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Risk Factors For Homelessness And Sex Trade Among Incarcerated Women: A Structural Equation Model, Seijeoung Kim, Timothy P. Johnson, Samir Goswami, Michael Puisis

Journal of International Women's Studies

Incarcerated women are among the most vulnerable and perhaps the least studied populations in the US. Significant proportions of female inmates are substance users, and many living in unstable housing conditions or being homeless. Female inmates are often at high risk of engaging in sex exchange for drugs or housing needs. While a disproportionate number of incarcerated women have experienced childhood household adversities and maltreatments, the effects of these childhood experiences on psychosocial and behavioral outcomes of this population in later life. We apply a life course perspective to examine these pathways in a sample of incarcerated women in Cook …

Use Of Mushroom Extract To Enhance Quality And Health Benefits Of Dairy Products, Osman A. Hassan

Dissertations

Bifidobacteria and Lactobacilli are purportedly beneficial to human health and are called probiotics which are live microorganisms, when administered in adequate amounts conferring a health benefit on the host. It is believed that the maximum probiotics effect can be achieved if the organisms adhere to intestinal mucosal cells. Probiotics, perhaps in combination with prebiotics, may become an important means of preventing and treating disease. In fact, several types of diarrhea have been successfully treated with probiotics. The mechanisms behind favorable clinical outcome are still largely unknown, however, the potential benefits of probiotic therapy promise to be almost limitless. Organic acids …

Natural Products Chemistry Of Leads Acting On Mrsa, Hcv, Malaria, And Depression Disorders, Mohamed Ali Mohamed Ali Ibrahim

Electronic Theses and Dissertations

Nature has proven to be an endless source of abundant diversity of chemical entities with varying biological activities. The World Health Organization (WHO) estimates that 80% of the world's population depends on traditional medicine for treating their everyday health problems. According to Gordon Cragg, former director of the natural products branch of the NCI, ″Nature has produced wonderfully complex molecules that no synthetic chemist could ever dream up.″ Moreover, he emphasized that over 60% of cancer therapeutics have been derived from nature whether directly through isolation or indirectly through semi-synthesis. Various examples have been reported such as extracts from Catharanthus …

Icts Research Collaboration Survey Results, Center For Public Health Systems Science, Douglas Luke

Center for Public Health Systems Science

This report provides the results from the Institute of Clinical and Translational Sciences (ICTS) Research Collaboration Survey. The ICTS Research Collaboration Survey was developed to better understand the collaborative research partnerships of ICTS members. The survey included demographic, collaboration network, and general attitude and satisfaction questions.

Enrichment Of Intersubtype Hiv-1 Recombinants In A Dual Infection System Using Hiv-1 Strain-Specific Sirnas, Yong Gao, Measho Abreha, Kenneth N. Nelson, Heather Baird, Dawn M. Dudley, Awet Abraha, Eric J. Arts

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Intersubtype HIV-1 recombinants in the form of unique or stable circulating recombinants forms (CRFs) are responsible for over 20% of infections in the worldwide epidemic. Mechanisms controlling the generation, selection, and transmission of these intersubtype HIV-1 recombinants still require further investigation. All intersubtype HIV-1 recombinants are generated and evolve from initial dual infections, but are difficult to identify in the human population. In vitro studies provide the most practical system to study mechanisms, but the recombination rates are usually very low in dual infections with primary HIV-1 isolates. This study describes the use of HIV-1 isolate-specific siRNAs to …

Factors Affecting Susceptibility Of Goats To Coccidia, Yaser Ahmed

Theses

Natural Resistance Associate Macrophages Protein one (NRAMP1) gene encodes a transmembrane protein that regulates divalent cation transport that hinders intracellular pathogen proliferation. The objective of this study was to determine how NRAMP1 expression and other factors may be associated with coccidia infections in goats. Clinically healthy Boer, Spanish, and Spanish-Boer cross goats (N=140) from the NCA&T Small ruminant unit were used. The FAMACHA© score, body condition score, body weight, and age were recorded. Fecal samples were evaluated for the levels of haemonchus eggs and coccidia oocytes using McMaster slides. Blood samples were evaluated for packed cell volume and …

Analysis Of The Streptococcal Cpsa Protein In Dna-Binding And Regulation Of Capsule And Cell Wall Maintenance, Brett R. Hanson

