Digital Commons Network^™

Ecology And Transmission Of Buruli Ulcer Disease: A Systematic Review, Richard W. Merritt, Edward D. Walker, Pamela L. C. Small, John R. Wallace, Paul D. R. Johnson, Mark Eric Benbow, Daniel A. Boakye

Biology Faculty Publications

Buruli ulcer is a neglected emerging disease that has recently been reported in some countries as the second most frequent mycobacterial disease in humans after tuberculosis. Cases have been reported from at least 32 countries in Africa (mainly west), Australia, Southeast Asia, China, Central and South America, and the Western Pacific. Large lesions often result in scarring, contractual deformities, amputations, and disabilities, and in Africa, most cases of the disease occur in children between the ages of 4–15 years. This environmental mycobacterium, Mycobacterium ulcerans, is found in communities associated with rivers, swamps, wetlands, and human-linked changes in the aquatic environment, …

Breaking The Dress Code: Protecting Transgender Students, Their Identities, And Their Rights., Zenobia V. Harris

The Scholar: St. Mary's Law Review on Race and Social Justice

Abstract Forthcoming.

Alternative Scheduling Models And Their Effect On Science Achievement At The High School Level, Jay Roland Dostal

Student Work

This study will evaluate alternative scheduling methods implemented in secondary level schools. Students were selected based on parent selection of programs. Traditional scheduling involves numerous academic subjects with small increments of time in each class and block scheduling focuses on fewer academic subjects and more instructional time. This study will compare office referral numbers, absence frequency, and Essential Learner Outcome (ELO) science strand scores in the 8th-grade (pretest) to the same students office referrals, absence frequency, and ELO science strand scores in the 11th-grade (posttest) between Seven Period Traditional Scheduling (SPTS) and Four Period Block Scheduling (FPBS) in the hopes …

Cigarette Smoke, Dna Damage And Repair In Human Cervical And Vaginal Cells In Vitro And Ex Vivo., Afsoon Moktar

Electronic Theses and Dissertations

Among gynecological malignancies, carcinoma of the cervix is the leading cancer type worldwide. Conversely, vaginal tumors account for an incidence of approximately 1-2% of lower genital tract malignancies. Interestingly, the major shared risk factor among women with cervical and vaginal tumors is infection with cancer-associated human papillomaviruses (HPVs). In fact, HPV infection is the necessary causative factor in the development and progression of cervical and vaginal neoplasia in the majority of cases. Epidemiological studies support that cervical and vaginal pre-cancerous lesions that are initiated by HPV infection generally regress in the absence of known risk factors such as cigarette smoking. …

Dimensional Relationships Between The Sphenoid Sinus, Maxillary Sinuses And Other Craniomaxillofacial Structures Using Cone-Beam Computed Tomography Analysis., Richard Michael Halpern

Electronic Theses and Dissertations

Introduction: The study investigated dimensional relationships between the sphenoid and maxillary sinuses and other selected craniomaxillofacial structures by using traditional cephalometric and volumetric procedures based on cone beam computed tomographic (CBCT) data. Methods and Materials: A retrospective three-dimensional (volumetric) and two-dimensional (conventional cephalometric) analyses were conducted on CBCT datasets of 27 subjects who met the inclusional criteria from a sampled database of 2,290 individuals. Subjects were divided into 3 groups: (1) pre- fused spheno-occipital synchondrosis < 18 years (n=8), (2) fused spheno-occipital synchondrosis < 18 years (n=9), and (3) = 18 years with fused spheno-occipital synchondosis (n= 10). Results: Differences between studied groups were found for linear and angular measurement. Specific correlations were found between certain topographic and internal measurements, and some sinus dimensions and other selected craniomaxillofacial structures. Conclusion: Dimensional correlations exist between the sphenoid and maxillary sinuses and development of other selected craniomaxillofacial structures.

