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2011

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Optimization And Characterization Of Bioactive Glass Nanofibers And Nanocomposites, Reginna Evette Scarber Jan 2011

Optimization And Characterization Of Bioactive Glass Nanofibers And Nanocomposites, Reginna Evette Scarber

All ETDs from UAB

Disease affects different areas of the bone and can impact individuals of all pathologies and ethnicities. These bone diseases can result in weakening which leads to trauma during ordinary function, the need for reconstructive surgery, and eventual bone replacement. Tissue engineering can provide a less traumatic and more fundamental solution to the current therapies. Bioactive glasses are promising materials in tissue engineering applications because of their ability to form hydroxycarbonate apatite in the presence of simulated body fluid, support cell adhesion, growth, and differentiation, induce bone formation, and concentrate bone morphogenic proteins in vivo. The research in this dissertation will …

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Thesis- Clinical Evaluation Of Non-Carious Cervical Lesion- A Longitudinal Study., Shreya D. Shah Jan 2011

Thesis- Clinical Evaluation Of Non-Carious Cervical Lesion- A Longitudinal Study., Shreya D. Shah

All ETDs from UAB

Non-carious cervical lesions (NCCL) are non-bacterial in origin and defined as the loss of tooth substance at the cemento-enamel junction (Mair, 1992). There is growing evidence that NCCLs may be associated with occlusal and lateral. OBJECTIVE: To develop a non invasive, highly reproducible technique to measure the occlusal forces (biting pressure) and to correlate it with lesion progression. MATERIALS & METHODS: Twenty-six subjects and 60 teeth were measured for biting force. Digital images and elastomeric impressions were made ateach of three visits (baseline restoration, one and two years). Casts were prepared and a fixture which aligned each patients cast in …

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Effect Of Different Percentages Of Silica Nanofibers Filler Loads On Mechanical And Physical Properties Of Flowable Composite Resins, Shashikant Singhal Jan 2011

Effect Of Different Percentages Of Silica Nanofibers Filler Loads On Mechanical And Physical Properties Of Flowable Composite Resins, Shashikant Singhal

All ETDs from UAB

Dental composites are important in the spectra of restorative materials. Ability to match the color of natural dentition is an appealing characteristic of composite restorations. Additionally, they can be bonded physically to the tooth, which limits the amount of tooth preparation required and thereby conserves healthy tooth structure. In relation to other restorations like amalgams, non-metallic compositions of dental composites have exhibited good biocompatibility. The dental composites are composed of a resin matrix containing a blend of bis-GMA (bis-phenol A-glycidyldimethacrylate) or urethane dimethacrylate (UDMA) along with TEGDMA (tetraethylglycidylmethacrylate). Novel techniques for the reinforcement of these resin-based composites continue in a …

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Social Support, Social Stigma, Health, Coping, And Quality Of Life In Older Gay Men With Hiv, Larry Zuendel Slater Jan 2011

Social Support, Social Stigma, Health, Coping, And Quality Of Life In Older Gay Men With Hiv, Larry Zuendel Slater

All ETDs from UAB

With the advent of antiretroviral therapy, people with HIV/AIDS are living longer and managing their HIV infection as would an individual with any other chronic disease. As life expectancy increases, quality of life has progressed as an emerging issue for older adults with HIV/AIDS. A majority of people living with HIV in the U.S. are still gay men, who thus comprise a large portion of those who are growing older with the disease. The aims of the descriptive, correlational study were to: (1) explore the relationships among age, race, socioeconomic status, health, social support, social stigma, coping, perceived health, and …

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The Effect Of Curricular Sequencing Of Human Patient Simulation Learning Experiences On Students’ Self-Perceptions Of Clinical Reasoning Abilities, Rebecca Jensen Phd, Rn Jan 2011

The Effect Of Curricular Sequencing Of Human Patient Simulation Learning Experiences On Students’ Self-Perceptions Of Clinical Reasoning Abilities, Rebecca Jensen Phd, Rn

