Digital Commons Network^™

Switches, Excitable Responses And Oscillations In The Ring1b/Bmi1 Ubiquitination System., Lan K Nguyen, Javier Muñoz-García, Helene Maccario, Aaron Ciechanover, Walter Kolch, Boris N Kholodenko

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

In an active, self-ubiquitinated state, the Ring1B ligase monoubiquitinates histone H2A playing a critical role in Polycomb-mediated gene silencing. Following ubiquitination by external ligases, Ring1B is targeted for proteosomal degradation. Using biochemical data and computational modeling, we show that the Ring1B ligase can exhibit abrupt switches, overshoot transitions and self-perpetuating oscillations between its distinct ubiquitination and activity states. These different Ring1B states display canonical or multiply branched, atypical polyubiquitin chains and involve association with the Polycomb-group protein Bmi1. Bistable switches and oscillations may lead to all-or-none histone H2A monoubiquitination rates and result in discrete periods of gene (in)activity. Switches, overshoots …

Switches, Excitable Responses And Oscillations In The Ring1b/Bmi1 Ubiquitination System., Lan K Nguyen, Javier Muñoz-García, Helene Maccario, Aaron Ciechanover, Walter Kolch, Boris N Kholodenko

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

In an active, self-ubiquitinated state, the Ring1B ligase monoubiquitinates histone H2A playing a critical role in Polycomb-mediated gene silencing. Following ubiquitination by external ligases, Ring1B is targeted for proteosomal degradation. Using biochemical data and computational modeling, we show that the Ring1B ligase can exhibit abrupt switches, overshoot transitions and self-perpetuating oscillations between its distinct ubiquitination and activity states. These different Ring1B states display canonical or multiply branched, atypical polyubiquitin chains and involve association with the Polycomb-group protein Bmi1. Bistable switches and oscillations may lead to all-or-none histone H2A monoubiquitination rates and result in discrete periods of gene (in)activity. Switches, overshoots …

An Evaluation Of Neuroplasticity And Behavior After Deep Brain Stimulation Of The Nucleus Accumbens In An Animal Model Of Depression., Steven M Falowski, Ashwini Sharan, Beverly A S Reyes, Carl Sikkema, Patricia Szot, Elisabeth J Van Bockstaele

Department of Neurosurgery Faculty Papers

BACKGROUND: Recent interest has demonstrated the nucleus accumbens (NAcc) as a potential target for the treatment of depression with deep brain stimulation (DBS).

OBJECTIVE: To demonstrate that DBS of the NAcc is an effective treatment modality for depression and that chemical and structural changes associated with these behavioral changes are markers of neuroplasticity.

METHODS: A deep brain stimulator was placed in the NAcc of male Wistar-Kyoto rats. Groups were divided into sham (no stimulation), intermittent (3 h/d for 2 weeks), or continuous (constant stimulation for 2 weeks). Exploratory and anxietylike behaviors were evaluated with the open-field test before and after …

Stimulation Of The Hypothalamic Ventromedial Nuclei By Pituitary Adenylate Cyclase-Activating Polypeptide Induces Hypophagia And Thermogenesis, Jon M. Resch, Joanne P. Boisvert, Allison E. Hourigan, Christopher R. Mueller, Sun Shin Yi, Sujean Choi

Biomedical Sciences Faculty Research and Publications

Numerous studies have demonstrated that the hypothalamic ventromedial nuclei (VMN) regulate energy homeostasis by integrating and utilizing behavioral and metabolic mechanisms. The VMN heavily express pituitary adenylate cyclase-activating polypeptide(PACAP) type I receptors (PAC1R). Despite the receptor distribution, most PACAP experiments investigating affects on feeding have focused on intracerebroventricular (icv) administration or global knockout mice. To identify the specific contribution of PACAP signaling in the VMN, we injected PACAP directly into the VMN and measured feeding behavior and indices of energy expenditure. Following an acute injection of PACAP, nocturnal food intake was significantly reduced for six hours after injections without evidence …

The Theory And Practice Of Genetically Engineered Crops And Agricultural Sustainability, David E. Ervin, Leland L. Glenna, Raymond Adelard Jussaume

