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Identification, State Estimation, And Adaptive Control Of Type I Diabetic Patients, Ali Mohamad Hariri

Wayne State University Dissertations

ABSTRACT

IDENTIFICATION, STATE ESTIMATION, AND ADAPTIVE CONTROL OF TYPE I DIABETIC PATIENTS

by

ALI MOHAMAD HARIRI

May 2012

Advisor: Dr. Le Yi Wang

Major: Electrical Engineering

Degree: Doctor of Philosophy

During the past few decades, biomedical modeling techniques have been applied to improve performance of a wide variety of medical systems that require monitoring and control. Diabetes is one of the most important medical problems. Most of the existing techniques assume the system to be time-invariant, and the original minimal model was modified by deleting some important parameters. In this research, the original minimal model that consists of three differential …

Mechanical Forces And Tumor Cells: Insight Into The Biophysical Aspects Of Cancer Progression, Indrajyoti Indra

Wayne State University Dissertations

Mechanical forces play an important role in the regulation of cellular behavior and physiological processes including adhesion, migration, proliferation, tissue repair, embryogenesis and development. In addition, a number of diseases including cancer, have been linked to changes in cellular and extracellular mechanical properties. However, whether a correlation exists between the progression of cancer towards metastasis and mechanical factors has not been clearly defined. Additionally, how a cell responds to changes in extracellular mechanical cues as it gains metastatic abilities is poorly understood. To address these questions, we have utilized a panel of murine breast cancer cell lines with progressive metastatic. …

Mechanisms Of Persistent Translation Arrest Following Global Brain Ischemia And Reperfusion, Jill Theresa Jamison

Wayne State University Dissertations

ABSTRACT

MECHANISMS OF PERSISTENT TRANSLATION ARREST FOLLOWING GLOBAL BRAIN ISCHEMIA and REPERFUSION

by

JILL T. JAMISON

December 2011

Advisor: Donald J. DeGracia, Ph.D.

Major: Physiology

Degree: Doctor of Philosophy

The information presented here studies the mechanisms that underlie persistent translation arrest (TA) following global brain ischemia and reperfusion (I/R). To summarize the main findings I have discovered a new mechanism for prolonged post-ischemic TA that correlated exactly with in vivo translation rates and correlated precisely with cell outcome. Through the extensive colocalization studies, my results indicate that the mRNA granules are ribonomic structures involved with mRNA regulation. This finding is …

Slavery And Abortion: The Paradox Of American Liberalism, Mark A. Ladd

Wayne State University Dissertations

Louis Hartz proposed that America possesses a liberal tradition that works toward a Lockean equality for all people. I argue that Hartzs' theory is still applicable to America even though illiberal institutions have and do exist. My contention is that it is the paradox of liberalism that allows for this. Slavery is the quintessential illiberal institution, yet liberal concepts allowed it to exist in America for over 200 years. It is my contention that abortion is another illiberal institution that is being promoted by the paradox of liberalism. With the use of John Rawls theory of distributive justice abortion can …

Processing Random Signals In Neuroscience, Electrical Engineering And Operations Research, Kalyan Raman

Wayne State University Dissertations

The topic of this dissertation is the study of noise in electrical engineering, neuroscience, biomedical engineering, and operations research through mathematical models that describe, explain, predict and control dynamic phenomena. Noise is modeled through Brownian Motion and the research problems are mathematically addressed by different versions of a generalized Langevin equation. Our mathematical models utilize stochastic differential equations (SDEs) and stochastic optimal control, both of which were born in the soil of electrical engineering. Central to this dissertation is a brain-physics based model of cerebrospinal fluid (CSF) dynamics, whose structure is fundamentally determined by an electrical circuit analogy. Our general …

Impairment Of Na/K-Atpase Signaling In Renal Proximal Tubule Contributes To Dahl Salt-Sensitive Hypertension, Jiang Liu, Yanling Yan, Lijun Liu, Zijian Xie, Deepak Malhotra, Bina Joe, Joseph I. Shapiro

Pharmaceutical Science and Research

We have observed that, in renal proximal tubular cells, cardiotonic steroids such as ouabain in vitro signal through Na/K-ATPase, which results in inhibition of transepithelial 22Na transport by redistributing Na/K-ATPase and NHE3. In the present study, we investigate the role of Na/K-ATPase signaling in renal sodium excretion and blood pressure regulation in vivo. In Sprague-Dawley rats, high salt diet activated c-Src and induced redistribution of Na/K-ATPase and NHE3 in renal proximal tubules. In Dahl salt sensitive (S) and resistant (R) rats given high dietary salt, we found different effects on blood pressure but, more interestingly, different effects on renal salt …

