Digital Commons Network^™

P53 Mediated Cell Motility In H1299 Lung Cancer Cells, Mi-Yon Choi

Theses and Dissertations

Studies have shown that gain-of- function mutant p53, AKT, and NFκB promote invasion and metastasis in tumor cells. Signals transduced by AKT and p53 are integrated via negative feedback between the two pathways. Tumor derived p53 was also indicated to induce NFκB gene expression. Due to the close relationship between p53/AKT and p53/NFκB, we hypothesized that AKT and NFκB can enhance motility in cells expressing mutant p53. Effects on cell motility were determined by scratch assays. CXCL5- chemokine is also known to induce cell motility. We hypothesized that enhanced cell motility by AKT and NFκB is mediated, in part, by …

In-Vitro Metabolism And Protein Binding Of 5-Hmf, A Potential Antisickling Agent, Taghrid Obied

Theses and Dissertations

Purpose. 5-HMF is a potential antisickling agent forming a Schiff-adduct with hemoglobin (Hb). In-vitro studies were designed to identify the metabolic pathways of 5-HMF in human hepatic cytosol, to assess inter-species differences in its hepatic metabolism, and to predict in-vivo PK properties. Moreover, metabolism of 5-HMF in human RBCs was investigated. Finally, in-vitro studies were done to characterize 5-HMF binding kinetics with human Hb and albumin (HSA). Methods. NAD+ reduction was monitored at 340 nm in human hepatic cytosol for 5-HMF (26 mM) and prototypical ADH and ALDH substrates in the presence or absence of their inhibitors. Furthermore, concentration-dependency studies …

Mulieris Dignitatem: Pornography And The Dignity Of The Soul - An Exploration Of Dignity In A Protected Speech Paradigm, Mary Graw Leary

Scholarly Articles

This article, part of a symposium celebrating the 20th anniversary of Mulieris Dignitatem, reflects on Mulieris Dignitatem’s teachings, and how they can inform the issue of pornography. Modern day pornography has increased in both its quantity and severity of content. Mulieris Dignitatem offers a pathway out of this reality with its focus on the concept of dignity. The article reviews John Paul II’s emphasis on the dignity of woman and applies it to the modern day issue of pornography. The article suggests a paradigm shift from examining pornography solely through a speech and expression lens to examining the issue through …

The Impact Of Mathematics Professional Development On Elementary Teachers' Mathematics Content Knowledge For Teaching And Implementation Of Innovative Pedagogical Practices, Vicki Oleson

Dissertations and Theses @ UNI

This study sought to understand the process of change elementary teachers experienced as they participated in mathematics professional development. This investigation explored the impact of mathematics professional development on teachers' content knowledge for teaching, their ability to implement innovative pedagogical practices, and the relationship between these two components of teacher change. Data collected from a semester-long professional development course involving 20 teachers from rural southwest Iowa was analyzed for this study.

Data was collected from six teachers involved in the professional development course. Data collected during the professional development course included a pre and post test of teachers' content knowledge, …

Risk-Taking Propensity And Its Relationship To Achievement Motivation Among Selected Municipal Parks And Recreation Directors In The State Of Iowa, Jiangong (Brad) Tan

Dissertations and Theses @ UNI

The purpose of the study was to examine the risk-taking propensity and achievement motivation among selected park and recreation directors in the state of Iowa. More specifically, the study is designed to determine the relationships between risk-taking propensity and achievement motivation. In addition, the study seeks to explore the relationships between various demographic variables such as age, gender, education level, city size, agency size, organizational budget, and years of professional experience in the park and recreation field and either risk-taking propensity or achievement motivation.

Atkinson's Theory of Achievement Motivation and McClelland's Need for Achievement were employed to better understand the …

Understanding Environmental Health Disparities Of Roma Populations In Romania, Jennifer L. Hall

Dissertations and Theses @ UNI

The Roma are the largest and most marginalized minority group of Central and Eastern Europe (CEE) with the highest number residing in Romania. Their problems and struggles are multi-faceted and deeply rooted in a long history of discrimination and stigmatization. Over the years, many strategies have been developed and implemented across CEE, yet very few studies have addressed their environmental and occupational health issues. Moreover, because the vast majority of these studies have employed quantitative methodology, they have had the unfortunate effect of dehumanizing and devaluing the Roma people through scientific reductionism.

