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Controlled Release Of 6-Aminonicotinamide From Aligned, Electrospun Fibers Alters Astrocyte Metabolism And Dorsal Root Ganglia Neurite Outgrowth, Nicholas J. Schaub, Ryan J. Gilbert

Chemical and Biochemical Engineering Faculty Research & Creative Works

Following central nervous system (CNS) injury, activated astrocytes form a glial scar that inhibits the migration of axons ultimately leading to regeneration failure. Biomaterials developed for CNS repair can provide local delivery of therapeutics and/or guidance mechanisms to encourage cell migration into damaged regions of the brain or spinal cord. Electro spun fibers are a promising type of biomaterial for CNS injury since these fibers can direct cellular and axonal migration while slowly delivering therapy to the injury site. In this study, it was hypothesized that inclusion of an anti-metabolite, 6-aminonicotinamide (6AN), within poly-l-lactic acid electro spun fibers could attenuate …

Design And Development Of A Sustainability Toolkit For Simulation Modeling And Analysis, Xi Zhou

Theses

A simulation-based sustainability toolkit is developed in this research, in order to efficiently provide the capability of modeling and evaluating the sustainability related performance measures in systems of interest. As sustainability related issues, such as energy consumption, emissions, and waste generation are becoming a more integrated part of operational and long-term planning decisions, simulation modeling is needed to analyze the system performance not only from the traditional system performance measures such as productivity and efficiency, but also taking into account the environmental impacts within the studied system in order to aid in decision-making. This research introduces the concept and general …

Evaluation Of Cfd Based Hemolysis Prediction Methods, Oyuna Myagmar

Theses

Accurate quantitative evaluation of shear stress-related hemolysis (destruction of red blood cells) could be used to improve blood handling devices, including left ventricular assist devices (LVAD). Computational Fluid Dynamics (CFD) predicts the fluid dynamics of complex pump geometry and has been used to track the shear stress history of red blood cells as they travel through these devices. Several models that predict the relationship between hemolysis, shear stress and exposure time have been used to evaluate the hemolysis in the pumps. However, the prediction accuracy has not reached the satisfactory level. The goal of my thesis is to investigate the …

Dendroclimatic Reconstruction From Bald Cypress In Southwestern Indiana, Robin Lyn Van De Veer

All-Inclusive List of Electronic Theses and Dissertations

In the United States, bald cypress (Taxodium distichum) is generally recognized as an important component of the forested wetlands found in the Southwestern Coastal Plain and the Mississippi River Valley (which extends to the southern Midwest). The lifespan of this deciduous species is important not only commercially, but also in an ecological capacity. This study focuses mainly upon the role the tree plays in its environment and how it can be used as an indicator of climate through drought/flood signals in the rings. Bald cypress is a long-lived tree that can be over 1000 years old and is sensitive to …

Impacts Of Different Forest Tree-Harvest Methods On Diets And Populations Of Insectivorous Forest Bats, Megan K. Caylor

All-Inclusive List of Electronic Theses and Dissertations

The Hardwood Ecosystem Experiment (HEE) in central Indiana presents an excellent opportunity to study species reactions to different forestry practices: clearcutting, shelterwood cutting, and single tree selections. This project focuses on the differences in the populations and diets of the various insectivorous bat species in the HEE management units. Bats studied were Myotis septentrionalis, Lasiurus borealis, Eptesicus fuscus, Perimyotis subflavus, Myotis sodalis, Myotis lucifugus, and Lasionycteris noctivagans. Since insectivorous bats do not simply eat whatever is available, and I hypothesize that the diets of these bats will not change despite their changing environment and changing populations. To test these ideas, …

Novel Phytol-Derived Immunostimulants (Phis-01) For Enhancement Of Vaccine Efficacy: A Comparative Study, Youssef Aachoui

All-Inclusive List of Electronic Theses and Dissertations

Adjuvants are used widely in vaccine formulations. However for humans, choices are very limited. Since they are selected empirically, it is not expected that any two adjuvants would influence immune mechanisms the same way. However they all influence host microenvironment, antigen presentation, and retention of immunological memory. This study focuses on new terpenoid adjuvants based on phytol derivatives. We previously observed that phytol and one of its derivatives PHIS-01 (a phytol-based immunostimulant, phytanol) are excellent adjuvants. To gain an understanding of the structural features important for adjuvanticity, we further studied compounds derived from a diterpene Phytol. We designed two new …

Analysis Of Urban Heat Islands By Using Multi-Sensor And Multi-Temporal Remote Sensing Images, Umamaheshwaran Rajasekar

