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Methods And Compositions For Optimizing Blood And Tissue Stability Of Camptothecin And Other Albumin-Binding Therapeutic Compounds, Thomas G. Burke, Daniel C. Carter

Pharmaceutical Sciences Faculty Patents

The present invention provides methods and formulations for optimizing the anti-cancer and anti-HIV activities of a camptothecin drug, including camptothecin and its related analogs including 9-aminocamptothecin and 9-nitrocamptothecin. The invention involves methodologies and formulations that limit human serum albumin-mediated reduction of the anti-cancer and anti-HIV effects of the camptothecins, and the methods and formulations provide combination therapies in which binding of the camptothecin agent to human serum albumin can be modulated by the administration of a competing agent that also binds human serum albumin. Reduced camptothecin drug binding to human serum albumin can result in elevated camptothecin free drug levels …

Inhibition Of Ship To Enhance Stem Cell Harvest And Transplantation, Caroline Desponts, Joseph Wahle, John Ninos, William G. Kerr

USF Patents

The instant invention teaches the inhibition of SHIP expression, or function, for the increased efficacy of autologous stem cell transplants. In another embodiment, interference with SHIP function can be used to temporarily expand and mobilize the hematopoietic stem cell compartment to assist with leukapheresis, to promote hematopoietic recovery after myeloablation treatments, to deplete target stem cell clones (such a leukemic clones and other tumor stem cell types), and to deplete, or damage, the repopulating ability of the endogenous hematopoietic stem cell pool in order to allow transplanted hematopoietic stem cells to better home and engraft and to promote in vivo …

Method For Preventing, Or Reducing The Severity Of, Graft-Versus-Host Disease Using Pluri-Differentiated Mesenchymal Progenitor Cells, Beerelli Seshi

USF Patents

There is provided an isolated pluri-differentiated human mesenchymal progenitor cells (MPCs), a method for isolating and purifying human mesenchymal progenitor cells from Dexter-type cultures, and characterization of and uses, particularly therapeutic uses for such cells. Specifically, there is provided isolated MPCs which can be used for diagnostic purposes, to enhance the engraftment of hematopoietic progenitor cells, enhance bone marrow transplantation, or aid in the treatment or prevention of graft versus host disease.

Spectrophotometric Method And Apparatus For The Cross-Matching Of Platelets, Luis Humberto Garcia-Rubio, Robert Potter, German Leparc, Sharyn Orton, Yvette Mattley, Christina Bacon

USF Patents

A method and apparatus for characterizing the type of a blood sample and a variety of blood components are provided wherein a transmission spectrum of the sample is collected over a predetermined wavelength range. For blood typing, this spectrum is then compared with a set of control spectra collected from control blood samples having known blood types, from which the type of the blood sample can be determined. Further methods and apparatus are provided for determining the viability of and for cross matching a platelet unit Additional method and apparatus permit analysis of the sample for the presence of a …

Process For Hydrogen Production Via Integrated Processing Of Landfill Gas And Biomass, Nazim Muradov, Ali Raissi, Franklyn Smith

UCF Patents

Hydrogen production is provided via integrated closed-loop processing of landfill gas (LFG) and solid biomass feedstocks such as various agricultural wastes with minimal environmental impact. LFG is purified of harmful contaminants over a bed of activated charcoal (AC) and is catalytically reformed to synthesis gas, which is further processed to pure hydrogen via CO-shift and pressure-swing adsorption stages. Biomass is gasified in the presence of steam with production of a producer gas and AC. The producer gas is mixed with LFG and is processed to hydrogen as described above. High-surface area AC produced in the gasifier is used for the …

The Current Volume 20 : Issue 27, Nova Southeastern University

Student Newspapers

No abstract provided.

Examination Of A Co2 Monitoring System For The Mechanical Ventilation System Of A Gas Exchange Cuvette, Keith V. Spence

Purdue Polytechnic Directed Projects

No abstract provided.

Multi-Host Model-Based Identification Of Armillifer Agkistrodontis (Pentastomida), A New Zoonotic Parasite From China, Shao-Hong Chen, Qin Liu, Yong-Nian Zhang, Jia-Xu Chen, Hao Li, Ying Chen, Peter Steinmann, Xiao-Nong Zhou

Harold W. Manter Laboratory of Parasitology: Library Materials

Background: Pentastomiasis is a rare parasitic infection of humans. Pentastomids are dioecious obligate parasites requiring multiple hosts to complete their life cycle. Despite their worm-like appearance, they are commonly placed into a separate sub-class of the subphylum Crustacea, phylum Arthropoda. However, their systematic position is not uncontested and historically, they have been considered as a separate phylum.

