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2011

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Dtorsin, The Drosophila Ortholog Of The Early-Onset Dystonia Tor1a (Dyt1), Plays A Novel Role In Dopamine Metabolism, Noriko Wakabayashi-Ito, Olugbenga M. Doherty, Hideaki Moriyama, Xandra O. Breakefield, James F. Gusella, Janis M. O’Donnell, Naoto Ito Jan 2011

Dtorsin, The Drosophila Ortholog Of The Early-Onset Dystonia Tor1a (Dyt1), Plays A Novel Role In Dopamine Metabolism, Noriko Wakabayashi-Ito, Olugbenga M. Doherty, Hideaki Moriyama, Xandra O. Breakefield, James F. Gusella, Janis M. O’Donnell, Naoto Ito

School of Biological Sciences: Faculty Publications

Dystonia represents the third most common movement disorder in humans. At least 15 genetic loci (DYT1-15) have been identified and some of these genes have been cloned. TOR1A (formally DYT1), the gene responsible for the most common primary hereditary dystonia, encodes torsinA, an AAA ATPase family protein. However, the function of torsinA has yet to be fully understood. Here, we have generated and characterized a complete loss-of-function mutant for dtorsin, the only Drosophila ortholog of TOR1A. Null mutation of the X-linked dtorsin was semi-lethal with most male flies dying by the prepupal stage and the few surviving …

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Effects Of Postmortem Interval And Preservation Method On Rna Isolated From Field-Preserved Avian Tissues Efectos Del Intervalo Post-Mortem Y Del Método De Preservación En El Arn Aislado De Tejidos De Aves Preservados En El Campo, Zachary A. Cheviron, Matthew D. Carling, Robb T. Brumfield Jan 2011

Effects Of Postmortem Interval And Preservation Method On Rna Isolated From Field-Preserved Avian Tissues Efectos Del Intervalo Post-Mortem Y Del Método De Preservación En El Arn Aislado De Tejidos De Aves Preservados En El Campo, Zachary A. Cheviron, Matthew D. Carling, Robb T. Brumfield

School of Biological Sciences: Faculty Publications

Studies of gene expression and transcriptome profiling often require the isolation of high-quality mRNA. Here, we examined how preservation method and the lag between collection and processing (postmortem interval; PMI) affect RNA quality and yield in field-collected samples. We subjected tissue samples of 11 House Sparrows (Passer domesticus) to two preservation treatments (flash freezing in liquid nitrogen versus treatment with Ambion’s RNAlater prior to freezing) and eight PMI treatments (intervals ranging from 0 to 360 min). Mean RNA yields were significantly higher for flash-frozen tissues. Total RNA yield, as measured by a UV-vis spectrophotometer (Nanodrop), was not negatively associated with …

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Evidence For Air Movement Signals In The Agonistic Behaviour Of A Nocturnal Arachnid (Order Amblypygi), Roger D. Santer, Eileen A. Hebets Jan 2011

Evidence For Air Movement Signals In The Agonistic Behaviour Of A Nocturnal Arachnid (Order Amblypygi), Roger D. Santer, Eileen A. Hebets

School of Biological Sciences: Faculty Publications

Many arthropods possess filiform hair sensilla (termed trichobothria in arachnids), which are extremely sensitive detectors of medium particle displacement. Electrophysiological evidence in some taxa suggests that these sensilla can detect air particle displacements resulting from intraspecific communication signals. However, it has not yet been shown for any species that the air particle displacements detected by the filiform hairs are themselves perceived as a ‘signal’ (i.e. that individuals make behavioural decisions based upon the responses of these organs to the displays of conspecifics). We investigate the agonistic behaviour of the whip spider Phrynus marginemaculatus and the role of its trichobothria in …

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Epigenetic Regulatory Mechanisms In Plants, Zoya Avramova Jan 2011