Nursing Publications, Posters, & Presentations

It is unknown whether timing of human patient simulation (HPS) in a semester, demographic (age, gender, and ethnicity), and situational (type of program and previous baccalaureate degree and experience in healthcare) variables affects students‘ perceptions of their clinical reasoning abilities. Nursing students were divided into two groups, mid and end of semester HPS experiences. Students‘ perceptions of clinical reasoning abilities were measured at Baseline (beginning of semester) and Time 2 (end of semester), along with demographic and situational variables. Dependent variable was Difference scores where Baseline scores were subtracted from Time 2 scores to reveal changes in students‘ perceptions of …

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Predictors Of The Decision To Terminate Pregnancy Following Prenatal Diagnoses Of Fetal Abnormalities, Cynthia Renee Hall Jan 2011

Predictors Of The Decision To Terminate Pregnancy Following Prenatal Diagnoses Of Fetal Abnormalities, Cynthia Renee Hall

All ETDs from UAB

The purpose of the present study was to examine several factors and their contri-butions to termination decisions and address limitations associated with previous re-search. Specifically, type of prenatally diagnosed disorder, perception of parenting, atti-tude toward abortion, attachment, religiosity, and attitude toward disabled persons were examined as predictors of the decision to terminate pregnancy. Also, the role of familiari-ty with persons having developmental disabilities was explored as a covariate. In addi-tion, priming effect of labeled disorders was investigated. Participants (N = 144) were college students aged 19 - 56 years (M = 22.07, SD = 6.62). Participants completed the Experiences in …

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Calciotropic Hormonal Influence On Energy Homeostasis, Lynae J. Hanks Jan 2011

Calciotropic Hormonal Influence On Energy Homeostasis, Lynae J. Hanks

All ETDs from UAB

Energy balance exists when intake is equivalent to expenditure. It has become evident that beyond quantitative aspects of intake, dietary components also have directive impact. On the expenditure side, an underappreciated yet key contributor is resting energy expenditure (REE). As the largest constituent of overall energy output, REE encompasses physiologic, dietary and genetic influence on body composition. While cellular and overall systemic contribution cannot be ignored, the relative proportion of adipose, bone and lean body tissue (i.e., body composition) represents the primary determinant underlying REE. It is possible that the mineral calcium is a common denominator encompassing energy balance influenced …

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In Vivo Analysis Of The Natural Diversity Of The Igr Ires Family And Characterization Of The Role Of Ribosomal Protein S25 In Ires-Mediated Translation, Marla Ilene Hertz Jan 2011

In Vivo Analysis Of The Natural Diversity Of The Igr Ires Family And Characterization Of The Role Of Ribosomal Protein S25 In Ires-Mediated Translation, Marla Ilene Hertz

All ETDs from UAB

Translation of the majority of eukaryotic mRNAs is initiated upon recognition of its 5' cap structure by translation initiation factors in so-called cap-dependent translation. Cap-dependent translation is repressed during cell stress and translation initiation by internal ribosome entry sites (IRESs) predominates. IRESs, located in the 5' untranslated region of specific mRNAs, recruit the ribosome independent of the 5' cap and are essential regulatory elements in many RNA viruses and cellular messages. The dysregulation of cellular IRESs has been linked to cancer because they regulate the expression of genes involved in growth, development and stress response. In comparison to cap-dependent translation, …

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Risk Associations Between Perceived Stress, Allostatic Load, And Insulin Resistance Among Nondiabetic African American Women Of The Jackson Heart Study, Alethea N. Hill Jan 2011

Risk Associations Between Perceived Stress, Allostatic Load, And Insulin Resistance Among Nondiabetic African American Women Of The Jackson Heart Study, Alethea N. Hill

