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Articles 99601 - 99630 of 103589
Full-Text Articles in Entire DC Network
Platelet Alpha- And Beta- Secretase Activities Are Not Significantly Affected By Dementia Or Mild Cognitive Impairment In Swedish Patients., Paul Gorham, Natalie Bark, Steve Meaney, Ingemar Bjorkhem, Milita Crisby
Platelet Alpha- And Beta- Secretase Activities Are Not Significantly Affected By Dementia Or Mild Cognitive Impairment In Swedish Patients., Paul Gorham, Natalie Bark, Steve Meaney, Ingemar Bjorkhem, Milita Crisby
Articles
The processing of the Amyloid Precursor Protein (APP) is a critical event in the formation of amyloid plaques which are composed of the 4kDa amyloid beta-peptide (Abeta). Processing of APP occurs through a non-amyloidogenic pathway, mediated by initial alpha-secretase cleavage or through an amyloidogenic pathway via sequential cleavage by beta- and gamma-secretase enzymes, which produces Abeta peptides. Currently, the diagnosis of probable or possible Alzheimer's disease (AD) is primarily based on neuropsychological and neuroradiological assessment. Recent reports indicate that platelet beta-secretase activity is moderately increased in patients with AD and mild cognitive impairment (MCI). To our knowledge platelet alpha-secretase activity …
Genetic Connections Between Neurological Disorders And Cholesterol Metabolism, Ingemar Bjorkhem, Valerio Leoni, Steve Meaney
Genetic Connections Between Neurological Disorders And Cholesterol Metabolism, Ingemar Bjorkhem, Valerio Leoni, Steve Meaney
Articles
Cholesterol is an essential component of both the peripheral and central nervous systems of mammals. Over the last decade, evidence has accumulated that disturbances in cholesterol metabolism are associated with the development of various neurological conditions. In addition to genetically defined defects in cholesterol synthesis, which will be covered in another review in this Thematic Series, defects in cholesterol metabolism (cerebrotendinous xanthomatosis) and intracellular transport (Niemann Pick Syndrome) lead to neurological disease. A subform of hereditary spastic paresis (type SPG5) and Huntington's disease are neurological diseases with mutations in genes that are of importance for cholesterol metabolism. Neurodegeneration is generally …
Selective Solubilisation Of Single Walled Carbon Nanotubes Using Polycyclic Aromatic Hydrocarbons, Sourabhi Debnath
Selective Solubilisation Of Single Walled Carbon Nanotubes Using Polycyclic Aromatic Hydrocarbons, Sourabhi Debnath
Doctoral
Single-walled carbon nanotubes (SWCNTS) are proposed to be one of the most promising nanomaterials, with unique electronic and mechanical properties which lend themselves to a variety of applications. In all cases the quality of the SWCNT material is important, and for some applications it is paramount. Despite sustained efforts, all currently known SWCNT synthetic techniques generate significant quantities of impurities. They also grow in bundles or ropes and are largely insoluble in common organic solvents. SWCNTS can have a range of structures and their electronic properties (metallic or semiconducting) depend on their structure and as well on their diameters. Currently …
A Phenomenographic Study Of Introductory Physics Students: Approaches To Their Learning And Perceptions Of Their Learning Environment In A Physics Problem-Based Learning Environment, Paul Irving
Doctoral
This phenomenographic study describes students’ approaches to learning and their perceptions of the learning environment in an introductory physics course which is taught using a problem-based learning approach. This research builds on previous studies which showed that these students develop a greater conceptual knowledge than their counterparts in a more traditional learning environment while others showed very little development even though they engaged fully with the pedagogy. This study aimed to examine and describe the students’ approaches to learning. The definitions of surface, strategic and deep approaches to learning are not appropriate in this context and could not be applied …
Efficacy Of Ozone And Ultrasound For Microbial Reduction In Fruit Juice, Sonal Patil
Efficacy Of Ozone And Ultrasound For Microbial Reduction In Fruit Juice, Sonal Patil
Doctoral
Concerns have arisen regarding the microbiological safety of fruit juices due to a number of outbreaks associated with pathogens. Non-thermal technologies for the inactivation of microorganisms are of increasing interest to the food industry for the control of spoilage as well as safety concerns. The objective of this thesis was to investigate the efficacy of ultrasound and ozone treatments for control of microbial issues associated with fruit juices. Inactivation of Escherichia coli (ATCC 25922, NCTC 12900) using power ultrasound was found to be influenced by strain, prior acid adaptation and suspension liquid, but the effect was negated at the higher …
