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Targeting Of Long Chain Triacylglycerol Hydrolase Gene For Tuberculosis Treatment (Con), Pappachan Kolattukudy, Jaiyanth Daniel, Chirajyoti Deb

UCF Patents

Disclosed herein are novel methods for screening for compounds useful in treating or preventing tuberculosis. In exemplary embodiments, screening methods are based on the implementation or manipulation of triacylglycerol hydrolase like polypeptides or polynucleotides encoding the same. The methods are useful in identifying agents active against TB infection.

The Chanticleer, 2011-10-17, Coastal Carolina University

The Chanticleer Student Newspaper

The editorially independent student produced weekly newspaper of Coastal Carolina University.

Hilltopics: Volume 8, Issue 1, Hilltopics Staff

Hilltopics

"Hello Peruna IX, Farewell Peruna VIII." page 1

"Hobbies may be closer than they appear." page 2

"Hilltopics staffer greets us from Belgium." page 3

"SMU meets world through CEL." page 4

"Heroes partner with Dallas orgs." page 4

"Mayisha Nakib on studying physics at SMU." page 7

Ada News - 10/17/2011, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Curated Exhibit: Civil War Medicine, Laura J. Hall

Posters and Presentations

The Civil War Medicine exhibit, curated by Laura J. Hall, MFA, explored the medical practices and challenges faced during the American Civil War. With more than 620,000 deaths, many from disease rather than battlefield injuries, the war presented unprecedented challenges for medical personnel who were often unprepared for the trauma of battle. The exhibit delved into the history of Civil War medicine, including amputations, disease, and the impact of the war on the evolution of American medical practices. The exhibit was on display from October 2011 to August 2012 at the UNM Domenici Center for Health Sciences Education.

Sexual And Injection-Related Risks In Puerto Rican-Born Injection Drug Users Living In New York City: A Mixed-Methods Analysis, Camila Gelpí-Acosta, Holly Hagan, Samuel M. Jenness, Travis Wendel, Alan Neaigus

Publications and Research

Background These data were collected as part of the National HIV Behavioral Surveillance (NHBS) study. NHBS is a cross-sectional study to investigate HIV behavioral risks among core risk groups in 21 U.S. cities with the highest HIV/AIDS prevalence. This analysis examines data from the NHBS data collection cycle with IDU conducted in New York City in 2009. We explored how the recency of migration from Puerto Rico (PR) to New York City (NYC) impacts both syringe sharing and unprotected sex among injection drug users (IDU) currently living in NYC. Methods We used a mixed-methods approach to examine differences in risk …

Genome-Wide Association Study Identifies Loci Influencing Concentrations Of Liver Enzymes In Plasma, John C. Chambers, Weihua Zhang, Joban Sehmi, Xinzhong Li, Mark N. Wass, Pim Van Der Harst, Hilma Holm, Serena Sanna, Maryam Kavousi, Chun Xu

Health & Biomedical Sciences Faculty Publications

Concentrations of liver enzymes in plasma are widely used as indicators of liver disease. We carried out a genome-wide association study in 61,089 individuals, identifying 42 loci associated with concentrations of liver enzymes in plasma, of which 32 are new associations (P = 10−8 to P = 10−190). We used functional genomic approaches including metabonomic profiling and gene expression analyses to identify probable candidate genes at these regions. We identified 69 candidate genes, including genes involved in biliary transport (ATP8B1 and ABCB11), glucose, carbohydrate and lipid metabolism (FADS1, FADS2, GCKR, JMJD1C, HNF1A …

Proliferating Cell Nuclear Antigen Is Required For Loading Of The Smcx/Kmd5c Histone Demethylase Onto Chromatin., Zhihui Liang, Marc Diamond, Johanna A Smith, Matthias Schnell, René Daniel

Department of Medicine Faculty Papers

UNLABELLED: ABSTRACT:

BACKGROUND: Histone methylation is regulated by a large number of histone methyltransferases and demethylases. The recently discovered SMCX/KMD5C demethylase has been shown to remove methyl residues from lysine 4 of histone H3 (H3K4), and constitutes an important component of the regulatory element-1-silencing transcription factor (REST) protein complex. However, little is known about the cellular mechanisms that control SMCX activity and intracellular trafficking.

