Digital Commons Network^™

Identifying Controls On Surface Carbon Dioxide Efflux In A Semi-Arid Ecosystem, Katrina Elsie Ladd

Boise State University Theses and Dissertations

This study focused on soil respiration, the least constrained process in the terrestrial carbon cycle, and a source of uncertainty for model predicted ecosystem response to climate change. Respiration processes that make up soil respiration respond to environmental influencing factors, temperature, and moisture. Respiration responses vary by site, time of year, and also year to year, confounding determination of individual influence of the factors, making soil respiration difficult to model. This research took advantage of the climate characteristics of a semi-arid system, in order to observe soil temperature and moisture influence on soil respiration. Field measurements of soil surface CO …

Islands In The Stream: Searching For Structure In The Aboriginal Fishery Along The Snake River, Travis Jay Pitkin

Boise State University Theses and Dissertations

The ethnographic literature describing indigenous groups that traditionally inhabited the course of the Snake River commonly cites anadromous fish as an integral and seasonal part of their subsistence pursuit. This study maps known fishing sites and associated landscape variables along the Snake River. A Geographic Information System (GIS) is used to analyze known fishing sites within the framework of surrounding physiographic features as they related to fishing strategy, salmon behavior, and decisions regarding fishing site selection. Examining the immediate stretch of adjacent river, relevant physiographic features are identified, inventoried, and their intervals recorded. The locations of Snake River fishing sites …

Does Mean Osteon Size Change With Age, Sex Or Handedness? Analysis Of The Second Metacarpal In A 19th Century Sample From Belleville, Ontario, Canada, Bridget Jennifer Denny

Boise State University Theses and Dissertations

Histological analysis of cortical bone can be used to provide information on age at death, health status, and the influence of biomechanical forces on bones. Specifically, a better understanding of the variation in mean osteon size can increase our knowledge about the influence of factors such as age and sex associated changes and their effects on bone metabolic functions. Previous studies suggest that these influences are bone specific and have produced varying results regarding the association between osteon size and the variables mentioned above. To date, no research has focused on mean osteon size in metacarpals. The purpose of this …

An Examination Of The Effectiveness Of An 8-Week Bikram Yoga Program On Mindfulness, Perceived Stress, And Physical Fitness, Zoe Louise Hewett

Boise State University Theses and Dissertations

Previous research has examined the effects of yoga on levels of mindfulness. The physical and psychological outcomes of participation in a Bikram yoga program have not been thoroughly researched, yet this type of yoga may be significant with regards to stress management and inactivity due to its unique method of practice. The purpose of this study was to observe the changes in the levels of mindfulness, perceived stress and physical fitness due to participation in an 8-week Bikram yoga program. It was hypothesized that participants would show improvements in mindfulness, perceived stress and physical fitness. Fifty-one males and females between …

An Exploratory Study Of 2007-08 Idaho Early Childhood Special Education Outcome Data, Brenda Mortensen Cannon

Boise State University Theses and Dissertations

Legislation such as No Child Left Behind (NCLB) and the Individuals with Disabilities Education Improvement Act (IDEA) of 2004 include accountability and enforcement provisions for the education of all children, including children with disabilities. The United States Department of Education, through the Office of Special Education Programs (OSEP), requires all local educational agencies (LEAs) to submit, on an annual basis, data regarding the developmental outcomes and academic achievement of preschool children and youth with disabilities ages 3 through 21 in accordance with NCLB and IDEA 2004. OSEP has established indicators that are meant to inform and support Early Childhood Special …

Cell(F), Nicole Lynn Herden

Boise State University Theses and Dissertations

I see the human experience as composed of both objectivity and subjectivity. Objectivity in that science has helped us better understand our physicality, such as defining biological processes within our body. Empirical knowledge has provided a level of truth in explaining a foundation for our existence.

