Digital Commons Network^™

Learning In Context: Land Use And Community Lawyering, Andrea Mcardle

Publications and Research

No abstract provided.

Movements And Home Ranges Of White-Tailed Deer In Response To Roadside Fences, William D. Gulsby, Daniel W. Stull, George R. Gallagher, David A. Osborn, Robert J. Warren, Karl V. Miller, Lawrence V. Tannenbaum

United States Army: Publications

Although roadside fences have been proven effective at reducing deer–vehicle collisions (DVCs), information on how these fences alter deer behavior is lacking. We evaluated the effects of a traditional and a novel fencing design, constructed alongside a roadway, on movements and home ranges of white-tailed deer (Odocoileus virginianus). From January to April 2009, we fitted 14 adult female deer with Global Positioning System collars, programmed to collect ≥ 24 locations/day. In June 2009 we constructed a 3.2-km fence that included a 1.6-km section of 2.4-m vertical-wire fence and a 1.6-km section of a prototype outrigger fence (i.e., 0.6 …

Safety And Protective Efficacy Of Ina-Inactivated Venezuelan Equine Encephalitis Virus: Implication In Vaccine Development, Anuj Sharma, Paridhi Gupta, Pamela J. Glass, Michael D. Parker, Radha K. Maheshwari

United States Army: Publications

We have previously shown that a hydrophobic alkylating compound, 1,5-iodonaphthyl-azide (INA) can efficiently inactivate the virulent strain of Venezuelan equine encephalitis virus (VEEV), V3000 in vitro. In this study, we have evaluated the safety of INA-inactivated V3000 and V3526 and the protective efficacy of INA-inactivated V3000. INA-inactivated V3000 and V3526 did not cause disease in suckling mice. RNA isolated from the INA-inactivated V3000 and V3526 was also not infectious. Immunization of adult mice with INA-inactivated V3000 induced an anti-VEEV antibody response and protected mice from virulent VEEV challenge. The protective efficacy of INA-inactivated V3000 increased with the use of adjuvants. …

Substituted Coumarin Derivatives: Synthesis And Evaluation Of Antiproliferative And Src Kinase Inhibitory Activities, Abha Kathuria, Sarah Jalal, Rakesh Tiwari, Amir Nasrolahi Shirazi, Shilpi Gupta, Shiv Kumar, Keykavous Parang, Sunil K. Sharma

Biomedical and Pharmaceutical Sciences Faculty Publications

Six classes of coumarin derivatives (i.e. 3-alkyl-4-methylcoumarins, pyranocoumarins, coumarin carboxamides, quaternary ammonium coumarins, 7-aminocoumarins, and 4-aminocoumarins) were synthesized and evaluated for inhibition of cell proliferation of colon adenocarcinoma (HT-29), breast carcinoma (MDA-MB-468 or MCF-7), and human ovarian adenocarcinoma (SK-OV-3) cells. C-3-Alkyl substituted analogs of 4-methylcoumarins and pyranocoumarins, 5 and 6, inhibited the cell proliferation of MDA-MB-468 and SK-OV-3 cells by 53-74%, while 3-decyl substituted pyranocoumarin 10 and triethyl substituted quaternary ammonium coumarin derivative 29 inhibited the cell proliferation of HT-29 and SK-OV-3 cells by 63-72% at a concentration of 50 μM. Among all the compounds studied, C-3 decyl substituted …

Monoamine Neurotransmitters As Substrates For Novel Tick Sulfotransferases, Homology Modeling, Molecular Docking, And Enzyme Kinetics, Emine Bihter Yalcin, Hubert Strangl, Sivakamasundari Pichu, Thomas N. Mather, Roberta S. King

Biomedical and Pharmaceutical Sciences Faculty Publications

Blacklegged ticks (Ixodes scapularis) transmit the causative agent of Lyme disease in the Northeastern United States. Current research focuses on elucidating biochemical pathways that may be disrupted to prevent pathogen transmission, thereby preventing disease. Genome screening reported transcripts coding for two putative sulfotransferases in whole tick extracts of the nymphal and larval stages. Sulfotransferases are known to sulfonate phenolic and alcoholic receptor agonists such as 17β-estradiol, thereby inactivating the receptor ligands. We used bioinformatic approaches to predict substrates for Ixosc Sult 1 and Ixosc Sult 2 and tested the predictions with biochemical assays. Homology models of 3D protein …

Repotting, Fr. Randy Roche

Spiritual Essays

No abstract provided.

