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2010

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Corporate Governance, Firm Characteristics And Internet Financial Reporting: Evidence From Egyptian Listed Companies, Ane Elsayed, Aa El-Masry, Im Elbeltag Jan 2010

Corporate Governance, Firm Characteristics And Internet Financial Reporting: Evidence From Egyptian Listed Companies, Ane Elsayed, Aa El-Masry, Im Elbeltag

Plymouth Business School

This study investigates the effect of corporate governance and firm characteristics on the Internet financial reporting (IFR) of the Egyptian listed companies. We develop a disclosure index to measure the three components of the IFR for the Egyptian listed corporations by using an un-weighted checklist. The results find a significant relationship between the three components of IFR (TOTAL, CONTENT and PRESENTATION) and firm size, ownership diffusion, type of business, profitability, audit type, institutional ownership and board size. The results indicate that large non-financial companies that are audited by the big four auditing companies with high diffusion in their ownership and …

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Online Disclosure: An Analysis Of Egyptian Listed Companies, Aa El-Masry, A Elsayed, I Elbeltagi Jan 2010

Online Disclosure: An Analysis Of Egyptian Listed Companies, Aa El-Masry, A Elsayed, I Elbeltagi

Plymouth Business School

The internet becomes a very useful information disclosure tool in the recent years. Many corporations begin to disseminate their information on their websites to support the different needs of their stakeholders. Internet financial reporting has unique characteristics. These include, the ability to disseminate the information to wide audience on more timely basis and using different types of information format such as (hypertext, multiple file format (PDF, HTML) and using multimedia). As the internet financial reporting practices are voluntary, many companies can improve their disclosure with both the content and presentation of the disclosed information. Consequently, many studies in developed countries …

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Some Will Pay For What Others Will Pay To Avoid): Vernacular Typography And Popular Culture: Part Of Portfolio Kurl Up N Dye, I Rae Jan 2010

Some Will Pay For What Others Will Pay To Avoid): Vernacular Typography And Popular Culture: Part Of Portfolio Kurl Up N Dye, I Rae

School of Art, Design and Architecture

No abstract provided.

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Multidisciplined Individuals: Defining The Genre, Jacqueline Rhoda Rogers Jan 2010

Multidisciplined Individuals: Defining The Genre, Jacqueline Rhoda Rogers

Plymouth Business School Theses

Much of literature is predicated upon the assumption that learning occurring inside the workplace is related to developing expertise associated with the tasks for which the individual is employed and has a background in. This research investigates those individuals who acquire expertise in other disciplines and how the application of that additional expertise changes and enhances the individual and the organisation. By combining perspectives across the disciplinary boundaries and developing multidisciplinary expertise, these individuals demonstrate better methods of achieving business objectives, leading to faster, more imaginative solutions, more frequently, and with significantly less effort. The literature review commenced with defining …

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An Exclusive Countryside? Crime Concern, Social Exclusion And Community Policing In Two English Villages, Richard Yarwood Jan 2010

An Exclusive Countryside? Crime Concern, Social Exclusion And Community Policing In Two English Villages, Richard Yarwood

School of Geography, Earth and Environmental Sciences

No abstract provided.

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Erbb/Her Receptor Activation And Preclinical Efficacy Of Lapatinib In Vestibular Schwannoma, Sylwia Ammoun, Clare H. Cunliffe, Jeffrey C. Allen, Luis Chiriboga, Filippo G. Giancotti, David Zagzag, C. Oliver Hanemann, Matthias A. Karajannis Jan 2010

Erbb/Her Receptor Activation And Preclinical Efficacy Of Lapatinib In Vestibular Schwannoma, Sylwia Ammoun, Clare H. Cunliffe, Jeffrey C. Allen, Luis Chiriboga, Filippo G. Giancotti, David Zagzag, C. Oliver Hanemann, Matthias A. Karajannis

Peninsula Medical School

Vestibular schwannomas (VS) arising sporadically or in patients with neurofibromatosis type 2 (NF2) consistently lack expression of Merlin, a tumor suppressor. Conventional treatment options include surgery and radiotherapy but there is no validated medical option. Recent evidence suggests that Merlin deficiency may result in abnormal activation of receptor tyrosine kinases (RTKs) and downstream signaling, promoting tumor growth. Although small-molecule RTK inhibitors are widely available for clinical use, no such therapy has been validated in patients with VS. To screen for RTK activation, surgical VS specimens from patients with and without NF2 were analyzed by phospho-RTK profiling arrays. Downstream signaling pathway …

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Effects Of Hif-1 And Hif2 On Growth And Metabolism Of Clear-Cell Renal Cell Carcinoma 786-0 Xenografts, S Biswas, H Troy, R Leek, Y-L Chung, Et Al Jan 2010

Effects Of Hif-1 And Hif2 On Growth And Metabolism Of Clear-Cell Renal Cell Carcinoma 786-0 Xenografts, S Biswas, H Troy, R Leek, Y-L Chung, Et Al

Peninsula Medical School

In cultured clear-cell renal carcinoma (CCRCC) 786-0 cells transfected with HIF1α (HIF-1+), HIF-2α (HIF-2+), or empty vector (EV), no significant differences were observed in the growth rates in vitro, but when grown in vivo as xenografts HIF-2α significantly increased, and HIF-1α significantly decreased growth rates, compared to EV tumors. Factors associated with proliferation were increased and factors associated with cell death were decreased in HIF-2+ tumors. Metabolite profiles showed higher glucose and lower lactate and alanine levels in the HIF-2+ tumors whilst immunostaining demonstrated higher pyruvate dehydrogenase and lower pyruvate dehydrogenase kinase 1, compared to control tumors. Taken together, these …

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