Wayne State University Dissertations

The systemic pathogens Streptococcus agalactiae (GBS) and Streptococcus pneumoniae remain a significant threat to human health worldwide. The ability of these organisms to cause systemic disease is compounded by the production of a polysaccharide capsule that provides immune evasion function. The production of the polysaccharide capsule in systemic streptococcal pathogens is controlled in part by the membrane bound protein CpsA. These studies analyze the contribution of CpsA to regulation of capsule level in the model aquatic pathogen Streptococcus iniae and human specific pathogen GBS, and how this regulation affects virulence in in-vitro, ex-vivo, and in-vivo models of pathogenesis. We have …

Development And Bioavailability/Bioequivalence Of A Fixed-Dose Combination Antiretroviral Reconstitutable Suspension Intended For Pediatrics, Fredrick Esseku

Electronic Theses and Dissertations

This dissertation was designed to develop and assess bioavailability/ bioequivalence of age-appropriate fixed-dose combination granules of lamivudine/zidovudine/nevirapine as reconstitutable suspension for pediatrics for use in pediatric patients. The granules were developed via roller compaction process to improve granule flow characteristics, minimize segregation of the multi-component active pharmaceutical ingredients, and avoid introducing moisture into the formulation and thereby improve the stability of the product. Optimization of the roller compaction process for the roll pressure and the ratio of the horizontal feed screw speed to the roll speed showed that these parameters had minimal effect on granule quality. Subsequently, a replicated 32 …

The Contribution Of Foundational New Testament Theological Themes To The Meaning Of Basic Bioethics Principles, R. Dennis Macaleer

Electronic Theses and Dissertations

Beauchamp and Childress' Principles of Biomedical Ethics is a well accepted approach to contemporary bioethics. Those principles are based on what Beauchamp and Childress call the common morality. This dissertation employs New Testament theological themes to enhance the meaning of contemporary principles of bioethics. Beginning with the incarnation in the New Testament, the invitation-response hermeneutic is developed as a hermeneutic to use in studying the New Testament. The primary New Testament text for this study is the twin commands from Jesus to love God and love one's neighbor. Three theological themes are developed from this study and these three themes …

Optimization Of Calcium Aluminate For Use As A Bone Scaffold Material Through Physical And Chemical Surface Modification, Rachelle Nicole Palchesko

Electronic Theses and Dissertations

Calcium aluminates were tested as biomaterials and show promise as bone scaffolds. Initial concerns of biocompatibility led the field to focus on calcium phosphates. Here, the work focused on improving the biocompatibility and creating an optimized calcium aluminate biomaterial. To accomplish this, the physical and interfacial properties of the material were varied. The physical properties of the calcium aluminate were varied through the room temperature casting procedure and five different mixtures were created and evaluated for mechanical strength and biotolerability. The results showed that the optimal mixture had an average pore size of approximately 100 µm and that autoclaving the …

Immunoglobin And Fcγ Receptor Genes Influence The Control Of Hiv Replication And The Progression Of Hiv Infection, Ray Deepe

MUSC Theses and Dissertations

HIV is an infection affecting approximately 33 million people worldwide especially in Sub-Saharan Africa and Southeastern Asia. HIV infection is marked by the loss of CD4+ T-cells and is the causative agent of AIDS. Host genetic factors have been shown to influence the progression and outcome of HIV infection, but the genes identified thus far account for approximately 15% of the variance observed in viral load and progression, suggesting involvement of additional genes in HIV pathogenesis. FcyRIIa and FcyRIIIa genotypes have been shown to be influential in the transmission, control, and progression of HIV. These receptors contain polymorphisms that influence …

Laparoscopic Drainage Of A Hepatic Echinococcal Cyst: A Case Report, Steven B. Goldin, James J. L. Mateka, Michael J. Schnaus, Sujat Dahal

Surgery Faculty Publications

The Echinococcus granulosus tapeworm causes hepatic echinococcosis. It is endemic in the Mediterranean region, Middle East, and South America. Human infection is secondary to accidental consumption of ova in feces. Absorption through the bowel wall and entrance into the portal circulation leads to liver infection. This case involves a 34 y/o Moroccan male with an echinococcal liver cyst. His chief complaint was RUQ pain. The patient was treated with albendazole and praziquantel. His PMH and PSH was noncontributory. Patient was not on any other medications. ROS was otherwise unremarkable. The patient was AF VSS. He was tender to palpation in …

Moving Upstream: The Merits Of A Public Health Law Approach To Human Trafficking, Jonathan Todres

North Carolina Law Review

No abstract provided.

