Digital Commons Network^™

The Association Between Cancer-Related-Fatigue, Response To Fatigue Treatment, And Cytokines And Their Receptors, In Patients With Advanced Cancer, Sriram Yennu

Dissertations and Theses (Open Access)

Background: Inflammation is implicated in the development of cancer related fatigue (CRF). However there is limited literature on the mediators of inflammation (namely), cytokines and their receptors, associated with clinically significant fatigue and response to treatment.

Methods: We reviewed 37 advanced cancer patients with fatigue (≥4/10), who participated in two Randomized Controlled Trials, of anti-inflammatory agents (Thalidomide and Dexamethasone) for CRF. Responders showed improvement in FACIT-F subscale at the end of study (Day 15). Baseline patient characteristics and symptoms were assessed by FACIT-F, ESAS; serum cytokines [IL-1β and receptor antagonist (IL-1RA), IL-6, IL-6R, TNF-α and sTNF-R1 and R2, IL-8, …

Immune Modulation Of The Mycobacterium Tuberculosis Granulomatous Response, Kerry J. Welsh

Dissertations and Theses (Open Access)

Tuberculosis (TB) remains a major public health burden. The immunocompetant host responds to Mycobacterium tuberculosis (MTB) infection by the formation of granulomas, which initially prevent uncontrolled bacterial proliferation and dissemination. However, increasing evidence suggests that granuloma formation promotes persistence of the organism by physically separating infected cells from effector lymphocytes and by inducing a state of non-replicating persistence in the bacilli, making them resistant to the action of antibiotics. Additionally, immune-mediated tissue destruction likely facilitates disease transmission. The granulomatous response is in part due to mycobacterial glycolipid antigens. Therefore, studies were first undertaken to determine the innate mechanisms of mycobacterial …

Condemning The Decisions Of The Past, Christopher Serkin

Vanderbilt Law School Faculty Publications

This brief Essay, part of a Fordham Urban Law Journal Symposium on eminent domain in New York, argues that there is a seldom-recognized purpose to eminent domain: preserving the ability of elected representatives to respond to the will of the people. The essay proposes that eminent domain allows government to depart from the policy choices of administrations which came before and is therefore a tool for preserving "democratic legitimacy." It explores this theory by examining examples such as breaking up the adult use zones in Times Square and reclaiming New York's waterfront.

Biodiesel Production Using Chemical And Enzymatic Catalysts And Improvement Of Cold Flow Properties Using Additives, Hem Joshi

All Dissertations

Biodiesel production was carried out from soybean, canola and cottonseed oils along with poultry fat using catalytic potassium hydroxide. Further, the physical properties of biodiesel were studied with addition of ethyl levulinate (ethyl 4-oxopentanoate), short-chain alcohols (ethanol, isopropanol and butanol), and commercial cold flow improver (CFI) additives. The effects of adding ethyl levulinate, short-chain alcohols, and commercial additives were determined by studying their influence on the acid value (AV), cloud point (CP), pour point (PP), cold filter plugging point (CFPP), induction period (IP), kinematic viscosity (KV) and the flash point (FP). The results showed improved low temperature properties of the …

Information Seeking Behavior: The Effects Of Relationalism On The Selection Of Information Sources, Chris Zimmer

All Dissertations

In a world where 'Google' is a verb, this research asks the question 'what influences an individual's decision to select one information source over another?' Previous works have discussed relational versus nonrelational information sources (Rulke, Zaheer, & Anderson, 2000). Other research focuses on the information quality (O'Reilly, 1982), source accessibility (Culnan, 1984, 1985), or source richness (Daft, Lengel, & Trevino, 1987; Daft & Macintosh, 1981) but all these prior works do not address the social aspects of information sources.
This research defines and develops the construct of relationalism which is reflective of the social aspects of information sources. An important …

Regulation Of Trypanosoma Brucei Hexokinase 1 And 2 On Multiple Levels: Transcript Abundance, Protein Expression And Enzyme Activity, Heidi Dodson