Subjective experiences materialize as we engage within the environment. Walking in the park or purchasing food seem to be similar experiences for everyone in that we can envision the process of doing it; however, that process is an individual process composed of unique characteristics and perspectives. A subjective experience is as unique as one’s …

Preparation And Characterization Of Extraction Chromatography Resins Using N-Donor Extractants For Trivalent Actinide And Lanthanide Separations, Christopher L. Klug

UNLV Theses, Dissertations, Professional Papers, and Capstones

Actinide and lanthanide elements exist in the geosphere and biosphere due to both natural abundances and anthropogenic activities. The investigation of the presence and transport of actinides through the environment is of great scientific interest. In order to prepare environmental samples for precise measurements, the individual actinides must be separated from the chemically similar lanthanides, and from neighboring actinides. Existing extraction chromatography resins are either poorly suited for this separation, have bleeding problems, are not reusable, or fail the CHON principle. In an effort to resolve these issues, malonamides and N-donor extractants from the BTP and BTBP classes of solvent …

An Updated History Of The Teratology Society., Thomas H Shepard, Mason Barr, Robert L Brent, Andrew Hendrickx, Devendra Kochhar, Godfrey Oakley, William J Scott, John M Rogers

Department of Pediatrics Faculty Papers

BACKGROUND: The 49-year history of the Teratology Society is reviewed. An abbreviated history is outlined in table form, with listings of the Warkany Lectures, the Continuing Education Courses, and officers of the society. The original article was updated to include the years 2000 to 2010.

METHODS: A year-by-year description of the events is given, including the scientific and social content of the annual meetings and changes in the business of the society, in many cases using comments from the past presidents. The valuable and unique diversity of the members is discussed and illustrated, presenting the disciplines and main research areas …

Molecular Characterization Of The Murf Gene Family: Potential Role In Rainbow Trout Muscle Degradation, Jiannan Wang

Graduate Theses, Dissertations, and Problem Reports (ETD)

As United States and world seafood demand increases, aquaculture production becomes more important. Limited knowledge of molecular regulation of muscle growth and flesh quality hinders genetic improvement of these important traits in fish. Our goal is to enhance muscle growth and fillet quantity in rainbow trout, Oncorhynchus mykiss. Muscle growth is determined primarily by rate of protein turnover. Unlike mammals, rapidly growing fish have reduced protein degradation rather than increased protein synthesis. Studies in mammals showed that muscle atrophy results from increased protein breakdown, and is associated with activation of the ubiquitin proteasome pathway including induction of the muscle-specific ubiquitin …

A Proposed Method For Evaluation Of Morphological Changes In The Condyle And Glenoid Fossa By Cone Beam Computed Tomography, Michael R. Munn

Graduate Theses, Dissertations, and Problem Reports (ETD)

The difficulty with three-dimensional analyses remains with the myriad of data that is possible to derive from a volume. The goal of this study is to report 3D changes in the temporomandibular joint in a reliable and quantifiable way. The approach included plotting specific referents on the mandibular condyle and tracking them in magnitude (mm) and direction (°) on a reference plane after superimposing the cone beams three-dimensionally on the inferior alveolar nerve canal and the lower contour of the third molar tooth germ. Two sets of measurements were compared for reliability and each measurement showed varied correlation. Linear measurements …

Aging-Dependent Effects Of Repetitive Loading Exercise And Antioxidant Supplementation On Oxidative Stress In Skeletal Muscle, Michael J. Ryan

Graduate Theses, Dissertations, and Problem Reports (ETD)

Aging is associated with a reduced ability to buffer oxidants along with an increase in oxidant production, resulting in chronic oxidative stress. Oxidative stress is a putative factor responsible for reducing function ability of skeletal muscle and increasing oxidative damage. The objective of this set of investigations was to evaluate the efficacy of reducing oxidative stress on improving muscle function the adaptive response of skeletal muscle to repetitive loading exercise in aging rodents. To achieve this objective, three methods of reducing oxidative stress were utilized; the antioxidant vitamins E&C were used to buffer oxidants, the nutraceutical resveratrol was used to …

Stream Fish Metacommunity And Metapopulation Ecology In A Mined Appalachian Watershed, Roy Worth Martin

Graduate Theses, Dissertations, and Problem Reports (ETD)

Chapter one is a direct empirical evaluation of metacommunity theory using stream fishes in a heavily mined and least impaired region of the Monongahela River basin. Metacommunity ecology, a new multi-scale paradigm, has provided important insights into mechanisms controlling regional patterns of assemblage structure. Metacommunity ecology offers four competing hypothetical models---neutral, patch dynamic, species sorting, and mass effect---each differing slightly in its underlying mechanistic framework.;Our results overwhelmingly supported the mass effect metacommunity model, which suggests that regional patterns of diversity are maintained by local habitat heterogeneity and dispersal among local assemblages. However, our findings also indicated that natural communities are …