Citizen David Tames Gas Goliaths On The Marcellus Shale Stage: Citizen Action As A Form Of Dispute Prevention In The Internet Age, Elisabeth N. Radow

Cardozo Journal of Conflict Resolution

"Water, water everywhere and not a drop to drink." This could soon become the lament of millions of people who derive their drinking water from sources located near the latest natural gas boom site in the East, known as the "Marcellus Shale" region. Drilling is underway in Pennsylvania and West Virginia, but not yet in New York. The focus here is New York.

2010 Annual Symposium: Keynote Speech, Joseph A. Siegel

Cardozo Journal of Conflict Resolution

Thank you very much to the Board of the Cardozo Journal of Conflict Resolution for inviting me here today. I am honored to be speaking at this conference and participating in an event with so many distinguished experts in the conflict resolution field. I spend most of my time working on the challenging issue of climate change and, as we all know, energy is both a significant part of the problem and a significant part of the solution. I often have the opportunity to speak at and attend conferences on climate and energy and I like to monitor over time …

The Brains Behind Mediation: Reflections On Neuroscience, Conflict Resolution And Decision-Making, Daniel Weitz

Cardozo Journal of Conflict Resolution

On September 13, 1848, an explosives charge sent a three-foot tamping iron about an inch in diameter through the head of Phineas Gage. Although Gage survived, the tamping iron, which entered just under the left eye and exited through the frontal portion of his head, destroyed his prefrontal cortex. Prior to the accident, Gage was a popular foreman of a railroad construction crew. After the accident, he was a tactless, profane, and impulsive man with a dramatically altered personality.

Comments To The Consumer Financial Protection Bureau In Connection With Its Review Of Arbitration For Consumer Financial Products Or Services, Edna Sussman

Cardozo Journal of Conflict Resolution

This report is submitted by the Dispute Resolution Section of the New York State Bar Association to provide background and highlight issues the Bureau may wish to consider in fulfilling its charge. The report takes no position as to the appropriate treatment of consumer disputes, but strongly supports a thorough examination of dispute resolution processes to ensure that they are in the public interest and fair to consumers.

Contracting For Arbitration In Custody Disputes: Parental Autonomy Vs. State Responsibility, Christina Fox

Cardozo Journal of Conflict Resolution

New York and New Jersey are so close in location, but so far apart in their respective policies toward binding arbitration in child custody matters. Even though most family law matters now involve forms of alternative dispute resolution ("ADR"), courts are deeply divided on whether binding arbitration should be allowed in child custody disputes, and over which standard to adopt in reviewing custody arbitration awards. While New York has repeatedly disallowed binding arbitration in child custody, New Jersey has recently joined other states in approving binding arbitration and enforcing a parent's contractual determination of his child's welfare. The question is …

Can The Leopard Change His Spots?! Reflections On The 'Collaborative Law' Revolution And Collaborative Advocacy, Dafna Lavi

Cardozo Journal of Conflict Resolution

Much has been written about the social contribution of the ADR movement, and the many and diverse ways to implement it. This article focuses on collaborative law, one of the newer methods adopted by this movement, and observes that the full impact and implications of this movement have not yet been explored. One of the compelling implications discussed in this article is the collaborative law revolution.

This article presents both the observable and latent aspects of this revolution. According to this article, the main contribution of the revolution is in signaling a change in the design and conceptualization of the …

Courageous Conversations: Aligning The Occupy Wall Street And The Mediation Movements, Raymond Shonholtz

Cardozo Journal of Conflict Resolution

Originally prepared as a speech for the Oregon Mediation Conference, November 2011, the following has been modified for a wider audience concerned about the role of mediators and the mediation movement in relation to the Occupy Wall Street Movement ("OWS"). The author's intent is to provide a context for supporting the "courageous conversations" (theme of the Oregon Mediation Association Conference) of OWS by mediation and change management experts. The following was written a month after the Oregon Mediation Association speech and reflects comments made to the author to elaborate on the mediating modalities that might be useful to both OWS …

