Digital Commons Network^™

Time To Update The Nlrb's Election Procedure, Kenneth G. Dau-Schmidt

Public Testimony by Maurer Faculty

No abstract provided.

Marker Discovery In Allotetraploid Cotton Using 454 Pyrosequencing, Robert L. Byers

Theses and Dissertations

A narrow germplasm base and a complex allotetraploid genome have historically made the discovery of single nucleotide polymorphism (SNP) markers difficult in cotton (Gossypium hirsutum). We conducted a genome reduction experiment to identify SNPs from two accessions of G. hirsutum and two accessions of G. barbadense. Approximately 2 million sequence reads were assembled into contigs with an N50 of 508 bp and analyzed for SNPs. A total of 11,834 and 1,679 SNPs between the accessions G. hirsutum and G. barbadense, respectively, were identified with highly conservative parameters (a minimum read depth of 8x at each SNP …

Sr-A Ligand And M-Csf Dynamically Regulate Sr-A Expression And Function In Primary Macrophages Via P38 Mapk Activation, Dejan Nikolic, Lindsay Calderon, Liqin Du, Steven R. Post

Pharmacology and Nutritional Sciences Faculty Publications

BACKGROUND: Inflammation is characterized by dynamic changes in the expression of cytokines, such as M-CSF, and modifications of lipids and proteins that result in the formation of ligands for Class A Scavenger Receptors (SR-A). These changes are associated with altered SR-A expression in macrophages; however, the intracellular signal pathways involved and the extent to which SR-A ligands regulate SR-A expression are not well defined. To address these questions, SR-A expression and function were examined in resident mouse peritoneal macrophages incubated with M-CSF or the selective SR-A ligand acetylated-LDL (AcLDL).

RESULTS: M-CSF increased SR-A expression and function, and required the specific …

Identification Of Factors Associated With Good Response To Growth Hormone Therapy In Children With Short Stature: Results From The Answer Program®., Peter A Lee, John Germak, Robert Gut, Naum Khutoryansky, Judith Ross

Department of Pediatrics Faculty Papers

UNLABELLED: ABSTRACT:

OBJECTIVE: To identify factors associated with growth in children on growth hormone (GH) therapy using data from the American Norditropin Studies: Web-enabled Research (ANSWER) Program® registry.

METHODS: GH-naïve children with GH deficiency, multiple pituitary hormone deficiency, idiopathic short stature, Turner syndrome, or a history of small for gestational age were eligible (N = 1,002). Using a longitudinal statistical approach, predictive factors were identified in patients with GHD for change from baseline in height standard deviation score (ΔHSDS) following 2 years of treatment.

RESULTS: Gradual increases in ΔHSDS over time were observed for all diagnostic categories. Significant predictive factors …

Mechanical Characterization Of The Interspinous Ligament Using Anisotropic Small Punch Testing, Rachel Jane Bradshaw

Theses and Dissertations

Objective: The objective of this work was to characterize the nonlinear anisotropic material constitutive response of the interspinous ligament (ISL).

Methods: Cadaveric test samples of the interspinous ligament were tested using the anisotropic small punch test. The measured force-displacement response served as experimental input into a system identification optimization routine to determine the constitutive material parameters that replicated the measured material response.

Results: The constitutive behavior of the ISL is notably different from that reported for knee, shoulder, and hip ligaments. Specifically, the high collagen fiber content and unique collagen architecture provided a stiffer material response. The results from the …

Oncogene-Induced Nrf2 Transcription Promotes Ros Detoxification And Tumorigenesis., Gina M. Denicola, Florian A. Karreth, Timothy J. Humpton, Aarthi Gopinathan, Cong Wei, Kristopher Frese, Dipti Mangal, Kenneth H. Yu, Charles J. Yeo, Eric S. Calhoun, Francesca Scrimieri, Jordan M. Winter, Ralph H. Hruban, Christine Iacobuzio-Donahue, Scott E. Kern, Ian A Blair, David A. Tuveson

Department of Surgery Faculty Papers

Reactive oxygen species (ROS) are mutagenic and may thereby promote cancer. Normally, ROS levels are tightly controlled by an inducible antioxidant program that responds to cellular stressors and is predominantly regulated by the transcription factor Nrf2 (also known as Nfe2l2) and its repressor protein Keap1 (refs 2-5). In contrast to the acute physiological regulation of Nrf2, in neoplasia there is evidence for increased basal activation of Nrf2. Indeed, somatic mutations that disrupt the Nrf2-Keap1 interaction to stabilize Nrf2 and increase the constitutive transcription of Nrf2 target genes were recently identified, indicating that enhanced ROS detoxification and additional Nrf2 functions may …