The purpose of this study was to gain …

A Glance Backwards: An Analysis Of Youth Resiliency Through Autoethnographical And Life History Lenses, Toney Bissett Ford

Dissertations and Theses @ UNI

The purpose of this study was to investigate youth resiliency employing dual methodologies, auto-ethnography and life history research respectively, to reveal how two middle-aged adults (one African-American, the other Caucasian) achieved resiliency; and most importantly, how their experiences and insights might inform ongoing efforts to promote youth resiliency. This research project was a follow-up to a previous study (involving four African American participants – two males and two females) conducted to determine the roles that schools and communities play in promoting youth resiliency.

Offering insights into the usefulness of extended research, Herr and Anderson (2005) captured the essence of my …

Impact Of The Iowa Smoke-Free Ban Among The College Students Of The University Of Northern Iowa, Jean Marie Vianney Hirwa Kavamahanga

Dissertations and Theses @ UNI

The purpose of this study was to measure the effects of the Iowa Smoke-Free Ban impact on: smoking behavior, knowledge of the ban and knowledge of smoking health effect, reported smoking in both indoor and outside venues; support for smoke-free public venues; and self-reported effects of the law on consumption and quitting. A non-random sample of 113 students (49.44% male and 50.44% female) participated in this study.

The 35-item questionnaire was used to evaluate the impact of the Iowa smoke-free ban among college students of the University of Northern Iowa. Descriptive statistics were used to analyze the survey responses. The …

Leisure And Aging: A Content Analysis Of Leisure Textbooks And Leisure Academic Journal Articles, Leila Rod-Welch

Dissertations and Theses @ UNI

This study will review literature related to leisure and aging. We live in an aging society. People are expected to live healthier and longer. Therefore, there is a need to analyze how older adults are portrayed in leisure textbooks and academic journal articles which are typically used to educate and train recreation professionals. This study explores whether leisure textbooks published in the United States addressed the topic of aging and, if so, to what extent. In addition, any differences between leisure textbooks and specialty leisure and aging textbooks were analyzed. A content analysis of 54 leisure textbooks from six U.S. …

Language Exclusionary Behavior And Attitudes Toward Immigrants, Christine L. Bennett

Dissertations and Theses @ UNI

Immigrants often speak languages that natives do not understand, leading to intentional or inadvertent ostracism, which in turn may increase perceptions of threat. For example, English language participants excluded from a conversation in Spanish report more negative reactions than participants excluded in English (Hitlan, Kelly, & Zarate, 2010). Integrated threat theory (ITT) suggests that there are four threats that lead to prejudice toward outgroups such as immigrants: realistic threat, symbolic threat, intergroup anxiety, and negative stereotypes (Stephan, Ybarra, & Bachman, 1999). The current study expanded upon prior research by ostracizing participants in English, Spanish, or Arabic and then measuring participants' …

A Case Study Of The Perceptions Of Stakeholders From A School District In Iowa On The Impact Of No Child Left Behind On The Comprehensive High School, Brian Coppess

Dissertations and Theses @ UNI

The American comprehensive high school was designed for a diverse society (Wraga, 1998, p. 1 ). The concept originated in the 1920s as a result of a report entitled The Cardinal Principles of Secondary Education (Commission on the Reorganization of Secondary Education [CRSE], 1918). Since the adoption of The Cardinal Principles, the institution of the comprehensive high school has withstood years of continued review and reform efforts. Despite the many attempts to change it, the comprehensive high school has remained a constant of secondary education in America. The nation's most recent educational reform effort-the No Child Left Behind Act (NCLB, …

Helping Adolescents Forgive: The Use Of Forgiveness Education At An Inpatient Mental Health Facility, Tiffany R. Everding

