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2011

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Significance And Regulation Of Cd68 Expression In The Osteoclast, Jason Waid Ashley Jan 2011

Significance And Regulation Of Cd68 Expression In The Osteoclast, Jason Waid Ashley

All ETDs from UAB

The mucin-like Lysosome Associated Membrane Protein (LAMP) family member CD68 is a primarily myeloid lineage restricted transmembrane protein that is expressed in macrophages and osteoclasts. While the existence and expression pattern of human CD68 and mouse CD68 (sometimes called macrosialin) are well-known, and these molecules are routinely used as histological markers of tissue macrophages, the functional signific-ance of CD68 expression remains an unanswered question. Our overall goal is to deter-mine the significance and characterize the function of CD68 in osteoclasts and explore the effects of Receptor Activator of Nuclear Factor κB (RANK) signaling on CD68 post-translational modification. To achieve this …

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The Effect Of The Release Of A Thermal Stressor On Bluegill (Lepomis Macrochirus) Morphology And Physiology, Jessica Eagar Jan 2011

The Effect Of The Release Of A Thermal Stressor On Bluegill (Lepomis Macrochirus) Morphology And Physiology, Jessica Eagar

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Temperature is considered a very important abiotic factor in fish communities. An increase in water temperature, as is found with the use of nuclear production reactors, can act as a stressor in aquatic systems. The P-reactor, operational from 1954-1988, on the Savannah River Site near Aiken, South Carolina, utilized the Par Pond Reservoir System as part of its cooling mechanisms. During reactor operation, heated effluents were displaced into Pond C, causing the water to be heated to around 45° C. Fischer (1994) found that the bluegill population had adapted with changes to their morphology and physiology. The bluegill from the …

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Role Of The Cardiomyocyte Circadian Clock In Modulating Myocardial Physiology And Pathophysiology, David Joseph Durgan Jan 2011

Role Of The Cardiomyocyte Circadian Clock In Modulating Myocardial Physiology And Pathophysiology, David Joseph Durgan

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It is well established that multiple parameters of cardiovascular physiology and pathophysiology exhibit diurnal variations. For example, human heart rate and blood pressure peak during the morning and trough in the evening. Similarly, there is a morning prevalence for the onset of multiple adverse cardiovascular events, including myocardial ischemia, arrhythmias, and sudden cardiac death. Traditionally these rhythms have been attributed to rhythms in neurohumoral stimulation. However recent identification of the circadian clock mechanism in cardiovascular relevant cell types, including the cardiomyocyte, has prompted investigation into its role in modulating myocardial physiology and pathophysiology over the course of the day. Preliminary …

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The Role Of The Classical Nf-Kb Pathway In Hsc Self-Renewal And Acute Myeloid Leukemia, Robert Jason Flynn Jan 2011

The Role Of The Classical Nf-Kb Pathway In Hsc Self-Renewal And Acute Myeloid Leukemia, Robert Jason Flynn

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Acute myeloid leukemia (AML) comprises approximately 25% of newly diagnosed cases of leukemia each year. The constitutive activation of the classical NF-κB signaling pathway has been observed in up to 70% of AML cases, and could be due to mutations upstream involving the PI3K-Akt cascade, which is also constitutively active in a majority of cases. In mice, constitutive activation of Akt either through deletion of the negative regulator of PI3K-Akt, PTEN, or by expression of Myr-Akt induces rapid stem cell loss along with a lethal, transplantable myeloproliferative disorder and AML. These studies show that constitutive Akt and NF-κB signaling distinguish …

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Occupational Stress In Veterinary Support Staff, Sandra Morales Foster Jan 2011

Occupational Stress In Veterinary Support Staff, Sandra Morales Foster

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OCCUPATIONAL STRESS IN VETERINARY SUPPORT STAFF Sandra Morales Foster DOCTOR OF PUBLIC HEALTH ABSTRACT Limited information exists about veterinary support staff and the occupational stressors of this workforce. Concern for workers in occupations of high or prolonged stress such as caregivers in hospitals and emergency situations has been noted in many studies. Occupational stress can cause harmful physical and emotional outcomes when the homeostatic balance is upset. This study explored occupational stress, health status, and coping strategies of veterinary support staff. A mixed-method collected quantitative and qualitative data. Demographic information and three validated instruments were ad-ministered using a web-based survey; …

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The Study Of Intracellular Signaling Pathways In Schizophrenia, Adam Funk Jan 2011