Epigenetic Regulatory Mechanisms In Plants, Zoya Avramova

School of Biological Sciences: Faculty Publications

Genomes are defined by their primary sequence, which provides the genetic blueprint of a species. Eukaryotic DNA functions within the context of chromatin, which provides additional layers of gene regulation referred to as “epigenetic.” The commonly found definition of epigenetics is that of a “study of heritable changes in genome function that occur without a change in DNA sequence.” However, evidence that neuronal gene-expression states are also regulated by epigenetic mechanisms, despite evidence that neuronal cells do not divide, has opened space for a broader unifying definition that keeps “the sense of prevailing usage but avoids constraints imposed by stringently …

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The Arabidopsis Trithorax-Like Factor Atx1 Functions In Dehydration Stress Responses Via Aba-Dependent And Aba-Independent Pathways, Yong Ding, Zoya Avramova, Michael Fromm Jan 2011

The Arabidopsis Trithorax-Like Factor Atx1 Functions In Dehydration Stress Responses Via Aba-Dependent And Aba-Independent Pathways, Yong Ding, Zoya Avramova, Michael Fromm

School of Biological Sciences: Faculty Publications

Emerging evidence suggests that the molecular mechanisms driving the responses of plants to environmental stresses are associated with specific chromatin modifications. Here, we demonstrate that the Arabidopsis trithorax-like factor ATX1, which trimethylates histone H3 at lysine 4 (H3K4me3), is involved in dehydration stress signaling in both abscisic acid (ABA)-dependent and ABA-independent pathways. The loss of function of ATX1 results in decreased germination rates, larger stomatal apertures, more rapid transpiration and decreased tolerance to dehydration stress in atx1 plants. This deficiency is caused in part by reduced ABA biosynthesis in atx1 plants resulting from decreased transcript levels from NCED3, which …

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Geographic Distribution: Osteopilus Septentrionalis (Cuban Treefrog). Usa: Florida: Bradford Co., Linda S. Stevenson, Louis A. Somma Jan 2011

Geographic Distribution: Osteopilus Septentrionalis (Cuban Treefrog). Usa: Florida: Bradford Co., Linda S. Stevenson, Louis A. Somma

Papers in Herpetology

OSTEOPILUS SEPTENTRIONALIS (Cuban Treefrog). USA: FLORIDA: B IlAI)flOIlD Co.: Starke. 703 South Orange Street (29.940 15"N, 82. 11532S'W; WGS84) . 12 December 2009. Linda S. Sleven son. Verified by Melvin P. Gra.mke. Florida Museum of Natural History. University of Florida. UF 162973. First county record (Meshaka et al. 2004. The Exotic Amphibians and Reptiles of Florida. Krieger Publ. Co., Malabar, Florida; Somma 2009. In Nonindigenous Aq uatic Species. USGS: hI rp: II nas.e r.usgs.gov I q ue ries! FactSheet. asp?specieslD=57). One adult collected from inside a mailbox on wall of a residence. Individ ual O. septentrionalis have been sighted at …

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Complex Courtship Displays Facilitate Male Reproductive Success And Plasticity In Signaling Across Variable Environments, Dustin Wilgers, Eileen Hebets Jan 2011

Complex Courtship Displays Facilitate Male Reproductive Success And Plasticity In Signaling Across Variable Environments, Dustin Wilgers, Eileen Hebets

Eileen Hebets Publications

Effective signal transmission is essential for communication. In environments where signal transmission is highly variable, signalers may utilize complex signals, which incorporate multiple components and modalities, to maintain effective communication. Male Rabidosa rabida wolf spiders produce complex courtship signals, consisting of both visual and seismic components. We test the hypothesis that the complex signaling of R. rabida contributes to male reproductive success in variable signaling environments. We first examine the condition-dependence of foreleg ornamentation (a presumed visual signal) and seismic signal components and find that both may provide potentially redundant information on foraging history. Next, we assessed reproductive success across …

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Chemical Communication In A Multimodal Context, Eileen A. Hebets, Aaron S. Rundus Jan 2011

Chemical Communication In A Multimodal Context, Eileen A. Hebets, Aaron S. Rundus

