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2011

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Anti-Amyloid-Β Single-Chain Antibody Brain Delivery Via Aav Reduces Amyloid Load But May Increase Cerebral Hemorrhages In An Alzheimer's Disease Mouse Model, Jinghong Kou, Hong-Duck Kim, Hiroaki Taguchi, Sudhir Paul, Selvarangan Ponnazhagan, Ken-Ichiro Fukuchi Jan 2011

Anti-Amyloid-Β Single-Chain Antibody Brain Delivery Via Aav Reduces Amyloid Load But May Increase Cerebral Hemorrhages In An Alzheimer's Disease Mouse Model, Jinghong Kou, Hong-Duck Kim, Hiroaki Taguchi, Sudhir Paul, Selvarangan Ponnazhagan, Ken-Ichiro Fukuchi

NYMC Faculty Publications

Accumulation of amyloid-β protein (Aβ) in the brain is thought to be a causal event in Alzheimer's disease (AD). Immunotherapy targeting Aβ holds great promise for reducing Aβ in the brain. Here, we evaluated the efficacy and safety of anti-Aβ single-chain antibody (scFv59) delivery via recombinant adeno-associated virus (rAAV) on reducing Aβ deposits in an AD mouse model (TgAβPPswe/PS1dE9). First, delivery of scFv59 to the brain was optimized by injecting rAAV serotypes 1, 2, and 5 into the right lateral ventricle. Symmetrical high expression of scFv59 was found throughout the hippocampus and partly in the neocortex in both hemispheres via …

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Nomadic Amdo Tibetan Glu Folk Songs, Wendolyn Craun Jan 2011

Nomadic Amdo Tibetan Glu Folk Songs, Wendolyn Craun

Masters Theses

Tibetan glu folk songs are a literary and musical expression historically passed down from generation to generation. This regional study purposes to define the origins, influences, categories, qualities, and significance of nomadic Amdo Tibetan glu folk songs. These topics are explored within the settings of Tibetan culture, history, theory, and current usage. Recordings of twenty-seven glu folk songs accompanied by transcribed text and music offer contemporary examples of this song genre that is quickly disappearing. The ultimate goal of this study is to answer the question: What are the defining characteristics of nomadic Amdo Tibetan glu folk songs?

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Communication In Intercultural Marriages: Managing Cultural Differences And Conflict For Marital Satisfaction, Tiffany G. Renalds Jan 2011

Communication In Intercultural Marriages: Managing Cultural Differences And Conflict For Marital Satisfaction, Tiffany G. Renalds

Masters Theses

This qualitative study investigated the phenomenon of intercultural marriages, particularly the unique internal and external elements that impact communication and conflict within intercultural marriages of varying lengths and the intercultural communication competencies utilized by spouses in intercultural marriages. The research focused on three questions: (1) Which internal and external factors impact the effectiveness of communication between spouses in intercultural marriages the most? (2) Which communication competencies do spouses in intercultural marriages develop in order to address cross-cultural differences? (3) How do spouses in intercultural marriages experience and deal with conflict within their intercultural marriages? Data was obtained employing semi-structured interviews. …

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Not Giving Back: The Social Exchange Concern Hypothesis Of Physical Disability Stigma, Thomas P. Dirth Jan 2011

Not Giving Back: The Social Exchange Concern Hypothesis Of Physical Disability Stigma, Thomas P. Dirth

Dissertations and Theses @ UNI

The phenomenon of physical disability stigma has been examined from many different perspectives, but a comprehensive theory of its functionality has yet to be tested. The evolutionary theory of stigma provides two compelling hypotheses, for stigma in general, and physical disability stigma in particular. The pathogen avoidance hypothesis maintains that stigma is an evolved response for protection against infectious diseases, whereas the social exchange concern hypothesis proposes that stigma serves to maximize fitness by cueing which interaction partners will contribute or detract most from one's well-being. The social exchange concern hypothesis frames physical disability stigma, especially, in a way that …

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Nyar Savannah Program 2011, National Youth-At-Risk Conference, Savannah Jan 2011

Nyar Savannah Program 2011, National Youth-At-Risk Conference, Savannah

National Youth Advocacy & Resilience Conference

N/A

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Effective Personal Evangelism For Today's Church, Thomas M. Roatch Jan 2011