Heavenly Pets, Fr. Randy Roche

Spiritual Essays

No abstract provided.

Mapping The Renaissance Cosmos: A Prolegomenon To Robert Fludd’S Utriusque Cosmi, James S. Baumlin

College of Arts and Letters

No abstract provided.

The Arts And Australian Education: Realising Potential, Robyn Ewing

Australian Education Review

AER 58 surveys the international and national research on the role and effect of arts-rich programming in schools and in the broader community, and examines the policies and practices that inhibit or support these initiatives. It puts the case that embedding the Arts in learning would be a powerful catalyst for educational and social reform in Australia, since arts-rich experiences can benefit students academically and socially, revitalise school curricula and foster the development of much needed creativity and imaginative thinking. Section 1 discusses and defines ‘the Arts’ collectively, as a way of knowing and learning – embodying play, inquiry, experimentation, …

Is Thrombolytic Therapy Safe When Used To Treat Elderly Patients?, Daniel Yaeger

The Science Journal of the Lander College of Arts and Sciences

Recently, research has been conducted to determine if thrombolytic therapy works to dissolve clots and if it is a safe treatment option. The specific purpose of this study is to determine if thrombolytic therapy is safe for use in the elderly. This study was conducted by reviewing the relevant literature that has been published from the time that research began to test the usefulness of thrombolytic therapy. Numerous journals were examined to ensure impartiality and emerge with an unbiased conclusion. The journals were discovered using PubMed article finder, using Google as a search engine, and by scrutinizing relevant references found …

Transplant, Peter Grimes

Harpur Palate: a Literary Journal

page 74-80

Spatial And Tidal Variations Of Physico-Chemical Parameters In The Lower Gangetic Delta Region, West Bengal, India

Journal of Spatial Hydrology

The lower stretch of Gangetic delta in the Indian sub-continent is noted for its rich mangrove biodiversity, natural calamities, and livelihood-supporting matrix of millions of people and is the only mangrove base of Royal Bengal tiger (Panthera tigris tigris) in the planet Earth. The present trend of industrialization, urbanization and construction of barrage in the upstream zone has changed the landscape of the deltaic complex and the characteristics of the aquatic sub-system have also changed accordingly. This ecosystem offers an ideal site to study a number of physico-chemical parameters in relation to changing scenario of the region. The presence of …

Annual Reports Of The Town Officers And Inventory Of Ratable Property Of Surry, New Hampshire For The Year Ending December 31, 2010 And School District Officers For The Year Ending June 30, 2011., Surry Town Representatives

Surry, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Milton, New Hampshire 2010 Annual Report., Milton Town Representatives

Milton, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Town Of Sharon, New Hampshire Annual Report For The Year Ending December 31, 2010., Sharon Town Representatives

Sharon, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

2011 - Etsu Fact Book, Institutional Research, East Tennessee State University

ETSU Fact Books

No abstract provided.

Effects Of Erbb2 Peptide Vaccination On The Mouse Heart, Sumayya Ahmad

Yale Medicine Thesis Digital Library

EFFECTS OF ERBB2 VACCINATION ON THE MURINE HEART. Sumayya Ahmad, Renelle Gee, Kerry Russell, and Mark J. Mamula. Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510.

ErbB2, a member of the epidermal growth factor receptor family, is found in many tissues of the body. It is known to potentiate growth via vascularization and anti-apoptotic signals, amongst other things. Its presence on breast cancer cells results in a particularly poor prognosis. A novel monoclonal antibody targeting this receptor, Herceptin, allows precise targeting of these cells and results in longer life spans for these …

Partial Exchange Transfusion For Polycythemia Hyperviscosity Syndrome, Bridget L. Hopewell

Yale Medicine Thesis Digital Library

PARTIAL EXCHANGE TRANSFUSION FOR POLYCYTHEMIA HYPERVISCOSITY SYNDROME: A 21-YEAR REVIEW Bridget L. Hopewell, Laurie A. Steiner, Richard A. Ehrenkranz, Matthew J. Bizzarro, and Patrick G. Gallagher. Division of Perinatal Medicine, Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut.

