Digital Commons Network^™

Synthesis And Antimicrobial Activities Of S,S'-Heterosubstituted Disulfides, Praveen Ramaraju

USF Tampa Graduate Theses and Dissertations

Antibiotic resistance is a particularly critical health concern and has increased dramatically over the past two decades. For over a decade the Turos laboratory has been designing small molecules to target pathogenic microbes such as Staphylococcus aureus and the resistant variants like methicillin-resistant Staphylococcus aureus (MRSA). Previously, N-thiolated Β-lactams, N-thiolated 2-oxazolidinones and aromatic disulfides that were synthesized in Dr. Turos' lab have shown strong activity against these bacteria. The present work describes the synthesis and antimicrobial activities of a related structural class called S,S'-heterosubstituted disulfides. For ages, sulfur (elemental) has been used as an antibacterial for controlling infestation and bacterial …

Egyptian Body Size: A Regional And Worldwide Comparison, Michelle H. Raxter

USF Tampa Graduate Theses and Dissertations

Human body size and limb proportions can provide important information about adaptation, population movements, and health disparities. This study investigated changes in body size and limb proportions of adult Egyptians temporally and geographically in relation to climatological, sociopolitical and economic developments. It was predicted that Egyptian groups that experienced more environmental stress would be shorter and exhibit less sexual dimorphism. It was also predicted that Egyptians would be intermediate between higher and lower latitude populations in body form and limb length ratios. The main skeletal sample consisted of 492 males and 528 females, all adults from the Predynastic and Dynastic …

Characterization Of Aminopeptidase Pepz In Staphylococcus Aureus Virulence, Tiffany Marie Robison

USF Tampa Graduate Theses and Dissertations

Staphylococcus aureus is a remarkably successful pathogen, accounting for an estimated 95,000 invasive infections annually in the U.S. alone. The burden of MRSA infections on public healthcare continues to rise, particularly with the continued spread of antibiotic resistant strains and the hyper-virulent CA-MRSA strains. The pathogenic nature of S. aureus can be attributed to the cache of virulence factors encoded within the genome of this organism. Typically, these are secreted toxins which directly interact with the host during infection, and facilitate pathogenesis. A previous screen in our laboratory investigating proteases in S. aureus identified a mutant in aminopeptidase Z as …

Secreted Factors From Human Umbilical Cord Blood Cells Protect Oligodendrocytes From Ischemic Insult, Derrick Rowe

USF Tampa Graduate Theses and Dissertations

Oligodendrocytes (OL)s are the dominant cell type in the white matter and are integral for synaptic transmission essential for proper neuronal communication between brain areas. Previous studies have shown that intravenous administration of the mononuclear fraction of human umbilical cord blood (HUCB) cells in rat models of stroke reduced white matter injury, gray matter injury and behavioral deficits. Yet the mechanisms used by HUCB cells remain unknown in ischemic injury. These studies will investigate both in vitro and in vivo approaches to elucidate this mechanism in OLs. When mature primary OLs were coincubated with HUCB cells, HUCB cells secreted soluble …

Native-Led Contextualization Efforts In North America 1989-2009, Richard L. Twiss

ATS Dissertations

No abstract provided.

Using Virtual Reality To Enhance Electrical Safety And Design In The Built Environment, Martin Barrett, Jonathan Blackledge, Eugene Coyle

Articles

— Electricity and the inherent risks associated with its use in the built environment have long since been a priority for the electrical services industry and also the general public who must live and work in this environment. By its nature virtual reality has the advantage of being safe for both the user and equipment. In addition, it offers the user an opportunity to be exposed to a range of scenarios and conditions that either occur infrequently or are hazardous to replicate. This paper presents a prototype desktop virtual reality model, to enhance electrical safety and design in the built …

Criminalization Of Air Disasters: What Goal, If Any, Is Being Achieved, Elaine D. Solomon, Dina L. Relles

Journal of Air Law and Commerce

No abstract provided.

Cattle Ranchers And Conservation Easements, Roslynn Brain

Environment and Society Faculty Publications

No abstract provided.