All Dissertations

Trypanosoma brucei, a unicellular eukaryotic parasite, is the causative agent of African sleeping sickness in sub-Saharan Africa. The parasite encounters two main environments as it progresses through its life cycle: the tsetse fly and the mammalian
bloodstream. Nutrient availability is distinct in the two environments, requiring the parasite to utilize diverse metabolic pathways to efficiently produce ATP for survival. Bloodstream form parasites (BSF), residing in a glucose rich environment, rely solely on
glycolysis for energy, while procyclic form (PF) parasites metabolize readily available proline and threonine in addition to glucose.
T. brucei expresses two hexokinases, the first enzyme in the …

The Ethics Of Obstruction, Joshua Abboud

All Dissertations

This work engages the film The Five Obstructions (2003) as a configuration for multimodal composition. It explores a theory of general composition as a matter of confronting obstructions or creative constraints as a process of collaborative revision and pedagogy. Writing in this context constitutes ethical responses to the shifting constraints of communication and signification. The obstructions performed by the film as a series of revisions offer sources of proliferating rhetorical invention and play grounded on negotiated fields of operations.
The first two chapters explore the relations between image and ethics in a pedagogy of revision, while the third considers the …

Activities Of Muscadine Grape Skin And Polyphenolic Constituents Against Helicobacter Pylori, Joseph Brown

All Dissertations

Helicobacter pylori is a microaerophilic, gram-negative bacterium and among the most persistent of all human pathogens. Its presence in the gastric environment is corre-lated with diseases such as gastritis, peptic ulcers, mucosa-associated lymphoid tissue lymphoma, and gastric carcinoma. Multiple factors are believed responsible for disease progression and outcome including infecting strain(s) genetic composition, age of acqui-sition, host immune response, environment, and diet. Due to the complexity of H. pylori infection, all possible host-pathogen interactions should be considered. One important factor frequently underplayed is host dietary habits which may serve a more important role during and immediately following infection with H. …

The Original Public Understanding Of Privileges Or Immunities, James J. Ward

BYU Law Review

No abstract provided.

Mayb2011, Robert Kelly

Robert Kelly Manuscripts

From May 2011 Robert Kelly Archive

Maya2011, Robert Kelly

Robert Kelly Manuscripts

From May 2011 Robert Kelly Archive

Mayd2011, Robert Kelly

Robert Kelly Manuscripts

No abstract provided.

Forebrain Origins Of Glutamatergic Innervation To The Rat Paraventricular Nucleus Of The Hypothalamus: Differential Inputs To The Anterior Versus Posterior Subregions, Yvonne M. Ulrich-Lai, Kenneth R. Jones, Dana R. Ziegler, William E. Cullinan, James P. Herman

Biomedical Sciences Faculty Research and Publications

The hypothalamic paraventricular nucleus (PVN) regulates numerous homeostatic systems and functions largely under the influence of forebrain inputs. Glutamate is a major neurotransmitter in forebrain, and glutamate neurosignaling in the PVN is known to mediate many of its functions. Previous work showed that vesicular glutamate transporters (VGluTs; specific markers for glutamatergic neurons) are expressed in forebrain sites that project to the PVN; however, the extent of this presumed glutamatergic innervation to the PVN is not clear. In the present study retrograde FluoroGold (FG) labeling of PVN-projecting neurons was combined with in situ hybridization for VGluT1 and VGluT2 mRNAs to identify …

Echo, Summer/Fall 2011, Columbia College Chicago

Echo

Student-produced magazine formerly published as Chicago Arts and Communication, changed to Echo magazine in 1997. Cover Articles: Degrees of difficulty: undocumented and undeterred, school books and diaper bags; Game on!: inside Magic the Gathering; Mouthwatering movies: a feature and a feast; Metalmorphosis: a heavy metal geneology. 80 pages.

