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2011

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The Mechanics Of Embodiment: A Dialogue On Embodiment And Computational Modeling, G Pezzulo, Lw Barsalou, A Cangelosi, Et Al Jan 2011

The Mechanics Of Embodiment: A Dialogue On Embodiment And Computational Modeling, G Pezzulo, Lw Barsalou, A Cangelosi, Et Al

School of Engineering, Computing and Mathematics

Embodied theories are increasingly challenging traditional views of cognition by arguing that conceptual representations that constitute our knowledge are grounded in sensory and motor experiences, and processed at this sensorimotor level, rather than being represented and processed abstractly in an amodal conceptual system. Given the established empirical foundation, and the relatively underspecified theories to date, many researchers are extremely interested in embodied cognition but are clamouring for more mechanistic implementations. What is needed at this stage is a push toward explicit computational models that implement sensory-motor grounding as intrinsic to cognitive processes. In this article, six authors from varying backgrounds …

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Insights Into A Multidrug Resistant Escherichia Coli Pathogen Of The Globally Disseminated St131 Lineage: Genome Analysis And Virulence Mechanisms, Makrina Totsika, Scott A. Beatson, Sohinee Sarkar, P Minh-Duy, Nicola K. Petty, Nathan Bachmann, Marek Szubert, Hanna E. Sidjabat, David L. Paterson, Mathew Upton, Mark A. Schembri Jan 2011

Insights Into A Multidrug Resistant Escherichia Coli Pathogen Of The Globally Disseminated St131 Lineage: Genome Analysis And Virulence Mechanisms, Makrina Totsika, Scott A. Beatson, Sohinee Sarkar, P Minh-Duy, Nicola K. Petty, Nathan Bachmann, Marek Szubert, Hanna E. Sidjabat, David L. Paterson, Mathew Upton, Mark A. Schembri

School of Biomedical Sciences

No abstract provided.

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A Replicating Cytomegalovirus-Based Vaccine Encoding A Single Ebola Virus Nucleoprotein Ctl Epitope Confers Protection Against Ebola Virus, Yoshimi Tsuda, Patrizia Caposio, Christopher J. Parkins, Sara Botto, Ilhem Messaoudi, Luka Cicin-Sain, Heinz Feldmann, Michael A. Jarvis Jan 2011

A Replicating Cytomegalovirus-Based Vaccine Encoding A Single Ebola Virus Nucleoprotein Ctl Epitope Confers Protection Against Ebola Virus, Yoshimi Tsuda, Patrizia Caposio, Christopher J. Parkins, Sara Botto, Ilhem Messaoudi, Luka Cicin-Sain, Heinz Feldmann, Michael A. Jarvis

School of Biomedical Sciences

No abstract provided.

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Phytoestrogens Directly Inhibit Tnf-Α-Induced Bone Resorption In Raw264.7 Cells By Suppressing C-Fos-Induced Nfatc1 Expression., S Karieb, Sw Fox Jan 2011

Phytoestrogens Directly Inhibit Tnf-Α-Induced Bone Resorption In Raw264.7 Cells By Suppressing C-Fos-Induced Nfatc1 Expression., S Karieb, Sw Fox

School of Biomedical Sciences

TNF-α-induced osteoclastogenesis is central to post-menopausal and inflammatory bone loss, however, the effect of phytoestrogens on TNF-α-induced bone resorption has not been studied. The phytoestrogens genistein, daidzein, and coumestrol directly suppressed TNF-α-induced osteoclastogenesis and bone resorption. TRAP positive osteoclast formation and resorption area were significantly reduced by genistein (10(-7)  M), daidzein (10(-5)  M), and coumestrol (10(-7)  M), which was prevented by the estrogen antagonist ICI 182,780. TRAP expression in mature TNF-α-induced osteoclasts was also significantly reduced by these phytoestrogen concentrations. In addition, in the presence of ICI 182,780 genistein and coumestrol (10(-5) -10(-6)  M) augmented TNF-α-induced osteoclast formation and resorption. …

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Drilling For Micro-Foundations Of Human Capital Based Competitive Advantages, Russell Coff, David Kryscynski Jan 2011

Drilling For Micro-Foundations Of Human Capital Based Competitive Advantages, Russell Coff, David Kryscynski

Faculty Publications

From the origins of the Resource Based View, scholars have emphasized the importance of human capital as a source of sustained competitive advantage and recently there has been great interest in gaining a better understanding of the micro-foundations of strategic capabilities. Along these lines, there is little doubt that heterogeneous human capital is often a critical underlying mechanism for capabilities. Here, we explore how individual level phenomena underpin isolating mechanisms that sustain human capital-based advantages but also create management dilemmas that must be resolved in order to create value. The solutions to these challenges cannot be found purely in generic …

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