Effective Personal Evangelism For Today's Church, Thomas M. Roatch

Doctoral Dissertations and Projects

This project is designed to demonstrate that any church or group of Christians can be effective in personal evangelism. Christians gathered together in any location and number, and in any life situation form the taskforce to share the good news of salvation.
The rationale for the selection of this thesis topic rests on the recent heart felt need of many churches to share the Gospel and become active in personal evangelism. Secondly, another important part of the rationale for thesis is to encourage, and challenge small churches, missions, Bible studies and other smaller Christian ministries to be bold in new …

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Pornography Addiction: A Cognitive Approach In Combating The Lies Christian Males Believe, Farid Awad Jan 2011

Pornography Addiction: A Cognitive Approach In Combating The Lies Christian Males Believe, Farid Awad

Doctoral Dissertations and Projects

Pornography addiction has grown in epidemic numbers. Its bondage is evident within and outside the church walls. While sex and sexually explicit images saturate our daily lives, God continues to call His people to be holy as He is holy. Freedom from pornography addiction can be achieved only through intimate relationship with Jesus Christ and by accepting the atoning work of His cross for all believers. This thesis will redefine pornography through the lens of the Scripture and primarily focus on cognitive lies regarding oneself and others, which are crippling and ensnaring men into the trap of pornography. This study …

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Our Voices: A Descriptive Account Of African American Parental Involvement In An Urban Elementary School, Charletta D. Sudduth Jan 2011

Our Voices: A Descriptive Account Of African American Parental Involvement In An Urban Elementary School, Charletta D. Sudduth

Dissertations and Theses @ UNI

Parent involvement may have implications for student achievement (Epstein, 1986; Hoover-Dempsey, Bassler, & Brisse, 1987; Lopez, Scribner, & Mahitivanichcha, 2001). Today African-American parents are frequently criticized for not being involved enough in their students' education (Dearing, Kreider, Simpkins, & Weiss, 2006). African-American parent involvement can be limited due to a lack of time, monetary resources, or transportation; past negative experiences with school; a non-welcoming school environment; or a different definition of parent involvement (Epstein, 2001, Hamre & Pianta, 2001; Hill, Castellino, Lansford, Dodge, Bates, et al., 2004; Hughes & Kwok, 2007). Missing from the research of both Hoover Dempsey and …

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An Aloha State Of Mind: Performing Hawaiian Cultural Identities, Kirsten E. Ogden Jan 2011

An Aloha State Of Mind: Performing Hawaiian Cultural Identities, Kirsten E. Ogden

LSU Doctoral Dissertations

There are many Hawaiian identities currently in effect. This dissertation explores several representative and contested Hawaiian identities, and how these identities develop through key performances, plays, and other representational practices by Hawaiians and by Locals. Due to its unique situation as one of only two U.S. states formerly with its own government, and as one of only two U.S. states not connected to the main land-mass of the United States, Hawaiian identity is complicated by multiple factors: sanitized historical constructions, sovereignty, intermingling ethnic identities, tourism, and reclaimed cultural practices. Additionally, Hawaiians as a native people hold a unique place in …

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An Examination Of Errors Of Coherence In Adolescent Sentence Combining, Ginger Gunter Collins Jan 2011

An Examination Of Errors Of Coherence In Adolescent Sentence Combining, Ginger Gunter Collins

LSU Doctoral Dissertations

Young adolescents should be able to write organized multi-paragraph compositions that develop a central idea and unfold in logical and sequential order, unified through the use of transitional words and phrases. In other words, the compositions should not just consist of a string of related sentences, but represent a dynamic text that has coherence. It is important that speech-language pathologists develop quick and reliable methods for assessing coherence to aid in making data driven decisions and progress monitoring consistent with principles of Responsiveness to Intervention. Yet, the holistic quality of coherence makes it difficult to assess, both within a composition …

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Communication-Constrained Feedback Stability And Multi-Agent System Consensusability In Networked Control Systems, Laurentiu Dan Marinovici Jan 2011

Communication-Constrained Feedback Stability And Multi-Agent System Consensusability In Networked Control Systems, Laurentiu Dan Marinovici

