Digital Commons Network^™

Case For Non-Enforcement Of Anti-Recording Laws Against Citizen Recorders, Mark Brncik

Case Western Reserve Law Review

No abstract provided.

Taking Bubbles Seriously In Contract Law, John Patrick Hunt

Case Western Reserve Law Review

No abstract provided.

Single-Parent Families In Bangkok, Thailand: Factors Affecting Children Living In Single-Parent Families, Waruesporn Jiumpanyarach

Theses and Dissertations--Sociology

There has been a transformation in family structure in Thailand due to the changes in economic and social structures over time. Though not recorded in census data the rise in single-parent families can be expected due to a rise in divorce rates, that have been recorded, over the past decades. However, the literature on single-parent families is limited and little is known about the experiences of single-mothers and children of singlemother families in Thailand. This study examines the factors that have major impacts on the well-being of children of single-parent families in Bangkok, Thailand.

A qualitative methodology was employed to …

Rit Gtpase Signaling Mediates Oxidative Stress Resistance And Survival Of Adult Newborn Neurons After Traumatic Brain Injury, Weikang Cai

Theses and Dissertations--Molecular and Cellular Biochemistry

The small GTPases function as molecular switches to control diverse signaling cascades. The mammalian Rit and Rin, along with Drosophila Ric, comprise an evolutionarily conserved subfamily of the Ras-related GTPases. Previous studies using cultured cell models suggested that Rit was involved in the control of cell proliferation, transformation, neuronal differentiation, morphogenesis, and cell survival, but the principal physiological function of Rit remained uncharacterized.

To address this outstanding question, we employed a genetic approach, engineering a Rit knockout mouse. Using this animal model, we demonstrate a central role of Rit in governing cell survival in a p38-dependent fashion. Primary mouse embryonic …

Towards Recognizing And Reconciling The Multiplicity Of Values And Interests In Trademark Law, Michael S. Mireles Jr.

McGeorge School of Law Scholarly Articles

In the last seventy years, trademark rights have expanded enormously. Many commentators believe this has led to an unjustified increase in the rights and remedies available to trademark owners. This expansion has been approved and led by trademark owners, Congress, and courts, including the U.S. Supreme Court. However, in the last ten years or so, the Supreme Court and Congress have begun attempting to restrain trademark rights, and trademark law is striving to recognize the multiplicity of values implicated by trademark law and reconcile the interests of mark owners and the public generally—particularly users of marks, consumers, and the competitors …

Introduction—Creative Capital: Intellectual Property Creation And Venture Capital, Michael S. Mireles Jr.

McGeorge School of Law Scholarly Articles

No abstract provided.

John Henry Newman, Center For Catholic Studies, Seton Hall University

Center for Catholic Studies Faculty Seminars and Core Curriculum Seminars

No abstract provided.

Pornography As Pollution, John Copeland Nagle

Journal Articles

Pornography is often compared to pollution. But little effort has been made to consider what it means to describe pornography as a pollution problem, even as many legal scholars have concluded that the law has failed to control internet pornography. Opponents of pornography maintain passionate convictions about how sexually-explicit materials harm both those who are exposed to them and the broader cultural environment. Viewers of pornography may generally hold less fervent beliefs, but champions of free speech and of a free internet object to anti-pornography regulations with strong convictions of their own. The challenge is how to address the widespread …

Negotiated Regulation: The Ohio Livestock Care Standards Board As A Model Regulatory Process, Caroline E. Wellman

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Using a comparative framework and based on interviews with the primary actors involved in the debate for and against humane farm animal standards in Ohio, this thesis examines the roles of special and public interest groups, bureaucrats, technocrats, and the public in the rulemaking process of the Ohio Livestock Care Standards Board. This study finds that the creation of the board as a policy solution was likely impossible without the efforts of a policy entrepreneur and a "fixer;" that the board's relevance relies on a problem-setting approach to developing standards that includes a multitude of interests; and that continued public …

Aberrant Dna Replication At An Ectopic Chromosomal Site In Human Cells, Xiaomi Chen

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Aberrant DNA replication, including over-replication or under-replication may lead to life-threatening mutation or even cause human diseases. This thesis focused on three issues related to abnormal DNA replication in human chromosomes including: I) to define the function of DNA unwinding element (DUE) and DNA unwinding element-binding protein (DUE-B) to maintain an active c-myc replicator; II) to determine the role of trans-acting factors in defining a replication origin on human chromosomes; III) to investigate the mechanism by which hairpins affect DNA replication and instability of (CTG)n•(CAG)n trinucleotide repeat tracts in human cells.