Public Hearing Transcripts - North Eastern - Moyale - Rtjrc01.05 (Arid Lands Resource Management Project Guest House Hall) (Women’S Hearing), Truth, Justice, And Reconciliation Commission

I. Core TJRC Related Documents

No abstract provided.

Innovation And Development Of Biofuel Technologies, Nicole Lorenz

Chemical Engineering Undergraduate Honors Theses

The need for viable alternatives to gasoline has lead researchers to explore various options for renewable energy resources. This research study focuses on two major options for renewable energy. The first is biodiesel, which is a fuel that can be made from vegetable oils or animal fats. In this study, biodiesel was made from tall oil, a paper byproduct. A novel reaction method was used, employing high temperature methanol rather than acid or base catalysis. The second option that was investigated is butanol, which is an alcohol with advantages over ethanol. First, a two-step fermentation was examined to improve the …

A Novel Shear Thinning And Thixotropic Plga Micro Particulate Suspension System For Controlled Drug Delivery, Sonia Bedi

Theses and Dissertations (ETD)

Poly lactide‑co‑glycolide (PLGA) polymer has been the polymer of choice for many parenteral controlled drug release applications. This is mainly due to the inherent advantages of this polymer i.e. biodegradability, biocompatibility and non-toxic nature. The polymer, however, has a characteristic degradation pattern whereby the final erosion phase does not begin until the polymer reaches a certain molecular weight (MW) limit. After this, the accumulated acidic degradation byproducts initiate a bulk erosion phenomenon that leads to a disruption of the polymer matrix and release of the remaining drug in a short period of time. Furthermore, most of the delivery systems or …

Characterization Of The Sigma Factor Proteins And The Dna Binding Protein Euo Of Chlamydia, Cory L. Blackwell

Theses and Dissertations (ETD)

Chlamydia spp. are prokaryotic obligate intracellular pathogens with a unique, biphasic developmental cycle in which an infectious, extracellular form termed the elementary body (EB) interconverts with a metabolically active intracellular reticulate body (RB) within host cells. Subsets of genes are differentially expressed during the developmental cycle, and these genes are believed to be responsible for the transitions between the EB and RB forms. The goal of these studies was to explore two potential mechanisms that may function in regulating developmental cycle stage‑specific gene expression in chlamydiae: a cascade of sigma factor expression and the binding of the early stage protein …

Impact Of Adjuvants On The Antibody Responses To Pre-Pandemic H5n1 Influenza Vaccines, Ali Hassan Ellebedy

Theses and Dissertations (ETD)

Human influenza pandemics occur when influenza viruses to which the population has little or no immunity emerge and acquire the ability to transmit among humans. Since their emergence in 1996, human infections with highly pathogenic avian influenza A (H5N1) viruses presented a serious public health challenge. Additionally, H5N1 viruses caused significant agricultural and economic losses in the communities it has affected. Human infections with these viruses are rare but when they occur, these infections are highly fatal. A greater public health concern stems from the rapid evolution displayed by these viruses so far, which in turn might result in viruses …

Insights Into P53-Dependent Apoptotic Signaling And Cell Fate Vis-A-Vis Functional Cooperation Among Bcl-Xl, Cytoplasmic P53, And Puma, John C. Fisher

Theses and Dissertations (ETD)

Following DNA damage, nuclear p53 induces the expression of PUMA (p53 upregulated modulator of apoptosis), a BH3‑only protein that binds and inhibits the anti‑apoptotic BCL‑2 repertoire, including BCL‑xL. Structural investigations of PUMA and the BCL‑xL×PUMA BH3 domain complex by X‑ray crystallography and nuclear magnetic resonance (NMR) spectroscopy reveal a novel, PUMA‑induced, domain‑swapped dimerization of BCL‑xL that requires a π‑stacking interaction between PUMA W71 and BCL‑xL H113. PUMA is an intrinsically disordered protein, but upon interaction with BCL‑xL, PUMA W71 and the PUMA BH3 domain residues fold into an alpha helix and subtly remodel BCL‑xL to trigger its dimerization. Wild type …

