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Pericyte, Neural Crest And Adipocyte Differentiation Markers: Support For A Novel Hypothesis For The Origin Of Hemangiomas, Laura Tom

Yale Medicine Thesis Digital Library

Introduction: Hemangiomas are the most common benign tumor of infancy. They are unique in that their behavioral course is well-described with a microvascular proliferative phase, quiescent phase and regressive fatty involuting phase. First, it is posited in this work that the cell of origin will have angiogenic and adipogenic properties, like the pericyte. Second, the predilection of the lesion to areas of embryologic fusions in the head and neck indicate that the neural crest may be involved. Previous research focused on the angiogenic characteristics of proliferating hemangiomas, this work is novel in that it investigates markers involved in adipogenesis. This …

Social Impact, Edward F. Lawler, Keith Negley, Ellen Rostand, Julie Kennedy, Toky Branding + Design, Jessica Martin

Social Impact Publication

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