemonetes Pugio, And The Influence Of Salinity On Cardiac Physiology, Amie Lynn Romney

UNLV Theses, Dissertations, Professional Papers, and Capstones

The grass shrimp, Palaemonetes pugio, inhabit the brackish waters along the Atlantic coast of North America and are a key component of the estuarine ecosystem. These decapod shrimp can tolerate large fluctuations in environmental parameters including daily and seasonal fluctuations in salinity between 0 to 55 parts per thousand (seawater at 30-32 ppt). Any observed distribution patterns of adult P. pugio in relation to salinity may be accounted for by their relative ability to tolerate a range in salinity and their ability to maintain internal water volumes and cardiac performance in the earliest life stage, the embryonic period. This thesis …

Indigent Women And Access To Prenatal Care, Zoe Ann Zelazny

UNLV Theses, Dissertations, Professional Papers, and Capstones

One aspect of America's health care system that illustrates the great need for health care reform, but receives little attention, is prenatal care. The United States has the second worst newborn mortality rate in the developed world. Adequate prenatal care results in healthier babies, more full-term babies delivered, and a decrease in other serious problems related to pregnancy and health care costs. The purpose of this study is to examine the history of prenatal policy and how it has developed into what it is today, to understand why medically indigent women are not receiving adequate prenatal care, and to highlight …

Novel Irradiated Axial Rotational Flap Model In The Rodent, Adam J. Luginbuhl, Mara Modest, Bs, Kaiguo Yan, Joseph Curry, Ryan N. Heffelfinger

Department of Otolaryngology - Head and Neck Surgery Faculty Papers

Abstract

Objectives: To design an easily reproducible rodent rotational skin flap and to evaluate the effects of radiation on flap viability.

Methods: Ten rats received 40 Gy irradiation to the abdominal wall. Following a recovery period of one month, a 3 X 8 cm fasciocutaneous flap based axially on the inferior epigastric vessel, was raised and rotated 60 degrees into a contralateral deficit. Five non-irradiated rats underwent the identical procedure as a control. Animals were sacrificed seven days postoperatively, areas of flap necrosis were documented, and histological specimens were taken to compare flap viability and vessel density.

Results: 60% of …

Combined Amino Acid And Glucose Dialysate In Children On Automated Peritoneal Dialysis., Jameela A. Kari, Sherif M. El-Desoky, Al-Anoud Z. Abuduhair, Hamed S. Habib

Saudi Medical Journal

No abstract provided.

Effect Of Signage And Suggestive Selling On Sales Of Healthy Food Options In A University Setting, Ashley Lynn Hoffman

Theses

Making healthy eating choices as a college student can be challenging and the transition from adolescence to adulthood can be associated with an increased likelihood of obesity. Studies have shown that college students have poor eating habits and frequent consumption of fast food meals. Studies have reported menu labeling to be effective in influencing college students' purchasing decisions. During the fall 2009 semester, the Saluki Select Healthy Eating Program was implemented in the Southern Illinois University Carbondale (SIUC) Student Center to aid college students and the public in general to make healthier menu choices. The purpose of this research study …

Bjc Today

BJC Today

No abstract provided.

The Barriers And Enabling Factors To Public Health Advocacy Skills In Kentucky Local Health Departments., Joan Buchar

Electronic Theses and Dissertations

Background: One of the core functions of public health is to develop policies that support community and individual health. There are many historic examples in which public health practitioners have advocated successfully for policies that ultimately protected and improved populations' health. Prior research suggests that local health departments are not fully engaged in health policy advocacy, thereby missing opportunities to more effectively solve public health problems. Objective: To identify the barriers and enabling factors to advocacy in Kentucky local health departments. Methods: Kentucky health policymakers and advocates were interviewed to determine which advocacy skills were effective and appropriate for use …

Effects Of Lactate Dehydrogenase Haplotypes And Body Condition On Beef Cow Production, Olfat Taleb Alaamri

Graduate Theses and Dissertations

Lactate dehydrogenase (LDH) catalyzes the conversion of the pyruvate to lactate (forward) or lactate to pyruvate (reverse) in the last step of glycolysis. Objectives were to document the effects of LDH haplotypes and its SNPs, found in the promoter and coding sequence site, and body condition on beef cow production. Four single nucleotide polymorphisms (SNP) of LDH-B and Five single nucleotide polymorphisms of LDH-A were detected. Eight haplotypes of LDH-B were assigned with the same order of SNPs: G-348A, A-261G, N-222D, and C541A and four haplotypes of LDH-A were assigned with the same order of SNPs: T-327G, D-263C, G390A, A406G, …