Our laboratory previously demonstrated that both DUE and DUE-B, …

Development And Evaluation Of An Interface Aid To Support Web Based Information Seeking For The Blind Research Study, Carissa Ann Brunsman-Johnson

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Information seeking on websites has become more and more challenging for people who are blind. Screen readers attempt to make that task easier by introducing new commands and functionality but there still exists a fundamental gap in the difficulty for people who are blind compared to their sighted counterparts. This research identifies the strategies used by people who are blind and sighted to create an information seeking model, develop the Keywords Expected for Your Search (KEYS) conceptual model for assisting task performance and evaluate a KEYS prototype of this concept for information search and retrieval.

This information seeking model was …

Graphene Based Anode Materials For Lithium-Ion Batteries, Sree Lakshmi Cheekati

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Improvements of the anode performances in Li-ions batteries are in demand to satisfy applications in transportation. In comparison with graphitic carbons, transition metal oxides as well as graphene can store over twice amount of lithium per gram. Recently, graphene-based anodes for Li-ion batteries are under extensive development. In this research, lithium storage characteristics in graphene oxide (GO), GO/Manganese acetate (GO/MnAc), GO/manganese oxide (GO/MnOx) composites and Nano Graphene Platelets (NGP) were studied. The prepared GO delivered reversible capacities of 706mAh/g with an average columbic efficiency of 87%. Reversible capacities of 533 mAh/g were observed for GO/MnAc composite. GO/MnOx nanocomposite thermal annealed …

Cognitive Cyber Weapon Selection Tool Empirical Evaluation, Preethi Vinayak Ponangi

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Keeping in pace with the latest technological innovations in the cyber world, the misuse of this powerful infrastructure has also increased proportionally. Although a lot of recent attacks have been documented in the mainstream media, counter measures for cyber defense mechanism have only received some attention in the recent research literature. Most of the global attacks in the cyber space have proved to be carefully planned premeditated attacks. Considering that most of these attacks are co-coordinated by humans, a new area of psychological weaponry is being investigated by the research community. This study aims to empirically evaluate the effectiveness of …

A User Centered Design And Prototype Of A Mobile Reading Device For The Visually Impaired, Robert B. Keefer

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While mobile reading devices have been on the market and investigated by researchers in recent years, there is still work required to make these devices highly accessible to the visually impaired. A usability test with one such device revealed gaps in the current state of the art devices. These gaps focus mostly on the user interaction and his or her ability to quickly consume written reading material. In this dissertation a voice user interface (VUI) is presented that improves the ability of a blind user of a mobile reading device to interact with written material. The image processing techniques required …

Hsv-1 Infection In Keratinocyte Cell Lines Treated With Mitotic Inhibitors, Asma A. Abbas

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The hypothesis for this research was: Herpes simplex virus type 1 (HSV-1) infection of murine keratinocyte cell lines (HEL-30 and PAM-212) treated with mitotic inhibitors leads to silencing of virus replication. At 0.1 (Multiplicity of infection) MOI, PAM-212 keratinocytes showed some cell lysis and viral plaques were seen in HEL-30 keratinocyte cultures. PAM-212 keratinocytes, infected at 0.01 MOI, were more susceptible to the lytic effect of HSV-1 than were HEL-30 cells. In this study, 5-fluoro-2'-deoxyuridine (FUDR) treatment of both keratinocyte cell lines permitted an increase survival of HSV-1- infected keratinocytes especially for PAM-212 cell line which was further examined for …

Beyond Aurora, Ryan Patrick Ireland

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Set in 1888-9, this historical fiction narrative chronicles the events leading up to, and following the Martin brothers' failed quest for vengeance. The brothers work as mercenaries for a Plains sheriff before being sent into exile. They eventually part ways and each of them spirals into their own brand of madness.

The Kozeny-Carman Equation Considered With A Percolation Threshold, Lee Brenson Porter Ii

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A procedure has been developed for calculating permeability (k) from the Kozeny-Carmen equation, a procedure that links ideas from percolation theory with the ideas of Koltermann and Gorelick (1995) and Esselburn et al. (2011). The approach focuses on the proportion of coarser pores that are occupied by finer sediments and defines a threshold proportion. For proportions below this threshold, the unoccupied coarser pores percolate. Following the ideas of Koltermann and Gorelick (1995), the effective grain-size term in the Kozeny-Carman equation is calculated using the geometric mean if below the threshold proportion, and with the harmonic mean if above. Following ideas …

Bio-Functionalized Clay Nanoparticles For Wound Healing Applications, Christopher Anthony Vaiana