Mismatch.Com: Online Dispute Resolution And Divorce, Rebecca Brennan

Cardozo Journal of Conflict Resolution

This Note proposes that online dispute resolution (ODR) is a particularly therapeutic method of negotiating and settling a divorce, and in some circumstances may be a more appropriate method than traditional face-to-face mediation sessions. Part I will discuss divorce and its psychological and emotional consequences. Part II will discuss therapeutic jurisprudence and why it is especially beneficial as applied to the dissolution of marriages. Part III will discuss ODR in general, its development, and its application to a variety of legal fields. Part IV will discuss the advantages and disadvantages of ODR, particularly with regards to therapeutic jurisprudence and divorce …

A Solution To Holdouts In The National Football League: How Salary Arbitration Can Limit A Growing Problem, Roger Quiles

Cardozo Journal of Conflict Resolution

This Note will explore the intricacies of Major League Baseball's salary arbitration system, as established in the league's CBA with the MLB Players' Association (hereinafter, "MLBPA"), in order to create a suitable and similar forum for the NFL. The MLB salary arbitration model is not perfectly transposed to the NFL, but can be slightly modified to reflect the differences between the sports. The primary difference is that the NFL establishes a salary cap that a team's payroll may not exceed, whereas MLB teams can carry as big of a payroll as they want. Though the salary cap raises several questions …

Maternal Exposure To The Holocaust And Health Complaints In Offspring, Janine D. Flory, Linda M. Bierer, Rachel Yehuda

Publications and Research

Although the link between chronic stress and the development of cardiovascular and metabolic diseases of adulthood has been known for some time, there is growing recognition that early environmental influences may result in developmental programming via epigenetic mechanisms, thereby affecting the developmental trajectory of disease progression. Previous studies support the idea that offspring of Holocaust survivors may have been subjected to early developmental programming. We evaluated the relationship between parental exposure to the Holocaust and selfreported health ratings and disorders made by their adult offspring (i.e., second generation Holocaust survivors). A total of 137 subjects were evaluated. Regression analyses demonstrated …

Partitioning Of Anthropogenic Watering Sites By Desert Carnivores., Todd C. Atwood, Tricia L. Fry, Bruce Leland

United States Department of Agriculture Wildlife Services: Staff Publications

We investigated the role of water features as focal attractors for gray foxes (Urocyon cinereoargenteus), coyotes (Canis latrans), and bobcats (Felis rufus) in west Texas to determine if they were foci for interspecific interaction. Mixed effects models indicated that species partitioned use of water features spatially and temporally. Linear models indicated factors influencing relative activity at water features varied by species. For coyotes and bobcats, the water availability model, containing days since last rainfall and nearest-neighbor distance to water was best supported by the data, with relative activity increasing with time between rainfall and distance between waters. For gray foxes, …

Efficacy Of European Starling Control To Reduce Salmonella Enterica Contamination In A Concentrated Animal Feeding Operation In The Texas Panhandle, James C. Carlson, Richard M. Engeman, Doreene R. Hyatt, Rickey L. Gilliland, Thomas J. Deliberto, Larry Clark, Michael J. Bodenchuck, George M. Linz

United States Department of Agriculture Wildlife Services: Staff Publications

Background: European starlings (Sturnus vulgaris) are an invasive bird species known to cause damage to plant and animal agriculture. New evidence suggests starlings may also contribute to the maintenance and spread of diseases within livestock facilities. Identifying and mitigating the risk pathways that contribute to disease in livestock is necessary to reduce production losses and contamination of human food products. To better understand the impact starlings have on disease transmission to cattle we assessed the efficacy of starling control as a tool to reduce Salmonella enterica within a concentrated animal feeding operation. We matched a large facility, slated for operational …

Domestic Calf Mortality And Producer Detection Rates In The Mexican Wolf Recovery Area: Implications For Livestock Management And Carnivore Compensation Schemes., Stewart W. Breck, Bryan M. Kluever, Michael Panasci, John Oakleaf, Terry Johnson, Warren B. Ballard, Larry Howery, David L. Bergman

United States Department of Agriculture Wildlife Services: Staff Publications

Conserving large carnivores throughout the world will often require that they share the landscape with livestock. Minimizing depredations and increasing tolerance by livestock producers will be critical for conservation efforts. To investigate factors influencing calf mortality and producer detection rates (i.e., number of livestock killed by predators, found by producers, and correctly classified as to cause of death), we monitored radio-tagged domestic calves at two sites in the Mexican wolf recovery area (East Eagle [EE] and Adobe Ranch [AR]). Study areas differed in grazing practices, density of predators (mountain lions, black bears, coyotes, and Mexican wolves), and amount of effort …