The Study Of Intracellular Signaling Pathways In Schizophrenia, Adam Funk

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INTRACELLULAR SIGNALING AND INTEGRATION ABNORMALITIES IN SCHIZOPHRENIA Adam J. Funk DEPARTMENT OF NEUROBIOLOGY ABSTRACT The pathophysiology of schizophrenia is complex and diverse, with many classes of receptors, neurotransmitters, and brain regions implicated in this illness. The many hypotheses proposed have yet to fully explain the heterogeneity of the genetic, postmor-tem, and clinical evidence. It is the goal of this dissertation to integrate the current hy-potheses of schizophrenia into a unified hypothesis of abnormal intracellular signaling and signal integration. Inconsistencies in genetic and postmortem findings suggest that the development of schizophrenia is multifaceted, and the heterogeneity of symptoms supports the hypothesis …

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Intracellular Distribution Of Glycogen Synthase Kinase-3beta In The Brain, Johanna C. Gandy Jan 2011

Intracellular Distribution Of Glycogen Synthase Kinase-3beta In The Brain, Johanna C. Gandy

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The widely distributed serine/threonine kinase glycogen synthase kinase 3beta is well known for its multiple functions in the health brain tissue, which include cell fate, neuronal growth and remodeling, synaptic plasticity, and neuroinflammation. However much of GSK3beta focuses on its abnormal functions in neurological disorders like Alzheimer's Disease and psychiatric disorders. To maintain normal GSK3beta function in the brain, this constitutively active kinase must be strictly regulated. Many factors within the cell work together to influence GSK3beta activity. Two ways to regulate GSK3beta activity are through phosphorylation by upstream kinases or the formation of protein complexes that block substrate binding. …

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An Evaluation Of Dietary Lipids On Growth Performance In The Sea Urchin, Lytechinus Variegatus (Echinodermata: Echinoidea), Victoria K. Gibbs Jan 2011

An Evaluation Of Dietary Lipids On Growth Performance In The Sea Urchin, Lytechinus Variegatus (Echinodermata: Echinoidea), Victoria K. Gibbs

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Sea urchin fisheries are declining across the world, and sea urchin aquaculture will be an important alternative to wild-caught fisheries. A significant aspect of a successful sea urchin culture operation is the formulation of nutritionally-complete diets with the potential to support optimal growth and health to sea urchins at different life stages. Due to the ecological variety of sea urchin species, the inclusion level and source of the various macronutrients and micronutrients needed for a complete diet must be carefully considered for each sea urchin species. Lytechinus variegatus is an echinoid species commonly found in the northern Gulf of Mexico, …

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Human Cytomegalovirus Ul97 Kinase Activity Modifies Cell Cycle Checkpoint Regulators, Rachel Brooke Gill Jan 2011

Human Cytomegalovirus Ul97 Kinase Activity Modifies Cell Cycle Checkpoint Regulators, Rachel Brooke Gill

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Human cytomegalovirus (CMV) infection results in destructive infections in neonates and immunocompromised individuals. Being the primary congenital infection in the United States, it can often result in permanent neurological deficits in infants. The current therapies for CMV infections all target the viral DNA polymerase and also have dose-limiting toxicities. Isolates resistant to ganciclovir (GCV), the therapy of choice, can sometimes overwhelm immunocompromised hosts. Better therapies for this infection are required. The CMV UL97 kinase is a key enzyme in the treatment of CMV infection because it phosphorylates GCV. Additionally, maribavir (MBV) specifically inhibits UL97 kinase activity and inhibits viral replication. …

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Oxidative Stress And Xanthine Oxidase In Acute And Chronic Cardiac Volume Overload In Rats, James Douglas Gladden Jan 2011

Oxidative Stress And Xanthine Oxidase In Acute And Chronic Cardiac Volume Overload In Rats, James Douglas Gladden

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Mechanisms of left ventricular dysfunction in cardiac volume overload (VO) are not well understood and there is no medical therapy. Cardiac VO is marked by eccentric remodeling and contractile dysfunction ultimately resulting in cardiac failure. Oxidative stress is implicated in the pathophysiology of heart failure and recent evidence suggests xanthine oxidase (XO) plays a role in VO. To study VO, we used a rat model of aortocaval fistula (ACF). ACF results in early diastolic stress on the left ventricle (LV) and recapitulates the progressive nature of heart failure with contractile function being initially maintained and then depressed by 6 weeks. …

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Mitochondrial Genetics And Function In Cardiovascular Disease Susceptibility, Jessica L. Fetterman Jan 2011