Dissertations and Theses @ UNI

Understanding the concept of forgiveness has demonstrated to be a complex process (Walker & Gorsuch, 2004; McCullough & vanOyen Witvliet, 2002). Enright and the Human Development Study Group (1991) developed a process model of forgiveness as a way for people to constructively deal with their anger and improve overall psychological well-being after experiencing a deep hurt. Due to the reported benefits illustrated by forgiveness intervention studies, future research is needed to examine the effectiveness of forgiveness education with adolescents in a clinical setting. The current study implemented a forgiveness education intervention with adolescents at local inpatient mental health facility examining …

Baby Boomer And Genx Elementary Principals : Differing Perspectives On Schooling, Lisa M. Fry

Dissertations and Theses @ UNI

Studies on generational analysis inform us that each generation is shaped by the influences they share during their formative years. The common experiences and historical circumstances experienced during this time influences their generational identity and results in a world view that is unique to that generation. This world view and generational identity impacts their belief system and practices as they emerge as leaders in mid-life.

While the current structures and policies that guide today's educational system were established by the Baby Boomer generation, we could see significant changes as the Baby Boomer behemoth begins to leave the workforce. Around the …

Educational Applications Of Achievement Goal Theory, Michelle Hinzman

Dissertations and Theses @ UNI

In the past two decades, achievement goal theory has been found particularly useful in explaining student motivation (Kaplan & Maehr, 2007; Kaplan, Middleton, Urdan, & Midgley, 2002). The purpose of this study was to analyze differences between the achievement goals espoused by middle school and elementary teachers. A mixed-method approach was utilized that required teachers in an urban, eastern Iowa school district to complete a survey regarding their motivational beliefs. Select teachers were then identified based on survey results to be observed and interviewed in an attempt to further analyze instructional practices as they related to student motivation. Results of …

Do Pull-Out Programs Create A Mirage Of Long-Term Results For At-Risk Youth?, Varotta Mi'chele Johnson

Dissertations and Theses @ UNI

Educators and researchers cannot afford to ignore the achievement gap between at-risk students and their counterparts. The review examines educational practices for this targeted population. Historically, educational experts have supported the belief that teaching in isolated settings is one of the most effective practices for improving student achievement. Smaller class sizes are proposed as reform methods to substantially impact student performance (Odden, 1990). However, class size reduction must be coupled with research-based instructional strategies proven to further academic development. Traditionally, at-risk students receive instruction through pull-out interventions. A pull-out program in this study shall be defined as the removal of …

Sexting Or Self-Produced Child Pornography – The Dialogue Continues – Structured Prosecutorial Discretion Within A Multidisciplinary Response, Mary Graw Leary

Scholarly Articles

One need only read the newspaper to see a rising dangerous phenomenon among juveniles: the creation and subsequent sharing via the Internet of sexually explicit photographs. This self exploitation is not only a tragic social problem, but a growing legal one as well. Judges, attorneys, and legislators, are forced to address this activity because, in addition to being self destructive, it is also a violation of state and federal child pornography laws. Juvenile self exploitation illustrates a clash of two lines of jurisprudence and public policy: the aggressive opposition to child pornography and the more lenient rehabilitative treatment of juvenile …

Patient Education And Involvement In Care, Linda Reynolds Andiric

UNF Graduate Theses and Dissertations

A study conducted on patients who underwent total knee arthroplasty indicated that participants who were offered preadmission education for their procedure had statistically better outcomes than patients who had not attended an educational class. The study further focused on patients’ confidence in their ability to take control of their health situations as well as the effect of encouragement and motivation to provide active involvement. Two surveys, the Krantz Health Opinion Survey and the Multi Dimensional Health Locus of Control, were used to assess patients’ innate desires to be involved in their care and if they felt they could render any …

Ethnic Differences In Alcohol Use: A Comparison Of Black And White College Students In A Small Private University Setting, Kristie S. Gover

UNF Graduate Theses and Dissertations

An identified gap in the literature associated with college student alcohol use is the exploration of the problem based on ethnicity, specifically possible differences in use between Black and White college students. The purpose of the present study was to examine differences in alcohol use for Black and White college students at a small private university in the southeast United States. The study was conducted using the Core Alcohol and Drug Survey Long Form, which is designed to collect data related to self reported use of alcohol and perceptions of alcohol use among college students. A quantitative methodology was employed …

