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2011

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Articles 20131 - 20160 of 23822

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Renovating Space: The Future Of International Space Law, P. J. Blount Jan 2011

Renovating Space: The Future Of International Space Law, P. J. Blount

Denver Journal of International Law & Policy

No abstract provided.

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Strategies For Labeling Proteins With Paracest Agents, Olga Vasalatiy, Piyu Zhao, Mark Woods, Andrei Marconescu, Aminta Castillo-Muzquiz, Philip Thorpe, Garry Kiefer, A. Dean Sherry Jan 2011

Strategies For Labeling Proteins With Paracest Agents, Olga Vasalatiy, Piyu Zhao, Mark Woods, Andrei Marconescu, Aminta Castillo-Muzquiz, Philip Thorpe, Garry Kiefer, A. Dean Sherry

Chemistry Faculty Publications and Presentations

Reactive surface lysine groups on the chimeric monoclonal antibody (3G4) and on human serum albumin (HSA) were labeled with two different PARACEST chelates. Between 7.4 – 10.1 chelates were added per 3G4 molecule and between 5.6 – 5.9 chelates per molecule of HSA, depending upon which conjugation chemistry was used. The immunoreactivity of 3G4 as measured by ELISA assays was highly dependent upon the number of attached chelates: 88% immunoreactivity with 7.4 chelates per antibody versus only 17% immunoreactivity with 10.1 chelates per antibody. Upon conjugation to 3G4, the bound water lifetime of Eu-1 increased only marginally, up from …

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Imaging The Extracellular Ph Of Tumors By Mri After Injection Of A Single Cocktail Of T1 And T2 Contrast Agents, Gary V. Martinez, Xiaomeng Zhang, María L. García-Martín, David L. Morse, Mark Woods, A. Dean Sherry, Robert J. Gillies Jan 2011

Imaging The Extracellular Ph Of Tumors By Mri After Injection Of A Single Cocktail Of T1 And T2 Contrast Agents, Gary V. Martinez, Xiaomeng Zhang, María L. García-Martín, David L. Morse, Mark Woods, A. Dean Sherry, Robert J. Gillies

Chemistry Faculty Publications and Presentations

The extracellular pH (pH(e) ) of solid tumors is acidic, and there is evidence that an acidic pH(e) is related to invasiveness. Herein, we describe an MRI single-infusion method to measure pH(e) in gliomas using a cocktail of contrast agents (CAs). The cocktail contained gadolinium-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraaminophosphonate (GdDOTA-4AmP) and dysprosium-1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetrakis(methylenephosphonic acid) (DyDOTP), whose effects on relaxation are sensitive and insensitive to pH, respectively. The Gd-CA dominated the spin-lattice relaxivity ΔR(1) , whereas the Dy-CA dominated the spin-spin relaxivity ΔR(2)*. The ΔR(2)* effects were used to determine the pixel-wise concentration of [Dy] which, in turn, was used to calculate a value for [Gd] …

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Shouting "Fire!" In A Theater And Vilifying Corn Dealers, Vincent A. Blasi Jan 2011

Shouting "Fire!" In A Theater And Vilifying Corn Dealers, Vincent A. Blasi

Faculty Scholarship

Five years ago, Fred Schauer published an article with the intriguing title: "Do Cases Make Bad Law?" Playing off Holmes' observation that "[g]reat cases like hard cases make bad law," Schauer explored the possibility, as he put it, that "it is not just great cases and hard cases that make bad law, but simply the deciding of cases that makes bad law.” His concern, confirmed and deepened by his characteristically balanced inquiry, was that general principles forged in the resolution of specific legal disputes can suffer by virtue of that provenance. Because such principles by definition are meant to carry …

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A Populist Threat To China's Courts?, Benjamin L. Liebman Jan 2011

A Populist Threat To China's Courts?, Benjamin L. Liebman

Faculty Scholarship

Is the Chinese party-state too responsive to public opinion? In the case of the courts, this may be the case. Western literature has devoted extensive attention to the problems in the Chinese legal system, in particular in the courts, describing a system that continues to be undermined by a range of problems, from corruption to lack of competence to continued Communist Party intervention. Likewise, existing literature describes a legal system that often is unresponsive to individual demands for justice. In this chapter, I examine another possibility: that one impediment to the development of courts that are able to protect individual …

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Copyright Publication: An Empirical Study, Deborah R. Gerhardt Jan 2011

Copyright Publication: An Empirical Study, Deborah R. Gerhardt

Faculty Publications

No abstract provided.