All ETDs from UAB

Objectives: The purpose of this study was to evaluate the associations between perceived stress, allostatic load, and insulin resistance measured by HOMAIR among nondiabetic African American women of the Jackson Heart Study. Methods: The investigative team examined the cross-sectional associations (2000-2004) of perceived stress, summary indices of allostatic load, and insulin resistance in 2,245 nondiabetic African American women, stratified by glycemic profile, participating in the Jackson Heart Study. Measurements include physiological markers, anthropometric measures, and (3) stress instruments: Weekly Stress Inventory (WSI), Global Stress (STS), and JHS Discrimination Questionnaire (DIS). t-tests, ÷2 test, bivariate correlations, and forward hierarchical linear regression …

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The Effects Of Supplemental Dietary Vitamins On Weight Gain And Organ Production In The Variegated Sea Urchin, Lytechinus Variegatus (Echinodermata: Echinoidea), Warren T. Jones Jan 2011

The Effects Of Supplemental Dietary Vitamins On Weight Gain And Organ Production In The Variegated Sea Urchin, Lytechinus Variegatus (Echinodermata: Echinoidea), Warren T. Jones

All ETDs from UAB

Due to the global decline in sea urchin fisheries, there has been an increased need to produce nutritionally-complete sea urchin diets for the emerging sea urchin aquaculture industry. Previous studies have established various macronutrient requirements; however, micronutrient requirements have not been well-researched in sea urchins. Vitamins are important micronutrients in both vertebrates and invertebrates, but their importance has not been established in any sea urchin species. To establish the essentiality and nutritional requirements of vitamins in sea urchins, a suite of important vitamins were tested in nutritional trials in the sea urchin, Lytechinus variegatus. Sea urchins fed moderate levels of …

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Testing For The Presence Of Methamphetamine Residues On Clothing From Suspected Clandestine Labs, Sarah J. Keasey Jan 2011

Testing For The Presence Of Methamphetamine Residues On Clothing From Suspected Clandestine Labs, Sarah J. Keasey

All ETDs from UAB

Methamphetamine is an addictive drug that can be clandestinely manufactured using common household products. Several recipes have been developed for clandestine “cooks,” including the Nazi/Birch Method, the Red Phosphorous Method (Red P Method), the Phenol–2–Propanone Method, and the one pot “cook.,” The goal of this research was to develop a Gas Chromatography/Mass Spectroscopy (GC/MS) method to detect methamphetamine (meth) residues and/or its precursors on areas of a user's or a meth cook's clothing that are likely to contain high amounts of perspiration. Areas that were likely to have been in contact with residues or meth contaminated surfaces in a clandestine …

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Biological Characterization Of Transmitted Human Immunodeficiency Virus Type-1, Tara Grant Edmonds Jan 2011

Biological Characterization Of Transmitted Human Immunodeficiency Virus Type-1, Tara Grant Edmonds

All ETDs from UAB

Heterosexual transmission of human immunodeficiency virus type&ndash1 (HIV&ndash1) accounts for the majority of infections worldwide, with women representing the larger percentage of infected individuals. The events leading to the transmission of HIV&ndash1 at mucosal surfaces are not well defined. Based on the observations that transmitted viruses nearly exclusively utilize the CCR5 coreceptor, and that in 80% of heterosexual transmissions a single virus variant establishes infection, there appears to be a selection mechanism that allows only a subset of viruses to be transmitted. This genetic bottleneck suggests that transmitted viruses may possess specific phenotypic and/or genotypic properties that allow for their …

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Molecular Mechanisms Regulating Caenorhabditis Elegans Sperm Migration, Johnathan Wesley Edmonds Jan 2011

Molecular Mechanisms Regulating Caenorhabditis Elegans Sperm Migration, Johnathan Wesley Edmonds

All ETDs from UAB

Fertilization is the process by which male and female gametes join to give rise to a new organism. Union of sperm and ova requires that sperm be able to successfully locate and migrate towards oocytes in the female reproductive tract. By analyzing the in vitro migration of sperm from diverse species and mapping the complex architecture of their female reproductive tracts, we can infer that sperm must respond to directional cues to seek out the mature oocyte. However, the internal fertilization schemes of most complex animals complicate the analysis of in vivo sperm migration. The transparent epidermis of the nematode …