The Morality Of Special Relationships, Joshu Davis

XULAneXUS

This essay originated as a senior thesis paper, attempting to address the problem various normative ethical theories had when put in the realm of “special relationships.” Special relationships are the relationships people have with family and close friends, which often have special duties or rights associated with them. Furthermore, the duties and rights associated with special relationships are often very different and more complex than those associated with strangers. The focus of the thesis was to see whether or not the various normative ethical theories within philosophy could be applied to special relationships without compromising the unique aspects of special …

Application Of Differential Transform Method To The Generalized Burgers–Huxley Equation, J. Biazar, F. Mohammadi

Applications and Applied Mathematics: An International Journal (AAM)

In this paper, the differential transform method (DTM) will be applied to the generalized Burgers-Huxley equation, and some special cases of the equation, say, Huxley equation and Fitzhugh-Nagoma equation. The DTM produces an approximate solution for the equation, with few and easy computations. Numerical comparison between differential transform method, Adomian decomposition method and Variational iteration method for Burgers-Huxley, Huxley equation and Fitzhugh-Nagoma equation reveal that differential transform method is simple, accurate and efficient.

Approximate Approach To The Das Model Of Fractional Logistic Population Growth, S. Das, P. K. Gupta, K. Vishal

Applications and Applied Mathematics: An International Journal (AAM)

In this article, the analytical method, Homotopy perturbation method (HPM) has been successfully implemented for solving nonlinear logistic model of fractional order. The fractional derivatives are described in the Caputo sense. Using initial value, the explicit solutions of population size for different particular cases have been derived. Numerical results show that the method is extremely efficient to solve this complicated biological model.

Tennessee Forestry Commission Annual Report 2010, Tennessee. Department Of Agriculture.

Forestry Commission Annual Report

No abstract provided.

Analysis Of An Online Support Group For Women With Breast Cancer, Laura Boxley

Loma Linda University Electronic Theses, Dissertations & Projects

With over 200,000 new diagnoses in 2004, breast cancer is one of the most commonly diagnosed cancers among women in the United States. Both the stress of treatment and the threat of a potentially lethal illness present significant challenges to an individual's emotional well-being and coping skills, yet paradoxically many women report benefits from dealing with this adversity. The aims of this investigation were to describe the characteristics of benefit finding as expressed by breast cancer survivors participating in an online breast cancer support group, and to assess the relationship between symptom distress, emotional well-being and benefit finding using baseline …

Parental Divorce, Attachment, And Self-Other Conceptualization, Julia A. Hewett

Loma Linda University Electronic Theses, Dissertations & Projects

The formation of strong attachment bonds in childhood and adolescence has a significant effect on adult self and other concepts operationalized here as self-esteem and hostility. These self-other conceptualizations are posited to facilitate the formation of successful relationships and well-being in adulthood. To determine whether parental separations before the age of 16 years disrupt attachment bonds and subsequent self-other conceptualizations, participants from three naturally formed parental marital status groups were compared on attachment, self-esteem and hostility: divorced parents (N = 622), married parents (N = 7, 424), or divorced but remarried parents (N = 313). Individuals who had divorced or …

Protein Preservation In Fossil Whale Bones Of The Miocene/Pliocene Pisco Formation, Peru, Uriel Leme Vidal

Loma Linda University Electronic Theses, Dissertations & Projects

Fossil remains have recently been the focus of considerable attention due to several independent reports of protein and soft-tissue preservation in ancient biological remains. The fossil whales from the Pisco Formation in Peru were previously reported to be very well preserved. A considerable percentage of these whales have their bones still articulated, and not a few have fossil baleen in life position. In this study we assayed bone samples from some fossil whales for ultrastructure preservation and the presence of original protein/proteinaceous materials. For analysis of fine details of structural preservation we used light microscopy and Scanning Electron Microscopy (SEM). …

Long-Term Hypoxia Regulates Cortisol Biosynthesis In The Ovine Fetal Adrenal Cortex, Vladimir Enrique Vargas