Merging Resource Availability With Isotope Mixing Models: The Role Of Neutral Interaction Assumptions, Justin D. Yeakel, Mark Novak, Paulo R. Guimarães, Nathaniel J. Dominy, Paul L. Koch, Eric J. Ward, Jonathan W. Moore, Brice X. Semmens

Dartmouth Scholarship

Bayesian mixing models have allowed for the inclusion of uncertainty and prior information in the analysis of trophic interactions using stable isotopes. Formulating prior distributions is relatively straightforward when incorporating dietary data. However, the use of data that are related, but not directly proportional, to diet (such as prey availability data) is often problematic because such information is not necessarily predictive of diet, and the information required to build a reliable prior distribution for all prey species is often unavailable. Omitting prey availability data impacts the estimation of a predator's diet and introduces the strong assumption of consumer ultrageneralism (where …

The George-Anne, Georgia Southern University

The George-Anne

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Download Entire Pdf: The Medicine Forum, Vol 9, 2007

The Medicine Forum

Download entire PDF: The Medicine Forum, Vol 9, 2007

Infliximab-Induced Interstitial Lung Disease In A Patient With Psoriatic Arthritis, Lan Quang, Md, Anthony Scarpaci, Md

The Medicine Forum

Introduction

Infliximab (Remicade, Centocor, Inc., Malvern, PA), a chimeric monoclonal antibody derived from both murine and human antibody sequences and directed against TNF-α, is one of the disease modifying anti-rheumatic drugs (DMARDs) used in the treatment of psoriatic arthritis and other autoimmune inflammatory conditions such as rheumatoid arthritis, ankylosing spondylitis, and Crohn’s disease. It is commonly used in combination with methotrexate for increased efficacy and reduction of the development of anti-infliximab antibodies. A concerning feature of infliximab therapy is its association with an increased risk of infection or reactivation of diseases that can cause pulmonary complications, most notably tuberculosis and …

A Case Report Of Idiopathic Giant Cell Myocarditis, Bao Bui, Md, Sumeet Chhabra, Md, Siva K. Kumar, Md

The Medicine Forum

Case Report

A 32 year old African American male was admitted to an outside hospital in July 2007 with symptoms of severe heart failure that required implantation of a short-term left ventricular assist device (LVAD). He was subsequently transferred to our facility due to worsening left ventricular heart failure, episodes of Torsades de Pointes, and monomorphic ventricular tachycardia. His device was replaced with a longer-term LVAD and he was discharged home in October. Fortunately, he underwent successful orthotopic heart transplant in November 2007.

Man With Spontaneous Intracranial Hemorrhage On Therapeutic Enoxaparin, Clopidogrel, And Aspirin, Mihir K. Patel, Md, Sumeet K. Chhabra, Md, Michael Pfeiffer, Md

The Medicine Forum

Case Presentation

A 65 year-old Caucasian male originally presented to an outside hospital complaining of worsening paroxysmal nocturnal dyspnea, orthopnea, and recent exertional chest pain associated with dyspnea. The patient’s past medical history was significant for coronary artery disease status post coronary bypass, severe aortic stenosis status post bioprosthetic aortic valve repair, congestive heart failure, atrial fibrillation on anticoagulation, dual-chamber pacemaker placement, history of a transient ischemic attack, and type 2 diabetes mellitus. At the outside hospital, coronary angiography revealed occlusion of native vessels and previous grafts. He was considered a poor surgical candidate. He was transferred to Thomas Jefferson …

Felony Animal Cruelty Laws In New York, Stephen Iannacone

Pace Law Review

No abstract provided.

Phoenix, 2011-07-06, Student Life

Phoenix

The Phoenix is a student newspaper published at Governors State University since August 2002. The newspaper features student reporting, opinions, news, and photos.

The Daily Gamecock, Wednesday, July 6, 2011, University Of South Carolina, Office Of Student Media

July

No abstract provided.