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Baum Lecture 2010, Lee C. Bollinger Jan 2011

Baum Lecture 2010, Lee C. Bollinger

Faculty Scholarship

As part of the Baum Lecture Series at the University of Illinois College of Law, Columbia University President Lee C. Bollinger delivered a lecture on September 14, 2010, on the essential role of a global free press in providing the information needed to understand the many problematic issues we face as a result of globalization. In this presentation, President Bollinger addressed the challenges of maintaining high-quality institutions of American journalism with an international reporting capacity in the face of rapidly changing market forces. He further discussed America’s interest in seeing the rise of a free and independent press in nations …

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Phenolic Composition, Antioxidant Capacity And Antibacterial Activity Of Selected Irish Brassica Vegetables, Amit Jaiswal, Gaurav Rajauria, Nissreen Abu-Ghannam, Shilpi Gupta Jan 2011

Phenolic Composition, Antioxidant Capacity And Antibacterial Activity Of Selected Irish Brassica Vegetables, Amit Jaiswal, Gaurav Rajauria, Nissreen Abu-Ghannam, Shilpi Gupta

Articles

Vegetables belonging to the Brassicaceae family are rich in polyphenols, flavonoids and glucosinolates, and their hydrolysis products, which may have antibacterial, antioxidant and anticancer properties. In the present study, phenolic composition, antibacterial activity and antioxidant capacity of selected Brassica vegetables, including York cabbage, Brussels sprouts, broccoli and white cabbage were evaluated after extraction with aqueous methanol. Results obtained showed that York cabbage extract had the highest total phenolic content, which was 33.5, followed by 23.6, 20.4 and 18.4 mg GAE/g of dried weight (dw) of the extracts for broccoli, Brussels sprouts and white cabbage, respectively. All the vegetable extracts had …

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Effect Of Processing Conditions On Phytochemical Constituents Of Edible Irish Seaweed Himanthalia Elongata., Sabrina Cox, Nissreen Abu-Ghannam, Shilpi Gupta Jan 2011

Effect Of Processing Conditions On Phytochemical Constituents Of Edible Irish Seaweed Himanthalia Elongata., Sabrina Cox, Nissreen Abu-Ghannam, Shilpi Gupta

Articles

Seaweed iswell recognized as an excellent source of phytochemicals. This study was a preliminary screening to investigate the effects of various food processing methods on the phytochemicals of Himanthalia elongata. Hydrothermal processing was carried out until an edible texture was achieved. The total phenolic content (TPC) of fresh H. elongata was 175.27 mg gallic acid equivalent (GAE)/100 g fresh weight (FW) while boiling significantly reduced the TPC to 25.4 mg GAE/100 g FW
(P < 0.05).A drying pretreatment before boiling reduced the cooking time therefore leading to less leaching of antioxidants upon boiling. In terms of extract, drying of H. elongata followed by boiling had the most significant effect on the phytochemicals as TPC increased by 174%. Boiled extracts had the most effective 2, 2-diphenyl- 1-picrylhydrazyl scavenging activity (EC50 of 12.5 mg/mL). As a comparison, seaweed subjected to the same treatments was studied in terms of antimicrobial activity.Overall, extracts fromfresh H. elongata achieved the highest inhibition.