Loma Linda University Electronic Theses, Dissertations & Projects

Previous studies demonstrated enhanced fetal adrenal cortisol biosynthesis following exposure to long-term hypoxia (LTH). The studies presented here were designed to determine the mechanism(s) regulating this important adaptive endocrine response. Ewes were maintained at high altitude (3,820 m) from approximately day 40 to 138-141 of gestation. Fetal adrenal glands were then collected from LTH and age matched normoxic controls. Dispersed fetal adrenal cortical cells (FACs) were untreated, treated with ACTH, treated in combination with ACTH precursors (POMC and 22-kDa pro-ACTH), or pre-treated with H-89 and or UO126 followed by ACTH treatment. Following ACTH treatment, cortisol biosynthesis increased in both groups …

Cerebral Amyloid Angiopathy And Transition Metals In Alzheimer's Disease, Matthew Schrag

Loma Linda University Electronic Theses, Dissertations & Projects

Alterations in brain metals homeostasis and particularly brain iron overload have been postulated to play a role in Alzheimer's disease, contributing to oxidative stress and neuronal injury; however, the source of this iron is not clear and may be due to metabolic derangement(s), failed iron clearance mechanisms or exogenous deposition such as through bleeding. This series of studies was designed to evaluate the extent of metals dyshomeostasis in the Alzheimer's disease brain and specifically whether microvascular bleeding is a major contributor to Alzheimer's disease-related iron overload. Cerebral amyloid angiopathy (CAA) is a vascular manifestation of Alzheimer's disease present to some …

Coronary Heart Disease Mortality And Long-Term Exposure To Ambient Particulate Air Pollutants In Elderly Nonsmoking California Residents, Lie Hong Chen

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study is to assess the effect of long-term concentrations of ambient PM on risks of all causes, cardiopulmonary, coronary heart disease (CHD), total cancer, and any mention of nonmalignant respiratory disease (NMRD) mortality.

The health effects of long-term ambient air pollution have been studied with up to 30 years of follow-up in the AHSMOG cohort, a cohort of 6,338 nonsmoking white California adults. Monthly concentrations of ambient air pollutants [particulate matter(PMio), Ozone (O3), sulfur dioxide (SO2), nitrogen dioxide (NO2) or particulate matter

In the AHSMOG cohort, each increment of 10 |ig/m3 in PMio in two-pollutant models …

The Role Of Ambient Air Pollution In The Occurrence Of Emphysema, Shiva Metghalchi

Loma Linda University Electronic Theses, Dissertations & Projects

Emphysema is the most common cause of death from respiratory disease in the United States. Emphysema is most common among people aged 50 and older. Those with a genetic predisposition to emphysema may experience the onset as early as their thirties or forties. Men are more likely than women to develop emphysema, but female cases are increasing as the number of female smokers rises.

In the past few years, etiological and pathogenic research has been carried out in an attempt to determine the reason for an increase in deaths and other health problems associated with air pollution, and there have …

Characterizing And Treating The Neuropathology Of Tuberous Sclerosis Complex In The Mouse, Sharon W. Way

Dissertations and Theses (Open Access)

Tuberous sclerosis complex (TSC) is a multisystem, autosomal dominant disorder affecting approximately 1 in 6000 births. Developmental brain abnormalities cause substantial morbidity and mortality and often lead to neurological disease including epilepsy, cognitive disabilities, and autism. TSC is caused by inactivating mutations in either TSC1 or TSC2, whose protein products are known inhibitors of mTORC1, an important kinase regulating translation and cell growth. Nonetheless, neither the pathophysiology of the neurological manifestations of TSC nor the extent of mTORC1 involvement in the development of these lesions is known. Murine models would greatly advance the study of this debilitating disorder. This thesis …

Rmi1 Is Essential For Early Embryonic Development And Attenuation Of Tumor Development, Haoyi Chen

Dissertations and Theses (Open Access)

RMI1 (BLM-Associated Protein 75 or Blap75) is highly conserved from yeast to human. Previous studies have shown that hRMI1 is required for BLM/TopoIIIα/RMI1 complex stability and function. However, in vivo functions of RMI1 remain elusive. To address this question, I generated RMI1 knockout mice by homologous replacement targeting. While RMI1+/- mice showed no obvious phenotype, deletion of both RMI1 alleles leads to early embryonic lethality before implantation. I then generated RMI1/p53 double knockout mice. After ionizing radiation treatment at 4Gy, RMI1/p53 double-heterzygous mice showed shortened tumor latency and aggressive tumor types when comparing with wild type, RMI1+/- and p53+/- control …