Mutational Analysis Of Hiv-1 Nucleocapsid Protein And Methods Development For Aptamer Discovery, Wei Ouyang

Chemistry - Dissertations

This dissertation focuses on structural and functional studies related to the interaction between proteins and nucleic acids and their applications. The work reported here includes two projects. The first part of the thesis is on the mutational and combinatorial analysis of HIV-1 nucleocapsid protein (NCp7). Sixteen mutants of NCp7 were constructed and over-expressed in E. coli . The dissociation constants (K _d ) between the mutant proteins and the major packaging signal in HIV-1, SL3 RNA, were measured using tryptophan fluorescence titration assay and/or isothermal titration calorimetry (ITC) assay. Most mutants show tolerance of the mutation but some mutants, including …

A Comparison Of Healthcare Between Nicaragua And The United States And The Feasibility Of Naturopathic Medicine, Alyssa Neph

Honors Projects

No abstract provided.

Pertussis In Ohio: A Descriptive Analysis Of The 2010 Columbus Outbreak And Patterns Of A Reemerging Childhood Disease, Christopher Rohde

Master of Public Health Program Student Publications

Objective: In 2010, Columbus, Ohio experienced the largest outbreak of pertussis that it has had in the past 25 years. Similar outbreaks are occurring across the nation on an increasing basis. This descriptive study examines the 2010 outbreak and describes the demographics of the affected population. Comparison is made to previous and current pertussis incidence in Ohio and outbreaks elsewhere in the United States. Contributing factors to the increasing occurrence of pertussis outbreaks are discussed.

Methods: Raw data was obtained from the Columbus Public Health epidemiology department and is gathered through the Ohio Disease Reporting System (ODRS). Pertussis cases are …

Gaps And Strengths In Us Policies On Infant And Young Child Feeding: An Analysis Based On The Global Strategy On Infant And Young Child Feeding, Linda J. Smith

Master of Public Health Program Student Publications

This research project reviews the evidence on the significance of infant and young child feeding to public health goals, analyzes US policy documents in relationship to the Global Strategy using the World Breastfeeding Trends Initiative (WBTi) to quantify the findings into a national score, and then summarizes the gaps and strengths in US policies and makes recommendations. Using the WBTi scoring system, strengths for the US exist in national policy, Baby-Friendly Hospital Initiative, monitoring and evaluation, and complementary feeding. Mother support and community outreach, information and support were moderate. Gaps exist in policies on infant feeding in emergencies and for …

Determining Evidence-Based Practices In Asthma Management, Erin Smiley

Master of Public Health Program Student Publications

Objective: One aim of this study will focus on determining what are evidence-based studies in asthma control. A second aim focuses on determining which asthma interventions, self-monitoring tools and asthma management programs have shown to be the most significant in improving outcomes in patients with asthma. Recommendations will be made to future asthma self-management programs based on the findings.

Methodology: The review of 15 evidence-based research studies is used to identify and analyze the best asthma self-management practices to be implemented in a community health education program. Using the Brownson framework a weighting schema was created based on the level …

Current Therapies For Chronic Hepatitis C, Mckenzie C. Ferguson

Pharmacy Faculty Research, Scholarship, and Creative Activity

Hepatitis C virus affects more than 180 million people worldwide and as many as 4 million people in the United States. Given that most patients are asymptomatic until late in the disease progression, diagnostic screening and evaluation should be performed in patients who display high-risk behaviors associated with acquisition of hepatitis C. Chronic hepatitis C is associated with cirrhosis, hepatic failure, and death; therefore, treatment is aimed at reducing these complications, as well as improving quality of life and minimizing adverse effects. The American Association for the Study of Liver Diseases Practice Guidelines on the Diagnosis, Management, and Treatment of …

Multi-Element Regulation Of The Tropical Forest Carbon Cycle, Alan R. Townsend, Cory C. Cleveland, Benjamin Z. Houlton, Caroline B. Alden, James W. C. White