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Efectos Benéficos Del Aloe En La Salud, Mariel Calderón Oliver, Maria Alejandra Quinones Peña, José Pedraza Chaverri Jan 2011

Efectos Benéficos Del Aloe En La Salud, Mariel Calderón Oliver, Maria Alejandra Quinones Peña, José Pedraza Chaverri

Health & Biomedical Sciences Faculty Publications

El Aloe es una planta originaria de regiones áridas que se ha empleado como remedio medicinal desde la antigüedad. Su uso en diferentes patologías depende de cuestiones biológicas, de la variedad de la planta e incluso de cuestiones culturales. Se conocen más de 360 especies de Aloe y se conocen estudios científicos sólo de algunas de las especies con propiedades medicinales, siendo el Aloe vera la especie más estudiada y comercializada en la actualidad. Ciertos compuestos del Aloe presentan propiedades benéficas en la salud, tal es el caso de algunos polifenoles y antracenos como el aloe-emodina, losacemananos, etc. Muchos de …

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Health Literacy: A Community-Based Mixed Methods Study Of Prescription Medication Self-Management Among Community Dwelling Older Adults, Joy P. Deupree Jan 2011

Health Literacy: A Community-Based Mixed Methods Study Of Prescription Medication Self-Management Among Community Dwelling Older Adults, Joy P. Deupree

All ETDs from UAB

During the next decade, it is estimated that 7,918 Americans will turn 60 years old every day. This increase is expected to impact future health care costs. The aging population must be knowledgeable about health care needs to self-manage chronic conditions requiring multiple medications. Nearly half of all American adults have limited literacy skills. Adults at the lowest literacy levels may misunderstand instructions from a health care professional. Confusion about health care instructions can put patients at risk for adverse drug events. The purpose of this two-phase, explanatory mixed methods study was to explore how community dwelling adults ages 60 …

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The Role Of Tgf-Ss Receptors In The Induction Of Mucosal Tolerance, Rebekah Sims Gilbert Jan 2011

The Role Of Tgf-Ss Receptors In The Induction Of Mucosal Tolerance, Rebekah Sims Gilbert

All ETDs from UAB

Oral tolerance, defined as the immunologic state of systemic and mucosal unresponsiveness to an antigen, is an essential function of the mucosal immune system. Although antigen presentation has been found to play an important role in oral tolerance, T cells are known to be the effector immune cells that perpetrate this state. Recent studies found that antigen-specific T regulatory (Treg) cells are important in the induction and maintenance of oral tolerance. The extrathymic development of these Tregs depends on the presence of TGF-ß1 during the differentiation process. However, it has also been shown that oral tolerance could be induced in …

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The Sodium-Potassium-Chloride Cotransporter In Glioma Biology, Brian R. Haas Jan 2011

The Sodium-Potassium-Chloride Cotransporter In Glioma Biology, Brian R. Haas

All ETDs from UAB

The most common malignant primary brain tumor, gliomas usually derive from glial cells including oligodendrocytes and astrocytes. These tumors are characterized by high rates of proliferation and aberrant migration which make them notoriously difficult to treat using standard treatment paradigms such as chemotherapy and radiation. In order for glioma cells to migrate into the surrounding brain tissue, they must undergo rapid and dynamic volume changes. Previous work published by the Sontheimer laboratory and others indicates glioma utilize the flux of ions across the cell membrane to aid in volume changes associate with cell migration. In this dissertation, I show the …

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Qualitative Analysis Of Hiv-1-Specific Cd8 T Cell Responses, Olusimidele Tolulope Akinsiku Jan 2011

Qualitative Analysis Of Hiv-1-Specific Cd8 T Cell Responses, Olusimidele Tolulope Akinsiku

