Digital Commons Network^™

Penitence [Dictionary Entry], M. Therese Lysaught

Theology Faculty Research and Publications

No abstract provided.

Infanticide [Dictionary Entry], M. Therese Lysaught

Theology Faculty Research and Publications

No abstract provided.

A Statin-Regulated Microrna Represses C-Myc Expression And Function., Apana Agha L. Takwi 1980-

Electronic Theses and Dissertations

c-Myc dysregulation is one of the most common abnormalities found in human cancer. MicroRNAs (miRNAs) are functionally intertwined with the c-Myc network as multiple miRNAs are regulated by c-Myc, while others directly suppress c-Myc expression. In this work, we identified miR-33b as a primate-specific negative regulator of c-Myc. The human miR-33b gene is located at 17pl1.2, a genomic locus frequently lost in medulloblastomas, which are pediatric brain tumors that display c-Myc overproduction. Through a small-scale screening with drugs approved by the US Food and Drug Administration (FDA), we found that lovastatin up-regulated miR-33b expression, reduced cell proliferation, and impaired c-Myc …

Cost Of A Tax Agenda: The Passage Of Proposition A And Its Effect On Kansas City And St. Louis City, The, Missy Mccoy

Missouri Law Review

This Law Summary begins with a discussion of the history of the earnings tax in Kansas City and St. Louis City starting with both cities' designations as home rule cities.10 Being home rule cities allowed them independence in governing their populace and the eventual implementation of an earnings tax through city charters and state enabling statutes. Next, this Law Summary discusses Proposition A's repeal of the previous enabling statutes, the institution of new statutes, and the prohibition of any other city from passing an earnings tax. This Law Summary takes the position that Proposition A, funded largely by St. Louis-area …

Picking Fights In Missouri: Baldwin's Non-Rule Embraces The Minority Approach To Internet Libel Jurisdiction, Allison Marie Isaak

Missouri Law Review

The competing standards of Internet libel jurisdiction reflect the tensions between the forum state's interest in providing convenient recovery for its injured residents and the defendant's constitutional right to foresee where he might be subject to jurisdiction. In an effort to pursue these two goals as well as integrate modem Internet-related concerns, lower courts have derived numerous divergent tests for Internet libel jurisdiction, leaving the issue in a state of disorder and ambiguity. To analyze this problem, this Note will first survey the historical background of traditional personal jurisdiction principles, with particular emphasis on the U.S. Supreme Court's Calder "effects" …

Forage News [2011-11], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• Brent White is Kentucky Forage Spokesman
• KFGC Presents Awards
• KFGC Nominating Committee Report
• AFGC Coming to Louisville
• Forages at KCA
• Selling & Shipping Hay to Texas and Other Southern Tier States
• Hay Production Changes in Kentucky
• Climate Change Effects on Forage Quality of Kentucky Hay Fields
• Be Alert to Health Risks When Grazing Turnips

Case Studies Of At-Risk Middle Grades Students And Literacy Applications Including Technology, Francine Falk-Rose, Principal Investigator

Cornerstone 1 Reports : Expansion and Enhancements of the Thinkfinity Platform

No abstract provided.

Does The Cycad Genotoxin Mam Implicated In Guam Als-Pdc Induce Disease-Relevant Changes In Mouse Brain That Includes Olfaction?, Glen Kisby, Valerie Palmer, Mike Lasarev, Rebecca Fry, Mihail Iordanov, Eli Magun, Leona Samson, Peter Spencer

CUP Faculty Research

Western Pacific amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia complex (PDC), a prototypical neurodegenerative disease (tauopathy) affecting distinct genetic groups with common exposure to neurotoxic chemicals in cycad seed, has many features of Parkinson's and Alzheimer's diseases (AD), including early olfactory dysfunction. Guam ALS-PDC incidence correlates with cycad flour content of cycasin and its aglycone methylazoxymethanol (MAM), which produces persistent DNA damage (O⁶-methylguanine) in the brains of mice lacking O⁶-methylguanine methyltransferase (Mgmt^-/-). We described in Mgmt^-/-mice up to 7 days post-MAM treatment that brain DNA damage was linked to brain gene …

Molecular Characterization Of The Host Defense Activity Of The Barrier To Autointegration Factor Against Vaccinia Virus, Nouhou Ibrahim, April Wicklund, Matthew S. Wiebe