RESULTS: In this study, we found that small interfering RNA-mediated knockdown of proliferating cell nuclear antigen (PCNA) resulted in the reduction of the chromatin-bound SMCX fraction. We identified a PCNA-interaction protein motif (PIP box) in the …

Timing The Origin Of Human Malarias: The Lemur Puzzle, M. Andreína Pacheco, Fabia U. Battistuzzi, Randall E. Junge, Omar E. Cornejo, Cathy V. Williams, Irene Landau, Lydia Rabetafika, Georges Snounou, Lisa Jones-Engel, Ananias A. Escalante

Harold W. Manter Laboratory of Parasitology: Library Materials

Background: Timing the origin of human malarias has been a focus of great interest. Previous studies on the mitochondrial genome concluded that Plasmodium in primates, including those parasitic to humans, radiated relatively recently during a process where host switches were common. Those investigations, however, assumed constant rate of evolution and tightly bound (fixed) calibration points based on host fossils or host distribution. We investigate the effect of such assumptions using different molecular dating methods. We include parasites from Lemuroidea since their distribution provides an external validation to time estimates allowing us to disregard scenarios that cannot explain their introduction …

Decontamination Of Endodontic Gutta-Percha: An In-Vitro Study, Mariya Shnaydman

Master's Theses

No abstract provided.

Wesley And Lynn Edens Establish Endowed Professorship In Global Health, Macalester College

College Press Releases

No abstract provided.

Viral Double-Strand Rna-Binding Proteins Can Enhance Innate Immune Signaling By Toll-Like Receptor 3, Yvonne Lai, Guanghui Yi, Alice Chen, Kanchan Bhardwaj, Brady J. Tragesser, Rodrigo A. Valverde, Adam Zlotnick, Suchetana Mukhopadhyay, C. T. Ranjith-Kumar, C. Cheng Kao

Faculty Publications

Toll-like Receptor 3 (TLR3) detects double-stranded (ds) RNAs to activate innate immune responses. While poly(I:C) is an excellent agonist for TLR3 in several cell lines and in human peripheral blood mononuclear cells, viral dsRNAs tend to be poor agonists, leading to the hypothesis that additional factor(s) are likely required to allow TLR3 to respond to viral dsRNAs. TLR3 signaling was examined in a lung epithelial cell line by quantifying cytokine production and in human embryonic kidney cells by quantifying luciferase reporter levels. Recombinant 1b hepatitis C virus polymerase was found to enhance TLR3 signaling in the lung epithelial BEAS-2B cells …

Crow's Nest, October 10, 2011, Crow's Nest Staff

Crow's Nest

The October 10, 2011, issue of the Crow's Nest.

Economic And Environmental Challenges, John A. Robb

Journal of Contemporary Water Research and Education

No abstract provided.

Commentary: The Hiv-Positive Resident: Questions And More Questions, Marguerite Blythe, Md

Jefferson Journal of Psychiatry

The resident physician who is infected with the human immunodeficiency virus (HIV) faces unique problems. In addition to the difficulties caused by a chronic and lethal disease, HIV-infected physicians-in-training face ethical, educational and practical problems that are unique to the interplay between residency training and the infection.

To date, physicians who have been found to be infected with HIV have faced public discrimination, many with devastating results. Dr. Hacib Aoun, a Venezulean-born cardiologist who contracted AIDS from a boy with leukemia while he was a resident at Johns Hopkins, overcame rumors about how he had contracted the disease only to …

Human Glial-Restricted Progenitor Transplantation Into Cervical Spinal Cord Of The Sod1 Mouse Model Of Als., Angelo C Lepore, John O'Donnell, Andrew S Kim, Timothy Williams, Alicia Tuteja, Mahendra S Rao, Linda L Kelley, James T Campanelli, Nicholas J Maragakis