New To Ols For Monitoring Gamma Camera Uniformity, Brad K. Lofton

Dissertations and Theses (Open Access)

Detector uniformity is a fundamental performance characteristic of all modern gamma camera systems, and ensuring a stable, uniform detector response is critical for maintaining clinical images that are free of artifact. For these reasons, the assessment of detector uniformity is one of the most common activities associated with a successful clinical quality assurance program in gamma camera imaging. The evaluation of this parameter, however, is often unclear because it is highly dependent upon acquisition conditions, reviewer expertise, and the application of somewhat arbitrary limits that do not characterize the spatial location of the non-uniformities. Furthermore, as the goal of any …

Analysis Of Β8 Integrin In Neurogenesis And Neurovascular Homeostasis, Aaron K. Mobley

Dissertations and Theses (Open Access)

Neurogenesis in the adult mouse brain occurs within the subventricular zone (SVZ) of the lateral ventricle. In the SVZ, neural stem cells (NSC) reside in a specialized microenvironment, or vascular niche, consisting of blood vessels and their basement membranes. Most NSCs in the SVZ differentiate into progenitor cells, which further differentiate to generate neuroblasts, which then migrate from the SVZ to the olfactory bulbs (OB) along the rostral migratory stream (RMS). ECM-mediated adhesion and signaling within the vascular niche likely contribute to proper NSC self-renewal, survival, differentiation and neuroblast motility. The mechanisms that control these events are poorly understood. Previous …

Anencephaly: Concepts Of Personhood, Ethical Questions, And Nursing Care, Jessica L. Ryskamp

Senior Honors Theses

Anencephaly is a neural tube defect that severely limits the lifespan of affected infants. While these infants have no higher brain function, they are still persons, and should be given the same moral and ethical considerations as healthy infants. With this in mind, organ donation procedures should follow the same guidelines that apply to other donors. Because a large part of nursing care for anencephalic infants is palliative care, nurses need appropriate training to care effectively for both the infant and the family, providing for physical, emotional, psychological, and spiritual needs.

The "Enlightened Barbarity" Of Inclusive Fitness And Wrongful Death: Biological Justifications For An Investment Theory Of Loss In Wycko V. Gnodtke, Ryan Shannon

University of Michigan Journal of Law Reform

Wrongful death laws should permit and encourage courts and juries to consider the survivors' investment in decedents when determining wrongful death damages, given new biological justifications for this theory of loss. The investment theory of damages, which permits an award of damages based on the investment of financial resources relatives make in one another, originated in Michigan's courts in the early 1 960s, but as of present day has been largely abrogated. In the context of modern understandings of evolutionary biology, including kin selection theory and sociobiology, the investment theory of recovery accords with the goals of corrective justice as …

Exhausted Or Unlicensed: Can Field-Of-Use Restrictions In Biotech License Agreements Still Prevent Off-Label Use Promotion After Quanta Computer?, Kristal M. Wicks

The University of New Hampshire Law Review

[Excerpt] “In the biotechnology (biotech) industry, companies must be increasingly aware of their intellectual property and how their licensing strategies can impact their rights. When licensing patented technology, it is common practice for biotech companies to include restricted field-of-use provisions in their license agreements. Such provisions permit a licensee to only use licensed technology in a defined field and restrict use or development in another field. This licensing strategy plays an important role within the biotech industry because it allows companies to more effectively control their intellectual property and to more efficiently research and develop pharmaceutical products.