All-Inclusive List of Electronic Theses and Dissertations

This doctoral dissertation research has developed models to facilitate in characterization, analysis and monitoring of urban heat islands (UHI). Over the past few years there has been evidence of mass migration of the population towards urban areas which has led to the increase in the number of mega cities (cities with more than 10 million in population) around the world. According to the UN in 2007 around 60% (from 40% in 2000) of world populations was living in urban areas. This increase in population density in and around cities has lead to several problems related to environment such as air …

Routing Protocol Evaluation And Development Of A Fully Functional Simulation Environment For Vehicular Ad Hoc Networks, Matthew Prokop

Theses

A Vehicular Ad-hoc Networks (VANET) is an area of wireless technologies that are attracting a great deal of interest. There are still several areas of VANETS, such as medium access control, security and routing protocols, that lack large amounts of research. There is also a lack of freely available simulators that can quickly and accurately simulate VANETs. One of the two main goals of this thesis was to develop a freely available VANET simulator and to evaluate popular mobile ad-hoc network routing protocols in several VANET scenarios. The VANET simulator consisted of a network simulator, a traffic (mobility simulator) and …

Lawyers Judging Experts: Oversimplifying Science And Undervaluing Advocacy To Construct An Ethical Duty?, David S. Caudill

Faculty Publications

My focus is on an apparent trend at the intersection of the fields of evidentiary standards for expert admissibility and professional responsibility, namely the eagerness to place more ethical responsibilities on lawyers to vet their proffered expertise to ensure its reliability. My reservations about this trend are not only based on its troubling implications for the lawyer’s duty as a zealous advocate, which already has obvious limitations (because of lawyers’ conflicting duties to the court), but are also based on the problematic aspects of many reliability determinations. To expect attorneys—and this is what the proponents of a duty to vet …

Augmented Cocaine Seeking In Response To Stress Or Crf Delivered Into The Ventral Tegmental Area Following Long-Access Self-Administration Is Mediated By Crf Receptor Type 1 But Not Crf Receptor Type 2, Jordan M. Blacktop, Chad Seubert, David A. Baker, Nathan Ferda, Geng Lee, Evan N. Graf, John R. Mantsch

Biomedical Sciences Faculty Research and Publications

Stressful events are determinants of relapse in recovering cocaine addicts. Excessive cocaine use may increase susceptibility to stressor-induced relapse through alterations in brain corticotropin-releasing factor (CRF) regulation of neurocircuitry involved in drug seeking. We previously reported that the reinstatement of cocaine seeking by a stressor (footshock) is CRF dependent and is augmented in rats that self-administered cocaine under long-access (LgA; 6 h daily) conditions for 14 d when compared with rats provided shorter daily cocaine access [short access (ShA) rats; 2 h daily]. Further, we have demonstrated that reinstatement in response to intracerebroventricular CRF administration is heightened in LgA rats. …

Natural And Synthetic Corticosteroids Inhibit Uptake2-Mediated Transport In Cns Neurons, Jonathan E. Hill, Khadijah Makky, Lalita Shrestha, Cecilia J. Hillard, Paul J. Gasser

Biomedical Sciences Faculty Research and Publications

In addition to exerting actions via mineralocorticoid and glucocorticoid receptors, corticosteroids also act by inhibiting uptake₂, a high-capacity monoamine transport system originally described in peripheral tissues. Recent studies have demonstrated that uptake₂ transporters are expressed in the brain and play roles in monoamine clearance, suggesting that they mediate some corticosteroid effects on physiological and behavioral processes. However, the sensitivity of brain uptake₂ to many natural and synthetic corticosteroids has not been characterized. Cultured rat cerebellar granule neurons (CGNs) were previously shown to exhibit corticosterone-sensitive accumulation of the uptake₂ substrate1-methyl-4-phenylpyridinium (MPP⁺). We examined the …

Janet Zweig's Pedestrian Drama: New Public Art On East Wisconsin Avenue, Curtis L. Carter

Philosophy Faculty Research and Publications

No abstract provided.

Extraction Of Super Colonies Of Crazy Ants From Soil And Wood, D. Aguillard, R. M. Strecker, L. M. Hooper-Bùi

Midsouth Entomologist

No abstract provided.

Lessons From Outstanding County Agents, Shanna Smith, Dana Hoag, Kraig Peel

Journal of Extension

This article examines outstanding agents, based on a qualitative survey of 10 successful agents from Colorado, Idaho, Wyoming, and Oregon. Interviewees completed a four-question survey about their perceptions about why they are successful, including their own behavior, their clientele, and the resources available to them from the county and state. Extension leadership can make agents more successful if they are mentored by successful agents, are provided resources, including research, and given flexibility. Agents can help their cause if they have a strong work ethic, are knowledgeable, build strong relationships in their territory, and deliver information in a timely manner.