Cosmetic Surgery Pictures: Does Type Of Picture Affect Acceptance Of Cosmetic Surgery And/Or Body Image?, Lindsay Nicole Fuzzell

UNF Graduate Theses and Dissertations

The researcher investigates the effect of viewing positive and negative cosmetic surgery images, with short descriptive scenarios, on acceptance of cosmetic surgery. Two hundred ninety-nine participants were assigned to view one of three conditions: positive before/after cosmetic surgery pictures and an accompanying scenario, negative pictures and scenario, or no pictures or scenario (control), followed by the Acceptance of Cosmetic Surgery Scale (ACSS, Henderson-King & Henderson-King, 2005), the Body Parts Satisfaction Scale (Berscheid, Walster, & Bohrstedt, 1973), and the Physical Self Description Questionnaire (Marsh, Richards, Johnson, Roche, & Tremayne, 1994). There was a significant relationship between ACSS Intrapersonal subscale and picture/scenario …

Parental Influences On Children’S Physical Activity, Molly Eshelman

Dissertations and Theses @ UNI

The general purpose of this study was to investigate the role of parental influence on children's physical activity (PA) behaviors. The specific purposes were to (1) determine the relationship between parental attitudes and their children's PA, (2) determine if parental exercise habits are related to their children's PA participation, (3) determine if parental knowledge of physical activity recommendations is related to their children's PA participation, ( 4) examine the nature of parenting practices on their children's PA participation, and (5) investigate the mediating effect of socio-economic status on the influence parents have on their children's PA participation. Questionnaires were obtained …

Body Type And Perceived Physical Competence In College Female Dancers, Brenna Marie Vogel

Dissertations and Theses @ UNI

The relationship between body type and perceived physical competence was determined among college female company dancers. Participants were from one of four technique based dance companies at a midwestern university. They were questioned as to their perceived physical competence in seven different styles of dance, all of which had been offered at the selected university over the previous academic year. Body type was calculated using both the Body Mass Index Scale and the Body Composition Analyzer, which is a bioelectrical impedance analysis of one's body fat percentage, total body water, and body weight. A total of 44 participants took part …

Substance Use And Injury With College Athletes: Does Injury Affect Perceptions?, Kristine Johnson

Dissertations and Theses @ UNI

Collegiate athletes may perceive the characteristics of substances differently following an injury. Therefore, the purpose of this research was to determine whether perceptions of substance use among collegiate athletes change after an injury occurs. The study also examined differences between sex, scholarship status, and academic level on perceptions of substance use. A total of 141 Division I college athletes participated in this study, with 96 completing the post-test. They were asked to complete a Perceptions of Substance Use Survey in the fall and again in the spring; participants' injury data was collected over a 6 month period from athletic trainers. …

Regional Differences In Jurors’ Attitudes And Knowledge, Heather M. Caspers

Dissertations and Theses @ UNI

Dynamic social impact theory (DSIT; Latane, 1996) suggests that social influence leads to four phenomena: clustering (regional differences in attitudes), correlation (emergent relationships between attitudes), consolidation (reduction in attitude variance), and continuing diversity (whereby minority opinions persist). These phenomena have been shown in a variety of settings (Harton & Bourgeois, 2004; Harton & Bullock, 2007), but geographic clustering in attitudes about crime have not been examined. These attitudes have the potential to affect a verdict in a trial if a defendant has a change of venue to a different area of the state or the country. Two datasets, the National …

Cultural Tolerance Of Americans In Canada, Benjamin Campbell Barclay

Dissertations and Theses @ UNI

The purpose of this research was to develop a cultural tolerance scale, and determine how well it correlates with certain personality dimensions as well as expected stress. The cultural tolerance scale was administered to 104 students from the University of Northern Iowa along with shortened versions of the IPIP and RWA. As expected, the findings showed that cultural tolerance is correlated with openness and agreeableness, but no other personality dimensions. Cultural tolerance is also negatively correlated with R WA and expected stress. Cultural tolerance is a very good predictor of expected stress. This scale could be used as an effective …