Institute for Sustainable Solutions Publications and Presentations

The development of genetically engineered (GE) crops has focused predominantly on enhancing conventional pest control approaches. Scientific assessments show that these GE crops generally deliver significant economic and some environmental benefits over their conventional crop alternatives. However, emerging evidence indicates that current GE crops will not foster sustainable cropping systems unless the negative environmental and social feedback effects are properly addressed. Moreover, GE crop innovations that promote more sustainable agricultural systems will receive underinvestment by seed and chemical companies that must understandably focus on private returns for major crops. Opportunities to promote crops that convey multi-faceted benefits for the environment …

Our Cities And The City: Incompatible Classics?, Carl Abbott

Urban Studies and Planning Faculty Publications and Presentations

At the end of the 1930s, Americans interested in the fates and futures of their cities had the opportunity to consider two new efforts to summarize urban problems and propose solutions. The first was Our Cities: Their Role in the National Economy, published in 1937 under the auspices of the National Resources Board. The second was The City, a film sponsored by the American Institute of Planners for showing at the New York world's fair in 1939. The report and the film arose out of different analytical traditions, the first from the approach that embedded urban planning within a larger …

Ethnic Disparity In 21-Hydroxylase Gene Mutations Identified In Pakistani Congenital Adrenal Hyperplasia Patient, Aysha Habib Khan, Muniba Aban, Jamal Raza, Naeem Ul Haq, Abdul Jabbar, Tariq Moatter

Department of Pathology and Laboratory Medicine

Background: Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders caused by defects in the steroid 21 hydroxylase gene (CYP21A2). We studied the spectrum of mutations in CYP21A2 gene in a multi-ethnic population in Pakistan to explore the genetics of CAH.

Methods: A cross sectional study was conducted for the identification of mutations CYP21A2 and their phenotypic associations in CAH using ARMS-PCR assay.

Results: Overall, 29 patients were analyzed for nine different mutations. The group consisted of two major forms of CAH including 17 salt wasters and 12 simple virilizers. There were 14 phenotypic males and 15 females …

Promoting Healthy Eating And Exercise Through Online Messages: A Pilot Study, Helen Nyquist, Yeong Rhee, Ardith Brunt, Julie Garden-Robinson

Journal of Extension

The effectiveness of online messages to change dietary intake and level of physical activity was assessed. Thirty-six volunteers completed a 26-item pre- and post-intervention online survey and received a total of 36 email messages about MyPyramid, food labels, healthier lifestyles, and physical activity. Participants reported increased fiber intake, decreased fat intake, and increased physical activity. Overweight/obese participants lost an average of 8.0 lbs. during the 12-week period. Online messages can contribute to an increase in healthy food consumption and level of physical activity and is a desirable intervention tool for Extension nutrition and health practitioners.

A Successful Multi-Institutional Blog For Transferring Garden And Landscape Information To The Public, Jeffrey Gillman, Linda Chalker-Scott, Holly Scoggins, Bert Cregg

Journal of Extension

In July 2009 four faculty members from four different institutions created a blog to educate consumers and professionals about plant-related issues. Online resources were used to measure the number of times that the blog was viewed and its impacts. The blog averages about 200 views a day, and 80% of those responding to a survey could name specific impacts that the blog had on their gardening and landscape practices.

Insights From Spanish-Speaking Employees In The Iowa Horticultural Industry, Emilie Justen, Cynthia Haynes, Ann Marie Vanderzanden, Nancy Grudens-Schuck

Journal of Extension

Addressing the needs of Latino workers can help improve working conditions, job satisfaction, and productivity of both employees and the companies hiring Latino workers. The study reported here assessed educational needs, communication gaps, and technical skills of Latino workers working in the horticultural industry in Iowa—an ethnic group that is relatively new to Iowa. Focus groups were conducted with Latino workers and produced topics for educational programming and suggestions that could improve communications between predominantly English-speaking managers and Spanish-speaking Latino employees, and the horticultural knowledge of the Latino employees.