Protein Replacement Therapy Partially Corrects The Cholesterol-Storage Phenotype In A Mouse Model Of Niemann-Pict Type C2 Disease, Gitte Krogh Nielsen, Frederik Dagnaes-Hansen, Ida Elisabeth Holm, Steve Meaney, Derek Symula, Niels Trolle Andersen, Christian Wurtz Heegaard

Articles

Niemann-Pick type C2 (NPC2) disease is a fatal autosomal recessive neurovisceral degenerative disorder characterized by late endosomal-lysosomal sequestration of low-density lipoprotein derived cholesterol. The breach in intracellular cholesterol homeostasis is caused by deficiency of functional NPC2, a soluble sterol binding protein targeted to the lysosomes by binding the mannose-6-phosphate receptor. As currently there is no effective treatment for the disorder, we have investigated the efficacy of NPC2 replacement therapy in a murine gene-trap model of NPC2-disease generated on the 129P2/OlaHsd genetic background. NPC2 was purified from bovine milk and its functional competence assured in NPC2-deficient fibroblasts using the specific cholesterol …

Too Close To Home: Limiting The Organizations Subsidized By The Charitable Deduction To Those In Economic Need, Shannon Weeks Mccormack

Articles

The charitable deduction allows taxpayers to deduct amounts donated to organizations pursuing statutorily designated purposes from their otherwise taxable income. By lowering the after-tax cost of giving and encouraging taxpayers to donate more than they otherwise would, the charitable deduction subsidizes a broad variety of organizations. Some of these organizations provide widespread societal benefits, while others provide narrower benefits that remain closer to the taxpayer-donor’s home. To evaluate these current laws, this Article focuses on efficiency criteria, which limit subsidized organizations to those with donor support that does not cover the costs needed to optimally provide goods and services. Existing …

Legal Education For The Future: Global Perspectives, Daniel H. Foote

Articles

This is a report on "FutureEd 2: Making Global Lawyers for the 21st Century," a conference on legal education held at Harvard Law School (HLS) on October 15-16, 2010, In which this author had the opportunity to participate. The conference was the second In a series of three conferences jointly organized by HLS and New York Law School (NYLS). The first conference was held at NYLS in April 2010; the third and final conference was held at NYLS, in April 2011．The goals of the conferences were to stimulate thinking and research about the future of legal education; to promote concrete …

Killing Good Patents To Wipe Out Bad Patents: Bilski, The Evolution Of Patentable Subject Matter Rules, And The Inability To Save Valuable Patents Using The Reissue Statute, Edward Van Gieson, Paul Stellman

Santa Clara High Technology Law Journal

No abstract provided.

Spring 2011

University of Richmond Magazine

No abstract provided.

The Beauty And The Beast: Civil Society And Nationalisms In Bosnia And Herzegovina, Joan Davison

Faculty Publications

Both ethnic nationalism and liberal civic nationalism exist with historical precedents in Bosnia-Herzegovina. Many elected elites privilege extremist ethnic nationalism. The power-sharing structure of the Dayton Peace Accords institutionalizes their influence and permits the current political stalemate. Further, a legacy of authoritarianism vitiates a political culture supportive of elite accountability and mass responsibility. Yet a nascent civil society witnesses to the past and potential future of liberal cosmopolitanism. This research includes interviews with leaders and members of civil society organizations to assess the impediments to and strength of civil society as a vehicle to promote civic nationalism. While interviewees acknowledge …

Gvsu Undergraduate And Graduate Catalog, 2011-2012, Grand Valley State University

Course Catalogs, 1963 - Current

Grand Valley State University 2011-2012 undergraduate and/or graduate course catalog published annually to provide students with information and guidance for enrollment.

Scary Monsters: Hybrids, Mashups, And Other Illegitimate Children, Rebecca Tushnet

Georgetown Law Faculty Publications and Other Works

Human creativity, like human reproduction, always makes new out of old in ways that copyright law has not fully recognized. The genre of vidding, a type of remix made mostly by women, demonstrates how creativity can be disruptive, and how that disruptiveness is often tied to ideas about sex and gender. The most frightening of our modern creations—the Frankenstein’s monsters that seem most appropriative and uncanny in light of old copyright doctrine—are good indicators of what our next generation of creativity may look like, especially if creators’ diversity in gender, race, and economic background is taken into account.

