Digital Commons Network^™

Mechanisms Of Alpha]-Synuclein-Induced Neurodegenertaion In Parkinson's Disease And Stroke, Cherine Belal

Electronic Theses and Dissertations

Parkinson’s disease (PD) is a debilitating neurodegenerative disorder affecting one million Americans. Despite its social and economic impact, the pathological cascades that lead to neuron dysfunction and degeneration in PD are poorly understood. Endoplasmic reticulum (ER) stress has been implicated as an initiator or contributing factor in neurodegenerative diseases including PD. The ER is an organelle central to protein folding and intracellular Ca2+ homeostasis. Perturbations of these functions result in ER stress and upregulation of ER stress proteins, of which some have been implicated in counteracting ER stress-induced cell death. The mechanisms that lead to ER stress and how ER …

Effect Of Dimethylarginine Dimethylaminohydrolase In The Development Of Salt Sensitivity, Samar Abdulla Nasser

Wayne State University Dissertations

Salt sensitivity is associated with a rise in blood pressure (BP) occurring during sodium loading and/or a fall in BP during sodium restriction that exceeds random fluctuations in BP. Salt sensitivity is more common in African American than Caucasian hypertensives and is also present, in normotensive African Americans. The mechanism or mechanisms resulting in salt-sensitive hypertension are multiple and include both activation of the renin angiotensin system via increases in angiotensin II and reductions in the endogenous vasodilator, nitric oxide (NO). An important means of NO downregulation is through asymmetric dimethylarginine (ADMA), an endogenous NO inhibitor, which is largely metabolized …

How Much Should China Pollute?, John Copeland Nagle

Journal Articles

The debate concerning how much China should pollute is at the heart of international negotiations regarding climate change and environmental protection more generally. China is the world’s leading polluter and leading emitter of greenhouse gases. It insists that it has a right to emit as much as it wants in the future. China interprets the principle of “common but differentiated responsibilities” to mean that China has a responsibility to help avoid the harmful consequences associated with climate change, but that its responsibility is different from that imposed on the United States and the rest of the developed world. In fact, …

From Larva To Butterfly: Sophia In Ding Ling’S Miss Sophia’S Diary And Coco In Wei Hui’S Shanghai Baby, Xiaoqing Liu

Scholarship and Professional Work - LAS

Sophia and Coco are two characters in Ding Ling's Miss Sophia's Diary (1928/1995) and Wei Hui's Shanghai Baby (1999), respectively. Like a larva, Sophia, who enters society in the early twentieth century, is weak and immobile. Coco, who lives at the end of the twentieth century, is like a butterfly leading an outlandish lifestyle. The differences between Sophia and Coco reflect the achievement of official feminism, which liberated Chinese women from traditional patriarchal control in the social sense. However, gender issues for women remain unresolved. To fight against traditional patriarchy and especially challenge gender oppression in official feminism, both Sophia …

Visual Rhetoric And The Promotion Of Scientific Ideas: The Strange Case Of The Prion, Carol Reeves

Scholarship and Professional Work - LAS

In the field that investigates infectious brain diseases such as mad cow disease, the verbal and visual packaging of scientific visuals associated with identifying the agent, prion, its processes, and structure served the community ritual of establishing belief in a highly unorthodox phenomenon. Visual promotion fed into cultural expectations of single agents and simple processes, even though the actual agency and disease process have proven highly complex and perhaps unknowable.

Positive Selection Shaped The Convergent Evolution Of Independently Expanded Kallikrein Subfamilies Expressed In Mouse And Rat Saliva Proteomes, Robert C. Karn, Christina M. Laukaitis

Scholarship and Professional Work - LAS

We performed proteomics studies of salivas from the genome mouse (C57BL/6 strain) and the genome rat (BN/SsNHsd/Mcwi strain). Our goal was to identify salivary proteins with one or more of three characteristics that may indicate that they have been involved in adaptation: 1) rapid expansion of their gene families; 2) footprints of positive selection; and/or 3) sex-limited expression. The results of our proteomics studies allow direct comparison of the proteins expressed and their levels between the sexes of the two rodent species. Twelve members of the Mus musculus species-specific kallikrein subfamily Klk1b showed sex-limited expression in the mouse saliva proteomes. …

Singular And General Causal Relations: A Mechanist Perspective, Stuart Glennan

Scholarship and Professional Work - LAS

My aim in this paper is to make a case for the singularist view from the perspective of a mechanical theory of causation (Glennan 1996, 1997, 2010, forthcoming), and to explain what, from this perspective, causal generalizations mean, and what role they play within the mechanical theory.