Land-Grant University Employee Perceptions Of Extension: A Baseline Descriptive Study, Kathleen D. Kelsey, Eric T. Stafne, Lance Greer

Journal of Extension

eXtension was publicly launched in 2008 as an online resource; however, adoption rates have been disappointing. The research reported here measured adoption of eXtension, willingness to participate in a Community of Practice, and adoption barriers among Oklahoma Extension employees. The adoption rate was 49%, and 43% of employees were willing to join a CoP. Lack of time and knowledge of eXtension were key barriers to adoption. Recommendations include training employees how to use eXtension and become a member of a CoP. Adopting scholarship guidelines to reward faculty and educators for contributing to eXtension may facilitate adoption of this innovation.

Factors Influencing Participant Perceptions Of Program Impact: Lessons From A Virtual Fieldtrip For Middle-School Students, Omolola A. Adedokun, Loran C. Parker, Jamie Loizzo, Wiella D. Burgess, Joseph P. Robinson

Journal of Extension

Participant perceptions of program effectiveness and impact are undoubtedly a popular focus of Extension program evaluations. However, the effects of participants' characteristics and contextual variables on program perceptions and how the resulting data can be used for program improvement are less explored in evaluation studies. Using data from the evaluation of an electronic fieldtrip as an exemplar case, this article describes a study that employed the method of linear regression to examine the influences of demographic variables and program contextual factors on participants' perceptions of program effectiveness. The implications for Extension evaluation and programming are also discussed.

Mapping Extension's Networks: Using Social Network Analysis To Explore Extension's Outreach, Tom Bartholomay, Scott Chazdon, Mary S. Marczak, Kathrin C. Walker

Journal of Extension

The University of Minnesota Extension conducted a social network analysis (SNA) to examine its outreach to organizations external to the University of Minnesota. The study found that its outreach network was both broad in its reach and strong in its connections. The study found that SNA offers a unique method for describing and measuring Extension outreach and that SNA can be effectively used to examine internal patterns around outreach while informing strategies toward improved alignment and greater leveraging of institutional knowledge. The findings indicate that SNA has great potential for improving reporting, developing internal collaboration, and conducting system-wide impact evaluations.

Development And Evaluation Of An On-Line Educational Module For Volunteer Leaders On Bio-Security In Washington State 4-H Livestock Projects, Jill L. Stevenson, Dale A. Moore, Jerry Newman, Janet L. Schmidt

Journal of Extension

An on-line module on disease prevention was created for 4-H volunteer leaders who work with livestock projects in Washington to better prepare them to teach youth about bio-security and its importance in 4-H livestock projects. Evaluation of the module and usage statistics since the module's debut were collected and evaluated. The module increases awareness of disease prevention and provides practical approaches to implementation of bio-security, but is underused by the target audience, possibly due to leaders' lack of computer access, time, or awareness of the module. Promotion of the module and incentives must be explored to increase module usage.

Social Network Analysis: A Tool To Improve Understanding Of Collaborative Management Groups, Adam C. Springer, Je De Steiguer

Journal of Extension

Social network analysis (SNA) is a tool used to analyze the connections between people and organizations. However, despite its usefulness to the study of these relations, there have been relatively few applications to situations in agriculture and natural resources. SNA was applied to the study of a watershed collaborative group in southern Arizona. We found that even a fundamental application of SNA was valuable to a watershed initiative and, furthermore, believe that U.S. Extension professionals are positioned to advance the effectiveness of participatory resource management groups through more widespread use of this methodology.

Conducting Research On Private Farms And Ranches: Approaches, Issues, And Tips, Kimberly A. Nicholas, Eve-Lyn S. Hinckley

Journal of Extension

We describe factors to consider when establishing collaborative research projects with agricultural growers, issues that can arise in establishing these relationships, and key steps that researchers can take to improve collaborations and increase the likelihood of project success. We conclude that the most important features of successful collaborations between researchers and agricultural cooperators include: (1) discussing research goals and objectives early in the project process, (2) identifying appropriate times and modes of communicating management and research activities, and (3) finding appropriate forums to disseminate research results to the participating growers and larger agricultural community.