Richmond Law Magazine: Winter 2011

Richmond Law Magazine

Features:

Putting the Law to Work

Environment for Growth

The Price of Pleasure

For the Public Good

Multivariate Anti-Inflammatory Approaches To Rescue Neurogenesis And Cognitive Function In Aged Animals, Sandra Antonieta Acosta

USF Tampa Graduate Theses and Dissertations

Studies have shown that there is a strong correlation between aging and neurodegenerative diseases. Aging is considered the number one risk factor to develop neuropathologies such as memory loss, senile dementia, Alzheimer's disease (AD), and Parkinson's disease. Neurodegenerative diseases tend to start during adulthood, and aggravate over time, making them difficult to prevent and to treat. In the Unites States, demographic studies by U.S. Bureau of the Census have determined that our aging population of >65 years is expected to increase from the present 35 million to 78 million in 2030. This would result, not only to an increase of …

Flexibility In The Foraging Strategies Of Spiders, Ximena J. Nelson, Robert R. Jackson

All Peer-Reviewed Publications

Although many spiders build prey-capture webs, spider foraging strategies include species that, instead of building webs, deploy silk in other ways for prey capture. Additionally, there are species that capture prey, either by ambush or by active pursuit, without making notable use of silk in the process. There are striking examples of predatory specialisation from spiders, particularly among the Salticidae, suggesting that assumptions about adaptive trade-offs, in which the small nervous systems of spiders might constrain their cognitive or sensory abilities, need to be carefully evaluated. Predatory versatility, whereby an individual spider adopts a conditional strategy with which it classifies …

Feminist Fumdamentalism As An Individual And Constitutional Commitment, Mary Anne Case

American University Journal of Gender, Social Policy & the Law

No abstract provided.

Eligible Patent Matter—Gender Analysis Of Patent Law: International And Comparative Perspectives, Shlomit Yanisky-Ravid

American University Journal of Gender, Social Policy & the Law

No abstract provided.

Welfare Reform’S Inadequate Implementation Of The Family Violence Option: Exploring Dual Oppression Of Poor Domestic Violence Victims, Rachel J. Gallagher

American University Journal of Gender, Social Policy & the Law

No abstract provided.

Toward An Integrated Approach To Perception And Action: Conference Report And Future Directions, Goren Gordon, David M. Kaplan, Benjamin Lankow, Daniel Ying-Jeh Little, Jason Sherwin, Benjamin A. Suter, Lore Thaler

Open Access Publications

No abstract provided.

Functional Metagenomic Investigations Of The Human Intestinal Microbiota, Aimee M. Moore, Christian Munck, Morten O.A Sommer, Gautam Dantas

Open Access Publications

No abstract provided.

Positive Affect Versus Reward: Emotional And Motivational Influences On Cognitive Control, Kimberly S. Chiew, Todd S. Braver

Open Access Publications

No abstract provided.

Bioluminescence Imaging Captures The Expression And Dynamics Of Endogenous P21 Promoter Activity In Living Mice And Intact Cells, Kelsey L. Tinkum, Luciano Marpegan, Lynn S. White, Jinwu Sun, Erik D. Herzog, David Piwnica-Worms, Helen Piwnica-Worms

Open Access Publications

No abstract provided.

Oxytocin Receptor (Oxtr) Polymorphisms And Attachment In Human Infants, Frances S. Chen, Maria E. Barth, Stephen L. Johnson, Ian H. Gotlib, Susan C. Johnson

Open Access Publications

No abstract provided.

Gs-8374, A Novel Hiv Protease Inhibitor, Does Not Alter Glucose Homeostasis In Cultured Adipocytes Or In A Healthy-Rodent Model System, Paul W. Hruz, Qingyun Yan, Luong Tsai, Joseph Koster, Lianhong Xu, Tomas Cihlar, Christian Callebaut

Open Access Publications

No abstract provided.

The Diverse Functions Of Short-Term Plasticity Components In Synaptic Computations, Pan-Yue Deng, Vitaly A. Klyachko

Open Access Publications

No abstract provided.

Organogenesis Of The Kidney Glomerulus: Focus On The Glomerular Basement Membrane, Jeffrey H. Miner

Open Access Publications

No abstract provided.