Robots, Rights And Religion, James F. Mcgrath

Scholarship and Professional Work - LAS

If there is one area in which science fiction has failed to quickly become historical fact, it is in the field of artificial intelligence (A.I.). While some continue to prophesy that machine minds that are indistinguishable from human ones are just around the corner, many others in the field have become far more skeptical. All the while, there have been at least a few who have consistently found the whole idea problematic for reasons unrelated to our technical abilities, in particular the implications A.I. seems to have for our understanding of human personhood. For example, in his 1993 book The …

Current Status And Future Directions Of Research In Complex Signaling, Eileen Hebets

Eileen Hebets Publications

The term ‘complex signaling’ reflects a recent scientific focus on the multiple elements frequently incorporated into animal signals (reviewed in Candolin, 2003; Hebets and Papaj, 2005; Partan and Marler, 2005; Bro-Jorgensen, 2010). It embodies a new appreciation that signals used in communication are regularly composed of numerous components and that each component may individually vary in a number of ways. For example, signal components may vary in their time or mechanism of production, in the efficacy of their transmission, and/or in their mechanism of reception, among others. Employing the term ‘complex signaling’ reminds us of the need to maintain a …

Greener Pastures 7 - A Fresh Look At Nutrient Losses From Intensively Managed Pastures, Don Bennett, Bill Russell, Martin Staines, Richard Morris, Mike Bolland, John Lucey

Bulletins 4000 -

Dairy farmers in Western Australia have a long history of being concerned for the environment in which they live and work, from early involvement with Landcare District Committees through to participating in the various programs run in DairyCatch.

They have planted trees, organised soil testing programs, carried out salinity surveys and, more recently, have signed up for effluent, nutrient and irrigation water management programs. Many of these programs produce benefits both on and off the farm—they can improve the farm environment, increase farm productivity and reduce nutrient losses to surface and ground water. The wider community has supported farmers with …

The "Right" To Be Trafficked, Charles Piot

Indiana Journal of Global Legal Studies

The post-Cold War dispensation in Togo, West Africa, ushered in a new lexicon of politically salient terms, among them droits de 1'homme. Initially deployed in the early 1990s by members of the political opposition to expose dictatorial abuse, this potent signifier then found its way into society at large and, spurred by NGO support, was taken up by women's groups in struggles over gender inequality. This essay explores droits de l'homme's itinerary in the villages of northern Togo where teenage children embraced the term in proclaiming their freedom from parental control. Ironically, the same children now leave their villages to …

Angler Survey Of The Connecticut River, Justin P. Davis

EEB Articles

The Connecticut River is the largest and most diverse inland fishery resource in the State of Connecticut. Significant improvements in water quality over the past 30 years have led to progressive increases in recreational use, presumably increasing fishing pressure on some species and possibly decreasing overall fishing quality. To address this concern, the Inland Fisheries Division (IFD) of the Connecticut Department of Energy and Environmental Protection (CT DEEP) conducted an angler survey on the entire portion of the Connecticut River within the state during March-October of 2008-09. The survey used a similar design as a smaller-scale survey of the river’s …

2010 Annual Town Report Freemont, New Hampshire., Fremont Town Representatives

Fremont, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Funding Stem Cell Research: The Convergence Of Science, Religion & Politics In The Formation Of Public Health Policy, Edward A. Fallone

Faculty Publications

The controversy over the funding of stem cell research by the federal government is used as a case study for examining how policy choices are made in the field of public bioethics. This article examines the manner in which the decision to fund stem cell research has been influenced by the convergence of evolving scientific knowledge, conflicting religious values, and the role of elected officials in a representative democracy. The article begins by reviewing the current state of scientific knowledge concerning adult stem cells, embryonic stem cells, induced pluripotent stem cells, and the process of direct cell re-programming. Because each …

Private Rights In Public Lands: The Chicago Lakefront, Montgomery Ward, And The Public Dedication Doctrine, Joseph D. Kearney, Thomas W. Merrill

Faculty Publications

No abstract provided.

2011 Annual Report, Tennessee. Department Of Audit, Tennessee. Comptroller Of The Treasury

Department of Audit Annual Reports

This document is the annual report for the Tennessee Department of Audit.

Down The Drain: Pharmaceutical Waste Disposal In The United States, Toby K. Morgan

Fordham Environmental Law Review

No abstract provided.

Rainwater Harvesting Under Colorado's Prior Appropriation Doctrine: Property Rights And Takings, Stephen N. Bretsen

Fordham Environmental Law Review

No abstract provided.