Kurt Vonnegut, Authorship And The Purpose Of Literature: A Study Of Kilgore Trout, Danielle M. Benesh

Dissertations and Theses @ UNI

The works of Kurt Vonnegut demonstrate the author's lifelong interest in the purpose of literature and the role of the author in a postmodern society. Through the use of his most frequently recurring character, the science-fiction writer Kilgore Trout, Vonnegut questions the ways in which an author's works influence readers and ponders the relationship between society and art. These themes are explored in detail in the four novels which feature Kilgore Trout most prominently: God Bless You, Mr. Rosewater, Slaughterhouse-Five, Breakfast of Champions and Timequake. A study of these novels reveals a progressive personification of the Trout figure, as …

A Master's Recital In Viola, Amy Beekhuizen

Dissertations and Theses @ UNI

Amy Beekhuizen performed her graduate recital on March 12, 2010 at 6:00 p.m. in Davis Hall at the Gallagher-Bluedorn Performing Arts Center, University of Northern Iowa. This recital was given in partial fulfillment of the Master of Music degree in viola performance. The program consisted of Suite No. 3 in C major, BWV 1009, by Johann Sebastian Bach, Sonate for Viola and Piano, Op. 25, No. 4, by Paul Hindemith, Elegy for Viola and Piano, Op. 44, by Alexander Glazunov, and Sonata for Viola and Piano, by Rebecca Clarke. Polina Khatsko, adjunct instructor of piano at the University of Northern …

From The Barrio To A Four-Year University: The Academic Success Stories Of Fifteen Socioeconomic Disadvantaged Latino Male College Students, Erineo Eddy Espinoza

Dissertations and Theses @ UNI

Review of the prior literature on the topic of academic achievement among U.S. Latino students reveals both problematic performance and systematic disadvantaged obstacles that impede their ability to achieve expected academic accomplishments. Despite such conditions, however, there are Latino students from disadvantaged backgrounds who graduated from high school and enrolled in a four year university. Interpretations of action theory were used as a theoretical framework to interview 15 collegiate Latino males, who grew up in disadvantaged socioeconomic communities (barrios) and enrolled in a four year university. Three findings emerged from their interviews that explained the academic achievements from both these …

Faculty Hiring Committees Perceptions Of Hiring Processes And Subjectivity, Laura Caraleen Foster

Dissertations and Theses @ UNI

Hiring the most capable applicants has a large impact on the bottom line of an organization. The most effective tools to identify talent are well known to IndustrialOrganizational Psychologists, but these analytical tools are used less frequently than less effective intuitive procedures, such as the traditional unstructured job interview. In a survey of university faculty, we found that the most important factor influencing the use of a selection tool was its perceived validity, but these perceptions were not wellcalibrated to actual criterion related validity. We found some evidence that perceived validity was influenced by implicit beliefs about hiring. A body …

The Relationship Between Aggression And Measures Of Neuroticism And Agreeableness In College Students, Ashley Alexandra Buol

Dissertations and Theses @ UNI

Past studies on aggression have typically focused on physical aggression (Crick & Grotpeter, 1995). Recently, however, researchers have started to look at a subtle form of aggression known as relational aggression (Crick & Grotpeter, 1995). There have also been few studies that have focused on perceptions of aggression, as well as the personality traits that may be associated with these perceptions. Thus, the current study was designed to explore the relationship between personality characteristics, specifically agreeableness and neuroticism, and perceptions of aggression. The relationship between the levels of aggression and perceptions of aggression was also examined. Four questionnaires were utilized …

A Study In Law And Literature: Themes Of Exceptionalism And Equity In British And American Culture, William J. Wagner

Scholarly Articles

The advent of a new scale of international terrorism on September 11, 2001 posed a case for moral and legal evaluation that appeared to some in the global community to evade the reach of received rules or principles of moral or political action. The perceived threat and a certain sense by some governmental actors to an entitlement of latitude in response seemed to sever the situation from rules and principles in a depth dimension of consciousness. For many, the case's enormity overwhelmed its abstract moral definition. The foreign policy response of the United States-the country which had been attacked-further reinforced …