Department of Neuroscience Faculty Papers

Cellular abnormalities are not limited to motor neurons in amyotrophic lateral sclerosis (ALS). There are numerous observations of astrocyte dysfunction in both humans with ALS and in SOD1(G93A) rodents, a widely studied ALS model. The present study therapeutically targeted astrocyte replacement in this model via transplantation of human Glial-Restricted Progenitors (hGRPs), lineage-restricted progenitors derived from human fetal neural tissue. Our previous findings demonstrated that transplantation of rodent-derived GRPs into cervical spinal cord ventral gray matter (in order to target therapy to diaphragmatic function) resulted in therapeutic efficacy in the SOD1(G93A) rat. Those findings demonstrated the feasibility and efficacy of transplantation-based …

Zinc Supplementation As An Adjunct To Antibiotics In The Treatment Of Pneumonia In Children 2 To 59 Months Of Age, Batool A. Haider, Zohra S. Lassi, Amina Ahmed, Zulfiqar Ahmed Bhutta

Woman and Child Health

Background:Diarrhoeal disorders and acute respiratory infections (ARIs), especially pneumonia, are the most common causes of death in low-income countries. Studies evaluating the impact of zinc supplementation as an adjunct in the management of pneumonia are limited and have shown variable results.
Objectives: To evaluate zinc supplementation, as an adjunct to antibiotics, in the treatment (clinical recovery) of pneumonia in children aged two to 59 months.
Search strategy: We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2011, Issue 1), which contains the Cochrane Acute Respiratory Infections (ARI) Group's and the Cochrane Infectious Diseases Group's Specialised …

Rumi Functions As Both A Protein O-Glucosyltransferase And A Protein O-Xylosyltransferase, Hideyuki Takeuchi, Rodrigo C. Fernańdez-Valdivia, Devin S. Caswell, Aleksandra Nita-Lazar, Nadia A. Rana, Thomas P. Garner, Thomas K. Weldeghiorghis, Megan A. Macnaughtan, Hamed Jafar-Nejad, Robert S. Haltiwanger

Faculty Publications

Mutations in rumi result in a temperature-sensitive loss of Notch signaling in Drosophila. Drosophila Rumi is a soluble, endoplasmic reticulum-retained protein with a CAP10 domain that functions as a protein O-glucosyltransferase. In human and mouse genomes, three potential Rumi homologues exist: one with a high degree of identity to Drosophila Rumi (52%), and two others with lower degrees of identity but including a CAP10 domain (KDELC1 and KDELC2). Here we show that both mouse and human Rumi, but not KDELC1 or KDELC2, catalyze transfer of glucose from UDPglucose to an EGF repeat from human factor VII. Similarly, human Rumi, but …

Ccl2/Mcp-I Genotype-Phenotype Relationship In Latent Tuberculosis Infection, Rabia Hussain, Ambreen Ansari, Najeeha Talat, Zahra Hasan, Ghaffar Dawood

Department of Pathology and Laboratory Medicine

Among the known biomarkers, chemokines, secreted by activated macrophages and T cells, attract groups of immune cells to the site of infection and may determine the clinical outcome. Association studies of CCL-2/MCP-1 -2518 A/G functional SNP linked to high and low phenotypes with tuberculosis disease susceptibility have shown conflicting results in tuberculosis. Some of these differences could be due the variability of latent infection and recent exposure in the control groups. We have therefore carried out a detailed analysis of CCL-2 genotype SNP -2518 (A/G transition) with plasma CCL-2 levels and related these levels to tuberculin skin test positivity in …

Comparative Immunogenicity Of Na-Gst-1 Human Hookworm Vaccine With Synthetic Glucopyranosyl Lipid Adjuvant (Gla) In Balb/C Mice, Amar R. Jariwala, Brian Keegan, Jordan L. Plieskatt, Maria Elena Bottazzi, Peter J. Hotez, Jeffrey M. Bethony