Sources Of Saturated Fat And Sucrose In The Diets Of Swedish Children And Adolescents In The European Youth Heart Study: Strategies For Improving Intakes, Emma Patterson, Julia Wärnberg, John Kearney, Michael Sjostrom
Sources Of Saturated Fat And Sucrose In The Diets Of Swedish Children And Adolescents In The European Youth Heart Study: Strategies For Improving Intakes, Emma Patterson, Julia Wärnberg, John Kearney, Michael Sjostrom
Articles
To compare macronutrient intakes of Swedish children and adolescents to population goals; to identify the major sources of energy, fat, saturated fat and sucrose; and to simulate the effect adherence to current food-based dietary guidelines (FBDG) would have on saturated fat and sucrose intakes. Cross-sectional study. From 24 h recall data, food groups contributing most to energy, fat, saturated fat and sucrose were identified. Based on the prevailing consumption of foods mentioned in the FBDG, we simulated five scenarios: changes in milk and yoghurt; cheese; energy-dense, nutrient-dilute foods; soft drinks; and burger and sausage consumption. Stockholm and Örebro (Sweden) in …
Multiple Asf/Sf2 Sites In The Human Papillomavirus Type 16 (Hpv-16) E4-Coding Region Promote Splicing To The Most Commonly Used 3'-Splice Site On The Hpv-16 Genome, Monika Somberg, Stefan Schwartz
Multiple Asf/Sf2 Sites In The Human Papillomavirus Type 16 (Hpv-16) E4-Coding Region Promote Splicing To The Most Commonly Used 3'-Splice Site On The Hpv-16 Genome, Monika Somberg, Stefan Schwartz
Articles
Our results presented here demonstrate that the most abundant human papillomavirus type 16 (HPV-16) mRNAs expressing the viral oncogenes E6 and E7 are regulated by cellular ASF/SF2, itself defined as a proto-oncogene and overexpressed in cervical cancer cells. We show that the most frequently used 3′-splice site on the HPV-16 genome, site SA3358, which is used to produce primarily E4, E6, and E7 mRNAs, is regulated by ASF/SF2. Splice site SA3358 is immediately followed by 15 potential binding sites for the splicing factor ASF/SF2. Recombinant ASF/SF2 binds to the cluster of ASF/SF2 sites. Mutational inactivation of all 15 sites abolished …
Dietary Energy Density As Marker Of Dietary Quality In Swedish Children And Adolescents: The European Youth Heart Study, Emma Patterson, J. Wärnberg, E. Poortvliet, John Kearney, M. Sjöström
Dietary Energy Density As Marker Of Dietary Quality In Swedish Children And Adolescents: The European Youth Heart Study, Emma Patterson, J. Wärnberg, E. Poortvliet, John Kearney, M. Sjöström
Articles
To investigate if dietary energy density is associated with measures of dietary quality (food group, micronutrient and macronutrient intakes) in children and adolescents.
Hypercapnic Acidosis Reduces Oxidative Reactions In Endotoxin-Induced Lung Injury, Alistair D. Nichol, Donall F. O'Cronin, Finola Naughton, Natalie Hopkins, John Boylan, Paul Mcloughlin
Hypercapnic Acidosis Reduces Oxidative Reactions In Endotoxin-Induced Lung Injury, Alistair D. Nichol, Donall F. O'Cronin, Finola Naughton, Natalie Hopkins, John Boylan, Paul Mcloughlin
Articles
Hypercapnic acidosis frequently occurs when patients with acute lung injury are initially ventilated with low tidal volume "protective" strategies. Hypercapnic acidosis per se, in the absence of any change in tidal volume or airway pressure, is protective when instituted before the onset of injury. However, the mechanisms by which hypercapnic acidosis confers this protection are incompletely understood, in particular, the effects on pulmonary oxidative reactions, which are potent mediators of tissue damage, have not been previously examined in vivo.
Faculty Masthead, Mjlst Editorial Board
Faculty Masthead, Mjlst Editorial Board
Minnesota Journal of Law, Science & Technology
No abstract provided.
Blaming The Brain, Steven K. Erickson
Blaming The Brain, Steven K. Erickson
Minnesota Journal of Law, Science & Technology
No abstract provided.
Imaging Genetics For Our Neurogenetic Future, Daniel Z. Buchman, Judy Illes
Imaging Genetics For Our Neurogenetic Future, Daniel Z. Buchman, Judy Illes
Minnesota Journal of Law, Science & Technology
No abstract provided.
Advancing Research On Stored Biological Materials: Reconciling Law, Ethics, And Practice, Leslie E. Wolf
Advancing Research On Stored Biological Materials: Reconciling Law, Ethics, And Practice, Leslie E. Wolf
Minnesota Journal of Law, Science & Technology
No abstract provided.
Health Care Reform And The Logic Of Emergence, M. Gregg Bloche, Sujata M. Jhaveri
Health Care Reform And The Logic Of Emergence, M. Gregg Bloche, Sujata M. Jhaveri
Minnesota Journal of Law, Science & Technology
No abstract provided.