Toward A More Multi-Functional Rural Landscape: Community Approaches To Rural Land Stewardship, Anthony B. Schutz

Fordham Environmental Law Review

No abstract provided.

Regional Foodsheds: Are Our Local Zoning And Land Use Regulations Healthy?, Patricia E. Salkin, Amy Lavine

Fordham Environmental Law Review

No abstract provided.

Foodshed Foundations: Law's Role In Shaping Our Food System's Future, Margaret S. Mccabe

Fordham Environmental Law Review

No abstract provided.

Climate Change, Food Security, And Agrobioversity: Toward A Just, Resilient, And Sustainable Food System, Carmen G. Gonzalez

Fordham Environmental Law Review

No abstract provided.

Milking It: Reconsidering The Fda's Refusal To Require Labeling Of Dairy Products Produced From Rbst Treated Cows In Light Of International Dairy Foods Association V. Boggs, Laurie J. Beyranevand

Fordham Environmental Law Review

No abstract provided.

Sustainable Habitat Restoration: Fish, Farms, And Ecosystem Services, Keith H. Hirokawa [email protected], Charles Gottlieb

Fordham Environmental Law Review

No abstract provided.

Efficacy Of The Jesness Inventory-Revised Conduct Disorder And Oppositional Defiant Disorder Scales, Terry B. Pinsoneault, Frank R. Ezzo

Contemporary Issues in Juvenile Justice

The authors investigated the Conduct Disorder (JR-CD) and Oppositional Defiant Disorder (JR-ODD) scales developed for the Jesness Inventory-Revised. Participants included 340 youth aged 12 to 18 seen at a juvenile court diagnostic clinic in Cleveland, Ohio. The authors also investigated the previously existing Social Maladjustment (JR-SM) and Asocial Index (JR-ASO) scales. Participants were independently diagnosed as having CD, ODD, Disruptive Behavior Disorder NOS (a milder behavioral disorder), or no diagnosable behavioral disorder. Mean scores varied across the groups in the expected directions for all four scales. JR-CD and JR-ODD were better able to differentiate between their target groups and the …

America's New Agrarians: Policy Opportunities And Legal Innovations To Support New Farmers, Neil D. Hamilton

Fordham Environmental Law Review

No abstract provided.

Energy (In)Efficiency Of The Local Food Movement: Food For Thought, Lauren Kaplin

Fordham Environmental Law Review

No abstract provided.

Licensee Patent Validity Challenges Following Medimmune: Implications For Patent Licensing, Alfred C. Server, Peter Singleton

UC Law Science and Technology Journal

The recent Supreme Court decision in MedImmune v. Genentech, resolved a jurisdictional question while refusing to address questions regarding application of the common law doctrine of licensee estoppel. This doctrine prevents a licensee enjoying the benefits of a license agreement from challenging the validity of the underlying patent. Although the Supreme Court in Lear v. Adkins rejected application of the doctrine where the licensee had ceased making payments under the agreement, it left open the same question which the MedImmune Court mentioned, but refused to address. Namely: Whether the doctrine still applies to a non-repudiating licensee in good standing. In …

Heat Shock Protein Induced Protection Against Cisplatin-Induced Hair Cell Death, Tiffany Gray Baker

MUSC Theses and Dissertations

Cisplatin is a highly successful and widely used chemotherapy for the treatment of various solid malignancies in both adult and pediatric patients. Side effects of cisplatin include nephrotoxicity and ototoxicity. Cisplatin's ototoxic effect results in part from damage to and death of cochlear hair cells. Mechanisms underlying cisplatin-induced hair cell death are poorly understood and have been attributed to DNA damage, oxidative stress, and inflammation. This study was designed to determine the role of p53 in cisplatin-induced hair cell death and to investigate heat shock proteins (HSPs) as potential protectants against cisplatin-induced hair cell death using adult mouse utricle as …

Cell Cycle Regulation In The Florida Red Tide Dinoflagellate, Karenia Brevis, Stephanie Alexandra Brunelle

MUSC Theses and Dissertations

The dinoflagellate, Karenia brevis, produces harmful algal blooms in the Gulf of Mexico that cause extensive marine animal mortalities and human illness nearly annually. The molecular mechanisms controlling cell cycle entry in this dinoflagellate are important because bloom development occurs through asexual cell division. The cell cycle of K. brevis is phased to the diel cycle such that any cells entering the cell cycle on a given day do so synchronously. However, a microarray study of gene expression over a diel/cell cycle found no change in cell cycle transcript levels in actively dividing populations, including genes that code for replication …