Access To Essential Medicines: In Pakistan Identifying Policy Research And Concerns, Shehla Zaidi, Noureen Nishtar

Community Health Sciences

The fundamental importance of ensuring access to medicines, particularly for the poor, is reflected in MDG 8 however remains poor in many low and middle income countries (LMICs). Country specific evidence on access to medicines is weak in LMICs and research has rarely been from an integrated health systems perspective. This study used an evidence based approach to identify key priority concerns and emerging research questions related to access to medicines in Pakistan. WHO’s Access to Medicine Framework was used as the conceptual basis for data collection on rational usage, affordability, financing and health systems. Methods involved a systematic desk …

The Evaluation Of The Use Of A Paper Tracking Form To Improve Provider Adherence To Lipid Guidelines, Diane Ladd

Graduate Theses, Dissertations, and Problem Reports (ETD)

Heart disease is the leading cause of death in men and women in the United States. Significant research into the risk factors for cardiovascular disease has been done, and the effect of hyperlipidemia on cardiovascular risk has been well documented. Recent research has shown that there is a lack of adherence to lipid guidelines by primary care providers. Failure to follow clinical guidelines for lipid disorders leads to increased cardiovascular morbidity and mortality. The objective of the project was to evaluate whether a simple, paper-based, lipid tracking form could improve provider adherence to current lipid guidelines. This descriptive study used …

Youth Physical Activity Opportunities In Lower And Higher Income Neighborhoods, Richard Suminski, Ding Ding, Rebecca Lee, Linda E. May, Tonya Tota, David Dinius

Faculty and Staff Publications

The presence of youth physical activity opportunities is one of the strongest environmental correlates of youth physical activity. More detailed information about such opportunities is needed to maximize their contributions to physical activity promotion especially in under resourced, lower income areas. The objectives of this study were to construct a comprehensive profile of youth physical activity opportunities and contrast profile characteristics between lower and higher income neighborhoods. Youth physical activity opportunities in eight lower (median household income <$36,000) and eight higher (>$36,000) income neighborhoods were identified and described using interviews, neighborhood tours, site visits, and systematic searches of various sources (e.g., Internet). Lower income …

Remarkable Features Of The Hotdog-Fold Thioesterases Involved In Phylloquinone (Vitamin K1) Biosynthesis, Joshua R. Widhalm

Department of Agronomy and Horticulture: Dissertations, Theses, and Student Research

Phylloquinone (vitamin K₁) is a bipartite molecule, consisting of a naphthoquinone ring attached to a phytyl side chain, that is synthesized by plants and certain cyanobacteria to serve as an electron carrier in photosystem I. The coupling of the ring and isoprenyl moieties relies on the cleavage of the CoA-thioester linkage with 1,4-dihydroxy-2- naphthoate (DHNA). It has long been a mystery if this hydrolysis is an enzymatic or chemical process. Using comparative genomics, protein biochemistry, genetics and metabolic profiling, we identified a cyanobacterial thioesterase responsible for the in vivo hydrolysis of DHNA-CoA. This enzyme bears a signature domain …

Acid Maltase Deficiency--Pompe's Disease, Sajjad Jamil, Shahid Ahmed, M. Tariq

Section of Internal Medicine

Mutation in genes encoding for proteins involved in glycogen synthesis, degradation or regulation results in various inborn errors of glycogen metabolism. The disorders that result in abnormal storage of glycogen are known as glycogen storage diseases (GSD). We report a rare and interesting case of a young boy who presented with generalized weakness and reduced muscle bulk since childhood. He was diagnosed to have acid maltase deficiency, also known as Pompe's disease, one of the rare types of glycogen storage disease. The case is presented here in the form of a case study, including a review of the pertinent literature …

Child Nutrition And Physical Activity In The Monteverde Zone: An Exploratory Study, August 2011, Simone Green, James Shuford, Coralia Vázquez-Otero, Melissa Whitney

Monteverde Institute: Culture, Community, and Health

This study assesses objective levels of children's physical activity as well as children's subjective perceptions of nutritional knowledge and physical activity in the Monteverde zone.