LSU Doctoral Dissertations

With the advances in wireless communication, the topic of Networked Control Systems (NCSs) has become an interesting research subject. Moreover, the advantages they offer convinced companies to implement and use data networks for remote industrial control and process automation. Data networks prove to be very efficient for controlling distributed systems, which would otherwise require complex wiring connections on large or inaccessible areas. In addition, they are easier to maintain and more cost efficient. Unfortunately, stability and performance control is always going to be affected by network and communication issues, such as band-limited channels, quantization errors, sampling, delays, packet dropouts or …

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Interpretation And Expressive Imagery In The Butterfly Lovers Violin Concerto On Double Bass: Transcribed By Yung-Chiao Wei, Min-Tzu Chao Jan 2011

Interpretation And Expressive Imagery In The Butterfly Lovers Violin Concerto On Double Bass: Transcribed By Yung-Chiao Wei, Min-Tzu Chao

LSU Doctoral Dissertations

The purpose of this research paper is to show the interpretation of the Chinese piece—The Butterfly Lovers Violin Concerto—through expressing imagery. The concerto is composed by Chen Gang (陳鋼) and He Zhan-hao (何占豪) in 1959. In 2004, Yung-Chiao Wei, a double bass professor at Louisiana State University transcribed the piece for double bass. It is a very useful repertoire for double bass players to experience Chinese music through the plot’s expressing imagery. The Chinese musical language is different from Western music language in the concept of pentatonic scale, tone color, and tempo. I believe that double bass players can effectively …

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Cognitive Radio Network With A Distributed Control Channel And Quality-Of-Service Solution, Urban Terrell Wiggins Jan 2011

Cognitive Radio Network With A Distributed Control Channel And Quality-Of-Service Solution, Urban Terrell Wiggins

LSU Doctoral Dissertations

The proliferation of wireless access and applications to the Internet and the advent of a myriad of highly evolved portable communication devices; creates the need for an efficiently utilized radio spectrum. This is paramount in the licensed and unlicensed radio frequency bands, that spawn an exponential growth in Dynamic Spectrum Access (DSA) research, Cognitive Radio (CR) and Cognitive Radio Networks (CRN) research. DSA research has given way to the paradigm shift toward CR with its dynamic changes in transmission schemas. This paradigm shift from a fixed and centralized frequency spectrum environment has morphed into a dynamic and decentralized one. CR …

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The Louisiana Alternative Career Diploma As Institutionalized Cultural Capital: High School Principals' Perceptions Of Its Value, Marcil C. Seals Jan 2011

The Louisiana Alternative Career Diploma As Institutionalized Cultural Capital: High School Principals' Perceptions Of Its Value, Marcil C. Seals

LSU Doctoral Dissertations

In an effort to address dropout, the Louisiana state legislature mandated an initiative in 2009 which required all school districts to offer an alternative vocational high school diploma. Because this alternative diploma, known as the Career Diploma, is being implemented in all high schools throughout Louisiana, this research was designed to ascertain high school principals’ perceptions regarding the Career Diploma’s value. Participants were principals of traditional four-year high schools located within the state of Louisiana. A researcher-designed survey instrument was disseminated to 258 high school principals throughout the state. Findings of the data analysis indicated differences in perceptions of value …

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Molecular Dynamics Simulation Studies Of Surface-Stress Effects In Metallic Nanostructures, Jijun Lao Jan 2011

Molecular Dynamics Simulation Studies Of Surface-Stress Effects In Metallic Nanostructures, Jijun Lao

LSU Doctoral Dissertations

Using molecular dynamics (MD) simulations we investigate the surface-stress-induced structural transformations and pseudoelastic behavior in palladium (Pd) crystalline nanowires. For a <100> initial crystal orientation our studies indicate that the surface stress can cause Pd nanowires to spontaneously undergo structural changes with characteristics that are determined by the wire cross-sectional area. Specifically, when the cross-sectional area is below 2.18nm x 2.18nm the wire changes spontaneously its crystal structure from the initial fcc structure to a body-centered-tetragonal (bct) structure. In wires of larger cross-sectional area (i.e., 2.57nm x 2.57nm) the structural transformation is achieved via a spontaneous lattice reorientation leading to an …

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Pharmacological And Non-Pharmacological Approaches To Prevent Hypertension-Induced Renal Disease In The Spontaneously Hypertensive Rate, Carrie Marie Elks Jan 2011

Pharmacological And Non-Pharmacological Approaches To Prevent Hypertension-Induced Renal Disease In The Spontaneously Hypertensive Rate, Carrie Marie Elks