Eileen Hebets Publications

All animals are equipped with multiple sensory systems (e.g., visual, chemical, acoustic, tactile, electrical, thermal), and signals perceived via these sensory systems facilitate communication. Such communication often involves displays that incorporate more than one signal from more than one sensory modality, resulting in multimodal signaling. The number of empirical and theoretical studies addressing issues of multimodal signaling is ever-increasing and this chapter highlights why crustaceans, as a taxonomic group, are ideal for advancing such studies. Early classifications of multimodal signaling sought to categorize signal components as either redundant or nonredundant, while more recent classifications lay out specific hypotheses relating to …

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The Degree Of Response To Increased Predation Risk Corresponds To Male Secondary Sexual Traits, Kasey Fowler-Finn, Eileen Hebets Jan 2011

The Degree Of Response To Increased Predation Risk Corresponds To Male Secondary Sexual Traits, Kasey Fowler-Finn, Eileen Hebets

Eileen Hebets Publications

Secondary sexual traits are expected to reflect a balance between sexual selection and natural selection. We test the hypothesis that plasticity in sexual advertisement behaviors can influence this trade-off, allowing showier traits than expected for a given level of predation risk. Specifically, we tested whether the degree of behavioral plasticity exhibited in response to chemical cues of a co-occurring predatory wolf spider corresponds to courtship rate and the degree of ornamentation in male wolf spiders. Both ornamented (brush-legged) males and non-ornamented males decreased locomotion, decreased their likelihood to court, and increased their time to initiate courtship in response to predator …

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Sex Chromosome-Specific Regulation In The Drosophila Male Germline But Little Evidence For Chromosomal Dosage Compensation Or Meiotic Inactivation, Colin D. Meiklejohn, Emily L. Landeen, Jodi M. Cook, Sarah B. Kingan, Daven C. Presgraves Jan 2011

Sex Chromosome-Specific Regulation In The Drosophila Male Germline But Little Evidence For Chromosomal Dosage Compensation Or Meiotic Inactivation, Colin D. Meiklejohn, Emily L. Landeen, Jodi M. Cook, Sarah B. Kingan, Daven C. Presgraves

School of Biological Sciences: Faculty Publications

The evolution of heteromorphic sex chromosomes (e.g., XY in males or ZW in females) has repeatedly elicited the evolution of two kinds of chromosome-specific regulation: dosage compensation—the equalization of X chromosome gene expression in males and females— and meiotic sex chromosome inactivation (MSCI)—the transcriptional silencing and heterochromatinization of the X during meiosis in the male (or Z in the female) germline. How the X chromosome is regulated in the Drosophila melanogaster male germline is unclear. Here we report three new findings concerning gene expression from the X in Drosophila testes. First, X chromosome-wide dosage compensation appears to be absent from …

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Developmental Regulation Of Hemoglobin Synthesis In The Green Anole Lizard Anolis Carolinensis, Jay F. Storz, Federico G. Hoffmann, Juan C. Opazo, Thomas J. Sanger, Hideaki Moriyama Jan 2011

Developmental Regulation Of Hemoglobin Synthesis In The Green Anole Lizard Anolis Carolinensis, Jay F. Storz, Federico G. Hoffmann, Juan C. Opazo, Thomas J. Sanger, Hideaki Moriyama

Jay F. Storz Publications

Tetrapod vertebrates possess multiple alpha- and beta-like globin genes that are ontogenetically regulated, such that functionally distinct hemoglobin (Hb) isoforms are synthesized during different stages of development. The alpha- and beta-like globin genes of amphibians, birds and mammals are differentially expressed during embryonic development and postnatal life, but little is known about the developmental regulation of globin gene expression in non-avian reptiles. Here we report an investigation into the developmental regulation of Hb synthesis in the green anole lizard Anolis carolinensis. We tested two hypotheses derived from comparative genomic studies of the globin gene clusters in tetrapod vertebrates. First, …

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Evolutionary Origins Of Oxygen Sensing In Animals, Kalle T. Rytkönen, Jay F. Storz Jan 2011