Open Source Drug Development: A Path To More Accessible Drugs And Diagnostics?, Emily Marden
Open Source Drug Development: A Path To More Accessible Drugs And Diagnostics?, Emily Marden
Minnesota Journal of Law, Science & Technology
No abstract provided.
Integrating Social And Ethical Concerns Into Regulatory Decision-Making For Emerging Technologies, Gary Marchant, Ann Meyer, Megan Scanlon
Integrating Social And Ethical Concerns Into Regulatory Decision-Making For Emerging Technologies, Gary Marchant, Ann Meyer, Megan Scanlon
Minnesota Journal of Law, Science & Technology
No abstract provided.
A Burkean Perspective On Patent Eligibility, Part Ii: Reflections On The (Counter)Revolution In Patent Law, Thomas F. Cotter
A Burkean Perspective On Patent Eligibility, Part Ii: Reflections On The (Counter)Revolution In Patent Law, Thomas F. Cotter
Minnesota Journal of Law, Science & Technology
No abstract provided.
Preparation To Infringe After Medimmune V. Genentech: Why The Federal Circuit's Declaratory Judgment Jurisdiction Test Is Still Too Stringent, Hugh D. Brown
Minnesota Journal of Law, Science & Technology
No abstract provided.
Who Is John Doe And Why Do We Care? Why A Uniform Approach To Dealing With John Doe Defamation Cases Is Needed, Craig Buske
Who Is John Doe And Why Do We Care? Why A Uniform Approach To Dealing With John Doe Defamation Cases Is Needed, Craig Buske
Minnesota Journal of Law, Science & Technology
No abstract provided.
Quanta And Patent Exhaustion: The Implications Of The Supreme Court's Decision In Quanta Computer, Inc. V. Lg Electronics, Inc. One Year Later, Emily Van Vliet
Quanta And Patent Exhaustion: The Implications Of The Supreme Court's Decision In Quanta Computer, Inc. V. Lg Electronics, Inc. One Year Later, Emily Van Vliet
Minnesota Journal of Law, Science & Technology
No abstract provided.
Student Masthead, Mjlst Editorial Board
Student Masthead, Mjlst Editorial Board
Minnesota Journal of Law, Science & Technology
No abstract provided.
Introduction — Rising Stars: Recognizing Important New Voices In Law, Medicine, Science & Technology, Michele B. Goodwin
Introduction — Rising Stars: Recognizing Important New Voices In Law, Medicine, Science & Technology, Michele B. Goodwin
Minnesota Journal of Law, Science & Technology
No abstract provided.
Corporate Cyborgs And Technology Risks, Andrea M. Matwyshyn
Corporate Cyborgs And Technology Risks, Andrea M. Matwyshyn
Minnesota Journal of Law, Science & Technology
No abstract provided.
Global Legal Triage In Response To The 2009 H1n1 Outbreak, James G. Hodge, Jr.
Global Legal Triage In Response To The 2009 H1n1 Outbreak, James G. Hodge, Jr.
Minnesota Journal of Law, Science & Technology
No abstract provided.
Synthesizing Law For Synthetic Biology, Andrew W. Torrance
Synthesizing Law For Synthetic Biology, Andrew W. Torrance
Minnesota Journal of Law, Science & Technology
No abstract provided.
Marking The Fine Line: Ethics And The Regulation Of Innovative Technologies In Human Reproduction, Anne Drapkin Lyerly
Marking The Fine Line: Ethics And The Regulation Of Innovative Technologies In Human Reproduction, Anne Drapkin Lyerly
Minnesota Journal of Law, Science & Technology
No abstract provided.
Why Not Take All Of Me? Reflections On The Immortal Life Of Henrietta Lacks And The Status Of Participants In Research Using Human Specimens, Gail Javitt
Minnesota Journal of Law, Science & Technology
No abstract provided.
Restoring Truth: An Argument To Remove The Qui Tam Provision From The False Marking Statute Of The Patent Act, Craig Deutsch
Restoring Truth: An Argument To Remove The Qui Tam Provision From The False Marking Statute Of The Patent Act, Craig Deutsch
Minnesota Journal of Law, Science & Technology
No abstract provided.
Dwi Source Code Motions After Underdahl, David Liebow
Dwi Source Code Motions After Underdahl, David Liebow
Minnesota Journal of Law, Science & Technology
No abstract provided.
Taking Off: Recent Changes To Venue Transfer Of Patent Litigation In The Rocket Docket, Li Zhu
Taking Off: Recent Changes To Venue Transfer Of Patent Litigation In The Rocket Docket, Li Zhu
Minnesota Journal of Law, Science & Technology
No abstract provided.