All ETDs from UAB

In the absence of antiretroviral therapy (ART), the majority of individuals infected with human immunodeficiency virus-1 (HIV-1) will develop AIDS. HIV-1-infected controllers are exceptions to the rule; without the use of ART, these individuals spontaneously control virus replication. A better understanding of the immune mechanisms that mediate delayed disease progression, as seen in controllers, will provide valuable insight to the design and development of an effective HIV-1 vaccine. CD8 T cells are important mediators of the antiviral immune response. However, it is unclear which components of the response are critical for long-lasting protection during HIV-1 infection. We first review methods …

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The Role Of Protease-Activated Receptor-1 In Synaptic Plasticity And Memory, Antoine Gabriel Almonte Jan 2011

The Role Of Protease-Activated Receptor-1 In Synaptic Plasticity And Memory, Antoine Gabriel Almonte

All ETDs from UAB

Protease-activated receptor-1 (PAR1) is an unusual G-protein coupled receptor (GPCR) that is activated through proteolytic cleavage by extracellular serine proteases. While previous work has shown that inhibiting PAR1 activation is neuroprotective in models of ischemia, traumatic injury, and neurotoxicity, surprisingly little is known about PAR1's contribution to normal brain function. In the central nervous system (CNS), PAR1 is expressed in glial cells in the hippocampus, a brain region critical for memory formation. I am particularly interested in PAR1 because its activation enhances the function of N-methyl-D-aspartate receptors (NMDARs), which are required for some forms of behavioral learning and synaptic plasticity. …

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Structural Brain Changes Produced By Different Motor Therapies After Stroke, Lynne Vonda Gauthier Jan 2011

Structural Brain Changes Produced By Different Motor Therapies After Stroke, Lynne Vonda Gauthier

All ETDs from UAB

Changes in afferent input have been associated with structural and functional changes to brain tissue. Increased use through an intense neurorehabilitation treatment such as CI therapy has been shown to result in increased grey matter in sensorimotor cortex, more anterior motor areas, and hippocampus. In contrast, decreased use of an arm after stroke results in a contraction of the cortical representation zone involved in its movement. The chronic effects of ischemia and subsequent prolonged nonuse of an extremity on the structure of stroke-affected brains was unknown prior to this investigation, however. This study employed voxel-based morphometry, an MRI analysis technique, …

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Structural Analyses Of Streptococcus Agalactiae Sortases, Baldeep Khare Jan 2011

Structural Analyses Of Streptococcus Agalactiae Sortases, Baldeep Khare

All ETDs from UAB

Multi-drug resistance in Gram-positive bacteria is a growing and unwavering challenge for twenty-first century medicine. The enzyme sortase, identified just around the turn of the century, has since become a promising target for development of anti-infective drugs. Streptococcus agalactiae or Group B Streptococcus (GBS), encodes multiple sortases, which participate in various processes and whose functions are only beginning to be understood in detail. Sortases are cysteine proteases that are crucial for Gram-positive pili biogenesis. Two classes of sortases, class C and class A, participate in the assembly of structural components (pilins) to form the pili and subsequent anchoring of the …

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A Cluster Analysis Based On The Health Belief Model Of Alacare Patients At High Risk For Osteoporosis, Elizabeth M. Kitchin Jan 2011

A Cluster Analysis Based On The Health Belief Model Of Alacare Patients At High Risk For Osteoporosis, Elizabeth M. Kitchin

All ETDs from UAB

The prevalence of osteoporosis and subsequent fragility fractures will continue to rise as the American population ages. The high personal and medical costs of fragility fractures have been well documented. Taking calcium and vitamin D supplements are important strategies for lowering the risk of sustaining a fragility fracture and for improving the efficacy of prescription osteoporosis medications. The purpose of this study was to determine if patients in a home health setting in Alabama (Alacare) who are defined as high risk for a fragility fracture could be segmented via cluster analysis based on the constructs of the Osteoporosis Health Belief …