Evolutionary Origins Of Oxygen Sensing In Animals, Kalle T. Rytkönen, Jay F. Storz

Jay F. Storz Publications

All animal life requires molecular oxygen as the terminal electron acceptor in aerobic energy production. A lack of oxygen can reduce the rate of energy production, whereas an excess of oxygen leads to the accumulation of toxic reactive oxygen species. Hence, animals have evolved sophisticated mechanisms with which to monitor and respond to fluctuations in oxygen availability, in order to maintain cellular homeostasis. In all animal taxa examined so far, the maintenance of physiological oxygen homeostasis is mediated by the oxygen-dependent post-translational hydroxylation of a heterodimeric transcription factor, termed hypoxia-inducible factor (HIF; Kaelin & Ratcliffe, 2008). The hydroxylation reaction is …

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Differential Loss And Retention Of Cytoglobin, Myoglobin, And Globin-E During The Radiation Of Vertebrates, Federico G. Hoffmann, Juan C. Opazo, Jay F. Storz Jan 2011

Differential Loss And Retention Of Cytoglobin, Myoglobin, And Globin-E During The Radiation Of Vertebrates, Federico G. Hoffmann, Juan C. Opazo, Jay F. Storz

Jay F. Storz Publications

If rates of postduplication gene retention are positively correlated with levels of functional constraint, then gene duplicates that have been retained in a restricted number of taxonomic lineages would be expected to exhibit relatively low levels of sequence conservation. Paradoxical patterns are presented by gene duplicates that have been retained in a small number of taxa but which are nonetheless subject to strong purifying selection relative to paralogous members of the same multigene family. This pattern suggests that such genes may have been co-opted for novel, lineage-specific functions. One possible example involves the enigmatic globin-E gene (GbE), which …

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Experimental Approaches To Evaluate The Contributions Of Candidate Protein-Coding Mutations To Phenotypic Evolution, Jay F. Storz, Anthony J. Zera Jan 2011

Experimental Approaches To Evaluate The Contributions Of Candidate Protein-Coding Mutations To Phenotypic Evolution, Jay F. Storz, Anthony J. Zera

Jay F. Storz Publications

Identifying mechanisms of molecular adaptation can provide important insights into the process of phenotypic evolution, but it can be exceedingly difficult to quantify the phenotypic effects of specific mutational changes. To verify the adaptive significance of genetically based changes in protein function, it is necessary to document functional differences between the products of derived and wild-type alleles and to demonstrate that such differences impinge on higher-level physiological processes (and ultimately, fitness). In the case of metabolic enzymes, this requires documenting in vivo differences in reaction rate that give rise to differences in flux through the pathway in which the enzymes …

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Glypican-3 Targeting Of Liver Cancer Cells Using Multifunctional Nanoparticles, James O. Park, Zachary Stephen, Conory Sun, Omid Veiseh, Forrest M. Kievit, Chen Fang, Matthew Leung, Hyejung Mok, Miqin Zhang Jan 2011

Glypican-3 Targeting Of Liver Cancer Cells Using Multifunctional Nanoparticles, James O. Park, Zachary Stephen, Conory Sun, Omid Veiseh, Forrest M. Kievit, Chen Fang, Matthew Leung, Hyejung Mok, Miqin Zhang

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Imaging is essential in accurately detecting, staging, and treating primary liver cancer (hepatocellular carcinoma [HCC]), one of the most prevalent and lethal malignancies. We developed a novel multifunctional nanoparticle (NP) specifically targeting glypican-3 (GPC3), a proteoglycan implicated in promotion of cell growth that is overexpressed in most HCCs. Quantitative real-time polymerase chain reaction was performed to confirm the differential GPC3 expression in two human HCC cells, Hep G2 (high) and HLF (negligible). These cells were treated with biotin-conjugated GPC3 monoclonal antibody (aGPC3) and subsequently targeted using superparamagnetic iron oxide NPs conjugated to streptavidin and Alexa Fluor 647. Flow cytometry demonstrated …