LSU Doctoral Dissertations

Hypertension affects 50 million Americans and remains the second leading cause of renal failure in the United States. Current pharmacological and non-pharmacological approaches to treat hypertension have proven effective, but the complexities of the disease and its renal effects warrant the need for new treatments. The hypothesis of this dissertation was that pharmacological or non-pharmacological approaches to reducing inflammation and oxidative stress would prevent hypertension-induced renal injury in the spontaneously hypertensive rat (SHR). In the first study, we blocked the inflammatory transcription factor, nuclear factor-kappa B (NF-ĸB), with pyrrolidine dithiocarbamate in the SHR kidney. In treated SHR, blood pressure decreased, …

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The Influence Of Selected Demographic Characteristics On The Reading Ability Of Fourth Grade Students In Louisiana, Johnny W. Morgan Jan 2011

The Influence Of Selected Demographic Characteristics On The Reading Ability Of Fourth Grade Students In Louisiana, Johnny W. Morgan

LSU Doctoral Dissertations

The primary purpose of this study was to determine the influence of selected demographic characteristics on the reading ability of fourth grade students in Louisiana. The dependent variable for this study was reading ability of fourth grade students. Independent variables were demographic characteristics as measured by reading achievement (overall reading score and subscale reading score on the LEAP assessment). The Louisiana Educational Assessment Program (LEAP) exam is a high-stakes test that is administered to fourth grade students in Louisiana. Students must pass specific portions of the test to be promoted to fifth grade. Academic achievement data on the LEAP test …

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Comparison Of The Diagnostic Evaluation Of Language Variation-Screening Test (Delv-St) To Two Other Screeners For Low-Income, African American Children, Christy Wynn Moland Jan 2011

Comparison Of The Diagnostic Evaluation Of Language Variation-Screening Test (Delv-St) To Two Other Screeners For Low-Income, African American Children, Christy Wynn Moland

LSU Doctoral Dissertations

The purpose of this study was to examine the validity of the DELV-ST by comparing it to two other screeners, the Fluharty-2 and the Washington-Craig Language Screener (WCLS). The participants were 73 African American Pre-K and Head Start children, aged four- to five-years-old. Fail rates were higher than what has been reported in the literature. They were highest for the Fluharty-2 (57%), lower for the DELV-ST (52%), and lowest for the WCLS (46%); however, there were no statistical differences in the fail rates by screener. Approximately 54% of the children passed or failed all screeners. Unfortunately, the remaining 46% failed …

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Small Footprint High Flow Rate Microdevice For Rare Target Cell Capture, Taehyun Park Jan 2011

Small Footprint High Flow Rate Microdevice For Rare Target Cell Capture, Taehyun Park

LSU Doctoral Dissertations

A novel high flow rate cell capture design was introduced to overcome the limitations of the current technologies or methods for rare target cell capture. Even though the rare target cell capture using BioMEMS technology has great potential for cancer diagnosis, previous rare cell capture research could not overcome the limitations of low flow rate or low recovery rate. Rare cell research requires precise sample preparation for accurate results. A new method of preparation for a single or a precise number of target cell was introduced. Current sample preparation methods which are not suitable for rare cell research, such as …

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Development Of Self-Determination In Youth With Intellectual And Developmental Disabilities In 4-H Programming: A Qualitative Study, Myra Jo Monroe Jan 2011

Development Of Self-Determination In Youth With Intellectual And Developmental Disabilities In 4-H Programming: A Qualitative Study, Myra Jo Monroe

LSU Doctoral Dissertations

The purpose of this qualitative case study was to examine how 4-H programming may support positive youth development in youth with intellectual and developmental disabilities (IDD). Using Wehmeyer‟s Functional Model of Self-Determination as the theoretical framework, sixteen youth aged 14-21 years in an intact vocational training classroom engaged in a semester-long program utilizing direct instruction and environment theorized by Wehmeyer to enhance the emergence of self-determination in youth with IDD. This study drew from the fundamental principle that a person who was self-determined exhibited behaviors that reflected certain essential characteristics (Wehmeyer & Field, 2007). The study utilized data collected from …

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Student Problem Solving Communication Processes While Completing Multimedia Case Studies: A Look Into The Relationship Among Levels Of Collaboration, Problem Solving Processes, And Problem Solving Performance On Individual And Group Levels, Jan Elizabeth Broussard Jan 2011