Inhibition Of Monocyte Chemotaxis And Chemokine Macrophage Inflammatory Protein-1 Alpha, And Interleukin-8 Secretion By Lipopolysaccharide Isolated From Periodontal Pathogens, Andrew Karl Gray

Theses and Dissertations (ETD)

The vast majority of periodontal pathogens are classified as gram negative bacteria. These bacteria have an outermost membrane consisting of lipopolysaccharide (LPS), a molecule that can act as an endotoxin and elicit an immune response. The lipopolysaccharide structure consists of three major regions: oligosaccharide, core, and lipid A. Oligosaccharide is exposed on the cell surface, and lipid A anchors LPS in the outer membrane. LPS has been known to hinder certain defensive mechanisms of the immune system by secreting products that interfere with signals that promote chemotaxis of leukocytes enabling the pathogens to go unrestricted. When LPS binds to the …

A Behavioral And Anatomical Analysis Of Conditioned Taste Aversion In C57bl/6j And Dba/2j Mice, April Rebecca Glatt

Theses and Dissertations (ETD)

Conditioned taste aversion (CTA) has been commonly used as a model of learning and memory. Traditionally, CTA approaches have used a paradigm that follows the model of classical conditioning. This involves presentation of a novel tastant, such as sucrose (conditioned stimulus, CS), followed by an intraperitoneal injection of lithium chloride that induces gastric malaise (unconditioned stimulus, US), which results in the aversion of sucrose (conditioned response, CR). However, a more natural classical conditioning paradigm involves the consumption, rather than injection, of the US by using a self‑administration paradigm that allows for time‑dependent analysis of formation, generalization, and extinction of CTA …

The Treatment Of Breast Cancer Tumor Growth And Metastasis With An Anti-Mmp9 Dnazyme, Miranda A. Hallett

Theses and Dissertations (ETD)

BACKGROUND: Tumor cell proliferation, invasion and metastasis are known to be mediated, at least in part, through degradation of basement membrane by neutral metalloproteinases (MMP) produced by tumor and stromal cells. MMP-9 is known to play a significant role in breast tumor cell invasion and metastasis via degradation of ECM components and activation of cytokines and chemokines. MMP-9 is known to cleave type IV collagen, one of the most abundant collagens of the extracellular matrix. Our lab has found that the fully processed (68 kDa) form of MMP-9 generated in tumor and stromal cells is also capable of cleaving type …

Application Of A High‑Resolution Computed Radiography System In Detecting An Iodinated X‑Ray Contrast Agent: Small Animal Phantom Study, Anobel Maghsoodpour

Theses and Dissertations (ETD)

Tumor angiogenesis, the creation of new blood vessels, is the characteristic of solid tumors and crucial for their development. Iodinated contrast agents are used to increase the X‑ray detectability of zone of angiogenesis, and thus providing a means for tracking tumor growth.

The overall objective of this project was to evaluate the performance of Kodak CR 7400, a high‑resolution compact computed radiography (CR) system in detection of Omnipaque‑240, an iodinated contrast agent, in a phantom mimicking small animal tumor model.

The first phase of the project was dedicated to a comprehensive assessment of CR image quality by measuring presampled Modulation …

Pharmacokinetic And Pharmacodynamic Studies Of A Novel Spectinamide Series Of Antituberculosis Agents, V. N. R. Pavan Kumar Vaddady

Theses and Dissertations (ETD)

Spectinamides are novel amide derivatives of the antibiotic spectinomycin that have emerged as a new class of agents to treat tuberculosis. These agents showed potent in vitro activity against Mycobacterium tuberculosis (MTB) compared to spectinomycin and in a preliminary in vivo study in interferon gamma (IFN‑γ) knockout mice, spectinamide Lee1329 reduced the lung bacillary load of TB comparable to streptomycin. We hypothesized that the application of an iterative pharmacokinetics and pharmacodynamics (PK/PD) guided approach would facilitate the optimization of these lead compounds suitable for further development.