Star Messangers, Paul Zimet, Ellen Maddow

Kahn Institute Projects

Star Messengers is a musical theater work about two scientists, Galileo Galilei and Johannes Kepler, who changed our view of the universe. Writer Paul Zimet and composer Ellen Maddow have created a carnival of genres—opera, Com- media dell’Arte, Strindbergian Dream Play, and contemporary dance/theater—to produce a theatrical language that conveys the wonder of Galileo’s and Kepler’s discoveries.

While some aspects of Galileo’s life and discoveries are well known, hardly anything is popularly known of his scientific contemporaries. Johannes Kepler’s realization that the planets moved not in perfect circles, but in elliptical paths, was a leap of mind as extraordinary as …

Heterogeneity, Control, Social Infrastructure, And Possibilities Of Participation: Their Interplay In Modern Understandings Of Heredity And In Interpretation Of Science, Peter J. Taylor

Working Papers on Science in a Changing World

This working paper is a prospectus for research, writing, and engagement. It consists of vignettes, sketches of lines of inquiry, and proposals for engagement, all of which concern modern understandings of heredity and development over the life course as well as the social interpretation of science. The various items address a range of areas of science and of its interpretation: heritability studies, the social uses of genetic information, gene-by-environment interaction, personalized medicine, IQ paradoxes, racial group membership, biobanks, and life events and difficulties research. Fresh perspectives in these areas are opened up by examining the ways that research and application …

Technical Assistance For The Revision Of The Conservation Agreement For The Spring Mountains National Recreation Area: Final Closeout Report, Public Lands Institute

Public Lands Institute Publications

Technical Assistance for the revision of the Conservation Agreement for the Spring Mountains National Recreation Area was cooperative agreement between the U.S. Fish and Wildlife Service (USFWS) and the Board of Regents of the Nevada System of Higher Education. The cooperator was the Public Lands Institute (PLI) of the University of Nevada, Las Vegas (UNLV) working directly with staff of the USFWS Southern Nevada Field Office and the U.S. Forest Service’s (USFS) Humboldt-Toiyabe National Forest. The mechanism of cooperation was a Cooperative Ecosystem Studies Unit (CESU) Task Agreement. The purpose of the project was to provide technical assistance to the …

Midwest Institute Of Opera: Die Zauberflöte, July 31, 2011, John Koch Artistic Director, Joshua Greene Conductor, Brenden Moffitt Director

School of Music Programs

Center for the Performing Arts
July 31, 2011
Sunday Afternoon
3:00 p.m.

Proceedings Of The Ii International Meeting In Exercise Physiology

International Journal of Exercise Science: Conference Proceedings

Proceedings of the II International Meeting in Exercise Physiology. Meeting held May 5-7, 2011. This meeting was promoted by the Exercise Physiology Laboratory / UFSCar, in collaboration with UNICAMP and UNIMEP universities. The event was designed to bring Brazilian scientists, especially from São Paulo state that work with Exercise Physiology and Health. The main objective was to put together these students and scientists interested in developing joint researches in this area.

Midwest Institute Of Opera: Die Zauberflöte, John Koch, Artistic Director, Joshua Greene, Conductor, Brenden Moffitt, Director

School of Music Programs

Center for the Performing Arts
July 30, 2011
Saturday Evening
8:00 p.m.

Numenrology: A Poetic Exploration Of The Lives And Work Of Famous Mathematicians, Mari-Lou Rowley

Journal of Humanistic Mathematics

No abstract provided.

A Mathematician Weighs In On The Evolution Debate, Kris H. Green

Journal of Humanistic Mathematics

There are a variety of reasons underlying the lack of public acceptance for the theory of evolution in the United States. An overlooked cause is related to problems with the mathematics curriculum in the K-12 setting. In this essay, we examine this relationship and propose changes to the mathematics curriculum that could improve mathematical thinking while also providing a basis for understanding theories, like evolution, that are poorly understood.

State V. Long Clerk's Record Dckt. 38578

Idaho Supreme Court Records & Briefs, All

No abstract provided.

Graduate Commencement, Philadelphia (2011), Philadelphia College Of Osteopathic Medicine

Commencements

Philadelphia Campus Graduate Program Commencement program, Class of 2011. Degrees include Doctor of Psychology in Clinical Psychology, Doctor of Psychology in School Psychology, Educational Specialist in School Psychology, Master of Science in School Psychology, Master of Science in Counseling and Clinical Health Psychology, Master of Science in Organizational Development and Leadership, Master of Science in Forensic Medicine, Master of Science in Biomedical Sciences, and Master of Science in Health Sciences – Physician Assistant Studies.