Mitochondrial Genetics And Function In Cardiovascular Disease Susceptibility, Jessica L. Fetterman

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While progress has been made in understanding the development and progression of cardiovascular disease (CVD), the mechanisms of CVD risk and initiation are not completely understood. It is widely accepted that CVD is the result of a combination of genetic and environmental factors but it is not known why some populations with otherwise similar risk factors appear more susceptible to CVD than others. It is also known that different strains of laboratory mice have distinct susceptibilities to CVD development. For example, C3H mice are resistant to diet induced atherogenesis whereas C57 animals are susceptible. We have also found that the …

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Pathophysiology Of Dyt1 Dystonia: Targeted Mouse Models, Chad Christopher Cheetham Jan 2011

Pathophysiology Of Dyt1 Dystonia: Targeted Mouse Models, Chad Christopher Cheetham

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DYT1 dystonia is an inherited movement disorder caused by a trinucleotide deletion (DeltaGAG) in the DYT1 (TOR1A) gene, which codes for the torsinA protein. Dr. Yuqing Li's laboratory previously reported the characterization of a DYT1 dystonia mouse model, a knock-in carrying DeltaGAG in Dyt1 (KI), which displays a motor learning deficit of motor skill transfer. We report here that this motor learning deficit was reversed with an anticholinergic drug, trihexyphenidyl (THP), a drug commonly used to treat movement problems in dystonia patients. We further show a potential substrate for the pathophysiology, a reduction in D2 receptors in the striatum in …

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Analysis Of The Structural And Kinetic Properties Of Sult2a1 Induced By The Binding Of 3'-Phosphoadenosine-5'-Phosphosulfate, Ian Thomas Cook Jan 2011

Analysis Of The Structural And Kinetic Properties Of Sult2a1 Induced By The Binding Of 3'-Phosphoadenosine-5'-Phosphosulfate, Ian Thomas Cook

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Sulfation is an important Phase II drug metabolism reaction catalyzed by the cytosolic sulfotransferases (SULTs). SULT2A1 is a major SULT in liver and adrenal cortex that has been reported to sulfate a wide variety of substrates including bile acids, steroids, and drugs. The crystal structures of SULT2A1 suggest that PAPS binding causes a structural change. This study examines the kinetic changes in SULT2A1 caused by PAPS binding using computer modeling, enzyme kinetics, binding studies, and mammalian cells expressing SULT2A1. The data presented clearly demonstrate that the binding of PAPS changes the affinity of some substrates to SULT2A1 resulting in different …

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Differential Contributions Of C-Kit Activating Mutations To Promotion Of Aml1-Eto Associated Neoplasia, Heidi Jean Nick Jan 2011

Differential Contributions Of C-Kit Activating Mutations To Promotion Of Aml1-Eto Associated Neoplasia, Heidi Jean Nick

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The t(8;21) translocation, which generates an AML1-ETO fusion protein (also known as RUNX1-ETO), is one of the most frequent cytogenetic abnormalities in acute myeloid leukemia (AML). Murine studies have demonstrated that AML1-ETO promotes the accumulation of myeloid progenitor cells with self-renewal capability and impaired differentiation capacity. However, AML1-ETO+ mice do not progress to AML in the absence of additional mutations, suggesting that expression of the translocation is insufficient for leukemogenesis. This hypothesis is supported by studies demonstrating the persistence of AML1-ETO-expressing hematopoietic progenitors obtained from patients in long-term clinical remission. Mutations affecting receptor tyrosine kinases, particularly c-KIT, are commonly detected …

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Behavior Of Midbrain Vergence Cells During Stepwise Transfers Of Gaze And Oblique Tracking In Depth, Leah Corthell Jan 2011

Behavior Of Midbrain Vergence Cells During Stepwise Transfers Of Gaze And Oblique Tracking In Depth, Leah Corthell

All ETDs from UAB

A long standing debate regarding the neural organization of oculomotor control began in the late 1800's with Hering and von Helmholtz proposing two opposing ideologies. Von Helmholtz proposed a monocular structure of the oculomotor circuitry in which each eye receives separate motor commands. Hering offered his law of equal innervation, which states that all eye movements are the sum of binocular vergence and conjugate commands. As a test of Hering's binocular proposal, this project compared the behavior of midbrain vergence cells during: 1) saccade-free stepwise transfers of gaze in depth; 2) combined saccade-vergence eye movements; 3) pure vergence tracking, and …