Nebraska Center for Virology: Faculty Publications

The barrier to autointegration factor (BAF) is an essential cellular protein with functions in mitotic nuclear reassembly, retroviral preintegration complex stability, and transcriptional regulation. Molecular properties of BAF include the ability to bind double-stranded DNA in a sequence-independent manner, homodimerize, and bind proteins containing a LEM domain. These capabilities allow BAF to compact DNA and assemble higher-order nucleoprotein complexes, the nature of which is poorly understood. Recently, it was revealed that BAF also acts as a potent host defense against poxviral DNA replication in the cytoplasm. Here, we extend these observations by examining the molecular mechanism through which BAF acts …

Species D Adenoviruses As Oncolytics Against B-Cell Cancers, Christopher Y. Chen, Julien S. Senac, Eric A. Weaver, Shannon M. May, Diane F. Jelinek, Philip Greipp, Thomas Witzig, Michael A. Barry

Nebraska Center for Virology: Faculty Publications

Purpose: Oncolytic viruses are self-amplifying anticancer agents that make use of the natural ability of viruses to kill cells. Adenovirus serotype 5 (Ad5) has been extensively tested against solid cancers, but less so against B-cell cancers because these cells do not generally express the coxsackie and adenoviral receptor (CAR). To determine whether other adenoviruses might have better potency, we "mined" the adenovirus virome of 55 serotypes for viruses that could kill B-cell cancers.

Experimental Design: Fifteen adenoviruses selected to represent Ad species B, C, D, E, and F were tested in vitro against cell lines and primary patient B-cell cancers …

Law Library Newsletter, Volume 3, Issue 4 - November/December 2011, Kresge Law Library

Law Library Newsletter

Learn helpful info about exam time, Explore some recent rare ac-quisitions to the library collection, Hear an account about the late Stanley Kresge, for whom the library is named, See photos from the annual law school trick-or-treat, Rare books, STANLEY KRESGE: A BRIEF REFLECTION

Family Affairs Newsletter 2011-11-01, Zack Paakkonen

Family Affairs newsletter (2004-2016)

FAMILY AFFAIRS was a free, twice-a-month, social activities newsletter for the GLBTQI (gay/lesbian/bisexual/trans/queer/intersex) community, sent out around the 1st and 15th of each month. It covered the State of Maine only. The list was begun and maintained for many years by Jean Vermette in Bangor, and later operated by Zack Paakkonen of Portland. Over the years it evolved from a social activities newsletter into a business directory, classified ad service, and community bulletin board.

“That’S How You Know.”: Exploring Young Children’S Roles In Meaning Construction, Anne E. Gregory, Mary Ann Cahill

Literacy, Language and Culture Faculty Publications and Presentations

Within the classroom, literacy learning plays a central role in what children are asked to adopt to be full functioning members of the culture. Children are asked to negotiate the signs of texts, as well as those of the classroom and larger society. The process of learning to read and write, needless to say, is a complex one. Research in reading has shown that to teach children how to participate in this culture successfully, teachers must build upon what children do well in a meaningful context (Calkins, 1980; Wray, 1997) as opposed to the teaching of skills and items in …

Histomorphometric Changes In Repaired Mouse Sciatic Nerves Are Unaffected By The Application Of A Scar-Reducing Agent, Wei Cheong Ngeow, S. Atkins, C.R. Morgan, A.D. Metcalfe, F.M. Boissonade, A.R. Loescher, P.P. Robinson

Research Publications (2011 to 2015)

Microsurgical repair of transected peripheral nerves is compromised by the formation of scar tissue and the development of a neuroma, thereby limiting the success of regeneration. The aim of this study was to quantify histomorphometrically the structural changes in neural tissue that result from repair, and determine the effect of mannose-6-phosphate (M6P), a scar-reducing agent previously shown to enhance regeneration. In anaesthetised C57-black-6 mice, the left sciatic nerve was sectioned and repaired using four epineurial sutures. Either 100 mu L of 600 mM M6P (five animals) or 100 mu L of phosphate-buffered saline (placebo controls, five animals) was injected into …

Histomorphometric Changes In Repaired Mouse Sciatic Nerves Are Unaffected By The Application Of A Scar-Reducing Agent, W. C. Ngeow, S. Atkins, C. R. Morgan, A. D. Metcalfe, F. M. Boissonade, A. R. Loescher, P. P. Robinson

Research Publications (2011 to 2015)