Clinical And Pathologic Responses Of American Crows (Corvus Brachyrhynchos) And Fish Crows (C Ossifragus) To Experimental West Nile Virus Infection, N. M. Nemeth, B. V. Thomsen, T. R. Spraker, J. M. Benson, A. M. Bosco-Lauth, P. T. Oesterle, J. M. Bright, J. P. Muth, T. W. Campbell, T. L. Gidlewski, R. A. Bowen

United States Department of Agriculture Wildlife Services: Staff Publications

West Nile virus (WNV)-associated disease has a range of clinical manifestations among avian taxa, the reasons for which are not known. Species susceptibility varies within the avian family Corvidae, with estimated mortality rates ranging from 50 to 100%. We examined and compared virologic, immunologic, pathologic, and clinical responses in 2 corvid species, the American crow (Corvus brachyrhynchos) and the fish crow (C ossifragus), following experimental WNV inoculation. Unlike fish crows, which remained clinically normal throughout the study, American crows succumbed to WNV infection subsequent to dehydration, electrolyte and pH imbalances, and delayed or depressed humoral immune …

Interspecific Variation In Wildlife Hazards To Aircraft: Implications For Airport Wildlife Management, Travis L. Devault, Jerrold L. Belant, Bradley F. Blackwell, Thomas W. Seamans

United States Department of Agriculture Wildlife Services: Staff Publications

Understanding the relative hazards of wildlife to aircraft is important for developing effective management programs. We used Federal Aviation Administration National Wildlife Strike Database records from 1990 to 2009 in the United States to rank the relative hazard of wildlife to aircraft. We summarized data for 77 species or species groups with ≥20 records where collisions occurred ≥500 ft (152 m) above ground level. We also assessed the effects of avian body mass, body density, and group size on relative hazard scores. The 3 most hazardous species or species groups were mule deer (Odocoileus hemionus), white-tailed deer ( …

Assessment Of Human-Coyote Conflicts: City And County Of Broomfield, Colorado, Stan Grant, Julie K. Young, Seth Riley

United States Department of Agriculture Wildlife Services: Staff Publications

In the summer of 2011, the Anthem Highlands neighborhood of the City and County of Broomfield (Broomfield), Colorado experienced multiple serious incidents between humans and coyotes. Broomfield has a detailed policy about coexisting with wildlife in general, and coyotes in particular, that includes extensive public education and outreach. Because of the serious nature of the incidents, the Colorado Division of Parks and Wildlife, with assistance from USDA-Wildlife Services and in collaboration with Broomfield, engaged in coyote removal efforts. One coyote was lethally removed after the first incident, another was shot after the second incident, 8 coyotes were lethally removed (7 …

With Malice Towards None: Six Stories And A Novella, Burke Nixon

Electronic Theses and Dissertations

A fiction collection consisting of six short stories folloby a novella. The pieces attempt to be comic, but also--with debatable success--to be more than just comic. As the title suggests, one of the collection's thematic concerns is mercy and its absence. Most of the pieces are set in Texas; characters in the collection include a female student in an absurdly incompetent public high school, a parking cop, the best friend of a stand-up comedian, an Abilene man whose life goal is to be struck by lightning, and an unselfconscious grandfather character, who bookends the beginning and end of the collection. …

Analysis Of Two Urban Middle Schools: Factors Affecting Student Achievement, V. Douglas Neufeld

Theses and Dissertations

Because of increasing student enrollment, a new school was formed in a small low-income Southern California school district. Teachers could choose to transfer to the new school or remain at the existing school. Over five years, quantitative analyses of demographic data showed little differences between the two schools across the years except for a difference in student academic achievement. This mixed-method study examined the demographics and perceptions of academic life at these two middle schools to ascertain an explanation for differences in academic achievement as measured by the same standardized test. Team interviews combined the focus group approach within teams, …

Challenging Balance Between Productivity And Environmental Quality: Tillage Impacts, D. C. Reicosky, T. J. Sauer, J. L. Hatfield