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Broad And Potent Neutralizing Antibody Responses Elicited In Natural Hiv-2 Infection, Rui Kong Jan 2011

Broad And Potent Neutralizing Antibody Responses Elicited In Natural Hiv-2 Infection, Rui Kong

All ETDs from UAB

Little is known about the potency, breadth and epitope specificities of neutralizing antibody (Nab) responses elicited in natural HIV-2 infection. Analysis of plasma specimens from 64 HIV-2 chronically-infected subjects in a single round infectivity assay (JC53bl-13/TZM-bl) revealed median reciprocal IC50 Nab titers of 1.7x105, 2.8x104 and 3.3x104 against three primary virus strains, HIV-27312A, HIV-2ST and HIV-2UC1, respectively. A subset of 5 plasma samples was tested on 17 additional HIV-2 strains, and similarly high Nab titers were observed against all but four viruses. These Nab titers were higher, by orders of magnitude, than HIV-1 Nab titers in plasma from chronically infected …

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Structural And Functional Studies On Group A Streptococcal Bacteriophage Hyaluronidase, Joo Hyoung Lee Jan 2011

Structural And Functional Studies On Group A Streptococcal Bacteriophage Hyaluronidase, Joo Hyoung Lee

All ETDs from UAB

Aberrant hyaluronan production is frequently associated with tumors where the elevated levels of tumoral hyaluronan are often associated with higher expression levels of cellular hyaluronidases that produce saturated hyaluronan fragments with divergent pro-tumoral activities. In this thesis, we provide evidence that different hyaluronan metabolism of bacteriophage hyaluronidase (HylP) elicits distinct alteration in breast cancer cell behavior. We demonstrate through comparative analysis with bovine testicular hyaluronidase (BTH) that higher enzyme activity, specificity for hyaluronan and production of unsaturated oligosaccharides render HylP to have profound effects on growth, migration and invasion activities of breast carcinoma cells, whereas BTH and its saturated metabolites …

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Multilayered Nanostructured Diamond Coatings For Temporomandibular Joint Prostheses, Leigh Booth Jan 2011

Multilayered Nanostructured Diamond Coatings For Temporomandibular Joint Prostheses, Leigh Booth

All ETDs from UAB

Disorders of the temporomandibular joint (TMJ) may lead to pain, discomfort and reduced function in many patients. When less invasive treatment methods have been exhausted, a TMJ prosthesis may be used to restore joint mobility and function. Currently available TMJ prosthesis designs feature metal-polyethylene or metal-on-metal wear couples; though these devices have been used to successfully restore joint function, the generation of wear debris may lead to adverse reactions at the implant site (such as inflammation or osteolysis). To further reduce wear and potentially increase the lifetime of these devices, nanostructured diamond (NSD) coatings on the articulating surfaces of Ti-6Al-4V …

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Estrogen Increases Stress Resilience And Hippocampal Synaptic Physiology In The Learned Helplessness Model Of Depression In Female Rats, Teruko Michelle Bredemann Jan 2011

Estrogen Increases Stress Resilience And Hippocampal Synaptic Physiology In The Learned Helplessness Model Of Depression In Female Rats, Teruko Michelle Bredemann

All ETDs from UAB

A recent focus of psychiatric research is estrogen related mood disorders such as postpartum depression and major depressive disorder in women. It is now clear that women are more susceptible to depression in response to stress during reproductive events when ovarian hormones are low or fluctuating. Depressive episodes are characterized by feelings of helplessness and despair as well as learning and memory impairments that have been linked to the hippocampus. Thus, decreased functioning of hippocampal circuits likely contributes to the cognitive symptoms associated with depression. Preclinical research shows that stress, which triggers depressive episodes, decreases the ability of excitatory synapses …

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The Predictability Of C-Reactive Protein, Lipoprotein-Associated Phospholipase A2, And Depression On Later Health Outcomes In Patients Experiencing A First-Time Stroke, Mary King Brethour Jan 2011