Methodology/Principal Findings: An appraisal of Armillifer agkistrodontis was performed in terms of morphology and genetic identification after its lifecycle had been established in a multi-host model, that is, mice and rats as intermediate hosts, and snakes (Agkistrodon acutus and Python molurus) …

Immune Redistribution To Skin In Wild And Domesticated Songbirds, Joshua Ryan Kuhlman

USF Tampa Graduate Theses and Dissertations

Implantation of dental sponges under the skin of lab rodents has been used to evaluate whether acute stress enhances leukocyte infiltration to a surgical site. First, I replicated this technique in house sparrows to test whether transient stressors cause similar immunoredistribution (i.e., movement of immune cells out of circulation and to the periphery) in a wild animal. As placement into captivity alone may serve as a stressor to wild animals, I compared sponge infiltration over different periods of captivity. Second, I compared how domestication affects immunoredistribution by comparing results of wild sparrows to domesticated zebra finches. Zebra finches were chosen …

2010 Abstract Booklet, Undergraduate Research Center, Minnesota State University, Mankato

Undergraduate Research Symposium

Complete Schedule of Events for the 12th Annual Undergraduate Research Symposium at Minnesota State University, Mankato.

2010 April 5

Minutes

No abstract provided.

Brief Of Amici Curiae Dinah Bear, Robert Glicksman, Oliver Houck, Daniel Mandelker, Thomas Mcgarity, Robert Percival, Zygmunt Plater, Nicholas Robinson, And Gary Widman In Support Of Respondents, Monsanto Co. V. Geertson Seed Farms, No. 09-475 (U.S. Apr. 5, 2010), Hope M. Babcock

U.S. Supreme Court Briefs

No abstract provided.

Governors State Receives $7.1 Million Department Of Education Grant, Office Of Public Affairs

Press Releases

Governors State University, with the assistance of a $7.1 million federal education grant, will expand and refine teaching programs designed to raise student achievement and improve instruction in nine high-need Chicago Southland school districts.

Program Review: Office Of Graduate Studies And Research, University Of Nebraska At Kearney Office Of Graduate Studies And Research

Academic Program Reviews

No abstract provided.

This Week At Stony Brook Southampton/In The News | This Week At Sbs, V.5, N.10, Darren Johnson

Southampton Announcements and News

No abstract provided.

Commonwealth Times 2010-04-05 [Front Page Has 2010-04-01]

Commonwealth Times, 1969-

No abstract provided.

Columbia Chronicle (04/05/2010), Columbia College Chicago

Columbia Chronicle

Student newspaper from April 5, 2010 entitled The Columbia Chronicle. This issue is 48 pages and is listed as Volume 45, Number 25. Cover story: "Eating their words" Editor-in-Chief: Bethany Reinhart

Cytotoxicity Of Cu(Ii) And Zn(Ii) 2,2′-Bipyridyl Complexes: Dependence Of Ic 50 On Recovery Time, Yi Shi, Bonnie B. Toms, Namrata Dixit, Jerry Goodisman, James C. Dabrowiak

Chemistry - All Scholarship

We measure the cytotoxicity of three metal complexes containing the 2,2′-bypyridine ligand, Cu(bpy)(NCS) ₂, 1, [Cu(bpy) ₂(H ₂O)](PF ₆) ₂, 2, and Zn(bpy) ₂(NCS) ₂, 3, toward neuroblastoma cells (SK-N-SH) and ovarian cancer cells (OVCAR-3) using two different cell assays. The cells were exposed to various concentrations of the compounds for 1 h and the percent inhibition of cell growth, I, measured for various times after exposure, i.e., as a function of the recovery time t. After developing the theory showing the relationship between I and t, the cytotoxicity data were analyzed to …

04-05-2010 Swosu Biology Club Plant Sale This Thursday, Southwestern Oklahoma State University

THE BARK ARCHIVE 2010

Southwestern Oklahoma State University's Biology Club will host its annual plant sale this Thursday, April 8, from 8 a.m. to 4 p.m. in the Memorial Student Center on the Weatherford campus.

The Daily Gamecock, Monday, April 5, 2010, University Of South Carolina, Office Of Student Media

April

No abstract provided.