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Comparison Of Vitamin D Supplementation Regimens In Pediatric Patients With Cystic Fibrosis, Julianna Bailey Jan 2011

Comparison Of Vitamin D Supplementation Regimens In Pediatric Patients With Cystic Fibrosis, Julianna Bailey

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COMPARISON OF VITAMIN D SUPPLEMENTATION REGIMENS IN PEDIATRIC PATIENTS WITH CYSTIC FIBROSIS JULIANNA BAILEY CLINICAL NUTRITION ABSTRACT The objective of this randomized prospective study was to determine the most efficacious form of vitamin D supplementation for pediatric patients with Cystic Fibrosis (CF). We hypothesized that 50,000 IU monthly cholecalciferol would be as effective in raising serum 25-hyrdroxyvitamin D [25(OH)D] concentrations as routine daily supplementation of 1000-2000 IU cholecalciferol in pediatric patients with CF, birth to 20 years of age, over a period of 3 months. Data collected at baseline included serum 25(OH)D concentration, gender, genotype, race, age, FEV1, height, weight, …

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Sensitization Of Glioma To Death Receptor 5-Mediated Apoptosis Through Genotoxic Stress And Cell Cycle Disruption: A Study Of Mechanism, Michael L. Belenky Jan 2011

Sensitization Of Glioma To Death Receptor 5-Mediated Apoptosis Through Genotoxic Stress And Cell Cycle Disruption: A Study Of Mechanism, Michael L. Belenky

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Our laboratory reported that a combination of ionizing radiation (IR) or temozolomide (Tmz), a DNA methylating agent clinically approved against glioblastoma multiforme (GBM), a type of human brain cancer, and TRA-8, an anti-DR5 monoclonal antibody produced synergistic cytotoxicity in GBM cells in culture and in mouse xenograft models through an yet unknown mechanism. I hypothesized that understanding of the synergy phenomenon can offer an insight into the nature of GBM vulnerability. The goals of this investigation were two-fold - to elucidate the mechanism of this enhancement in cytotoxicity, and to improve understanding of DR5 mediated apoptosis toward improvement of current …

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Hierarchical And Bayesian Approaches For Estimating Prevalence Based On Pool Screening, Thomas Birkner Jan 2011

Hierarchical And Bayesian Approaches For Estimating Prevalence Based On Pool Screening, Thomas Birkner

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Pool screening is a method that combines individual items into pools. Each pool will either test positive (at least one of the items is positive) or negative (all items are negative). Pool screening is commonly applied to the study of tropical diseases where pools consist of vectors (e.g. black flies) that can transmit the disease. The goal is to estimate the proportion of infected vectors. In paper 1, we present a frequentist Bernoulli-Beta hierarchical model to relax the constant prevalence assumption underlying the traditional frequentist prevalence estimation approach. This assumption is called into question when sampling from a large geographic …

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Exopolysaccharide: A Multi-Faceted Role In Mycoplasma Pulmonis, Jeffrey R. Bolland Jan 2011

Exopolysaccharide: A Multi-Faceted Role In Mycoplasma Pulmonis, Jeffrey R. Bolland

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The recently characterized exopolysaccharide of Mycoplasma pulmonis, EPS-I, has been identified as modulating the susceptibility to complement-mediated lysis and binding to host mucosal epithelium. M. pulmonis produces family of size- and phase-variable lipoproteins called Vsa. Previous evidence has strongly demonstrated that the length of the tandem repeat region of the M. pulmonis Vsa protein is associated with the susceptibility to the host innate immune system through complement-mediated lysis. Mycoplasmas producing a long form of Vsa, containing about 40 repeats, are resistant complement whereas strains that produce the short form of Vsa, 5 repeats or fewer, are susceptible. Furthermore, the size …

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The Role Of Protein Folding And Protein Trafficking In Human Disease, Cristy Davette Tower-Gilchrist Jan 2011

The Role Of Protein Folding And Protein Trafficking In Human Disease, Cristy Davette Tower-Gilchrist

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This dissertation documents my findings in two unrelated projects. Project 1: Expansion of CAG repeats encoding glutamine in huntingtin and ataxin 3 causes the neurodegenerative diseases Huntington's disease (HD) and spinocerebellar ataxia 3 (SCA3), respectively. Both poly-glutamine (polyQ) expanded proteins misfold and ag-gregate within the cell. Preventing aggregation of polyQ proteins through molecular or pharmacological approaches provide therapeutic advantage in animal models of HD and SCA3. I hypothesized that the UL97 kinase encoded by the human cytomegalovirus (HCMV) may be able to prevent the aggregation of polyQ proteins. Initially, I showed that the UL97 kinase prevents the deposition of aggregates …