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Dur3 Is The Major Urea Transporter In Candida Albicans And Is Co-Regulated With The Urea Amidolyase Dur1,2, Dhammika H. M. L. P Navarathna, Aditi Das, Joachim Morschhauser, Kenneth W. Nickerson, David D. Roberts Jan 2011

Dur3 Is The Major Urea Transporter In Candida Albicans And Is Co-Regulated With The Urea Amidolyase Dur1,2, Dhammika H. M. L. P Navarathna, Aditi Das, Joachim Morschhauser, Kenneth W. Nickerson, David D. Roberts

Kenneth Nickerson Papers

Hemiascomycetes, including the pathogen Candida albicans, acquire nitrogen from urea using the urea amidolyase Dur1,2, whereas all other higher fungi use primarily the nickel-containing urease. Urea metabolism via Dur1,2 is important for resistance to innate host immunity in C. albicans infections. To further characterize urea metabolism in C. albicans we examined the function of seven putative urea transporters. Gene disruption established that Dur3, encoded by orf 19.781, is the predominant transporter. [14C]Urea uptake was energy-dependent and decreased approximately sevenfold in a dur3D mutant. DUR1,2 and DUR3 expression was strongly induced by urea, whereas the other putative transporter genes …

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Use Of Nape Tags For Marking Offspring Of Precocial Waterbirds, Todd W. Arnold, Daizaburo Shizuka, Bruce E. Lyon, Jeffrey T. Pelayo, Katherine R. Mehl, Joshua J. Traylor, Wendy L. Reed, Courtney L. Amundson Jan 2011

Use Of Nape Tags For Marking Offspring Of Precocial Waterbirds, Todd W. Arnold, Daizaburo Shizuka, Bruce E. Lyon, Jeffrey T. Pelayo, Katherine R. Mehl, Joshua J. Traylor, Wendy L. Reed, Courtney L. Amundson

Papers in Ornithology

Individualized markers that allow organisms to be identified without recapture are invaluable for studies of survival, movement, and behavior. Nape tags consisting of brass safety pins with unique combinations of two or three colored plastic beads were used to mark 5,868 American Coot (Fulica americana) chicks and 331 Ruddy Duck (Oxyura jamaicensis), 157 King Eider (Somateria spectabilis) and 664 White-winged Scoter (Melanitta fusca deglandi) ducklings. These markers allowed for documentation of parent-offspring interactions, post-hatching survival, brood movements and brood-mixing behaviors. Nape tags were inexpensive, easy to make, easy to observe with binoculars …

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Sparrows Use Multiple Status Signals In Winter Social Flocks, Alexis S. Chaine, Kris A. Tjernell, Daizaburo Shizuka, Bruce E. Lyon Jan 2011

Sparrows Use Multiple Status Signals In Winter Social Flocks, Alexis S. Chaine, Kris A. Tjernell, Daizaburo Shizuka, Bruce E. Lyon

Papers in Ornithology

Status signals are thought to reduce the potential costs of social conflict over resources by advertising social status to other group members and reducing unnecessary contests between individuals of differing abilities. Nearly all studies of status signals to date have focused on single signaling traits, and most studies that have investigated multiple traits did not examine whether different traits are used in different contexts, as is required for them to function as multiple signals. We examined the role of gold and black crown patches of wintering golden-crowned sparrows, Zonotrichia atricapilla, in determining social dominance during experimentally staged encounters between unfamiliar …

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Maize Cellulosic Biofuels: Soil Carbon Loss Can Be A Hidden Cost Of Residue Removal, Amy Kochsiek, Johannes Knops Jan 2011

Maize Cellulosic Biofuels: Soil Carbon Loss Can Be A Hidden Cost Of Residue Removal, Amy Kochsiek, Johannes Knops