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

The increasing pressure to provide food security, enhance environmental quality, and address societal problems creates challenges for agriculture and requires we consider how to change our current systems to become more sustainable. Wiebe (2003) stated, “Not only is the contemporary food system inherently unsustainable, increasingly it is damaging the environment.” There have been adverse eff ects in all parts of the world on soils, water, and biodiversity. Poor management of our agricultural systems has contributed to human-induced climate change, and, in turn, human-induced climate change threatens agricultural productivity. In many developed countries, access to quality food is taken for granted, …

Indices For Soil Management Decisions, Douglas L. Karlen, Brian J. Wienhold, Shujiang Kang, Ted M. Zobeck, Susan S. Andrews

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

Global efforts to identify and develop soil quality indices that can accurately and efficiently quantify effects of soil and crop management began to emerge around the world during the latter portion of the 20th century. This occurred as people became more aware that soil is a unique, nonrenewable resource that nurtures and sustains human civilizations (McNeill and Winiwater, 2004). These efforts have been further encouraged by a growing awareness of the multiple ecosystem services that soil resources provide to sustain food security, environmental quality, ecological functions, and most recently feedstock production for biofuels (Doran et al., 1996; Bouma, 2005; Lal, …

Disease Management, Timothy C. Paulitz

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

Plants can be attacked by a variety of parasitic microorganisms, primarily fungi, bacteria, nematodes, and viruses. From 2001 to 2003, an average of 7% to 15% of the major world crops (wheat, rice, potato, maize, and soybean) were lost due to fungi and bacteria (Oerke, 2005). Along with weeds and insects, plant pathogens are the major biotic limitation to crop health and yield. Many of these pathogens are foliar and attack aboveground parts of plants, with inoculum spread by wind and rain. Examples are rust, powdery mildew, and foliar leaf pathogens such as the fungus Septoria. However, some of …

Agroforestry, Thomas J. Sauer, Guillermo Hernandez-Ramirez

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

Humans have long exploited the climate-altering eff ects that trees provide through shade from a hot sun and shelter from strong winds (Hall et al., 1958). Behavior that initially produced greater physical comfort evolved into purposeful planting, selection, and tending to increase and expand the multiple benefits trees can provide including food, fiber, fuel, and medicinal products. Agroforestry systems (AFS) integrate woody perennial plants with agricultural crops or animal production on the same land area. A fundamental advantage of AFS is that the combination of trees with understory plants or animals has greater potential for production of food, forage, and …

Regulatory Considerations Surrounding The Deployment Of Bt-Expressing Cowpea In Africa Report Of The Deliberations Of An Expert Panel, Joseph E. Huesing, Jörg Romeis, Norman C. Ellstrand, Alan Raybould, Richard L. Hellmich, Jeffrey D. Wolt, Jeffrey D. Ehlers, L. Clémentine Dabiré-Binso, Christian A. Fatokun, Karen E. Hokanson, Mohammad F. Ishiyaku, Venu M. Margam, Nompumelelo Obokoh, Jacob D. Mignouna, Francis Nang'ayo, Jeremy T. Ouedraogo, Rémy S. Pasquet, Barry R. Pittendrigh, Barbara A. Schaal, Jeff Stein, Manuele Tamò, Larry L. Murdock

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

Cowpea (Vigna unguiculata ssp unguiculata) is adapted to the drier agro-ecological zones of West Africa where it is a major source of dietary protein and widely used as a fodder crop. Improving the productivity of cowpea can enhance food availability and security in West Africa. Insect predation—predominately from the legume pod borer (Maruca vitrata), flower thrips (Megalurothrips sjostedti) and a complex of pod-sucking bugs (e.g., Clavigralla spp)—is a major yieldlimiting factor in West African cowpea production. Dramatic increases in yield are shown when M. vitrata is controlled with insecticides. However, availability, costs and safety …

The Infancy Defense In The Modern Contract Age: A Useful Vestige, Victoria Slade

Seattle University Law Review

This Note argues that the state of a modern consumer society, when evaluated against the culture of marketing and consumerism surrounding America’s youth, calls for persisting protection of children in contract formation through retention of the infancy defense. Part II of this Note introduces the infancy defense, the philosophy behind it, the various exceptions to the defense, and how these exceptions have adapted to the modern marketplace to assure equitable results for adults. This Part also discusses other arenas of the law in which children are afforded special protection. Part III addresses the current state of the infancy doctrine as …