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Low And High Let Irradiation Of Human Aortic Endothelial Cells Induces Dose And Time Dependent Adhesion Of Monocytes Which Is Mediated By Chemokines Expressed By The Irradiated Endothelium., Saman Fatima Khaled Jan 2011

Low And High Let Irradiation Of Human Aortic Endothelial Cells Induces Dose And Time Dependent Adhesion Of Monocytes Which Is Mediated By Chemokines Expressed By The Irradiated Endothelium., Saman Fatima Khaled

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Exposure to radiation from a variety of sources is associated with increased risk of heart disease and stroke. Since radiation also induces inflammation, a possible mechanism is a change in the adhesiveness of vascular endothelial cells, triggering pro-atherogenic accumulation of leukocytes. To investigate this mechanism at the cellular level, the effect of xrays, iron (Fe56) ions, and protons on adhesiveness of cultured human aortic endothelial cells (HAECs) was determined. HAECs were grown as monolayers and exposed to 0 to 30 Gy X-rays, 0, 2, and 5 Gy Fe56 ions, and 0, 0.5, and 2 Gy protons followed by measurement of …

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An Examination Of Secondary Metabolites And Inorganic Acids As Chemical Defenses Against Predation And Fouling In Antarctic And Sub-Tropical Ascidians, Gil Koplovitz Jan 2011

An Examination Of Secondary Metabolites And Inorganic Acids As Chemical Defenses Against Predation And Fouling In Antarctic And Sub-Tropical Ascidians, Gil Koplovitz

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Palatability of outer tissues of 12 species of ascidians from the Western Antarctic Peninsula was evaluated using the sympatric, omnivorous predator fish Notothenia coriiceps and sea star Odontaster validus. Tissues of 100% of those tested were unpalatable to fish, while 58% were unpalatable to sea stars. Lipophilic and hydrophilic extracts of 11 species were incorporated into pellets and tested in fish and sea star bioassays. Only the lipophilic extract from Distaplia colligans caused sea star and fish feeding deterrence. Organic extracts from 10 ascidian species were also examined in food pellet assays using the sympatric, omnivorous amphipod Gondogeneia antarctica. Only …

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The Role Of Trib3 In Insulin Resistance: Its Action As Nutrient Sensor And Regulator Of Insulin Action, Jiarong Lamiquiz Jan 2011

The Role Of Trib3 In Insulin Resistance: Its Action As Nutrient Sensor And Regulator Of Insulin Action, Jiarong Lamiquiz

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THE ROLE OF TRIB3 IN INSULIN RESISTANCE: ITS ACTION AS NUTRIENT SENSOR AND REGULATOR OF INSULIN ACTION JIARONG LIU LAMIQUIZ PATHOLOGY ABSTRACT Insulin resistance is a hallmark of Type 2 diabetes (T2DM). A reduced capacity for insulin to stimulate increases in glucose uptake and glucose oxidation in insulin sensitive tissues, such as skeletal muscle and adipose tissue, are common defects in patients with insulin resistance, T2DM, and other related diseases. Tribbles homolog 3 (TRIB3) has been demonstrated to play a role in insulin resistance by serving as a negative regulator of Akt in mouse liver, fat, and pancreas. In a …

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Functional Imaging Of Excitable Cells: Retinal Neurons And Pancreatic Islet Beta Cells, Yichao Li Jan 2011

Functional Imaging Of Excitable Cells: Retinal Neurons And Pancreatic Islet Beta Cells, Yichao Li

All ETDs from UAB

Stimulus-evoked fast intrinsic optical signals (IOSs) have time courses comparable to electrophysiological kinetics, and thus promise a sub-cellular and sub-second resolution method for functional evaluation of excitable biological tissues. The objective of my thesis research is to validate and characterize IOS imaging of stimulus-evoked activities in the retina and pancreatic islet ß-cells. In order to achieve this objective, three sets of experiments have been conducted. 1) Simultaneous measurement of retinal neurons functioning can enhance our understanding of the visual signal processing. In this stage of my study, I propose to demonstrate IOS imaging of retina slices that allows simultaneous monitoring …

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Erythropoiesis In The Absence Of Adult Hemoglobin, Shanrun Liu Jan 2011