The objective of this study was to examine the use of partial exchange transfusion (PET) performed for polycythemia hyperviscosity syndrome (PHS) over time. A retrospective review of 141 infants who received a PET for PHS at Yale-New Haven Hospital, between 1986-2007 was performed, querying maternal and neonatal medical records. Patient demographics, risk factors for PHS, indications for PET, and …

Collateral Damage: The History Of United States Case Law On Today's Military Hunger Strike Doctrine, Adrian Mora

Yale Medicine Thesis Digital Library

HYPOTHESIS/AIMS: In the Global War on Terror (GWOT), hunger strikes by detainees in Guantanamo Bay, Cuba have been managed by military physicians through force feedings. This thesis answers the question of how did the United States justify its current practice of force feeding prisoners against prevailing medical ethics? The author hypothesizes that U.S. case law history of approximately 1979 to 1997 enabled the current military doctrine to force feed international detainees in GWOT.

METHODS: A qualitative and comprehensive review of the relevant literature was undertaken. The sources used for conclusive analysis included press releases, ethics commentary, law reviews, medical association …

Investigating Contributions Of Langerhans Cells To The Epidermal Oxidative Stress Response, Debra Smith

Yale Medicine Thesis Digital Library

INVESTIGATING THE CONTRIBUTIONS OF LANGERHANS CELLS TO THE EPIDERMAL OXIDATIVE STRESS RESPONSE. Debra A. Smith, Julia Lewis, Renata Filler, Kseniya Golubets, Michael Girardi. Department of Dermatology, Yale University, School of Medicine, New Haven, CT.

Langerhans cells (LC) play an essential role in the development of skin cancer in a chemical carcinogenesis mouse model. To elucidate the mechanism of this effect, LC-deficient (Langerin-dipheria toxin A or human Langerin-diphtheria toxin receptor transgenic) mouse epidermis was compared to normal littermate controls (NLC) to assess whether levels of oxidative stress or DNA damage are affected by LC. Groups of mice were treated with either …

Is Aggressive Mediastinal Control Needed After Neoadjuvant Therapy For Distal Esophagus Carcinomas?, Chantae Sullivan

Yale Medicine Thesis Digital Library

The pattern of recurrence after neoadjuvant chemoradiotherapy followed by transhiatal esophagectomy with limited mediastinal lymphadenectomy among 73 patients with carcinoma of the distal esophagus, gastroesophageal junction (GEJ) and/or gastric cardia, was investigated in this retrospective study. Results indicate that among the 30 patients with recurrence, distant sites (n = 24) were more common than local sites (n = 6) and this difference was statistically significant (P = 0.001). Lungs and liver were the most common sites of first recurrence, 51%, while mediastinal nodes were the sites of first recurrence in 6% of cases. Twenty patients (27.4%) had pathologic complete response, …

Biodiversity Assessment Of Tetranychid Mites In Kenya And The Conservation Hotspots Of Tanzania, Faith Jebet Toroitich

All PhD Dissertations

The aims of this study were to develop a detailed record of the tetranychid mites of Kenya and Tanzania, to assess the diversity of tetranychid mites in the east African biodiversity hotspots and to determine female characters that can be used to identify the species of the economically important Tetranychus species found in these countries. The genetic diversity of the most abundant Tetranychus species (Tetranychus evansi Baker & Pritchard) was also assessed. The Tetranychidae (Acari) contain some of the most important pest species of phytophagous mites worldwide. Out of the almost 1,300 species in this family, 256 species are known …

Development Of A Fungal Based-Product For The Control Of Western Flower Thrips Frankliniella Occidentalis (Pergande), Niassy Saliou