The Predictability Of C-Reactive Protein, Lipoprotein-Associated Phospholipase A2, And Depression On Later Health Outcomes In Patients Experiencing A First-Time Stroke, Mary King Brethour

All ETDs from UAB

Stroke is the third leading cause of death and the most common cause of neurologic disability for adults in developed nations. Strokes trigger an acute inflammatory response prompted by brain tissue injury at the infarct site and the surrounding ischemic penumbra raising plasma levels of inflammatory markers. C-reactive protein (CRP), an acute-phase inflammatory marker, has been significantly correlated with infarct size and post-stroke complications. Lipoprotein-associated phospholipase A2 (Lp-PLA2) may also predict long-term cardiovascular risk in the stroke population. In addition to physiologic changes, up to 60% of all stroke survivors are known to experience depression, which may contribute to decreased …

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Role Of Ras Proteins In Malignant Peripheral Nerve Sheath Tumors, Nicole Marie Brossier Jan 2011

Role Of Ras Proteins In Malignant Peripheral Nerve Sheath Tumors, Nicole Marie Brossier

All ETDs from UAB

Malignant peripheral nerve sheath tumors (MPNSTs) arising in patients with neurofibromatosis type I (NF1) are null for the tumor suppressor neurofibromin, a negative regulator of signaling from both classic Ras (H-Ras, N-Ras and K-Ras) and R-Ras (R-Ras, R-Ras2/TC21, M-Ras/R-Ras3) subfamily members. Treatment of these tumors with Ras-targeted agents such as farnesyltransferase inhibitors has proven unsuccessful, likely due to the inability of these agents to successfully target all of the Ras isoforms regulated by neurofibromin. Thus, determining which Ras isoforms are critical for MPNST pathogenesis would be of therapeutic value. In this dissertation, we first review the clinical manifestations of NF1 …

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Altered Dna Methylation Of Repetitive Elements May Explain The Modified Risk Of Cervical Intraepithelial Neoplasia (Cin) Associated With Genetic Polymorphisms Of The Folate Metabolic Pathway In The Us Post Folic Acid Fortification Era, Suguna Badiga Jan 2011

Altered Dna Methylation Of Repetitive Elements May Explain The Modified Risk Of Cervical Intraepithelial Neoplasia (Cin) Associated With Genetic Polymorphisms Of The Folate Metabolic Pathway In The Us Post Folic Acid Fortification Era, Suguna Badiga

All ETDs from UAB

Despite the controversy regarding the adverse effects of exposure to higher folate concentrations on health outcomes particularly cancer, there has been paucity of research to understand the biological mechanisms affected by such exposures in relation to the risk of developing pre-cancer or cancer. We have recently addressed this concern by demonstrating that higher plasma folate concentrations were not associated with greater risk of being diagnosed with higher grades of cervical intraepithelial neoplasia (CIN 2+) especially in women with sufficient plasma vitamin B12 concentrations. Higher plasma folate was also associated with a pre-cancer protective level of peripheral blood mononuclear cells (PBMC) …

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Fracture Strength Of All-Ceramic Restorations After Fatigue Loading, Balasudha Baladhandayutham Jan 2011

Fracture Strength Of All-Ceramic Restorations After Fatigue Loading, Balasudha Baladhandayutham

All ETDs from UAB

Fracture strength of monolithic and bilayered LAVA and e. max lower molar crowns after load cycling was measured and compared. The study included three groups (n = 8) from LAVA zirconia and three groups from e. max lithium disilicate to compare influences of different layers, thicknesses and manufacturing techniques. Prefabricated anatomically designed crowns were cemented to dies made from Z 100 composite resin using Rely X Luting Plus resin modified glass ionomer cement. Cemented crowns were stored at 37° C for 24 hours then cyclic loaded to test fatigue properties. The crowns were loaded to 200,000 cycles at 25N at …

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