A series of in vitro experiments including parallel artificial membrane permeability assay (PAMPA), microsomal …

Pten Function In Postnatal Brain Development And Tumorigenesis, Guo Zhu

Theses and Dissertations (ETD)

PTEN (Phosphatase and Tensin homolog deleted on chromosome 10) is a tumor suppressor gene that is commonly mutated in multiple types of human cancers including endometrial, prostate, breast cancers and glioblastoma multiforme (GBM). PTEN functions as a phospholipid phosphatase antagonizing phosphorylation by phosphatidylinositol‑3‑OH kinases (PI3Ks) and thus serves as a major negative regulator of the PI3K pathway. Homozygous Pten knock-out mice die during embryogenesis. Conditional Pten knock-out in the nervous system showed that Pten negatively regulates self-renewal and proliferation of neural stem cells, negatively controls neuronal size, is required for proper neuronal positioning and is involved in the development and …

Systemic Aav-Mediated Gene Therapy Using Epo-R76e To Protect Retinal Ganglion Cells From Optic Nerve Injury And Disease, Timothy A. Sullivan

Theses and Dissertations (ETD)

Neuroprotection is a strategy to prevent or reduce neuronal cell death regardless of the underlying cause. Erythropoietin (EPO) exhibits neuroprotective effects in a variety of in vitro and in vivo models of neuronal cell death although its classical function is the regulation of red blood cell production. EPO crosses the blood brain barrier and therefore can be delivered systemically. However, long term treatment with exogenous EPO causes over stimulation of the erythropoietic pathway which can be lethal. The erythropoietic and neuroprotective pathways are regulated by different receptors; further, it is possible to modify EPO to primarily, if not solely, activate …

Temperature-Induced Activation Of Freshwater Cyanophage As-1 Prophage, Tin-Chun Chu, Sean R. Murray, Shi-Fang Hsu, Quinn Vega, Lee H. Lee

Department of Mathematics Faculty Scholarship and Creative Works

Synechococcus sp. IU 625 is one of the freshwater cyanobacteria responsible for harmful algal blooms (HAB). Cyanophages can serve as natural control agents and may be responsible for algal bloom prevention and disappearance. Cyanophage AS-1, which infects Synechococcus sp. IU 625 (Anacystis nidulans) and Synechococcus cedrorum, plays an important role in the environment, significantly altering the numbers of its hosts. Since seasonal (temperature-dependent) lytic induction of cyanobacterial prophage has been proposed to affect seawater algal blooms, we investigated if the AS-1 lytic cycle could be induced by a shift to high temperature. Our hypothesis was confirmed, as more phages were …

Leonardo's Virgin Of The Rocks: The History, The Mystery, And The Museums' Considerations Of The Two Paintings, Nicole Wagner

History Theses

The two versions of the Virgin of the Rocks have generated continued debate amongst art historians. Scholars such as Pietro Marani, Martin Davies and William Cannall have compiled opposing theories on the subject while referencing the same material. Despite the discovery of original documents pertaining to the commission of the painting, researchers continue to argue over the following: why do two versions of the same painting exist that are both associated with Leonardo da Vinci, where did the original version go after its completion, and who was responsible for the second painting? The following research will answer these questions …

The Effect Of The Chemical Composition Of Low Salinity Water On The Growth, Development, And Survival Of Cultured Juvenile Blue Crabs, Dyan Patricia Gibson

Master's Theses

Cultured juvenile blue crabs ( Callinectes sapidus Rathbun) were held for up to 77 days and monitored for survival, growth and development in low salinity water containing various compositions of ions. ~rabs were isolated in separate containers and placed in thirty gallon aquaria containing 2ppt of ion solution. Temperature, ambient, humidity, and nitrite levels were monitored daily. Molts were measured to determine growth, and molt increments were recorded to determine rate of development. The first part of the study compared ratios of sodium chloride (NaCl) to commercial sea salt (SS) in five treatments: 100% NaCl, 100% SS, 25:75 NaCl/SS, 50:50 …