Evaluating Nutrient Availability In Low Fertility Soils With Resin Capsules And Conventional Soil Tests, Mary Pletsch Jones

Theses and Dissertations

Commonly used soil analysis and resin capsule procedures are used to assess nutrient status in fertile soils, but their validity in semi-arid ecosystems is unknown. Three studies were performed to assess resin capsule effectiveness in semi-arid ecosystems. An incubation study was completed in which loamy sand and sandy clay loam soils were treated with rates of N, P, Fe and Zn. Each soil treatment was implanted with a resin capsule and incubated for 60 or 120 days. Resin capsules reflected NH4-N and P fertilizer at low rates in the loamy sand. NO3-N reflected rates in both soils, but did not …

Microglial P38Α Mapk Is A Key Regulator Of Proinflammatory Cytokine Up-Regulation Induced By Toll-Like Receptor (Tlr) Ligands Or Beta-Amyloid (Aβ), Adam D. Bachstetter, Bin Xing, Lucia De Almeida, Edgardo R. Dimayuga, D. Martin Watterson, Linda J. Van Eldik

Sanders-Brown Center on Aging Faculty Publications

BACKGROUND: Overproduction of proinflammatory cytokines from activated microglia has been implicated as an important contributor to pathophysiology progression in both acute and chronic neurodegenerative diseases. Therefore, it is critical to elucidate intracellular signaling pathways that are significant contributors to cytokine overproduction in microglia exposed to specific stressors, especially pathways amenable to drug interventions. The serine/threonine protein kinase p38α MAPK is a key enzyme in the parallel and convergent intracellular signaling pathways involved in stressor-induced production of IL-1β and TNFα in peripheral tissues, and is a drug development target for peripheral inflammatory diseases. However, much less is known about the quantitative …

Transcriptome Sequencing, And Rapid Development And Application Of Snp Markers For The Legume Pod Borer Maruca Vitrata (Lepidoptera: Crambidae), Venu M. Margam, Brad S. Coates, Darrell O. Bayles, Richard L. Hellmich, Tolulope Agunbiade, Mandredo J. Seufferheld, Weilin Sun, Jeremy A. Kroemer, Malick N. Ba, Clementine L. Binso-Dabire, Ibrahim Baoua, Mohammad F. Ishiyaku, Fernando G. Covas, Ramasamy Srinivasan, Joel Armstrong, Larry L. Murdock, Barry R. Pittendrigh

Department of Entomology Faculty Publications

The legume pod borer, Maruca vitrata (Lepidoptera: Crambidae), is an insect pest species of crops grown by subsistence farmers in tropical regions of Africa. We present the de novoassembly of 3729 contigs from 454- and Sanger-derived sequencing reads for midgut, salivary, and whole adult tissues of this non-model species. Functional annotation predicted that 1320M. vitrata protein coding genes are present, of which 631 have orthologs within the Bombyx mori gene model. A homology-based analysis assigned M. vitrata genes into a group of paralogs, but these were subsequently partitioned into putative orthologs following phylogenetic analyses. Following sequence quality filtering, …

The Molecular Mechanism Of Migraine, Kristin Dawn Watson

Theses and Dissertations

Migraine is a common, episodic neurological disorder that includes headache, nausea and hypersensitivity to sensory stimuli. During the headache phase of migraine, migraine patients can be especially hypersensitive to thermal stimuli. The unpredictable and episodic nature of migraine makes it difficult to treat and much of the mechanism of migraine has yet to be elucidated. A T44A substitution in casein kinase 1δ is inherited with migraine with aura. A transgenic mouse model suggests that animals with this mutation exhibit increased sensitivity to thermal stimuli after injection with nitroglycerin (NTG). We performed behavior assays that measure animal responses to thermal stimuli, …

Ethanol Enhances Neurosteroidogenesis In Hippocampal Pyramidal Neurons By Paradoxical Nmda Receptor Activation, Kazuhiro Tokuda, Yukitoshi Izumi, Charles F. Zorumski

Open Access Publications

Using an antibody against 5α-reduced neurosteroids, predominantly allopregnanolone, we found that immunostaining in the CA1 region of rat hippocampal slices was confined to pyramidal neurons. This neurosteroid staining was increased following 15 min administration of 60 mm but not 20 mm ethanol, and the enhancement was blocked by finasteride and dutasteride, selective inhibitors of 5α-reductase, a key enzyme required for allopregnanolone synthesis. Consistent with a prior report indicating that N-methyl-D-aspartate (NMDA) receptor (NMDAR) activation can promote steroid production, we observed that D-2-amino-5-phosphonovalerate (APV), a competitive NMDAR antagonist, blocked the effects of 60 mm ethanol on staining. We previously reported that …

Structures Of Poliovirus And Antibody Complexes Reveal Movements Of The Capsid Protein Vp1 During Cell Entry, Jun Lin

Theses and Dissertations

In the infection process, native poliovirus (160S) first converts to a cell-entry intermediate (135S) particle, which causes the externalization of capsid proteins VP4 and the N-terminus of VP1 (residues 1-53). The externalization of these entities is followed by release of the RNA genome, leaving an empty (80S) particle. Three antibodies were utilized to track the location of VP1 residues in different states of poliovirus by cryogenic electron microscopy (cryo-EM). "P1" antibody binds to N-terminal residues 24-40 of VP1. Three-dimensional reconstruction of 135S-P1 showed that P1 binds to a prominent capsid peak known as the "propeller tip". In contrast, our initial …