School of Biological Sciences: Faculty Publications

Second generation biofuels, like cellulosic ethanol, have potential as important energy sources that can lower fossil fuel carbon emissions without affecting global food commodity prices. Agricultural crop residues, especially maize, have been proposed for use as biofuel, but the net greenhouse warming effect of the gained fossil fuel carbon offset needs to account for any ecosystem carbon losses caused by the large-scale maize residue removal. Using differential 13C isotopic ratios between residue and soil in an incubation experiment, we found that removal of residue increased soil organic matter decomposition by an average of 16%, or 540–800 kg carbon ha -1. …

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Erection Of Ibirhynchus Gen. Nov. (Acanthocephala: Polymorphidae), Based On Molecular And Morphological Data, Martin Garcia-Varela, Gerardo Pérez-Ponce De León, Francisco J. Aznar, Steven A. Nadler Jan 2011

Erection Of Ibirhynchus Gen. Nov. (Acanthocephala: Polymorphidae), Based On Molecular And Morphological Data, Martin Garcia-Varela, Gerardo Pérez-Ponce De León, Francisco J. Aznar, Steven A. Nadler

Harold W. Manter Laboratory of Parasitology: Faculty Publications

The genus Southwellina is composed of 3 described species, i.e., S. hispida (the type species), S. dimorpha, and S. macracanthus. All 3 are endoparasites of fish-eating birds that have worldwide distributions. Morphologically, the genus is characterized by possessing a short and compact trunk, 2 fields of spines in the anterior region of the trunk (in at least 1 sex), a short cylindrical proboscis (sometimes with a swollen region armed with numerous longitudinal rows of hooks), a double-walled proboscis receptacle, and 4 tubular cement glands in males. In the current study, specimens identified as S. dimorpha were collected from …

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Helminths Of Squirrels (Sciuridae) From Mongolia, David S. Tinnin, Sumiya Ganzorig, Scott Lyell Gardner Jan 2011

Helminths Of Squirrels (Sciuridae) From Mongolia, David S. Tinnin, Sumiya Ganzorig, Scott Lyell Gardner

Harold W. Manter Laboratory of Parasitology: Faculty Publications

Two species of ground squirrels, Urocitellus undulatus and Spermophilus alashanicus, were collected and examined for parasites from two localities in Mongolia in 1999. A total of 24 individuals of U. undulatus were examined resulting in a total of six taxa of helminths found, including: Ascaris tarbagan, Physaloptera massino, Streptopharagus kutassi, Anoplocephaloides transversaria, Hymenolepis suslica, and Moniliformis sp. This represents four new species records and an additional host record for the country. Two individuals of S. alashanicus were examined and found to be uninfected.

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Description Of Scottnema Lindsayae Timm, 1971 (Rhabditida: Cephalobidae) From Taylor Valley, Antarctica And Its Phylogenetic Relationship, Sven Boström, Oleksandr Holovachov, Steven A. Nadler Jan 2011

Description Of Scottnema Lindsayae Timm, 1971 (Rhabditida: Cephalobidae) From Taylor Valley, Antarctica And Its Phylogenetic Relationship, Sven Boström, Oleksandr Holovachov, Steven A. Nadler

Harold W. Manter Laboratory of Parasitology: Faculty Publications

The endemic Antarctic nematode Scottnema lindsayae is described from specimens collected in Taylor Valley, McMurdo Dry Valleys, Victoria Land. The recently collected material is compared with the original description and other subsequent descriptions of the species. A more complete scanning electron microscopy (SEM) study of the species is presented. The phylogenetic position of S. lindsayae is inferred using a secondary structure-based alignment of a partial sequence of nuclear Large Subunit (LSU) ribosomal DNA. Phylogenetic trees were inferred using base-paired substitution models implemented in PHASE 2 software and Bayesian inference, and show S. lindsayae as the sister group to Stegelletina taxa.