The Collegian (2010-04-05), Julianna Sosa

UTB/TSC Archives - The Collegian [Newspaper]

Vol. 62, No. 24

University Of Northern Iowa Faculty Senate Meeting Agenda, April 5, 2010, University Of Northern Iowa. Faculty Senate.

Documents - Faculty Senate

Meeting agenda from the Faculty Senate of the University of Northern Iowa.

University Of Northern Iowa Faculty Senate Meeting Minutes, April 5, 2010, University Of Northern Iowa. Faculty Senate.

Documents - Faculty Senate

Meeting minutes from the Faculty Senate of the University of Northern Iowa.

April 5, 2010 Reporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Grand Valley Forum, Volume 034, Number 28, April 5, 2010, Grand Valley State University

2009-2010, Volume 34

Grand Valley Forum is Grand Valley State's faculty and staff newsletter, published from 1976 to the present.

Cytotoxicity Of Cu(Ii) And Zn(Ii) 2,2′-Bipyridyl Complexes: Dependence Of Ic_50 On Recovery Time, Yi Shi, Bonnie B. Toms, Namrata Dixit, Jerry Goodisman, James C. Dabrowiak

Chemistry - All Scholarship

We measure the cytotoxicity of three metal complexes containing the 2,2′-bypyridine ligand, Cu(bpy)(NCS)2, 1, [Cu(bpy)2(H2O)](PF6)2, 2, and Zn(bpy)2(NCS)2, 3, toward neuroblastoma cells (SKN- SH) and ovarian cancer cells (OVCAR-3) using two different cell assays. The cells were exposed to various concentrations of the compounds for 1 h and the percent inhibition of cell growth, I, measured for various times after exposure, i.e., as a function of the recovery time t. After developing the theory showing the relationship between I and t, the cytotoxicity data were analyzed to reveal that the two copper complexes, 1 and 2, cause the cells to …

Pcdp1 Is A Central Apparatus Protein That Binds Ca2+-Calmodulin And Regulates Ciliary Motility, Christen G. Dipetrillo, Elizabeth F. Smith

Dartmouth Scholarship

For all motile eukaryotic cilia and flagella, beating is regulated by changes in intraciliary calcium concentration. Although the mechanism for calcium regulation is not understood, numerous studies have shown that calmodulin (CaM) is a key axonemal calcium sensor. Using anti-CaM antibodies and Chlamydomonas reinhardtii axonemal extracts, we precipitated a complex that includes four polypeptides and that specifically interacts with CaM in high [Ca²⁺]. One of the complex members, FAP221, is an orthologue of mammalian Pcdp1 (primary ciliary dyskinesia protein 1). Both FAP221 and mammalian Pcdp1 specifically bind CaM in high [Ca²⁺]. Reduced expression of Pcdp1 complex …

2010-04-05 Unm News Minute, University Of New Mexico Communication And Marketing Department

UNM News Minute 2010

No abstract provided.

The Effects Of A Prescribed Burn On Streambed Sediments, Macroinvertebrate Assemblages, And Water Quality In The Valle Toledo, Valles Caldera National Preserve, New Mexico, Jeanine K. Mcgann

Water Resources Professional Project Reports

Lotic ecosystems of the southwestern U.S. can be severely affected by wildfires causing alterations in water chemistry, sedimentation from runoff events, and changes in macro invertebrate community structure. In these same systems, the use of prescribed burns as forest and/or grassland management tools also may cause changes. The severity of these changes in comparison to wildfires is of primary importance to the effectiveness of these management tools, as any degradation of aquatic habitats is of serious concern in a semi-arid region. This study evaluates the effects of a recent prescribed burn in the Valle Toledo section of the Valles Caldera …

An Intergroup Perspective On Stepchildren's Communication With Their Nonresidential Parent's Family, Rebecca Diverniero

Department of Communication Studies: Dissertations, Theses, and Student Research

Communicating and negotiating boundaries can be a challenge to family members who have experienced a divorce and remarriage. In particular, stepchildren and their nonresidential parent‘s family must manage potential changes and challenges to their communication and relationship as the stepchild transitions into stepfamily life. Centered in the interpretive paradigm and Communication Accommodation Theory (CAT), the researcher interviewed 29 current and former stepchildren about their transition into stepfamily life to address six research questions: (1) What are the turning points in stepchildren‘s communication with their nonresidential parent‘s family? (2) How do stepchildren perceive and describe family identification with their nonresidential parent‘s …