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Efficacy Of Biocides Used In The Modern Food Industry To Control Salmonella Enterica, And Links Between Biocide Tolerance And Resistance To Clinically Relevant Antimicrobial Compounds, Orla Condell, Carol Iversen, Shane Cooney, Karen Power, Ciara Walsh, Catherine Burgess, Seamus Fanning Jan 2011

Efficacy Of Biocides Used In The Modern Food Industry To Control Salmonella Enterica, And Links Between Biocide Tolerance And Resistance To Clinically Relevant Antimicrobial Compounds, Orla Condell, Carol Iversen, Shane Cooney, Karen Power, Ciara Walsh, Catherine Burgess, Seamus Fanning

Articles

Biocides play an essential role in limiting the spread of infectious disease. The food industry is dependent on these agents, and their increasing use is a matter for concern. Specifically, the emergence of bacteria demonstrating increased tolerance to biocides, coupled with the potential for the development of a phenotype of cross-resistance to clinically important antimicrobial compounds, needs to be assessed. In this study, we investigated the tolerance of a collection of susceptible and multidrug-resistant (MDR) Salmonella enterica strains to a panel of seven commercially available food-grade biocide formulations. We explored their abilities to adapt to these formulations and their active …

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Evolutionary History And Spread Of Multidrug Resistant Inchi1 Plasmids In Salmonella Typhi, Kathryn Holt, Minh Duy Phan, Stephen Baker, Pham Thanh Duy, Tran Vu Thieu Nga, Satheesh Nair, Arthur Keith Turner, Ciara Walsh, Seamus Fanning, Sinead Farrell-Ward, Shanta Dutta, François-Xavier Weill, Julian Parkhill, Gordon Dougan, John Wain Jan 2011

Evolutionary History And Spread Of Multidrug Resistant Inchi1 Plasmids In Salmonella Typhi, Kathryn Holt, Minh Duy Phan, Stephen Baker, Pham Thanh Duy, Tran Vu Thieu Nga, Satheesh Nair, Arthur Keith Turner, Ciara Walsh, Seamus Fanning, Sinead Farrell-Ward, Shanta Dutta, François-Xavier Weill, Julian Parkhill, Gordon Dougan, John Wain

Articles

Typhoid fever, infection with Salmonella enterica serovar Typhi (S. Typhi), remains a serious health concern in many parts of the world, particularly where sanitation is poor. While vaccines against S. Typhi are available, coverage in endemic regions is low, leaving antimicrobial therapy central to disease control. Unfortunately, drug resistant S. Typhi emerged in the mid-1970s and multi-drug resistance (MDR) is now a significant problem in many typhoid endemic areas. In the S. Typhi population, MDR is almost exclusively conferred by self-transmissible IncHI1 plasmids carrying a suite of antimicrobial resistance genes. We compared eight IncHI1 plasmid sequences and identified single nucleotide …

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Developmental Biology (Embryology), Steelman Library, Todd Schraw Jan 2011

Developmental Biology (Embryology), Steelman Library, Todd Schraw

Syllabus Repository

No abstract provided.

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Fundamentals Of Speech, Steelman Library, David Yates Jan 2011

Fundamentals Of Speech, Steelman Library, David Yates

Syllabus Repository

No abstract provided.

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Photography, Steelman Library, Chad Neuman Jan 2011

Photography, Steelman Library, Chad Neuman

Syllabus Repository

No abstract provided.

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Characterization Of Spiroplasma Mirum And Its Role In Transmissible Spongiform Encephalopathies, Hilari Maree French Jan 2011

Characterization Of Spiroplasma Mirum And Its Role In Transmissible Spongiform Encephalopathies, Hilari Maree French

LSU Doctoral Dissertations

There are many contradictory reports in the literature involving the culture of Spiroplasma mirum, its resistance to disinfectants and antibiotics, and its potential role in Transmissible Spongiform Encephalopathies (TSEs). These contradictions led to an interest in a possible link between spiroplasma and TSEs and the development of a research plan to elucidate this connection. It was hypothesized that Spiroplasma was associated with a neurodegenerative disease such as TSE. In this work we further characterized S. mirum laboratory strains and continued to evaluate the possible correlations they have with TSE infections and the prion. To optimize recovery of S. mirum from …