Microbiology, Immunology, and Tropical Medicine Posters and Presentations

More than 740 million people worldwide are infected with Hookworm. Hookworm infection is most prevalent in the poorest of the poor populations of the world, and has serious health effects. Hookworm infection causes blood loss leading to iron deficiency anemia and protein energy malnutrition, which results in a compromised immune response. Consequently, the target human population suffers from an increased susceptibility to infectious diseases including hookworm infection. We have developed recombinant adult hookworm vaccines against hookworm infection to break this vicious cycle. Toll-like receptor (TLR) 4 agonist are known to boost immune response in healthy and immunocompromised individuals. We believe …

Clinic Connection: Fall 2011, Centracare Clinic

Clinic Connection

• President’s Message: "It’s not what we say. It’s what patients hear!"
• Computer-based testing can help with evaluation and management of concussions
• Small bowel capsule endoscopy helps to detect gastrointestinal bleeding
• Patient-physician interaction in the EMR era
• Introducing our new CentraCare Clinic Specialist
• Patient’s race, ethnicity and language are important for routine medical care

Medicine + Health, Fall 2011, George Washington University, School Of Medicine And Health Sciences, Office Of Communications And Marketing

Medicine + Health Magazine

No abstract provided.

Chemistry & Biochemistry Newsletter, Department Of Chemistry & Biochemistry, South Dakota State University

Chemistry & Biochemistry Newsletter: 2002-2015

Inside:

Page 2 International Year of Chemistry Recognizes SDSU program

Page 3 Student Research Focuses on Soil Health

Page 4 Medial Laboratory Science Receives Accreditation; Pat Tille is Honored by ASCLS and Alpha Mu Tau

Page 5 Mass Spec Open House; Foundation Donors; Grad Student Chosen NSF Scholar

Page 6 Researcher Featured on SDSU’s Web site; Recent Grants

Page 7 New Graduate Students

Page 8 New Faculty; Alumni Updates

Progress Notes, Lehigh Valley Health Network

Progress Notes

No abstract provided.

Researching A Deadly Disease With Leading Research Firm

Madison Magazine

No abstract provided.

Madison Magazine, Vol. 34, No. 3, Fall 2011 Full Issue

Madison Magazine

No abstract provided.

Macalester Today Fall 2011, Macalester College

Macalester Today

No abstract provided.

Improving The Population’S Health: The Affordable Care Act And The Importance Of Integration, Lorian E. Hardcastle, Katherine L. Record, Peter D. Jacobson, Lawrence O. Gostin

O'Neill Institute Papers

Heath care and public health are typically conceptualized as separate, albeit overlapping, systems. Health care’s goal is the improvement of individual patient outcomes through the provision of medical services. In contrast, public health is devoted to improving health outcomes in the population as a whole through health promotion and disease prevention. Health care services receive the bulk of funding and political support, while public health is chronically starved of resources. In order to reduce morbidity and mortality, policymakers must shift their attention to public health services and to the improved integration of health care and public health. In other words, …

Wsu Research News, Fall 2011, Office Of Research And Sponsored Programs, Wright State University

WSU Research News

A nineteen page newsletter of the WSU Research News. The WSU Research News was published monthly beginning in June of 1968 and issued by the Office of Research Development. This newsletter was created to provide information to the WSU faculty about the availability of outside funds for research and educational programs, new developments that may affect availability of funds, and general information on research and educational activities at Wright State University.

Guiding Health Care Policy Through Applied Public Health Modeling And Simulation, Jonathan P. Leidig, Chris L. Barrett, Madhav Marathe

Transactions of the International Conference on Health Information Technology Advancement

The risk of a widespread epidemic is a primary public health concern with implications for healthcare providers and organizations. Modeling and simulation techniques have been successfully applied at the national level to set governmental polices and mitigation strategies through simulation-based predictions. Existing research in this field has been non-uniform in its coverage of local systems and region-specific findings. New collaborations between on the ground providers and modeling groups are required for successful simulation-based experimentation of region-specific health systems. These proposed collaborations are expected to contribute high-quality sub-population datasets to be used in experiments at the national level and allow for …