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Wound healing is a complex, multi-step process that can be summarized into three stages, namely hemostasis and inflammation, proliferation, and finally tissue remodeling. Battlefield wound healing demands rapid hemostasis using clotting or cauterizing agents to immediately limit blood loss, but this occurs at the expense of proper tissue repair beyond hemostasis. Layered silicate clays such as kaolin and montmorillonite (MMT) have been previously shown to induce blood clotting due to their ability to form charged interactions with clotting factors. The charge characteristics of sodium MMT (Na-MMT) also enable functionalization with active biomolecules. Herein we first functionalize three types of alumoinosilicate …

Interrogation Of The Distal Gut Microbiota Of Healthy Adolescents And Those With Irritable Bowel Syndrome, Laura J. Rigsbee

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The human-associated microbiota has been the focus of much current research, with the microbiota inhabiting the gastrointestinal tract of particular interest. These organisms play many roles in human health and well-being. However, shifts in the composition of the intestinal microbiota have been associated with diseases such as irritable bowel syndrome, inflammatory bowel disease, and colon cancer. Several recent studies have reported on the distal gut microbiota composition of healthy adults and those with IBS, while there is a lack of studies devoted to adolescents. This study utilized a custom-designed Affymetrix Microbiota Array capable of detecting 775 phylo-species of intestinal bacteria …

Aquaporin 4 Expression And Distribution During Osmotic Brain Edema And Following Chronic Treatment Of Desipramine, Sergei Alexander Robinson

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Osmotic brain edema or chronic treatment with desipramine alters brain water permeability. In this study we investigated aquaporin 4 expression and distribution in these two conditions. Brain edema development was induced by intraperitoneal water injection. Blood serum osmolality decreased from 296 ± 1 mOsm to 278 ± 2 mOsm within 15 min. Cerebral cortex water content increased from 79.8 ± 0.2 % to 81.3 ± 0.5% during 120 min of this hyposmotic exposure. Aquaporin 4 immunostaining intensity at the astrocytic endfeet increased in water injected animals from 2.6 ± 0.04 intensity unites (IU) to 3.2 ± 0.21 IU, while total …

Response Of Monovalent Cation Transporters To Pro-Apoptotic Protein Kinase C Modulators In Human Lens Epithelial Cells, Michael Anthony Lepera

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Protein kinase inhibition by staurosporine causes apoptotic volume decrease involving potassium (K) channels in immortalized human B3 lens epithelial cells (LECs). Here, the effect of two pro-apoptotic protein kinase C (PKC) inhibitors [12-O-tetradecanoyl-phorbol-13-acetate (TPA) and chelerythrine (CET)] were studied on membrane K transport in a fetal human LEC line (FHL124) by western blotting, immunofluorescence, ion flux, ATP, apoptosis, and biotinylation assays. Long term TPA exposure (0-6 h) inhibited 75% of Na-K-2Cl cotransport (NKCC). In contrast, short term (0-20 min) exposure to 50 μM CET reduced Na/K pump and NKCC by >90% and >70%, respectively, without retrieval from the membrane into …

Parallel Sorting On Multi-Core Architecture, Wei Wang

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With the limitations given by the power consumption (power wall), memory wall and the instruction level parallelism, the computing industry has turned its direction to multi-core architectures. Nowadays, the multi-core and many-core architectures are becoming the trend of the processor design. But how to exploit these architectures is the primary challenge for the research community. To take advantage of the multi-core architectures, the software design has undergone fundamental changes.

Sorting is a fundamental, important problem in computer science. It is utilized in many applications such as databases and search engines. In this thesis, we will investigate and auto-tune two parallel …

Process Sequencing For Fatigue Life Extension Of Large Scale Laser Peened Components, Thomas Joshua Spradlin

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Mechanical surface enhancement techniques have been used to successfully increase the fatigue life of metallic components. These techniques impart compressive surface residual stresses that reduce the tensile stresses experienced during service loading. Laser Peening (LP) is a surface enhancement technique that uses high intensity, short duration laser pulses to create plastic shockwaves in metallic components. Experimental investigations and limited simulation studies have been conducted to determine the effects on the fatigue life of simple coupons when key LP parameters are varied. Used primarily in the aerospace and biomedical engineering fields, LP has been limited to industries that can afford its …

Optimizing Memory Cost With Loop Transformations, Hailong Shi

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Embedded systems are usually constrained in terms of timing, power, and memory. Many embedded applications, especially in the multi-media and telecom domains, are inherently data dominant. These embedded DSP applications usually exhibit intensive computations in the form of multi-level loops. The performance of these embedded DSP applications mainly depends on the code quality of the loops and the memory hierarchy design. During the design phase of the embedded system, it is important to estimate the overall storage requirement to guide the memory system design and take advantage of the memory system by program transformations and loop transformations.