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Ns-3 Simulation Of Wimax Networks, Christopher Thomas Jan 2011

Ns-3 Simulation Of Wimax Networks, Christopher Thomas

All Theses and Dissertations (ETDs)

Simulation is a powerful tool for analysis and improvement of networking technologies, and many simulation packages are available. One that is growing in popularity is NS-3, the successor to the popular NS-2. It is a significant departure from NS-2, and offers many advantages and disadvantages. In this thesis, we translate and update a sophisticated WiMAX simulation model from NS-2 to NS-3, and use this experience to investigate the major differences between NS-2 and NS-3, and the relative strengths of each package. We then use the NS-3 simulation model to provide analysis on a new WiMAX OFDMA downlink subframe mapping algorithm.

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Memorializing Destruction: Preservation Of Bombed Churches As Second World War Memorials In Britain And Germany, Julia Reardon Jan 2011

Memorializing Destruction: Preservation Of Bombed Churches As Second World War Memorials In Britain And Germany, Julia Reardon

All Theses and Dissertations (ETDs)

No abstract provided.

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Empirical Studies For Reliable Home Area Wireless Sensor Networks, Mo Sha Jan 2011

Empirical Studies For Reliable Home Area Wireless Sensor Networks, Mo Sha

All Theses and Dissertations (ETDs)

Home Area Networks: HANs) consisting of wireless sensors have emerged as the enabling technology for important applications such as smart energy and assisted living. A key challenge faced by HANs is maintaining reliable operation in real-world residential environments. In this thesis research, empirical studies on the spectrum usage in the 2.4 GHz band as well as 802.15.4 wireless channels are performed in diversified real residential environments. Based on the insights drawn from empirical studies, network design guideline and practical solution for Home Area Sensor Network are provided.

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A Graph-Based Algorithm To Determine Protein Structure From Cryo-Em Data, Stephen Schuh Jan 2011

A Graph-Based Algorithm To Determine Protein Structure From Cryo-Em Data, Stephen Schuh

All Theses and Dissertations (ETDs)

Cryo-electron microscopy: cryo-EM) provides 3D density maps of proteins, but these maps do not have sufficiently high resolution to directly yield atomic-scale models. Previous work has shown that features known as secondary structures can be located in these density maps. A second source of information about proteins is sequence analysis, which predicts locations of secondary structures along the protein sequence but does not provide any information about the 3D shape of the protein. This thesis presents a graph-based algorithm to find the correspondence between the secondary structures in the density map and sequence. This provides an ordering of secondary structures …

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Decoding Brain Activation From Ipsilateral Cortex Using Ecog Signals In Humans, Yuzong Liu Jan 2011

Decoding Brain Activation From Ipsilateral Cortex Using Ecog Signals In Humans, Yuzong Liu

All Theses and Dissertations (ETDs)

Today, learning from the brain is the most challenging issue in many areas. Neural scientists, computer scientists, and engineers are collaborating in this broad research area. With better techniques, we can extract the brain signals by either non-invasive approach such as EEG: electroencephalography), fMRI, or invasive method such as ECoG: electrocorticography), FP: field potential) and signals from single unit. The challenge is, given the brain signals, how can we possibly decipher them? Brain Computer Interfaces, or BCIs, aim at utilizing the brain signals to control prothetic arms or operate devices. Previously almost all the research on BCIs focuses on decoding …

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The Impact Of Cultural And Environmental Factors On The Experiences Of Survivors Of Gendered Violence In The African American Community, Alana Fields Jan 2011

The Impact Of Cultural And Environmental Factors On The Experiences Of Survivors Of Gendered Violence In The African American Community, Alana Fields

All Theses and Dissertations (ETDs)

I propose to examine cultural factors mediating silence surrounding “gendered violence” in the African American community, utilizing St. Louis as a case study. I hypothesize that two phenomenon are in play, “Black Male Privilege” in conjunction with “collectivism”. I expect to demonstrate that - using an ethnographic methodology - these phenomena work to create and normalize a climate of silence relating to gendered violence. I suggest that these phenomena also work to perpetuate a culture of acceptability about gendered violence and preclude the understanding of the dynamic intersection of race, gender and class which cause insufficient access to culturally sensitive …