Creation Of Multilinage Adult Stem-Like Cells From Terminally Differentiatied Fibroblasts, John Moore

Theses and Dissertations

Induced Pluripotent Stem cells (iPScs) are artificially generated cells that demonstrate multilineage differentiation potential. These cells demonstrate similar morphology and high differentiation potential to Embryonic Stem Cells (ESCs). Generation of these cells from a terminally differentiated cell line requires activation of the core pluripotency genes Nanog, Oct4, and Sox2 as well as an oncogenic stimulus such as c-Myc. Here we examine the effect of the Human Pappiloma Virus derived proteins E6 and E7 on the ability of a terminally differentiated fibroblast cell line to a more primitive state and examine its multilineage differentiation capacity. In this paper, we attempt to …

Transcriptome Analysis Of Epithelial And Stromal Contributions To Mammogenesis In Three Week Prepartum Cows., Theresa Casey, Heather Dover, James Liesman, Lindsey Devries, Matti Kiupel, Michael Vandehaar, Karen Plaut

Department of Animal Sciences Faculty Publications

Transcriptome analysis of bovine mammary development has provided insight into regulation of mammogenesis. However, previous studies primarily examined expression of epithelial and stromal tissues combined, and consequently did not account for tissue specific contribution to mammary development. Our objective was to identify differences in gene expression in epithelial and intralobular stromal compartments. Tissue was biopsied from non-lactating dairy cows 3 weeks prepartum, cut into explants and incubated for 2 hr with insulin and hydrocortisone. Epithelial and intralobular stromal tissues were isolated with laser capture microdissection. Global gene expression was measured with Bovine Affymetrix GeneChips, and data were preprocessed using RMA …

Evolution Of Trefoil Factor(S): Genetic And Spatio-Temporal Expression Of Trefoil Factor 2 In The Chicken (Gallus Gallus Domesticus)., Zhengyu Jiang, Amy C. Lossie, Todd J. Applegate

Department of Animal Sciences Faculty Publications

Trefoil factors are essential healing initiators participating in mucosal reconstitution and tissue morphogenesis, especially on the surfaces of the gastrointestinal tract. This family has been cloned and characterized predominantly from mammals and amphibians. Avian species ingest stone and grit to help digest food, which may expose their gut to severe physical conditions. To further the understanding of the function of the TFF gene family across species, we undertook this research to clone, sequence, and characterize the spatio-temporal expression patterns of chicken TFF2 (ChTFF2) cDNA. Bioinformatics analysis of the promoter region and deduced amino acid sequence demonstrated that ChTFF2 …

Formulation Of A Killed Whole Cell Pneumococcus Vaccine - Effect Of Aluminum Adjuvants On The Antibody And Il-17 Response., Harm Hogenesch, Anisa Dunham, Bethany Hansen, Kathleen Anderson, Jean-Francois Maisonneuve, Stanley L. Hem

Department of Comparative Pathobiology Faculty Publications

Background

Streptococcus pneumoniae causes widespread morbidity and mortality. Current vaccines contain free polysaccharides or protein-polysaccharide conjugates, and do not induce protection against serotypes that are not included in the vaccines. An affordable and broadly protective vaccine is very desirable. The goal of this study was to determine the optimal formulation of a killed whole cell pneumococcal vaccine with aluminum-containing adjuvants for intramuscular injection.

Methods

Four aluminium-containing adjuvants were prepared with different levels of surface phosphate groups resulting in different adsorptive capacities and affinities for the vaccine antigens. Mice were immunized three times and the antigen-specific antibody titers and IL-17 responses …

Morphology, Material And Vibratory Properties Of The Swimbladder In The Carp, Cyprinus Carpio, Yasha Mohajer

Theses and Dissertations

The carp Cyprinus carpio has a two-chambered swimbladder and excellent hearing. I explored the hypothesis that the anterior chamber, which connects to Weberian ossicles, is adapted for hearing by testing both chambers for material properties. I also determined displacement and auditory responses to mechanical strikes. Wall stress is higher in the posterior, strain in the anterior and modulus lower in the anterior chamber. Strikes increase pressure followed by a variable rebound that rapidly decays. Displacement and sound amplitude increase with hammer force, and amplitude is similar in both chambers for within chamber strikes but lower across chambers. Normalized for equivalent …

Cistronic Stop Signal Ratio Of Mitochondrial Genes Suggests Multiple Waves Of Human Migrations In And Out Of Africa, Naby Yaya Sankhon

Electronic Theses and Dissertations Archive

The mitochondrial Cistronic Stop Signal Ratios (CSSR) is defined as a series of 12 numerals representing the ratio of TAA, TAG, AGG, and AGA nucleotide trimmers. Primate mitochondria use these nucleotide trimmers as stop codons and many of these trimmers are also found on the 2nd and 3rd reading frames of a cistron. We showed that the average value of the CSSR of all the 13 protein coding genes in mitochondria (genomic CSSR) could be used to define the phylogenetic relationship between the primates. However, the genic CSSR of most human mitochondria are essentially identical, except for the CSSR of …