Formation Of Testosterone's 5alpha-Reduced, Versus Aromatized, Products Can Have Beneficial Cognitive And Anti-Anxiety Effects Without Negative Effects On Prostate Or Sexual Behavior Of Male Rats, Daniel Dacosta

Biological Sciences

Testosterone (T) can alter sexual, social, anxiety-like, and/or cognitive behavior of male rodents and exert trophic effects on the prostate. However, whether these effects are due to actions of T, or its 5-reduced and/or aromatized metabolites, is of interest. We tested the hypothesis that T’s effects to enhance prostate proliferation, sexual, social, cognitive and/or anti-anxiety-like behavior require formation of 5-reduced and/or aromatized metabolites. Gonadectomized (GDX) or gonadally-intact rats were administered T-containing, or empty, silastic capsules in conjunction with a 5-reductase inhibitor (finasteride; Experiment 1) or an aromatase inhibitor (formestane; Experiment 2). The performance of rats in sexual, cognitive (object recognition, …

Activity-Dependent Sharpening Of The Retinotectal Map In Zebrafish: The Role Of The Par Complex, Laura Mariconda

Biological Sciences

Visual activity acts via NMDA (N-methyl D-aspartate) receptors in order to refine developing retinotectal maps by shaping retinal arbors. In zebrafish larvae, each arbor forms synapses by adding and deleting many trial and error branches. Branches with synapses in retinotopic sites are selectively stabilized and new branches are added next to existing synapses, while distant branches are deleted. The resulting arbor is compact and has a bushy appearance. When NMDARs are blocked, arbors become larger and dynamic rates increase almost twofold, suggesting that the release of a stabilizing signal has been prevented. A likely suspect for this retrograde stabilizing signal …

Biophysical Investigation Of The Cataract Associated Mutant, E107a Of Human Gamma-D Crystalline And Constructing A Fluorescent System For Manipulating Pip2 Concentration In The Plasma Membrane Of Xenopus Oocytes., Julita Patrosz

Biological Sciences

Chapter 1: Biophysical investigation of the cataract associated mutant, E107A of human gamma-D crystallin. Several human genetic cataracts are associated with mutations in a single amino acid residue of the protein known as D crystallin. Recently, the Glu107Ala (or E107A) mutation has been included in this list, and it has been associated with a nuclear congenital cataract. We have made recombinant human D crystallin and its E107A mutant and conducted preliminary comparisons of its structure and biophysical properties with that of the wild-type protein. In this process we made use of several techniques – Circular Dichroism (CD), Iso-electric focusing (IEF) …

Neural Crest Contributions To Dental Pulp Stem/Progenitor Cells And Craniofacial Structures: Alveolar Processes, Tongue And Temporomandibular Joint, Vinay Jain

Theses and Dissertations (ETD)

Background: The cranial neural crest, a transient embryonic structure in vertebrates, is crucial to craniofacial and dental development. Populations of multipotent stem cells have been identified in various dental tissues including dental pulp. Hence, identification of multipotent cells of neural crest lineage within dental pulp and delineation of neural crest contributions to various craniofacial tissues may be a step towards utilizing the potential of neural crest progenitor cells for therapeutic applications.

Objective: The overall purpose of the study was to identify a population of dental pulp stem/progenitor cells of neural crest lineage and demonstrate their neural differential potential and to …

Synthesis Of Novel Cannabinoid Ligands And Their Use As Anti-Glioma And Anti-Inflammatory Agents, Steven Neal Gurley

Theses and Dissertations (ETD)

Following the discovery of the cannabinoid receptors, research in the field of cannabinoids has grown exponentially over the last two decades. Cannabinoids have been shown to have tremendous therapeutic potential in the treatment of several pathological conditions ranging from inflammation to asthma, multiple sclerosis, Parkinson’s disease, epilepsy, glaucoma, septic shock, hemorrhagic shock, and cancer. Our research has focused on two major conditions for which cannabinoids hold great promise for drug development, namely, cancer and inflammation.