Student Problem Solving Communication Processes While Completing Multimedia Case Studies: A Look Into The Relationship Among Levels Of Collaboration, Problem Solving Processes, And Problem Solving Performance On Individual And Group Levels, Jan Elizabeth Broussard

LSU Doctoral Dissertations

In an effort to better prepare students to become productive members of the work force, educators must grant students the opportunities to become critical thinkers. Students need to be able to learn to inquire, create, and think critically in order to obtain meaningful information from the abundance of knowledge that is accessible to them through the Internet and the World Wide Web. This quasi-experimental study examined the effects of online collaborative problem solving processes during a multimedia case study. Sixty-one students in two undergraduate management information systems classes agreed to participate. The experimental class, section 01, was required to use …

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A Performer's Guide To Gene Scheer's Voices From World War Ii, Brandon Paul Hendrickson Jan 2011

A Performer's Guide To Gene Scheer's Voices From World War Ii, Brandon Paul Hendrickson

LSU Doctoral Dissertations

Though primarily known as a lyricist and librettist, Gene Scheer is beginning to emerge as an important composer of American art and popular song. This document presents Scheer’s song cycle for baritone, entitled Voices from World War II (Holding Each Other, The German U-Boat, At Howard Hawks’ House, Omaha Beach, and Morrison Shelter). The document includes biographical information about the composer and arranger, an overview of the song cycle, and a performer’s guide to each song. A conclusion of Voices from World War II follows the analysis of the songs. Appendices include the texts from Voices from World War II, …

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A Survey Of Rudy Davenport's Byna: Life Songs Of A Southern Appalachian Woman Of Cherokee Indian Descent (A Chamber Work For Soprano, Piano, Oboe And Cello), Tiffany I. Bostic-Brown Jan 2011

A Survey Of Rudy Davenport's Byna: Life Songs Of A Southern Appalachian Woman Of Cherokee Indian Descent (A Chamber Work For Soprano, Piano, Oboe And Cello), Tiffany I. Bostic-Brown

LSU Doctoral Dissertations

Composer Rudy Davenport aims to create music that is more relatable than the atonal compositions often associated with 20th century composers. Inspired by his own Appalachian and Cherokee heritages, Davenport, in collaboration with librettist Delilah Elsen, developed his own musical genre called “Appalachian Romanticism”. This genre is evident in his work BYNA: Life Songs of a Southern Appalachian Woman of Cherokee Descent for Soprano, Piano, Oboe & Cello. The purpose of this study is to understand and describe Rudy Davenport’s view on 20th century composition. To obtain this information I interviewed Davenport posing questions about his biography and musical preferences, …

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Application Of Counter-Stereotype Strategy For National Image Management: A Comparative Study Of U.S. And South Korean College Students' National Stereotypes Of China, Hyunmee Kang Jan 2011

Application Of Counter-Stereotype Strategy For National Image Management: A Comparative Study Of U.S. And South Korean College Students' National Stereotypes Of China, Hyunmee Kang

LSU Doctoral Dissertations

The study sought to explore the applicability of national stereotypes for implicit stereotype by measuring reaction times (RTs). Also, the study intended to suggest a more effective national image management in overseas practices by demonstrating the effect of counter-stereotype strategy on country-of-origin (COO) effect. A focus of the study was on China and Chinese people for national stereotypes and Chinese corporations and products made in China for the COO effect, considering unfavorable national images of China in news media and negative impressions on products made in China. The study compared national stereotypes of China and Chinese people and COO effect …

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Phase Noise In Cmos Phase-Locked Loop Circuits, Yang Liu Jan 2011

Phase Noise In Cmos Phase-Locked Loop Circuits, Yang Liu

LSU Doctoral Dissertations

Phase-locked loops (PLLs) have been widely used in mixed-signal integrated circuits. With the continuously increasing demand of market for high speed, low noise devices, PLLs are playing a more important role in communications. In this dissertation, phase noise and jitter performances are investigated in different types of PLL designs. Hot carrier and negative bias temperature instability effects are analyzed from simulations and experiments. Phase noise of a CMOS phase-locked loop as a frequency synthesizer circuit is modeled from the superposition of noises from its building blocks: voltage-controlled oscillator, frequency divider, phase-frequency detector, loop filter and auxiliary input reference clock. A …