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Kant On Animal Consciousness, Colin Mclear Jan 2011

Kant On Animal Consciousness, Colin Mclear

Department of Philosophy: Faculty Publications

Consider two different ways of characterizing the cognitive requirements necessary for perceptual awareness of an objective physical world.1 On the one hand, objective perceptual awareness may only require the sensory capacity for awareness of particular physical individuals and their features, perhaps along with the minimal kinds of cognitive processing needed to integrate received sensory information with behavior. On the other hand, objective perceptual awareness may require not only these low-level cognitive capacities but also conceptual capacities, or perhaps even specific concepts.2 Call these two lines of thought regarding objective perpetual awareness non-conceptualism and conceptualism respectively.

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Monophyly Of Clade Iii Nematodes Is Not Supported By Phylogenetic Analysis Of Complete Mitochondrial Genome Sequences, Joong-Ki Park, Tahera Sultana, Sang-Hwa Lee, Seokha Kang, Hyong Kyu Kim, Gi-Sik Min, Keeseon S. Eom, Steven A. Nadler Jan 2011

Monophyly Of Clade Iii Nematodes Is Not Supported By Phylogenetic Analysis Of Complete Mitochondrial Genome Sequences, Joong-Ki Park, Tahera Sultana, Sang-Hwa Lee, Seokha Kang, Hyong Kyu Kim, Gi-Sik Min, Keeseon S. Eom, Steven A. Nadler

Harold W. Manter Laboratory of Parasitology: Faculty Publications

Abstract Background: The orders Ascaridida, Oxyurida, and Spirurida represent major components of zooparasitic nematode diversity, including many species of veterinary and medical importance. Phylum-wide nematode phylogenetic hypotheses have mainly been based on nuclear rDNA sequences, but more recently complete mitochondrial (mtDNA) gene sequences have provided another source of molecular information to evaluate relationships. Although there is much agreement between nuclear rDNA and mtDNA phylogenies, relationships among certain major clades are different. In this study we report that mtDNA sequences do not support the monophyly of Ascaridida, Oxyurida and Spirurida (clade III) in contrast to results for nuclear rDNA. Results from …

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Evaluation And Comparison Of The Species-Specificity Of 3 Antiparvalbumin Igg Antibodies, Poi-Wah Lee, Julie A. Nordlee, Stef J. Koppelman, Joseph L. Baumert, Steve L. Taylor Jan 2011

Evaluation And Comparison Of The Species-Specificity Of 3 Antiparvalbumin Igg Antibodies, Poi-Wah Lee, Julie A. Nordlee, Stef J. Koppelman, Joseph L. Baumert, Steve L. Taylor

Department of Food Science and Technology: Faculty Publications

Parvalbumin is a pan-allergen in fish and frogs that triggers IgE-mediated reactions in fish-allergic individuals. Previous studies demonstrated that antibodies raised against fish and frog parvalbumins displayed varying specificity for different fish species, and thus, the applicability of these antibodies for potential use in immunoassays to detect fish residues were limited. We aimed to determine the specificity of 3 IgG antibodies for various fish species. Indirect enzyme-linked immunosorbent assay (ELISA) and IgG-immunoblotting were used to compare the reactivity of the polyclonal anticod parvalbumin antibody and the commercially available, monoclonal antifrog and monoclonal anticarp parvalbumin antibodies against raw muscle extracts of …

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Systematic Revision Of The Northern Short-Tailed Shrew, Blarina Brevicauda (Say), Wm. David Webster, Nancy D. Moncrief, Jerry R. Choate, Hugh H. Genoways Jan 2011

Systematic Revision Of The Northern Short-Tailed Shrew, Blarina Brevicauda (Say), Wm. David Webster, Nancy D. Moncrief, Jerry R. Choate, Hugh H. Genoways

University of Nebraska State Museum: Mammalogy Papers

Short-tailed shrews, genus Blarina, are common inhabitants of a variety of terrestrial habitats in most of eastern North America. Of the 4 species currently recognized, the northern short-tailed shrew, Blarina brevicauda (Say, 1823), is the most widely distributed, occurring from southern Canada southward to the central Great Plains and the Appalachian Mountains into Georgia and Alabama and along the East Coast as far south as southeastern North Carolina. It has been more than 65 years since geographic variation within this species has been studied. Accordingly, the objectives of this study were to examine geographic variation in Blarina brevicauda and …