Ecosystem and Conservation Sciences Faculty Publications

Tropical ecosystems dominate the exchange of carbon dioxide between the atmosphere and terrestrial biosphere, yet our understanding of how nutrients control the tropical carbon (C) cycle remains far from complete. In part, this knowledge gap arises from the marked complexity of the tropical forest biome, in which nitrogen, phosphorus, and perhaps several other elements may play roles in determining rates of C gain and loss. As studies from other ecosystems show, failing to account for nutrient–C interactions can lead to substantial errors in predicting how ecosystems will respond to climate and other environmental changes. Thus, although resolving the complex nature …

Lipopolysaccharide Animal Models For Parkinson's Disease, Mei Liu, Guoying Bing

Neuroscience Faculty Publications

Lipopolysaccharide (LPS), an endotoxin from Gram-negative bacteria, acts as a potent stimulator of microglia and has been used to study the inflammatory process in the pathogenesis of Parkinson's disease (PD) and anti-inflammatory therapy for PD treatment. Here, we review the growing body of literature on both in vitro and in vivo LPS PD models. Primary cell cultures from mesencephalic tissue were exposed to LPS in vitro; LPS was stereotaxically injected into the substantia nigra, striatum, or globus pallidus of brain or injected into the peritoneal cavity of the animal in vivo. In conclusion, the LPS PD models are summarized as …

A Retinoic Acid–Dependent Checkpoint In The Development Of Cd4+ T Cell–Mediated Immunity, Karina Pino-Lagos, Yanxia Guo, Chrysothemis Brown, Matthew P. Alexander, Raúl Elgueta, Kathryn A. Bennett, Victor De Vries, Elizabeth Nowak, Rune Blomhoff, Shanthini Sockanathan, Roshantha A. Chandraratna, Ethan Dmitrovsky, Randolph J. Noelle

Dartmouth Scholarship

It is known that vitamin A and its metabolite, retinoic acid (RA), are essential for host defense. However, the mechanisms for how RA controls inflammation are incompletely understood. The findings presented in this study show that RA signaling occurs concurrent with the development of inflammation. In models of vaccination and allogeneic graft rejection, whole body imaging reveals that RA signaling is temporally and spatially restricted to the site of inflammation. Conditional ablation of RA signaling in T cells significantly interferes with CD4⁺ T cell effector function, migration, and polarity. These findings provide a new perspective of the role of …

Exploiting Borders: The Political Economy Of Local Backlash Against Undocumented Immigrants, Jamie Longazel, Benjamin Fleury-Steiner

Sociology, Anthropology, and Social Work Faculty Publications

Four years prior to Arizona's passage of one of the most far-reaching pieces of anti-Latino immigrant legislation signed into law in decades,3 demands to "seal off the border"4 were being made thousands of miles from the U.S.-Mexico divide. In 2006, Hazleton, Pennsylvania, passed equally harsh legislation aimed at keeping undocumented immigrants out of their community. During this time, commentators described the local backlash in Hazleton and other small cities across the United States as akin to "the opening of a deep and profound fissure in the American landscape" 5 wherein "all immigration politics is local." 6 Yet, as the so-called …

Odd Association And Range Extension Of Caligus Rufimaculatus Wilson, 1905; Caligidae, Siphonostomatoida, Copepoda, G.W. Benz, E.C. Greiner, S.R. Bowen, L. Goetz, N. Evou

Gulf and Caribbean Research

The Caligidae (Siphonostomatoida, Copepoda) comprises more than 465 parasitic species, over 250 of which belong to Caligus Müller, 1785 (Boxshall and Halsey 2004). Caligus spp. are primarily marine; but some representatives routinely inhabit brackish or fresh water (Margolis et al. 1975). Some Caligus spp. have been widely reported from several oceans, others have been documented from a single location, and a few have only been collected as free-swimming individuals not associated with a host (Margolis et al. 1975). Caligus spp. range from being stenoxenous to euryxenous, with most species infecting actinopterygians (Actinopterygii), a much smaller group exclusively or non-exclusively infecting …

Efficacy Of The Pentavalent Rotavirus Vaccine, Rotateq (Rv5), Between Doses Of A 3-Dose Series And With Less Than 3 Doses (Incomplete Regimen), Penelope D. Dennehy, Timo Vesikari, David O. Matson, Robbin F. Itzler, Michael J. Dallas, Michelle G. Goveia, Mark J. Dinubile, Penny M. Heaton, Max Ciarlet