Reproductive Success And Soil Seed Bank Characteristics Of Astragalus Ampullarioides And A. Holmgreniorum (Fabaceae): Two Rare Endemics Of Southwestern Utah, Allyson B. Searle

Theses and Dissertations

Astragalus ampullarioides and A. holmgreniorum are two rare endemics of southwestern Utah. Over two consecutive field seasons (2009-2010) we examined pre-emergent reproductive success, based on F/F and S/O ratios, from populations of both Astragalus ampullarioides and A. holmgreniorum, estimated the density of the soil seed bank of A. holmgreniorum as a measure of potential post-emergent reproductive success, and estimated seed persistence within the soil seed bank. Fruit/flower (F/F) ratios and seed/ovule (S/O) ratios varied significantly between populations and among years in both species, and showed low reproductive output in both taxa. In Astragalus ampullarioides F/F and S/O were 0.06±0.01 …

Ceacam1 Separates Graft-Versus-Host-Disease From Graft-Versus-Tumor Activity After Experimental Allogeneic Bone Marrow Transplantation., Sydney X Lu, Lucy W Kappel, Anne-Marie Charbonneau-Allard, Renée Atallah, Amanda M Holland, Claire Turbide, Vanessa M Hubbard, Jimmy A Rotolo, Marsinay Smith, David Suh, Christopher King, Uttam K Rao, Nury Yim, Johanne L Bautista, Robert R Jenq, Olaf Penack, Il-Kang Na, Chen Liu, George Murphy, Onder Alpdogan, Richard S Blumberg, Fernando Macian, Kathryn V Holmes, Nicole Beauchemin, Marcel R M Van Den Brink

Department of Medical Oncology Faculty Papers

BACKGROUND: Allogeneic bone marrow transplantation (allo-BMT) is a potentially curative therapy for a variety of hematologic diseases, but benefits, including graft-versus-tumor (GVT) activity are limited by graft-versus-host-disease (GVHD). Carcinoembryonic antigen related cell adhesion molecule 1 (Ceacam1) is a transmembrane glycoprotein found on epithelium, T cells, and many tumors. It regulates a variety of physiologic and pathological processes such as tumor biology, leukocyte activation, and energy homeostasis. Previous studies suggest that Ceacam1 negatively regulates inflammation in inflammatory bowel disease models.

METHODS: We studied Ceacam1 as a regulator of GVHD and GVT after allogeneic bone marrow transplantation (allo-BMT) in mouse models. In …

July 6, 2011, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Technology Development In Water Resource Management, Daniel J. Epstein, Larry E. Brazil, Gerald N. Day

Journal of Contemporary Water Research and Education

In developed nations, technological advancements rapidly
are changing every aspect of our lives: how we work, how
we communicate with each other, and even how we are
entertained. The influence of technology is readily
apparent. The subtleties of technology and its less
apparent influences also are tremendous. Advances in
computer technology, communications, and manufacturing
are affecting all sectors, including engineering. In the
arena of water resources, technological advances have
helped to not only develop a better understanding of our
physical systems but have allowed improved operational
and institutional tools to be developed to support water
management. These advances have the …

After The State Farm: A Water User Association In Kazakhstan, Sydney Rosen, John Strickland

Journal of Contemporary Water Research and Education

No abstract provided.

Exome-Wide Dna Capture And Next Generation Sequencing In Domestic And Wild Species, Albano Beja-Pereira, Shanyuan Chen, Theodore F. Cosart, Gordon Luikart, Sarah B. Ng, Jay Shendure

Biological Sciences Faculty Publications

Our understanding of the molecular, genetic basis of adaptations and phenotypic differentiation among individuals will advance quickly thanks to new molecular techniques. This understanding is crucial given that accelerating environmental change and human population growth are increasingly threatening natural populations of fish and wildlife as well as increasing demands for agricultural production in domesticated species. This makes it urgent in many wild and domestic species to investigate the genetic basis of fitness, adaptation, and disease resistance [1], and to discover adaptive genes and speciation genes, i.e., the "loci of evolution" [2].

Hotline Press Newspaper- July 2011 Vol 29 No 5, Hotline Press Newspaper

Hotline Press Newspaper 2011

No abstract provided.

Bjc Today

BJC Today

No abstract provided.

State V. Davidson Appellant's Brief Dckt. 38266

Not Reported

No abstract provided.