A Role For Mir-296 In The Regulation Of Lipoapoptosis By Targeting Puma., Sophie C. Cazanave, Justin L. Mott, Nafisa A. Elmi, Steven F. Bronk, Howard C. Masuoka, Michael R. Charlton, Gregory J. Gores

Journal Articles: Biochemistry & Molecular Biology

Saturated free fatty acids (FFA) induce hepatocyte lipoapoptosis, a key mediator of liver injury in nonalcoholic fatty liver disease (NAFLD). Lipoapoptosis involves the upregulation of the BH3-only protein PUMA, a potent pro-apoptotic protein. Given that dysregulation of hepatic microRNA expression has been observed in NAFLD, we examined the role of miRNA in regulating PUMA expression during lipotoxicity. By in silico analysis, we identified two putative binding sites for miR-296-5p within the 3' untranslated region (UTR) of PUMA mRNA. Enforced miR-296-5p levels efficiently reduced PUMA protein expression in Huh-7 cells, while antagonism of miR-296-5p function increased PUMA cellular levels. Reporter gene …

Making Youth Gardens Grow With Captured Rainwater . . . And Video, Darcy Tessman, Kimberly Gressley

Journal of Extension

In the arid Southwest, water is a limiting resource. Rainwater harvesting is garnering favor, but many are unaware of the myriad uses for that water. Access to fresh, healthy food is also limited in many rural counties because the arid climate makes farming conditions difficult. Teaching youth gardening with rainwater increases the accessibility of local food and the importance of capturing water that might go unused. A series of videos made in youth and adult partnerships provides a tutorial for project duplication worldwide.

Quick And Easy: Use Screen Capture Software To Train And Communicate, Ellen Schuster

Journal of Extension

Screen capture (screen cast) software can be used to develop short videos for training purposes. Developing videos is quick and easy. This article describes how these videos are used as tools to reinforce face-to-face and interactive TV curriculum training in a nutrition education program. Advantages of developing these videos are shared. Suggestions for how these videos can be used in other ways are offered.

Cultural Perspectives On The Interactions Between Nutrition, Health, And Psychological Functioning, Frances E. Aboud

Online Readings in Psychology and Culture

Food and nutrition occupy the daily thoughts of most people, particularly the 178 million children who are malnourished and have been since their first birthday. While malnutrition is directly and indirectly responsible for one-third of child deaths in developing countries, overweight has been declared the number one health problem in other countries. More food is therefore not necessarily better when talking about health. This reading presents information on the major nutrients important for health and psychological functioning, including energy, protein, vitamin A, zinc, iron, and iodine. It also discusses how cultures differ in their food preferences and their beliefs about …

The Association Of Markers Of Endothelial Dysfunction And Incident Diabetes Mellitus, Hypertension, Chronic Kidney Disease And Cardiovascular Mortality, Loretta Rena Cain

Graduate Theses, Dissertations, and Problem Reports (ETD)

In recent years several mechanistic animal studies have proposed new insights, including the role of endothelial dysfunction, in the pathogenesis of common cardiometabolic disorders such as diabetes mellitus, hypertension, chronic kidney disease (CKD) and cardiovascular disease (CVD). However, few studies in humans have followed up these emerging leads from animal models. Because traditional risk factors have been shown not to completely explain all the observed risk of cardiometabolic outcomes in the general population, there is a need to examine novel mechanisms such as endothelial dysfunction in population-based studies, so as to identify new ways of preventing and/or treating these diseases. …

Effect Of Intravenous Treatment With The Oxytocin Antagonist Atosiban On Circulating Progesterone In The Ewe, Todd M. Ramboldt

Graduate Theses, Dissertations, and Problem Reports (ETD)

Effects of oxytocin on the ovine corpus luteum have been controversial for a number of years. The present study investigated the effects of atosiban, a combined oxytocin and vasopressin 1A antagonist, administered systemically to ewes on post estrus day 8 to 10. Atosiban was given in four bolus intravenous injections at 0, 60, 120 and 180 minutes with blood sampling every 15 minutes from -60 through 480 minutes. Concentrations of serum progesterone ng/ml were measured via radioimmunoassay. A log10 transformation of progesterone values was conducted to account for the heterogeneity of variance of the values. During the treatment interval (0 …

The Effect Of Conjugated Linoleic Acid (Cla) On Feed Efficiency And Carcass Composition In Barrows, Natasha R. Winslow

Graduate Theses, Dissertations, and Problem Reports (ETD)