A problem that …

Recommendations For The Chamlidere Petrified Forest Management Plan, Fatma Ertem

Graduate Theses and Dissertations

Anything inherited from our ancestors or from nature can be considered as our heritage. Heritage can be classified as cultural and natural heritage. Turkey has been the cradle of many civilizations, religions, and ethnic groups because of the unprecedented natural heritage and critical geopolitical location of Anatolia. Given all the treasure of cultural and natural heritage in Turkey, heritage management practices have not been emphasized as they deserve. A petrified forest was found in Chamlidere, Ankara (Turkey) in 2004. Chamlidere petrified forest preserves information related to the biodiversity of forests in the Galatian Volcanic Province during the Early-Middle Miocene. When …

History Of The Indian Caste System And Its Impact On India Today, Manali S. Deshpande

Social Sciences

The Indian Caste System is historically one of the main dimensions where people in India are socially differentiated through class, religion, region, tribe, gender, and language. Although this or other forms of differentiation exist in all human societies, it becomes a problem when one or more of these dimensions overlap each other and become the sole basis of systematic ranking and unequal access to valued resources like wealth, income, power and prestige. The Indian Caste System is considered a closed system of stratification, which means that a person’s social status is obligated to which caste they were born into. There …

The Parents' Role In Childhood Obesity, Heather M. Wintrup

Psychology and Child Development

This paper is an examination of the current childhood obesity crisis in the U.S. and how this epidemic is related to psychological issues. Specifically, the role of parental forces on children’s health attitudes and habits is addressed. The following chapters will define and explain the current situation of childhood obesity, investigate the role parents have in contributing to their children’s weight development, and cover methods of intervention for families dealing with this serious health issue.

A Generational Look Into The Occurrence Of Child Maltreatment Among Latinos And Their Effects On Developmental Growth, Maria Teresa Sanchez Diosdado

Psychology and Child Development

Little is known about the prevalence or risk factors associated with child maltreatment among Latino immigrant and native born families. As a result, Latino children and families are often treated as a homogeneous group, with little understanding of the potential differences that may exist between immigrant and native-born families. This paper attempts to explain the concept of child maltreatment and explore the differences between the two groups, while taking into account the effects of acculturation, Belsky’s Ecological Model of Maltreatment, childrearing practices, and the developmental consequences of maltreatment. Finally, the role that Child Protective Services plays in this issue will …

Epigenetic Regulation Of Neuronal Maturation: The Effect Of Mecp2 And Micrornas On The Maturation Of Hippocampal Neurons, Richard D. Smrt

Biomedical Sciences ETDs

Dendrites and the dendritic spines of neurons play key roles in the connectivity of the brain and have been recognized as the locus of long-term synaptic plasticity, which is correlated with learning and memory. The development of dendrites and spines in the mammalian central nervous system is a complex process that requires specific molecular events over a period of time. It has been shown that specific molecules are needed not only at the spines point of contact, but also at a distance, providing signals that initiate a cascade of events leading to synapse formation. The specific molecules that act to …

Structure Of Narratives: Applying Propp's Folktale Morphology To Entertainment-Education Films, Divya Sreenivas

Communication ETDs

This study examines narrative strategies through which feature films accomplish the dual role of entertainment-education to shape social reality surrounding health issues. More specifically, exploring films' narrative structures and characterization, this study illuminates how a coherent HIV/AIDS narrative is woven into cinematic artifacts laden with specific cultural values, beliefs and practices. The entertainment-education literature has rarely undertaken a study of films to demonstrate their entertainment-education potential. Moreover, by taking a structuralist perspective and utilizing narrative theories this study uncovers underlying elements that cut across narratives. According to Fisher (1987), the proponent of narrative theory, narratives are moral constructs with values …

Jewish Landscapes Rooted, Embedded, Enshrined, And Transcendent: Metaphor As Communicated In Jewish Museums In New York, Jerusalem, And San Francisco, Judith Stauber

Communication ETDs

As public places, museums negotiate authenticity and re-presentation, fact and ideology, memory and the present confronting a basic question for museums directors, curators, and visitors alike: what is the truth here? In this dissertation, the content and form of four Jewish museums are examined rhetorically: The Jewish Museum, and the Museum of Jewish Heritage: A Living Memorial to the Holocaust, both in New York City; the Holocaust History Museum at Yad Vashem in Jerusalem; and the Contemporary Jewish Museum in San Francisco. Four metaphors--rootedness, embeddedness, enshrinement, and transcendence--capture the ways each of these museums conceptualizes and presents Jewish culture.