Our focus in the field of cancer has been on the devastatingly lethal brain tumor glioblastoma multiforme. Due to the high expression of the CB2 …

T-Cell Receptor Cdr3 Sequence But Not Recognition Characteristics Distinguish Autoreactive Effector And Foxp3+ Regulatory T-Cells, Xin Liu

Theses and Dissertations (ETD)

Regulatory T-cells (Treg) play an important role in maintaining immune tolerance to self-antigens and in suppressing excessive immune responses in the host. The source, specificity, and plasticity of the forkhead box transcription factor 3 (Foxp3⁺) Treg and conventional T (Tconv) cell populations active at sites of autoimmune pathology are not well characterized. To evaluate this, we combined global repertoire analyses and functional assessments of isolated T-cell receptors (TCR) from TCRa retrogenic mice with autoimmune encephalomyelitis (EAE). Treg and Tconv cell TCR repertoires were distinct, and autoantigen-specific Treg and Tconv cells were enriched in diseased tissue. Autoantigen sensitivity and …

Pain Management In Nursing Home Residents With Cancer And Dementia With And Without Hospice Services, Todd Bryant Monroe

Theses and Dissertations (ETD)

Aims: We sought to identify differences in pain management between two groups; nursing home residents with malignant cancer and dementia with and without hospice services.

Methods: Decedent records from 2003-2009 were assessed for diagnosis of dementia and cause of death as cancer. Ten malignant cancer diagnoses were determined a priori from the CDC 2004 data on the top 10 malignant cancers for all races and genders. Fifty-five decedents from 10 nursing homes were included in the final sample. Four instruments were used: Minimum Data Set (MDS) a standardized assessment tool required of most U.S. nursing homes. A large …

Glycan Shielding Of The Influenza Virus Hemagglutinin Elicits Evasion Of The Adaptive Immune Response And T-Cell-Driven Pathology, Keith C. Wanzeck

Theses and Dissertations (ETD)

Three separate influenza pandemics have emerged in the human population since 1918, each characterized by viruses that lack N-linked glycosylation sites on the globular head of the hemagglutinin protein. In contrast, recent non-pandemic isolates have acquired such sites. Here we constructed isogenic viruses containing differing numbers of additional N-linked glycosylation sites to assess the impact on the host immune response. These studies show that mice infected with a glycosylated virus remain susceptible to challenge with a non-glycosylated virus, glycosylated viruses elicit an inferior immune response, and in this context T-cell pathology and death may occur. We conclude from these data …

Tdiscovery And Development Of Novel Therapeutic Agents For Advanced Melanoma, Zhao Wang

Theses and Dissertations (ETD)

Malignant melanoma is the most dangerous form of skin cancer and accounts for about 75% of skin cancer deaths. Once diagnosed at the metastatic stage, it has a very poor prognosis with a median survival rate of 6 months and a 5-year survival rate of less than 5%. In addition, melanoma has become an important public health hazard owing to its rising incidence, which has been well documented over the past 50 years. Currently there is no effective way to treat melanoma. It is highly resistant to existing chemotherapy, radiotherapy, and immunotherapy. Over the past 30 years, only two drugs …

Ns1 Of H5n1 Interacts With Sap-97 In A Pdz-Dependent Manner To Disrupt Epithelial Barrier Integrity, Veronica Garcia Conoley

Theses and Dissertations (ETD)

The ability of influenza A virus to cause global pandemics has been a great concern throughout history and poses a serious health risk worldwide. Pandemic outbreaks throughout history, such as the Spanish flu of 1918, have claimed the lives of millions of people worldwide. The current outbreak of avian influenza (H5N1) that began in 1997 is still claiming lives, and therefore efforts to understand the mechanisms of pathogenesis in this highly virulent virus are of the utmost importance. According to the World Health Organization, there have been 447 reported H5N1 human cases, resulting in 263 deaths. The pathology of H5N1 …

The Anti-Epileptic Drugs Phenytoin And Valproate Produce Reproductive Endocrine Dysfunction Among Reproductive Endocrine Dysfunction Among Female Rats Through Its Effects On Progesterone And Its 5 Alpha-Reduced Metabolites, Fareed Haddad

Biological Sciences

Background: Many people with seizure disorder experience reproductive endocrine dysfunction (RED). The extent to which RED is due to intrinsic aspects of seizure disorder, and/or therapies used to manage epilepsy, is not well understood. Many anti-epileptic drugs (AEDs), such as phenytoin or valproate, can have effects that alter endocrine status. Phenytoin is a cytochrome p450 enzyme-inducing drug. Valproate is a cytochrome p450 enzyme-reducing AED. Objective: To evaluate the effects and mechanism of some AEDs on RED in a rodent model. Hypothesis: If AEDs produce RED in part by altering the activities of cytochrome p450 enzymes, then AEDs that disrupt estrous …

1 The Mechanical Function Of The Postorbital Bar In Eulemur Fulvus Analyzed Using Finite Element Analysis, Danielle Parisi

Biological Sciences

No abstract provided.