The purpose of this study was to determine if conjugated linoleic acid (CLA) would have an effect on feeding efficiency and carcass composition of 20 finishing barrows obtained from the West Virginia University Animal Science Farm. A posttest experimental design was used to obtain data for the study. The barrows were matched for weight and placed two in a pen. The pens were randomly assigned to a diet consisting of either a 1% CLA oil or 1% soybean oil. The six week study found that weight gain, average daily feed intake, muscle lipids, loin eye area, and color were not …

The Lived Experiences Of 3rd Generation And Beyond U.S.-Born Mexican Heritage College Students: A Qualitative Study, Richard Galvan Edd

Dissertations

The purpose of this study was to describe the psychosocial and identity challenges of 3rd generation and beyond U.S.-born (3GAB-USB) Mexican heritage college students. Alvarez (1973) has written about the psychosocial impact "hybridity" can have on a U.S.- born (USB) Mexican individual who incorporates two distinct cultures (American and Mexican) in order to succeed in U.S. society, and yet, few empirical data is available beyond the 1st and 2nd generation on USB Mexican college students. As an example, there is no mention in the literature of two distinct and different worldviews present between immigrant and 3GAB-USB Mexican college students, which …

B. R. Wells Rice Research Studies 2010, R. J. Norman, K. A. K. Moldenhauer

Arkansas Agricultural Experiment Station Research Series

The 2010 Rice Research Verification Program ( RRVP) was conducted on twenty-two commercial rice fields across the state. Counties rarticirating in the program included Arkansas, Ashley, Chicot, Clark, Clay, Cross, Desha, Drew, Greene, Jackson, Jefferson, Lafayette, Lawrence, Lonoke, Mississippi, Phillips, Poinsett (2 fields), Prairie, Randolph, St. Francis, and White for a total of 1456 acres. Grain yield in the 2010 RRVP averaged 167 bu/acre ranging from 113 to 215 bu/acre. The 2010 RRVP average yield was 25 bu/acre greater than the estimated Arkansas state average of 142 bu/acre. The highest yielding field was in Clay County with a grain yield …

Latent Growth Modeling Of A Nutrition And Physical Activity Intervention, Alicia Dea Sample

Dissertations

The health, economic, and social impacts of physical inactivity and unhealthy dietary patterns are quite significant and evidenced by the fact that only 3-4% of American adults follow all the dietary advice recommended by the Dietary Guidelines for Americans (DGA; Kohatsu, Robinson, & Torner, 2004), and specific subpopulations, including the rural South, are affected even more drastically (McCabe-Sellers et al., 2007). Furthermore, the majority of the people in the United States do not currently meet recommended amounts of physical activity (PA) and have not since the mid 1980s (U.S. Department of Health and Human Services [USDHHS], 2008). To address the …

Is There A Relationship Between The Play Attention Program And Improved Student Achievement?, Jenny Ann Webber

Dissertations

Attention Deficit/Hyperactivity Disorder (ADHD) and its effects on student academic achievement have been researched for many years. There have been many interventions that have been used in treating ADHD that have been found successful when implemented consistently. Some of the interventions that have been researched in the past are behavior modification, pharmacotherapy with stimulants, educational interventions, and a combination of these. Play Attention is an intervention that incorporates aspects of behavior modification through computerized cognitive-training, which utilizes feedback-based technology. Through Play Attention, students wear a helmet or armband embedded with sensors. These sensors read students’ brain activity in order …

The Beta-2 Adrenergic Receptor Polymorphisms And Risk Of Breast Cancer Among Hispanic And Non-Hispanic White Women From The 4-Corners Breast Cancer Study : A Population-Based Case-Control Examination., Avonne Elish Connor

Electronic Theses and Dissertations

Polymorphisms in the adrenergic receptor beta-2 (ADRB2) gene have been studied in relation to risk of Type 2 diabetes and obesity, but few studies have investigated associations with breast cancer. The purpose of this research was to evaluate the primary hypothesis that ADRB2 variants (rs1042713-Arg16Gly and rs1042714-Gln27Glu) are associated with breast cancer risk in non-Hispanic white (NHW) and Hispanic (H) women using data from a population-based case-control study conducted in the southwestern United States: 'The 4-Corners Breast Cancer Study'. A total of 1,244 NHW and 606 H cases with incident primary breast cancer were ascertained and 1,330 NHW and 728 …