Microsurgical repair of transected peripheral nerves is compromised by the formation of scar tissue and the development of a neuroma, thereby limiting the success of regeneration. The aim of this study was to quantify histomorphometrically the structural changes in neural tissue that result from repair, and determine the effect of mannose-6-phosphate (M6P), a scar-reducing agent previously shown to enhance regeneration. In anaesthetised C57-black-6 mice, the left sciatic nerve was sectioned and repaired using four epineurial sutures. Either 100 mu L of 600 mM M6P (five animals) or 100 mu L of phosphate-buffered saline (placebo controls, five animals) was injected into …

Boron Stress Activates The General Amino Acid Control Mechanism And Inhibits Protein Synthesis, Irem Uluisik, Alaattin Kaya, Dmitri E. Fomenko, Huseyin C. Karakaya, Bradley A. Carlson, Vadim N. Gladyshev, Ahmet Koc

Department of Biochemistry: Faculty Publications

Boron is an essential micronutrient for plants, and it is beneficial for animals. However, at high concentrations boron is toxic to cells although the mechanism of this toxicity is not known. Atr1 has recently been identified as a boron efflux pump whose expression is upregulated in response to boron treatment. Here, we found that the expression of ATR1 is associated with expression of genes involved in amino acid biosynthesis. These mechanisms are strictly controlled by the transcription factor Gcn4 in response to boron treatment. Further analyses have shown that boron impaired protein synthesis by promoting phosphorylation of eIF2α in a …

Engaging The Legal Academy In Disaster Response, Davida Finger, Laila Hlass, Anne S. Hornsby, Susan S. Kuo, Rachel A. Van Cleave

Seattle Journal for Social Justice

No abstract provided.

Radical-Containing Particles Activate Dendritic Cells And Enhance Th17 Inflammation In A Mouse Model Of Asthma, Pingli Wang, Paul Thevenot, Jordy Saravia, Terry Ahlert, Stephania A. Cormier

Faculty Publications

We identified a previously unrecognized component of airborne particulate matter (PM) formed in combustion and thermal processes, namely, environmentally persistent free radicals (EPFRs). The pulmonary health effects of EPFRs are currently unknown. In the present study, we used a model EPFR-containing pollutant-particle system referred to as MCP230. We evaluated the effects of MCP230 on the phenotype and function of bone marrow - derived dendritic cells (BMDCs) in vitro and lung dendritic cells (DCs) in vivo, and the subsequent T-cell response. We also investigated the adjuvant role of MCP230 on airway inflammation in a mouse model of asthma. MCP230 decreased intracellular …

Draft Environmental Assessment - Biomedical Research Facility Ii, University Of Texas At Brownsville

Campus Master Plans (UTB/UTPA)

The Environmental Assessment (EA) was prepared in accordance with U.S. Department of Health and Human Services (HHS) guidelines, implementing the National Environmental Policy Act of 1969 (NEPA). The EA evaluates the environmental impacts of the proposed Biomedical Research Facility II (BRF II) laboratory expansion at the University of Texas at Brownsville/Texas Southmost College (UTB) campus. The NIH aims to partially fund this project, addressing the critical need for modern laboratory space to support transdisciplinary biomedical research. The No Action Alternative was also considered, but it would not meet the project’s purpose and need. Despite minor design changes, potential environmental impacts …

Unhinged, Gayane Bagdasaryan

Theses

"Unhinged" is an animated graduate thesis film 7 minutes, 30 seconds long, which was originally conceived as a story about decision making, and it turned into a story about loneliness and an acceptance of it. It tells a story of a troll, Lancelot, who carries on a lonely life in a neglected cabin in the middle of a desert. He entertains himself by playing masquerade with his friends, mannequins-hat-holders. One day he hears a knock on the door and struggles with fear to open the door. This film is a hand-drawn animation that was mostly produced in TVPaint Animation Software. …

Anthropology & Open Access: An Interview With Jason Baird Jackson, Ryan B. Anderson

Faculty Publications

During the last few weeks I had the chance to conduct an email based interview with Jason Baird Jackson about Open Access (OA), academic publishing, and anthropology...

Poem No. 106, November 2011, Huntsville Literary Association (Huntsvile, Ala.)

POEM

The Huntsville Literary Association was founded in 1967 to provide a community for writers, readers, and artists through workshops, readings, and educational programs. One of their key contributions is the literary magazine titled POEM which showcases original writings from both established and emerging writers. This issue features poems from various writers.