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Teaching Tactual Discrimination Of Braille Characters To Beginning Braille Readers, Karen A. Toussaint Jan 2011

Teaching Tactual Discrimination Of Braille Characters To Beginning Braille Readers, Karen A. Toussaint

LSU Doctoral Dissertations

We taught three children with visual impairments to make tactual discriminations of the braille alphabet within a matching-to-sample format. That is, we presented participants with a braille character as a sample stimulus and they were to select the matching stimulus from an array of three comparisons. In order to minimize participant errors, we arranged braille characters into training sets in which the target and non-target stimuli in the comparison arrays were initially maximally different in terms of the number of dots comprising each character. As participants mastered these discriminations, we then increased the similarity between target and non-target comparisons (i.e., …

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In The Ruins Of Zine Pedagogy: A Narrative Study Of Teaching With Zines, Karin H. Degravelles Jan 2011

In The Ruins Of Zine Pedagogy: A Narrative Study Of Teaching With Zines, Karin H. Degravelles

LSU Doctoral Dissertations

This study considers the educational significance of zines—small circulation, self-published magazines—by asking how educators who teach with zines encounter and negotiate zine pedagogy. Though the literature on zines and teaching describes many potential benefits, it also describes contradictions and failures, with some researchers even going so far as to claim that “zines do not belong in classrooms” (Guzzetti, Elliott, & Welsch, 2010, p. 71). Through this dissertation, I investigate and complicate these claims by examining the stories and perspectives of teacher/zinesters—educators who teach or have taught with zines in a classroom setting. The project is situated within theories of the …

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Advanced Linear Identification Techniques For Signal Processing And Digital Video Broadcasting, Xiaoyu Feng Jan 2011

Advanced Linear Identification Techniques For Signal Processing And Digital Video Broadcasting, Xiaoyu Feng

LSU Doctoral Dissertations

Linear identification technique is to linearly embed a piece of unique information into digital media data for the purpose of satisfying specific demands such as identification, annotation, and copyright, etc. We need to consider the quantity and the quality of identification data to be embedded as well as the corresponding interference to the original subject signal. However, there exist no generalized computationally-efficient optimization techniques for linear identification up to now. Therefore, in this dissertation work, we try to theoretically investigate the advanced linear identification techniques and combat the tradeoff problems between the quality of the embedded identification data and the …

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Differences Across Racial Groups In Caregiver Ratings Of Symptoms In Children Diagnosed With Autism Spectrum Disorders, Cindy Terlonge Graham Jan 2011

Differences Across Racial Groups In Caregiver Ratings Of Symptoms In Children Diagnosed With Autism Spectrum Disorders, Cindy Terlonge Graham

LSU Doctoral Dissertations

A great deal of attention from local, federal, and international communities has been focused on autism spectrum disorders (ASDs). As the prevalence of these disorders rise, researchers continue to investigate various unanswered questions. The goal of this study was to examine the differences across racial/ethnic groups in caregiver ratings of symptoms of children diagnosed with ASDs. Results from such research will help determine whether cultural background can influence the recognition of behaviors indicative of an ASD. Culturally-sensitive clinical practice stemming from the significant findings of this research project can help to reduce the age at which minority children are diagnosed. …

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Contributors To An Enterprising Sex: Examining The Influence Of Creativity On Entrepreneurial Intentions And The Moderating Role Of Political Skill Controlling For Gender, Simone Trixie Allison Phipps Jan 2011

Contributors To An Enterprising Sex: Examining The Influence Of Creativity On Entrepreneurial Intentions And The Moderating Role Of Political Skill Controlling For Gender, Simone Trixie Allison Phipps

LSU Doctoral Dissertations

Previous research indicates a positive relationship between creativity and entrepreneurship. Research also indicates a tendency for successful entrepreneurs to possess certain skills and abilities and to engage in activities that reflect their political astuteness. In addition, numerous studies have supported the importance of behavioral intentions as they relate to actions. Thus, this research endeavor focused on intentions, as it investigated the relationship between creativity and entrepreneurial intentions among female and male students, and attempted to determine whether political skill moderated the relationship. The results revealed that there was a statistically significant positive relationship between creativity and entrepreneurial intentions among both …

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