Community & Environmental Health Faculty Publications

Post-hoc analyses of the Rotavirus Efficacy and Safety Trial (RES T) were conducted to determine whether the pentavalent rotavirus vaccine (RV5) confers early protection against rotavirus gastroenteritis (RVGE) before completion of the 3-dose regimen. To evaluate the efficacy of RV5 between doses in reducing the rates of RVGE-related hospitalizations and emergency department (ED) visits in infants who ultimately received all 3 doses of RV5/placebo, events occurring from 2 weeks after the first and second doses to receipt of the subsequent dose (Analysis A) and events occurring from 2 weeks after the first and second doses to 2 weeks after the …

Alcohol Consumption In Lusaka Urban District, Zambia: A Population Based Survey, 2007, Selestine H. Nzala, Olusegun Babaniyi, Peter Songolo, Adamson S. Muula, Emmanuel Rudatsikira, Seter Siziya

Community & Environmental Health Faculty Publications

Alcohol use is an important preventable risk factor for several non-communicable diseases (NCDs) and injuries that is related to lifestyle choices. The objective of the study was to determine the prevalence of alcohol consumption and its correlates. A cross sectional study utilizing a WHO stepwise approach to surveillance of NCDs was conducted in Lusaka district, Zambia. Current alcohol consumption was defined as having consumed alcohol in the previous 30 days to the survey. Complex samples logistic regression was used to determine independent predictors. A total of 1928 individuals participated in the survey. A third of the participants were males and …

Mathematical Model To Assess The Relative Effectiveness Of Rift Valley Fever Countermeasures, Holly Gaff, Colleen Burgess, Jacqueline Jackson, Tianchan Niu, Yiannis Papelis, David Hartley

Biological Sciences Faculty Publications

Mathematical modeling of infectious diseases is increasingly used to explicate the mechanics of disease propagation, impact of controls, and sensitivity of countermeasures. The authors demonstrate use of a Rift Valley Fever (RVF) model to study efficacy of countermeasures to disease transmission parameters. RVF is a viral infectious disease that propagates through infected mosquitoes and primarily affects animals but also humans. Vaccines exist to protect against the disease but there is lack of data comparing efficacy of vaccination with alternative countermeasures such as managing mosquito population or destroying infected livestock. This paper presents a compartmentalized multispecies deterministic ordinary differential equation model …

Interactive Effects Of Wildfire And Disturbance History On Amphibians And Their Parasites, Blake Roger Hossack

Graduate Student Theses, Dissertations, & Professional Papers

Climate-driven changes in wildfire and other disturbance regimes are expected to affect populations and communities worldwide. Understanding how these changes will affect native species is critical for future conservation efforts, especially on managed forests. Using data from several wildfires that burned between 1988 and 2003 in and next to Glacier National Park, Montana, I examined how fire affected the distribution, abundance, and infection status of 3 native amphibians. In Chapter 1, I used long-term data on wetland occupancy to show the long-toed salamander (Ambystoma macrodactylum) and Columbia spotted frog (Rana luteiventris) were resistant to change during the first 6 years …

B.R., C.R., William M. Jeffs V. Trina West, Afnp, Hugo Rodier, Md, Pioneer Comprehensive Medical Clinic : Brief Of Appellee, Utah Supreme Court

Utah Supreme Court Briefs (2000–2020)

PLAINTIFF'S APPEAL FROM A JUDGMENT OF DISMISSAL, ENTERED BY THE THIRD JUDICIAL DISTRICT COURT, THE HONORABLE DENISE LINDBERG, PRESIDING

Sector-Switching In Transition Economies: A Case Study Of Kazakhstan's Health Care Sector, Dariga Chukmaitova

CGU Theses & Dissertations

The dissertation examines the economic and behavioral factors influencing 'sector-switching' in Kazakhstan's health care industry. Sector-switching involves doctors moving from the national to the private system, which is not well established, thereby raising questions about why the switch occurs. It addresses the question: why health care professionals in Kazakhstan switch from the public sector to similar jobs in the private or nonprofit sectors? This study addresses a key issue in public management (sector switching) and also offers insights into the dynamics of the transition from a centralized economy to a market economy. As such, its findings have `real-world' applications beyond …