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Online Sources Of Health Statistics In Saudi Arabia., Abdulmohsen H. Al-Zalabani Jan 2011

Online Sources Of Health Statistics In Saudi Arabia., Abdulmohsen H. Al-Zalabani

Saudi Medical Journal

Researchers looking for health statistics on the Kingdom of Saudi Arabia (KSA) may face difficulty. This is partly due to the lack of awareness of potential sources where such statistics can be found. The purpose of this paper is to review various online sources of health statistics on KSA, and to highlight their content, coverage, and presentation of health statistics. Five bibliographic databases where local research can be found are described. National registries available are summarized. Governmental agencies, as well as societies and centers where the bulk of health statistics is produced are also described. Finally, some potential international sources …

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A Study Of 131iodine Labeling Of Indomethacin, Its In Vivo Biological Distribution In Lewis-Bearing Lung Cancer, And Its Induction Of Apoptosis In Lung Cancer., Jiu-Bo Cai, Cai-Xia Zhang, Jia-Wen Luo, Dong Wang Jan 2011

A Study Of 131iodine Labeling Of Indomethacin, Its In Vivo Biological Distribution In Lewis-Bearing Lung Cancer, And Its Induction Of Apoptosis In Lung Cancer., Jiu-Bo Cai, Cai-Xia Zhang, Jia-Wen Luo, Dong Wang

Saudi Medical Journal

OBJECTIVES: To study the synthesis of 131iodine (I) labeled histamine-indomethacin (His-IN), its in vivo distribution in Lewis-bearing mice, and its effects on suppression of Lewis lung cancer growth and induction of apoptosis. METHODS: The present study was carried out in the Experimental Research Center, Sheng Jing Hospital of China Medical University Hospital, Shenyang China between December 2008 and October 2009. Chemical synthesis of His-IN was carried out. Ninety-five C57 mice were allocated into 12 groups, and a series of experiments including the in vivo biological distribution of 131I-His-IN in C57 mice bearing Lewis lung cancer was explored, and the therapeutic …

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Benchmarking Inadvertent Perioperative Hypothermia Guidelines With The National Institute For Health And Clinical Excellence., Ali S. Al-Qahtani, Farouk M. Messahel Jan 2011

Benchmarking Inadvertent Perioperative Hypothermia Guidelines With The National Institute For Health And Clinical Excellence., Ali S. Al-Qahtani, Farouk M. Messahel

Saudi Medical Journal

OBJECTIVES: To improve standards of patients9 care and safety, we benchmarked our practice guidelines of prevention of inadvertent perioperative hypothermia with those of the National Institute for Health and Clinical Excellence (NICE) of the United Kingdom. METHODS: The study started in November 2008 and lasted for 18 months and was conducted at the Armed Forces Hospital, Wadi Al-Dawasir, Kingdom of Saudi Arabia. The NICE clinical guidelines (CG65) published in April 2008 were downloaded from its website. Each practiced item in our guidelines was compared with its equivalent of NICE guidelines, absent equivalent NICE guidelines on our list were immediately added …

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Control Of Intravenous Medication Wastage At A Teaching Hospital In Saudi Arabia., Abdulatif A. Al-Dhawailie Jan 2011

Control Of Intravenous Medication Wastage At A Teaching Hospital In Saudi Arabia., Abdulatif A. Al-Dhawailie

Saudi Medical Journal

OBJECTIVES: To investigate the intravenous (IV) medication wastage within the inpatient pharmacy services at a teaching hospital, and to highlight the main causes for such waste and propose a policy to minimize wastage based on the study findings. METHODS: For a one month period starting from September until October 2009, the returned and unused IV medications to the inpatient pharmacy in a teaching hospital at King Khalid University Hospital of King Saud University, Riyadh, Kingdom of Saudi Arabia were observed daily. Data were collected and evaluated. The causes of this problem were analyzed. RESULTS: Approximately 265 items of IV medication …

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