All PhD Dissertations

The Western Flower Thrips (WFT) Frankliniella occidentalis (Pergande) is a major constraint to many cultivated crops in the world, causing important economical yield losses. They cause direct damage on plants and contribute exclusively in the propagation of tospovirus to plant. Thrips control is essentially based on the use of synthetic chemical pesticides; however most thrips species including Foccidentalis are resistant to a wide group of chemical pesticides. Hence there is the need to develop alternative strategies that are environmentally friendly. Entomopathogenic fungi are among the options being considered as a promising alternative for F. occidentalis management. The aim of this …

Remanentes Y Causalidades Críticas En “La Fiesta Del Monstruo” De Jorge Luis Borges Y Adolfo Bioy Casares, Juan Manuel Silva Barandica

Hipertexto

No abstract provided.

Contemporary And Historical Separation Of Transequatorial Migration Between Genetically Distinct Seabird Populations, M J. Rayner, M E. Hauber, T E. Steeves, H A. Lawrence, D R. Thompson, P M. Sagar, S J. Bury, R A. Phillips, T J. Landers, L Ranjard, Scott A. Shaffer

Faculty Publications, Biological Sciences

Pelagic seabirds are highly mobile, reducing the likelihood of allopatric speciation where disruption of gene flow between populations is caused by physically insurmountable, extrinsic barriers. Spatial segregation during the non-breeding season appears to provide an intrinsic barrier to gene flow among seabird populations that otherwise occupy nearby or overlapping regions during breeding, but how this is achieved remains unclear. Here we show that the two genetically distinct populations of Cook's petrel (Pterodroma cookii) exhibit transequatorial separation of non-breeding ranges at contemporary (ca. 2–3 yrs) and historical (ca. 100 yrs) time scales. Segregation during the non-breeding season per se appears as …

Commentary: Selecting Synaptic Partners: Grasping The Role Of Unc- 6/Netrin, Q L. Ch'ng

Faculty Publications, Biological Sciences

Forming synaptic connections of the appropriate strength between specific neurons is crucial for constructing neural circuits to control behavior. A recent paper in Neural Development describes the use of a synapse-specific label in Caenorhabditis elegans to implicate local UNC-6/netrin signaling in this developmental process. Thus, as well as their well known roles in cell migration and axon guidance, UNC-6/netrin signals distinguish an appropriate synaptic partner from other potential targets.

Assessing The Long-Term Effects Of The Bp Deepwater Horizon Oil Spill On Marine Mammals In The Gulf Of Mexico: A Statement Of Research Needs

United States Marine Mammal Commission

Assessing the Long-term Effects of the BP Deepwater Horizon Oil Spill on Marine Mammals in the Gulf of Mexico: A Statement of Research Needs

A Picture Of Eight Turtles: The Child’S Understanding Of Cardinality And Numerosity, Emily Slusser, B Sarnecka

Faculty Publications

An essential part of understanding number words (e.g., eight) is understanding that all number words refer to the dimension of experience we call numerosity. Knowledge of this general principle may be separable from knowledge of individual number word meanings. That is, children may learn the meanings of at least a few individual number words before realizing that all number words refer to numerosity. Alternatively, knowledge of this general principle may form relatively early and proceed to guide and constrain the acquisition of individual number word meanings. The current article describes two experiments in which 116 children (2½- to 4-year-olds) were …

Deathly Erichtho As Vital To Lucan’S Bellum Ciuile, John Byron Young

Theses, Dissertations and Capstones

Lucan’s Bellum Ciuile has provided much difficulty for scholars in the identification of a hero, as none of the main characters of the epic, Caesar, Pompey, and Cato, fully become a hero. I argue that a minor character, Erichtho, the necromancer in book 6, is not only the hero, but also the supreme uates and reflection of the poet. Through her comparison with Scaeva in book 6 as well as Aeneas of Vergil’s Aeneid and her interactions with Sextus Pompey, her heroism becomes fully developed. She creates a corpse uates through her vatic powers and gains access into the Underworld …

Ua41 University College Connection, Dennis K. George, Dean, Wendi Kelley

UC Publications

No abstract provided.