Strengthening 4-H Program Communication Through Technology, Karl Robideau, Karyn Santl

Journal of Extension

Advances in technology are transforming how youth and parents interact with programs. The Strengthening 4-H Communication through Technology project was implemented in eight county 4-H programs in Northwest Minnesota. This article outlines the intentional process used to effectively implement technology in program planning. The project includes: assessing current communication tools used; evaluating participants' preferences for receiving information; educating staff on current research trends; and training teams of youth and adults with the Forrester Research Model (2011) to implement social media as a program communication tool. The process helps staff identify audience and purpose of using technology for their specific needs.

Better Kid Care Program Improves The Quality Of Child Care: Results From An Interview Study, Carol S. Ostergren, David A. Riley, Jenny M. Wehmeier

Journal of Extension

More high quality child care is needed in the United States. This article evaluates the Better Kid Care (BKC) program produced by Pennsylvania State University Extension. Child care staff in Wisconsin were interviewed about changes they had made in their early childhood programs following participation in the BKC program. Findings show that 2 months post-program, most participants could name specific skills or knowledge they learned and improvements they made in their early childhood programs as a result of BKC. The BKC program improves child care quality, and increasing program participation is recommended.

"Lord Teach Us To Pray", Stuart Love

Leaven

No abstract provided.

Order Of The Owl Honors Distinguished Alumni, Jonella Frank, Evie Holzer

Sooner Lawyer Archive

No abstract provided.

Ou Law Updates

Sooner Lawyer Archive

No abstract provided.

25 Year Club: 30th Annual Gala, Western Michigan University

25 Year Club

25 Year Club: 30th Annual Gala

November 30, 2011

• New Inductees
• Members
• Retirees

Finance Minutes 11/30/2011, Finance Committee

Finance Committee

No abstract provided.

Powers Of Inspection Of The Polish Competition Authority. Question Of Proportionality, Maciej Bernatt

Yearbook of Antitrust and Regulatory Studies

The principle of proportionality applies to competition proceedings especially, when it comes to the exercise by the competition authority of its powers of inspection. Their use limits the economic freedom and right to privacy of the scrutinised undertakings in order to protect free competition. The use of inspection powers must thus be proportionate and remain the least onerous possible for the inspected companies. In consequence, legislation must provide procedural guarantees of proportionality of inspections. This article analyses whether the powers of inspection bestowed upon the Polish competition authority are regulated in a way that guarantees the observance of the principle …

Mr Hoefner, Mr Elser, Please Welcome To Poland. Some Comments On The Polish Healthcare System Reform From The Perspective Of State Aid Law, Łukasz Grzejdziak

Yearbook of Antitrust and Regulatory Studies

The purpose of this paper is to verify the hypothesis that a debt write-off implemented recently by Polish authorities in favour of public hospitals constitutes State aid within the meaning of Article 107(1) of the Treaty of the Functioning of the European Union. The paper contains a detailed description of the nature of the measure – its historical background, regulatory context, as well as its construction. It presents an in-depth analysis of the fulfilment by the measure of the conditions stipulated in Article 107(1) TFEU. As a preliminary issue, the analysis addresses the problem whether Polish public hospitals can be …

We Are...Marshall, November 30, 2011, Office Of Marshall University Communications

We Are ... Marshall: the Newsletter for Marshall University 1999-2023

No abstract provided.

Intimate Partner Violence On Campus: Assessing The Knowledge Of Female College Students, Lynn Barger

Honors Capstone Projects and Theses

No abstract provided.

Spartan Daily November 30, 2011, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily (School of Journalism and Mass Communications)

Volume 137, Issue 48

Easterner, Vol. 63, No. 10, November 30, 2011, Associated Students Of Eastern Washington University

Student Newspapers

This issue of the Easterner contains articles about missing Eastern Washington University (EWU) student Heather Higgins, further budget cuts, student musicians performing at Gatto's Pizzeria, a program titled "Pakistan through Students' Eyes," a state program called "Passport for Foster Youth," the construction of a trebuchet by EWU engineering students, the use of de-icer on sidewalks, an interview with track athlete Shene Davis, and the volleyball and football seasons.

The Good 5 Cent Cigar (11/30/2011), University Of Rhode Island

The Good 5 Cent Cigar (Student Newspaper Archives)

This is a digitized, downloadable version of the University of Rhode Island school newspaper.