Elimination Of The Nlrp3-Asc Inflammasome Protects Against Chronic Obesity-Induced Pancreatic Damage, Yun Hee Youm, Ayinuer Adijiang, Bolormaa Vandanmagsar, David Burk, Anthony Ravussin, Vishwa Deep Dixit

Faculty Publications

Clinical evidence that the blockade of IL-1β in type-2 diabetic patients improves glycemia is indicative of an autoinflammatory mechanism that may trigger adiposity-driven pancreatic damage. IL-1β is a key contributor to the obesity-induced inflammation and subsequent insulin resistance, pancreatic β-cell dysfunction, and the onset of type 2 diabetes. Our previous studies demonstrated that the ceramides activate the Nod-like receptor family, pyrin domain containing 3 (Nlrp3) inflammasome to cause the generation of mature IL-1β and ablation of the Nlrp3 inflammasome in diet-induced obesity improves insulin signaling. However, it remains unclear whether the post-translational processing of active IL-1β in pancreas is regulated …

Improving Commercial Fishing Access Rights In Western Australia, Department Of Fisheries

Fisheries Occasional Publications

Access Rights Working Group Report to the Hon Norman Moore, MLC Minister for Fisheries

The Characteristics Of Borrelia Hermsii Infection In Human Hematopoeitic Stem Cell-Engrafted Mice Mirror Those Of Human Relapsing Fever, Raja Vuyyuru, Hongqi Liu, Tim Manser, Kishore Alugupalli

Department of Microbiology and Immunology Faculty Papers

Rodents are natural reservoirs for a variety of species of Borrelia that cause relapsing fevers in humans. The murine model of this disease recapitulates many of the clinical manifestations of the human disease and has revealed that T cell-independent antibody responses are required to resolve the bacteremic episodes. However, it is not clear whether such protective humoral responses are mounted in humans.

November 2011 Newsletter, Career Center, Illinois Wesleyan University

Career Connections Newsletter

Issue Highlights:

• Beyond the Bubble - Student Profile: Lindsay Starr '12, Katie Rose Brosnan '13
• IWU Alum Dazzles Audiences Worldwide with Dreamworks
• What Do Employers Look For, Anyway?

Motive Strength As A Predictor Of Goal Importance, Jeffrey Dohm

Master's Theses or Doctor of Nursing Practice

The present study sought to examine whether motivation as measured by 16 motives the Reiss Profile of Fundamental Goals and Motivation Sensitivities could predict the relative importance of goals as measured by the Aspiration Index. Five motive goal relationships were targeted as being prime candidates, Status – Popularity, Social Contact – Affiliation, Romance – Hedonism, Acceptance – Conformity, and Idealism – Community Feeling. 101 undergraduate students were administered both surveys. The results indicated that motivation did predict goal importance in all but one motive and goal pair. In addition, multiple regression analysis indicated motivation predicted goal importance for nine of …

State Of The Nation: K–12 Online Learning In Canada, Michael K. Barbour

Education Faculty Publications

A variety of initiatives are driving online and blended learning in each of Canada’s provinces and territories. From teachers’ unions in Nova Scotia fighting to ensure online learning is an accepted method of educational delivery, to Ontario’s College of Teachers creating an e-learning endorsement for teachers or the British Columbia government creating policies to expand the growth and opportunities online learning provides, there are multiple, isolated initiatives happening across the country.

State of the Nation: K-12 Online Learning in Canada is now in its fourth year of publication and can be seen as a national guide for understanding the field …

Nebline, November/December 2011

NEBLINE Newsletter Archive from Nebraska Extension in Lancaster County

Feature: Avoid Guessing About Holiday Food Safety

Farm Views

Horticulture

Food & Fitness

Home & Family Living

Environmental Focus

Urban Agriculture

4-H & Youth

Community Focus

Extension Calendar

Nutrition Education Program

Family and Community Education (FCE) Clubs

and other extension news and events

Cultural Metaphors: Their Use In Management Practice As A Method For Understanding Cultures, Martin J. Gannon

Online Readings in Psychology and Culture

This paper argues that the dimensional perspective on culture, arguably the most important development in cross-cultural understanding in 50 years, needs to be supplemented by in-depth treatments of national cultures. Such a treatment is the goal of a cultural metaphor, which is any activity, phenomenon, or institution with which members of a given culture emotionally and/or cognitively identify. As such, cultural metaphors reflect the underlying values of a culture. Examples of national cultural metaphors include the Japanese garden, the Chinese family altar, and American Football. The paper also argues that the focus on specific national cultures can lead to the …