Loop transformations including …

Near Equilibrium Dissolution Of Calcite Using A Flow-Through Reactor (Ftr), Michael Mante

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In mineral dissolution reactions, surface morphologies play important roles particularly in near equilibrium fluids where generation of new sites of reactivity (e.g., pit nuclei) is thermodynamically disfavored. Following CO₂ injection in geologic formations, dissolution of primary carbonate minerals and crack-sealing cements will occur. The impact of these reactions on fluid chemistry requires better understanding of the reaction kinetics of major minerals at close-to-equilibrium conditions. Initial investigations have focused on quantifying calcite dissolution using short residence time (~ 10 min) flow through reactors to obtain dissolution rates at 60°C, pH = 8.33 and Pco₂ = 3.8 x 10^{-4 …}

Synthesis Of Isatin Derivatives Used For The Inhibition Of Pro-Apoptotic Jurkat T Cells, Charles Michael Clay

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A range of substituted 1H-indole-2,3-diones (isatins) was synthesized to assess their capability to inhibit caspases and prevent apoptosis in Jurkat T cells. The key steps in the synthesis of such molecules involved electrophilic substitution of the C-5 position of the isatin nucleus (if necessary), N-alkylation, Wolff-Kishner reduction of the C-3 carbonyl group and finally, Knoevenagel condensation. The design and synthesis of such potential inhibitors was guided by SAR studies of peptide based inhibitors such as "Q-VD-O-Ph", as well as small-molecule inhibitors based upon the isatins scaffold. Previously, 3-(2,6-difluorobenzylidene)-5-nitroindolin-2-one has been shown to inhibit apoptosis in human Jurkat T cells at …

Lithium-Ion Battery Anodes Of Randomly Dispersed Carbon Nanotubes, Nanofibers, And Tin-Oxide Nanoparticles, Gerard Klint Simon

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Lithium-ion battery anodes with a nanostructure of randomly dispersed carbon nanofibers (CNFs), carbon nanotubes (CNTs), and nanoparticles of tin-oxide or silicon were fabricated and tested in order to develop high capacity, easily manufactured anodes. In these anodes, a mesh of CNTs and CNFs form a conductive network within which the nanoparticles of tin-oxide are suspended. The CNT network directs electron flow to and from the nanoparticles while accommodating their volume changes. The CNFs were intended to aid electron transport by serving as conduction channels between the CNTs and the current collector. Secondarily, the CNFs reinforce the physical structure of the …

Cetyltrimethylammonium Halide-Coated Electrodes For The Detection Of Dopamine In The Presence Of Interferents, Amber J. Yeary

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Specially constructed carbon paste electrodes were coated with 10 mM cetyltrimethylammonium halide (CTAX) solutions, bromide and chloride being the counter anions. These surfactant modified electrodes were used to detect the catecholamine neurotransmitter dopamine using cyclic voltammetry. The coated electrodes gave reproducible quasi-reversible behavior for the analyte dopamine over a range of concentrations from 1 mM to 200 mM. When combined in solution with common interferents ascorbic acid (1 mM) and uric acid (300 μM), all cathodic and anodic current peaks maintained resolution at the biological pH of 7.4. When the coating solutions were below the critical micelle concentration (0.5 mM), …

Distribution Of Cellular Interferon Beta (Ifn-Β) In Murine Fibroblast Cell Lines Upon Infection Of Hsv-1, Rachael E. Curtis

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The hypothesis for this study was: IFN-β expression differs between murine fibroblasts (A2R1 and L929) of different mouse strains upon infection of HSV-1. Fluorescent microscopy was used to examine localization of IFN-β in the different murine fibroblast and keratinocyte cell lines after 6 hours of infection with herpes simplex virus type-1 (HSV-1). Because keratinocytes cell lines HEL-30 and PAM-212 grew in clusters, staining patterns in individual cells could not be determined. A notable difference in localization of IFN-β immune staining was seen between the two cell lines when infected with HSV-1. The A2R1 cell line showed perinuclear (PN) localization, while …

Real Time Semantic Analysis Of Streaming Sensor Data, Harshal Kamlesh Patni

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The emergence of dynamic information sources - like social, mobile and sensors, has led to ginormous streams of real time data on the web also called, the era of Big Data [1]. Research studies suggest, these dynamic networks have created more data in the last three years than in the entire history of civilization, and this trend will only increase in the coming years [1]. Gigaom article on Big data shows, how the total information generated by these dynamic information sources has completely surpassed the total storage capacity. Thus keeping in mind the problem of ever-increasing data, this thesis focuses …