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Motion-Based Video Games For Stroke Rehabilitation With Reduced Compensatory Motions, Gazihan Alankus Jan 2011

Motion-Based Video Games For Stroke Rehabilitation With Reduced Compensatory Motions, Gazihan Alankus

All Theses and Dissertations (ETDs)

Stroke is the leading cause of long-term disability among adults in industrialized nations, with 80% of people who survive strokes experiencing motor disabilities. Recovery requires daily exercise with a high number of repetitions, often without therapist supervision. Motion-based video games can help motivate people with stroke to perform the necessary exercises to recover. We explore the design space of video games for stroke rehabilitation using Wii remotes and webcams as input devices, and share the lessons we learned about what makes games therapeutically useful. We demonstrate the feasibility of using games for home-based stroke therapy with a six-week case study. …

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Quantitative Perfusion-Sensitive Mri Phantoms, Jeff Anderson Jan 2011

Quantitative Perfusion-Sensitive Mri Phantoms, Jeff Anderson

All Theses and Dissertations (ETDs)

Perfusion-sensitive MR methods are increasingly utilized in preclinical and clinical MR research studies with the promise of providing quantitative estimates of parameters that describe in vivo microvasculature. One of these techniques, dynamic contrast enhanced: DCE) MRI, has found particularly common use in oncology for the detection, staging, and monitoring of highly vascularized tumors. DCE-MRI has been qualitatively validated by various studies that show a high correlation between modeled parameters from DCE and histologically measured microvascular density: MVD). However, in the absence of a matching "gold-standard" technique, DCE-MRI has not yet been quantitatively validated: i.e., the accuracy of the estimated parameters …

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Lustmord And Loving The Other: A History Of Sexual Murder In Modern Germany And Austria (1873-1932), Amber Aragon-Yoshida Jan 2011

Lustmord And Loving The Other: A History Of Sexual Murder In Modern Germany And Austria (1873-1932), Amber Aragon-Yoshida

All Theses and Dissertations (ETDs)

Lustmord and Loving the Other: A History of Sexual Murder in Modern Germany and Austria: 1873–1932) examines the historical significance of German–speaking Europeans’ responses to crises of modernity vis–Ã –vis their fin de siècle cultural fascination with crimes and representations of Lustmord. I address the emergence and development of the concept of Lustmord, particularly the changing ways in which medical, legal, and criminal experts, survivors, perpetrators, neighbors, the press, and artists understood and attempted to explain this modern phenomenon. I demonstrate the ways in which a society came to name, understand, and, to some degree, even accept a troubling new …

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2010 Ohio Animal Welfare Compromise, J. David Aiken Jan 2011

2010 Ohio Animal Welfare Compromise, J. David Aiken

Cornhusker Economics

In June 2010, Ohio elected officials and animal welfare activists negotiated an animal welfare compromise agreement that kept an animal welfare proposition off the November ballot in Ohio.

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Mhc Class I-Dependent Acquisition And Maintenance Of Natural Killer Cell Function, Julie Chase Jan 2011

Mhc Class I-Dependent Acquisition And Maintenance Of Natural Killer Cell Function, Julie Chase

All Theses and Dissertations (ETDs)

Natural killer: NK) cells are hematopoietically derived immune cells of the lymphoid lineage. Their effector functions, including cytokine secretion and cytotoxicity, are controlled by the integration of signals received from both activating and inhibitory receptors. In a phenomenon known as "missing-self" recognition, NK cells eliminate self-tissues with aberrantly low or absent MHC class I surface expression, as is common in settings of viral infection and transformation, when these cells fail to engage the critical NK cell inhibitory receptors. Interestingly, NK cells that develop in an MHC class I-deficient environment are defective in natural killing and hyporesponsive to stimulation through their …