Tamoxifen: Mechanisms Of Resistance, Cyrus Mccoy Adams

Theses and Dissertations (ETD)

The role of estrogen in breast cancer has been recognized for decades. The selective estrogen receptor modulator tamoxifen was the first targeted therapy for the treatment of breast cancer. It was also the first drug approved by the FDA for the reduction of breast cancer risk. While tamoxifen has extended the lives of countless patients with breast cancer, resistance to tamoxifen remains a significant clinical problem. Work over the last two decades has greatly enhanced our understanding of the molecular mechanisms by which breast cancer cells may become resistant to tamoxifen treatment. Here I review our current understanding of the …

Systems Biology Approach To Identifying Host Interactive Pathways Modulating The Severity Of Streptococcal Sepsis, Nourtan Fatthy Abdeltawab

Theses and Dissertations (ETD)

Clinical outcomes of infectious diseases are controlled by complex interactions between the host and the pathogen. Epidemiological, genetic and molecular studies in my mentor’s laboratory provided evidence that in invasive Group A streptococcal (GAS) infections, genetic variations in both bacteria and patients influenced the severity of GAS sepsis. Allelic variations in class II human leukocyte antigens (HLA) contributed significantly to differences in the severity of group A streptococcal sepsis caused by the same virulent strain of the bacteria. HLA class II molecules present streptococcal superantigens (SAgs) to T cells, and variations in HLA class II molecules can strongly influence SAg …

The Design And Synthesis Of Novel Antimicrobial Agents For Use In The Battle Against Bacterial Resistance, Joshua Randal Brown

Theses and Dissertations (ETD)

There is an ever increasing need to develop new antimicrobial agents with novel mechanisms of action. These new agents will help to combat the steady rise of antibiotic-resistant bacteria which are becoming more and more difficult to treat due to the dwindling number of antibiotics available to treat such organisms. This body of work brings to light the many ways in which medicinal chemistry plays a vital role in the discovery of novel antimicrobial agents. Chapter 1 is an introduction into antimicrobial agents. It provides a brief history of the discovery of antimicrobial agents, and delves into reasons why new …

Transcriptional Regulation Of Azole Antifungal Resistance And Tolerance In Candida Glabrata, Kelly E. Caudle

Theses and Dissertations (ETD)

Azole antifungal resistance has emerged as a significant problem in the management of infections caused by fungi including Candida species. In recent years, Candida glabrata has become the second most common cause of mucosal and invasive fungal infections in humans second to Candida albicans. Not only are systemic C. glabrata infections characterized by high mortality rates, treatment failures to the azole class of antifungals, the most widely used antifungal for treatment of Candida infections, have been reported. Contributing to this problem, C. glabrata exhibits intrinsic reduced susceptibility to the azole antifungals, and the development of high-level azole resistance …

Population Pharmacokinetics Of Therapeutic Monoclonal Antibodies: Examples And Estimation Method Performance Differences, Nathanael Le Dirks

Theses and Dissertations (ETD)

Over the past two decades, there has been an increase in the research and development and therapeutic application of monoclonal antibodies (mAbs). An application of pharmacokinetic (PK) and pharmacodynamic concepts that has likely contributed to the success of the pre-clinical and clinical drug development of therapeutic mAbs is population PK, which attempts to quantify the typical disposition characteristics and sources of PK variability (such as between-subject, within-subject, and inter-occasion variability) within study populations. Population PK also attempts to identify and quantify the impact of covariates on systemic drug exposure and assess their potential implications for clinical dosing. The general theme …

Ethnobotanical History And Seed Oil Chemistry Of The Physic Nut, Jatropha Curcas, Nathan M. Leclear

Theses and Dissertations - UTB/UTPA

Jatropha curcas L., Euphorbiaceae, is a small tree native to the neotropics. Despite renewed economic interests in Physic Nut, mainly for biodiesel production, a comprehensive analysis of the ethnobotanical history of J. curcas is lacking. An account of the pre-Columbian neotropical distribution of this species and its historical uses are presented. Using capillary gas chromatography, studies were conducted to quantify the natural variation in seed oil content and fatty acid composition of the seed oil from several species of Jatropha, including assessment of how these parameters change during seed maturation. Natural variation in seed oil content was detected (F7,93 = …