Erythropoiesis In The Absence Of Adult Hemoglobin, Shanrun Liu

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The mammalian erythrocyte is a highly specialized blood cell that differentiates via an orderly series of committed progenitors in the bone marrow in a process termed erythropoiesis. During erythroid development, hemoglobin synthesis increases from early erythroid progenitors to mature enucleated red blood cells (RBCs). Although hemoglobin is the most extensively studied protein in history, the role, if any, that hemoglobin plays in erythroid development remains obscure. In this study, I ask the question what happens during erythropoiesis in the absence of hemoglobin. I demonstrate that my original hypothesis that excess free heme would accumulate in the absence of globin chain …

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Identification Of Putative Gene Targets Of Pgc-1alpha In The Brain: Insights Into Inhibitory Neuron Maturation, Physiology, And Behavior, Elizabeth Lucas Jan 2011

Identification Of Putative Gene Targets Of Pgc-1alpha In The Brain: Insights Into Inhibitory Neuron Maturation, Physiology, And Behavior, Elizabeth Lucas

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The transcriptional coactivator peroxisome proliferator activated receptor γ coactivator 1α (PGC-1α) is a master regulator of energy homeostasis in peripheral tissues, and it has been assumed that PGC-1α plays a similar role in the brain. Previous work has shown that PGC-1α localizes to neurons that express high levels of the enzyme glutamic acid decarboxylase of 67 kDa (GAD67) during early postnatal development, leading us to hypothesize that PGC-1α regulates gene expression primarily in GABAergic neurons. We initially investigated the distribution of inhibitory neuron markers in PGC-1α -/- mice and observed a striking reduction in expression of the Ca2+-binding protein parvalbumin …

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The Effects Of Simvastatin On Learning And Memory Mechanisms In Mice, Robert Mans Jan 2011

The Effects Of Simvastatin On Learning And Memory Mechanisms In Mice, Robert Mans

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Statins, a widely prescribed class of cholesterol-lowering drug, inhibit HMG-CoA reductase, the rate-limiting enzyme in the cholesterol biosynthetic pathway. Due to the identification of cholesterol as a risk factor for developing Alzheimer's disease (AD), a number of studies have examined whether statins are neuroprotective against developing AD or dementia. While some epidemiological studies do indicate a lower prevalence of AD in people taking statins, other reports are contradictory. A consensus has therefore not been reached regarding the neuroprotective effects of statin treatment. Aside from the well-characterized reduction in circulating cholesterol resulting from statin therapy, numerous cholesterol-independent, pleiotropic effects have been …

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Analysis Of Nphp Complex Genetic Interactions Associated With Human Cilia Disorders, Svetlana Viktorovna Masyukova Jan 2011

Analysis Of Nphp Complex Genetic Interactions Associated With Human Cilia Disorders, Svetlana Viktorovna Masyukova

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Primary cilia are antenna-like organelles that extend from the surface of almost all mammalian cell types. They regulate many signaling pathways and sense physical and chemical changes in the extracellular environment. Defects in primary cilia cause several human disorders of different severity collectively called ciliopathies, including nephronophthisis (NPHP), Joubert syndrome (JBTS), and Meckel-Gruber syndrome (MKS). Numerous MKS, JBTS and NPHP genes have been identified but in most cases of these ciliopathies the genetic defect is unknown. Despite the fact that NPHP, JBTS and MKS patients present with distinct clinical features, they have mutations in identical genes. This can be explained …

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Care For Development - Picture Booklet, Aga Khan University Jan 2011

Care For Development - Picture Booklet, Aga Khan University

The Centre of Excellence in Women and Child Health (CEWCH) Archives

Care For Development - Appraisal Tool For Assessing And Monitoring Child Development First Three Years (Picture Booklet)

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The Graphic Novel: A Frontier Literary Form Edges Towards The English Classroom, Malgorzata Pflueger-Pieczynska Jan 2011

The Graphic Novel: A Frontier Literary Form Edges Towards The English Classroom, Malgorzata Pflueger-Pieczynska

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Graphic novels, as not yet fully researched and examined forms under academia, suffer from their association in the public mind with the advertisement industry and cheap subject matter. This negative affiliation is especially popular in teachers' circles that use the graphic novel mostly as an instrument to improve reading skills rather than to present it as an extraordinary example of a frontier literary form. The graphic novel is one of many products that took off dynamically with the technological revolution using the visual as a communication's medium. Visual communication is not only one of the leading forms of passing information, …

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