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Mass Spectrometry For Determination Of Conformation And Dynamics Of Proteins And Structure And Biosynthesis Of Bacterial Peptidoglycan, Jiawei Chen Jan 2011

Mass Spectrometry For Determination Of Conformation And Dynamics Of Proteins And Structure And Biosynthesis Of Bacterial Peptidoglycan, Jiawei Chen

All Theses and Dissertations (ETDs)

Mass spectrometry: MS) has emerged as an important tool for analyzing and characterizing large biomolecules. In this dissertation, two aspects of the development and application of MS-based approaches are presented; they include: 1) protein conformation and folding dynamics: in Chapters 2 to 5) and bacterial peptidoglycan: PG) structure and biosynthesis: Chapters 6 to 8). Chapter 1 serves as the introduction for both aspects. Part I of the dissertation focuses on the development of analytical methods combining fast photochemical oxidation of proteins: FPOP) and mass spectrometry analysis. In chapter 2 to 4, we discuss protein folding with sub-millisecond time resolution by …

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Surface Wave Derived Shear Velocity Structure Of The Gamburtsev Subglacial Mountains, Transantarctic Mountains, And West Antarctica And Shallow Seismicity Of The Mariana And Tonga Subduction Zones, David Heeszel Jan 2011

Surface Wave Derived Shear Velocity Structure Of The Gamburtsev Subglacial Mountains, Transantarctic Mountains, And West Antarctica And Shallow Seismicity Of The Mariana And Tonga Subduction Zones, David Heeszel

All Theses and Dissertations (ETDs)

Recent advances in seismic instrumentation have allowed researchers to undertake focused investigations of regions previously inaccessible. From the bottom of the sea to the coldest, driest places on earth, we are now able to deploy seismometers to remote locations and be certain of collecting large amounts of useable data. By focusing regionally scaled seismic arrays in locations of tectonic and geodynamic interest we are able to better image the structure of these regions and place them in a global framework. This is particularly important in regions such as Antarctica and the ocean bottom where more traditional tools such as geologic …

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Non-Steady-State Catalyst Characterization With Thin-Zone Tap Experiments, Evgeniy Redekop Jan 2011

Non-Steady-State Catalyst Characterization With Thin-Zone Tap Experiments, Evgeniy Redekop

All Theses and Dissertations (ETDs)

Rational catalyst design must be advanced beyond its state-of-the-art given the significant economic and environmental relevance of catalytic technologies. To address this challenge, precise kinetic characterization of industrial catalysts is required for elucidating complex reaction mechanisms, establishing structure-activity relationships, and building scientifically-sound microkinetic models of catalytic processes. In this thesis, a novel framework for non-steady-state high-throughput kinetic characterization of complex catalytic reactions is theoretically developed, experimentally validated, and applied to a catalytic reaction of considerable interest. This novel framework of catalyst characterization is based on Temporal Analysis of Products: TAP) experiments. These pulse-response experiments employ Knudsen diffusion as a reliable …

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Design, Synthesis And Characterization Of Lipidated Pna-Peptide Conjugates As Potentialtherapeutic And Diagnostic Reagents, Yinyin Song Jan 2011

Design, Synthesis And Characterization Of Lipidated Pna-Peptide Conjugates As Potentialtherapeutic And Diagnostic Reagents, Yinyin Song

All Theses and Dissertations (ETDs)

Peptide Nucleic Acids: PNAs), are an ideal choice for antisense and antigene tools and probes because of their stability and high binding affinity, but have limited application as therapeutic and diagnostic agents because of poor membrane permeability. To increase membrane permeability, we conjugated hydrophobic lipids or phospholipid molecules and hydrophilic cell penetrating peptides to the N and C terminus of PNAs, and studied their physical and biological properties. After solid-phase automated synthesis, PNA-CPPs: TAT/Arg9) were coupled with lipids or phospholipids before cleavage from the support and then purified by HPLC. The conjugates were characterized by UV-vis and MALDI, and by …

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